Altered cytochrome P450 and P-glycoprotein levels in rats during simulated weightlessness

Aviation Space and Environmental Medicine

Volumn 73, Issue 2, 2002, Pages 112-118

  Lu, Shirley K ^a   Bai, Shuang ^a   Javeri, Khalid ^a   Brunner, Lane J ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Cytochrome P450; Microgravity; P glycoprotein; Simulated weightlessness; Tail suspension

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2C11; CYTOCHROME P450 2E1; GLYCOPROTEIN P;

ANIMAL TISSUE; ARTICLE; DRUG METABOLISM; LIVER; MALE; MICROGRAVITY; NONHUMAN; RAT; SIMULATION; SMALL INTESTINE; SPACE FLIGHT; WEIGHTLESSNESS; WESTERN BLOTTING;

ALKANE 1-MONOOXYGENASE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; ENERGY METABOLISM; MALE; MEMBRANE PROTEINS; MIXED FUNCTION OXYGENASES; MODELS, ANIMAL; P-GLYCOPROTEIN; RATS; RATS, SPRAGUE-DAWLEY; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; WEIGHTLESSNESS SIMULATION;

ANIMALIA;

EID: 0036165888     PISSN: 00956562     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Effect of simulated weightlessness on phase II drug metabolism in the rat
2. Cyclosporine suppresses rat hepatic cytochrome P450 in a time-dependent manner
3. Serum antipyrine concentrations determined by micellar electrokinetic capillary chromatography
4. Antipyrine pharmacokinetics in the tail-suspended rat model
5. Cardiovascular deconditioning during space flight and the use of saline as a countermeasure to orthostatic intolerance
6. Echocardiographic evaluation of space shuttle crewmembers
7. Metabolic consequences of fluid shifts induced by microgravity
8. Relationship between p-glycoprotein expression and cyclosporine A in kidney - An immunihistological and cell culture study
9. Models of disuse: A comparison of hindlimb suspension and immobilization
10. Structure and function of P-glycoprotein in normal liver and small intestine
11. Atrophy and growth failure of rat hind-limb muscles in tail-cast suspension
12. A comparison of the ontogeny of enterocytic and hepatic cytochromes P450 3A in the rat
13. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
14. Expression of P-glycoprotein in normal and malignant rat liver cells
15. Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver
16. Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in caco-2 cells
17. Effect of recovery mode following hind-limb suspension on soleus muscle composition in the rat
18. Altered carbohydrate, lipid, and xenobiotic metabolism by liver from rats flown on Cosmos 1887
19. Differences in glycogen, lipids, and enzymes in livers from rats flown on COSMOS-2044
20. Hepatic function in rats after spaceflight: Effects on lipids, glycogen, and enzymes
21. Spaceflight and bone turnover: Correlation with a new rat model of weightlessness
22. Overall physiological response to space flight
23. Identification and induction of cytochromes P450, P450IIE1 and P450 IA1 in rabbit bone marrow
24. Early central venous pressure changes in the rat during two different levels of head-down suspension
25. Alteration of renal function of rats following spaceflight
26. Hindlimb immobilization: Length-tension and contractile properties of skeletal muscle
27. 2max of rats
28. Skeletal response to simulated weightlessness: A comparison of suspension techniques