Macrocyclic diacylglycerol-bis-lactones as conformationally constrained analogues of diacylglycerol-lactones. Interactions with protein kinase C

Journal of Medicinal Chemistry

Volumn 47, Issue 16, 2004, Pages 4000-4007

  Kang, Ji Hye ^a   Kim, Su Yeon ^a   Lee, Jeewoo ^a   Marquez, Victor E ^b   Lewin, Nancy E ^c   Pearce, Larry V ^c   Blumberg, Peter M ^c  

^a Seoul National University   (South Korea)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 HYDROXYMETHYL 3,22 DIOXABICYCLO[18.2.1]TRIEICOS 19 ENE 4,21 DIONE; DIACYLGLYCEROL BISLACTONE DERIVATIVE; DIACYLGLYCEROL DERIVATIVE; DIACYLGLYCEROL LACTONE DERIVATIVE; LACTONE DERIVATIVE; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; ENTROPY; ENZYME BINDING; HYDROGEN BOND; HYDROPHOBICITY; ISOMERISM; LIGAND BINDING; LIPOPHILICITY; MOLECULAR DYNAMICS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

DIGLYCERIDES; LACTONES; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN KINASE C;

EID: 3242768357     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0497747     Document Type: Article

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