PPARs: Lipid Sensors that Regulate Cell Differentiation Processes

Nutritional Genomics: Impact on Health and Disease

Volumn , Issue , 2006, Pages 117-131

  Varnat, Frédéric ^a   Michalik, Liliane ^a   Desvergne, Béatrice ^a   Wahli, Walter ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Lipid sensors; Nutrigenomics; Nutritional genomics; Peroxisome proliferator activated receptor beta delta; Peroxisome proliferator activated receptor gamma; Regulate cell differentiation processes

Indexed keywords

EID: 32644488882     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/3527608109.ch7     Document Type: Chapter

References (50)

1. Nuclear Receptors Nomenclature Committee (1999) A unified nomenclature system for the nuclear receptor superfamily. Cell 97, 161-163.
2. Desvergne, B., W. Wahli (1999) Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 20, 649-688.
3. Kersten, S., B. Desvergne, W. Wahli (2000) Roles of PPARs in health and disease. Nature 405, 421-424.
4. Desvergne, B., L. Michalik, W. Wahli (2004) Be fit or be sick:peroxisome proliferator-activated receptors are down the road. Mol Endocrinol 18, 1321-1332.
5. Rosen, E.D., C.J. Walkey, P. Puigserver, B.M. Spiegelman (2000) Transcriptional regulation of adipogenesis. Genes Dev 14, 1293-1307.
6. Hu, E., P. Tontonoz, B.M. Spiegelman (1995) Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha. Proc Natl Acad Sci USA 92, 9856-9860.
7. Barak, Y., M.C. Nelson, E.S. Ong, Y.Z. Jones, P. Ruiz-Lozano, K.R. Chien, A. Koder, R.M. Evans (1999) PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell 4, 585-595.
8. Rosen, E.D., P. Sarraf, A.E. Troy, G. Bradwin, K. Moore, D.S. Milstone, B.M. Spiegelman, R.M. Mortensen (1999) PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell 4, 611-617.
9. Imai, T., R. Takakuwa, S. Marchand, E. Dentz, J.M. Bornert, N. Messaddeq, O. Wendling, M. Mark, B. Desvergne, W. Wahli, P. Chambon, D. Metzger (2004) Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci USA 101, 4543-4547.
10. Altiok, S., M. Xu, B.M. Spiegelman (1997) PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via downregulation of PP2A. Genes Dev 11, 1987-1998.
11. Morrison, R.F., S.R. Farmer (1999) Role of PPARgamma in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18(INK4c) and p21(Waf1/Cip1), during adipogenesis. J Biol Chem 274, 17088-17097.
12. Rieusset, J., C. Chambrier, K. Bouzakri, E. Dusserre, J. Auwerx, J.P. Riou, M. Laville, H. Vidal (2001) The expression of the p85alpha subunit of phosphatidylinositol 3- kinase is induced by activation of the peroxisome proliferator-activated receptor gamma in human adipocytes. Diabetologia 44, 544-554.
13. Michalik, L., B. Desvergne, W. Wahli (2004) Peroxisome-proliferatoractivated receptors and cancers:complex stories. Nat Rev Cancer 4, 61-70.
14. Demetri, G.D., C.D. Fletcher, E. Mueller, P. Sarraf, R. Naujoks, N. Campbell, B.M. Spiegelman, S. Singer (1999) Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci USA 96, 3951-3956.
15. Akune, T., S. Ohba, S. Kamekura, M. Yamaguchi, U.I. Chung, N. Kubota, Y. Terauchi, Y. Harada, Y. Azuma, K. Nakamura, T. Kadowaki, H. Kawaguchi (2004) PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 113, 846-855.
16. Ali, A.A., R.S. Weinstein, S.A. Stewart, A.M. Parfitt, S.C. Manolagas, R.L. Jilka (2005) Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation. Endocrinology 146, 1226-1235.
17. Rieusset, J., F. Touri, L. Michalik, P. Escher, B. Desvergne, E. Niesor, W. Wahli (2002) A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesity and antidiabetic activity. Mol Endocrinol 16, 2628-2644.
18. Lefebvre, M., B. Paulweber, L. Fajas, J. Woods, C. McCrary, J.F. Colombel, J. Najib, J.C. Fruchart, C. Datz, H. Vidal, P. Desreumaux, J. Auwerx (1999) Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells. J Endocrinol 162, 331-340.
19. Koeffler, H.P. (2003) Peroxisome proliferator-activated receptor gamma and cancers. Clin Cancer Res 9, 1-9.
20. Gupta, R.A., P. Sarraf, J.A. Brockman, S.B. Shappell, L.A. Raftery, T.M. Willson, R.N. DuBois (2003) Peroxisome proliferatoractivated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22. J Biol Chem 278, 7431-7438.
21. Gupta, R.A., J.A. Brockman, P. Sarraf, T.M. Willson, R.N. DuBois (2001) Target genes of peroxisome proliferator-activated receptor gamma in colorectal cancer cells. J Biol Chem 276, 29681-29687.
22. Osawa, E., A. Nakajima, K. Wada, S. Ishimine, N. Fujisawa, T. Kawamori, N. Matsuhashi, T. Kadowaki, M. Ochiai, H. Sekihara, H. Nakagama (2003) Peroxisome proliferatoractivated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice. Gastroenterology 124, 361-367.
23. Sarraf, P., E. Mueller, D. Jones, F.J. King, D.J. DeAngelo, J.B. Partridge, S.A. Holden, L.B. Chen, S. Singer, C. Fletcher, B.M. Spiegelman (1998) Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Nat Med 4, 1046-1052.
24. Gupta, R.A., P. Sarraf, E. Mueller, J.A. Brockman, J.J. Prusakiewicz, C. Eng, T.M. Willson, R.N. DuBois (2003) Peroxisome proliferatoractivated receptor gamma-mediated differentiation: a mutation in colon cancer cells reveals divergent and cell type-specific mechanisms. J Biol Chem 278, 22669-22677.
25. Michalik, L., B. Desvergne, W. Wahli (2003) Peroxisome proliferatoractivated receptors beta/delta:emerging roles for a previously neglected third family member. Curr Opin Lipidol 14, 129-135.
26. Amri, E.Z., F. Bonino, G. Ailhaud, N.A. Abumrad, P.A. Grimaldi (1995) Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors. J Biol Chem 270, 2367-2371.
27. Clarke, S.L., C.E. Robinson, J.M. Gimble (1997) CAAT/enhancer binding proteins directly modulate transcription from the peroxisome proliferator-activated receptor gamma 2 promoter. Biochem Biophys Res Commun 240, 99-103.
28. Bastie, C., D. Holst, D. Gaillard, C. Jehl-Pietri, P.A. Grimaldi (1999) Expression of peroxisome proliferatoractivated receptor PPARdelta promotes induction of PPARgamma and adipocyte differentiation in 3T3C2 fibroblasts. J Biol Chem 274, 21920-21925.
29. Vosper, H., G.A. Khoudoli, C.N. Palmer (2003) The peroxisome proliferator activated receptor delta is required for the differentiation of THP-1 monocytic cells by phorbol ester. Nucl Recept 1, 9.
30. Saluja, I., J.G. Granneman, R.P. Skoff (2001) PPAR delta agonists stimulate oligodendrocyte differentiation in tissue culture. Glia 33, 191-204.
31. Peters, J.M., S.S. Lee, W. Li, J.M. Ward, O. Gavrilova, C. Everett, M.L. Reitman, L.D. Hudson, F.J. Gonzalez (2000) Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta). Mol Cell Biol 20, 5119-5128.
32. Varnat, F., B. Bordier-ten Heggeler, N. Boucard, I. Corthésy, W. Wahli, B. Desvergne (2005) PPAR-beta mediates the intestinal innate immunity by controlling the Paneth cell differentiation. Thesis work, presented on 17 December 2004.
33. Nadra, K. (2005) Role of PPAR-beta in placenta development. Thesis work, presented on 25 February 2005.
34. Komuves, L.G., K. Hanley, A.M. Lefebvre, M.Q. Man, D.C. Ng, D.D. Bikle, M.L. Williams, P.M. Elias, J. Auwerx, K.R. Feingold (2000) Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo. J Invest Dermatol 115, 353-360.
35. Mao-Qiang, M., A.J. Fowler, M. Schmuth, P. Lau, S. Chang, B.E. Brown, A.H. Moser, L. Michalik, B. Desvergne, W. Wahli, M. Li, D. Metzger, P.H. Chambon, P.M. Elias, K.R. Feingold (2004) Peroxisomeproliferator- activated receptor (PPAR)- gamma activation stimulates keratinocyte differentiation. J Invest Dermatol 123, 305-312.
36. Schmuth, M., C.M. Haqq, W.J. Cairns, J.C. Holder, S. Dorsam, S. Chang, P. Lau, A.J. Fowler, G. Chuang, A.H. Moser, B.E. Brown, M. Mao-Qiang, Y. Uchida, K. Schoonjans, J. Auwerx, P. Chambon, T.M. Willson, P.M. Elias, K.R. Feingold (2004) Peroxisome proliferator-activated receptor (PPAR)- beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol 122, 971-983.
37. Tan, N.S., L. Michalik, N. Noy, R. Yasmin, C. Pacot, M. Heim, B. Fluhmann, B. Desvergne, W. Wahli (2001) Critical roles of PPAR beta/ delta in keratinocyte response to inflammation. Genes Dev 15, 3263-3277.
38. Rosenfield, R.L., A. Kentsis, D. Deplewski, N. Ciletti (1999) Rat preputial sebocyte differentiation involves peroxisome proliferatoractivated receptors. J Invest Dermatol 112, 226-232.
39. Kim, M.J., D. Deplewski, N. Ciletti, S. Michel, U. Reichert, R.L. Rosenfield (2001) Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development. Mol Genet Metab 74, 362-369.
40. Chen, W., C.C. Yang, H.M. Sheu, H. Seltmann, C.C. Zouboulis (2003) Expression of peroxisome proliferatoractivated receptor and CCAAT/ enhancer binding protein transcription factors in cultured human sebocytes. J Invest Dermatol 121, 441-447.
41. Michalik, L., B. Desvergne, N.S. Tan, S. Basu-Modak, P. Escher, J. Rieusset, J.M. Peters, G. Kaya, F.J. Gonzalez, J. Zakany, D. Metzger, P. Chambon, D. Duboule, W. Wahli (2001) Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J Cell Biol 154, 799-814.
42. Di-Poi, N., N.S. Tan, L. Michalik, W. Wahli, B. Desvergne (2002) Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol Cell 10, 721-733.
43. Tan, N.S., L. Michalik, N. Di-Poi, C.Y. Ng, N. Mermod, A.B. Roberts, B. Desvergne, W. Wahli (2004) Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression. EMBO J 23, 4211-4221.
44. Di-Poi, N., C.Y. Ng, N.S. Tan, Z. Yang, B.A. Hemmings, B. Desvergne, L. Michalik, W. Wahli (2005) Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development. Mol Cell Biol 25, 1696-1712.
45. Karam, S.M. (1999) Lineage commitment and maturation of epithelial cells in the gut. Front Biosci 4, D286-298.
46. Ganz, T. (2003) Microbiology: Gut defence. Nature 422, 478-479.
47. Stappenbeck, T.S., L.V. Hooper, J.I. Gordon (2002) Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc Natl Acad Sci USA 99, 15451-15455.
48. Porter, E.M., C.L. Bevins, D. Ghosh, T. Ganz (2002) The multifaceted Paneth cell. Cell Mol Life Sci 59, 156-170.
49. Barak, Y., D. Liao, W. He, E.S. Ong, M.C. Nelson, J.M. Olefsky, R. Boland, R.M. Evans (2002) Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci USA 99, 303-308.
50. Rossant, J., J.C. Cross (2001) Placental development: lessons from mouse mutants. Nat Rev Genet 2, 538-548.