Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space

Journal of Physiology

Volumn 538, Issue 1, 2002, Pages 321-329

  Ertl, Andrew C ^a,d,e   Diedrich, André ^a   Biaggioni, Italo ^a   Levine, Benjamin D ^b   Robertson, Rose Marie ^a   Cox, James F ^c   Zuckerman, Julie H ^b   Pawelczykd, James A ^d,e   Ray, Chester A ^d,e   Buckey Jr , Jay C ^f   Lane, Lynda D ^a   Shiavi, Richard ^a   Gaffney, F Andrew ^a   Costa, Fernando ^a   Holt, Carol ^a   Blomqvist, C Andrew ^b   Eckberg, Dwain L ^c   Baisch, Friedhelm J ^g   Robertson, David ^h  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d PENNSYLVANIA STATE UNIVERSITY   (United States)

^e PENN STATE COLLEGE OF MEDICINE   (United States)

^f DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^g Raumfahrt Institute of Aerospace Medicine   (Germany)

^h VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NORADRENALIN;

ADAPTATION; ADRENERGIC SYSTEM; ADULT; ANEMIA; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; COSMONAUT; FINGER; HEART HEMODYNAMICS; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPOTHESIS; HYPOVOLEMIA; KINETICS; MALE; MEASUREMENT; MICROGRAVITY; NORADRENALIN BLOOD LEVEL; NORMAL HUMAN; ORTHOSTATIC HYPOTENSION; PERONEUS NERVE; PHOTOELECTRIC PLETHYSMOGRAPHY; PLASMA CLEARANCE; PRIORITY JOURNAL; SIMULATION; SPACE FLIGHT; STANDING; SUPINE POSITION; SYMPATHETIC FUNCTION; SYNCOPE; LOWER BODY NEGATIVE PRESSURE; MUSCLE SYMPATHETIC NERVE ACTIVITY; ORTHOSTATIC STRESS;

NASA DISCIPLINE CARDIOPULMONARY; NON-NASA CENTER;

FLIGHT EXPERIMENT; MANNED; SHORT DURATION; STS-90 SHUTTLE PROJECT;

ADULT; ASTRONAUTS; BLOOD PRESSURE; HEART RATE; HUMANS; KINETICS; LOWER BODY NEGATIVE PRESSURE; MALE; MUSCLE, SKELETAL; NOREPINEPHRINE; SPACE FLIGHT; SYMPATHETIC NERVOUS SYSTEM;

EID: 0036403234     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2001.012576     Document Type: Article

References (47)

1. ALFREY, C. P., UDDEN, M. M., LEACH-HUNTOON, C., DRISCOLL, T. & PICKETT, M. H. (1996). Control of red blood cell mass in spaceflight. Journal of Applied Physiology 81, 98-104.
2. BAILY, R. G., PROPHET, S. A., SHENBERGER, J. S., ZELIS, R. & SINOWAY, L. I. (1990). Direct neurohumoral evidence for isolated sympathetic nervous system activation to skeletal muscle in response to cardiopulmonary baroreceptor unloading. Circulation Research 66, 1720-1728.
3. BAISCH, F. J. & PETRAT, G. (1993). Body fluid distribution in man in space and effect of lower body negative pressure treatment. The Clinical Investigator 71, 690-699.
4. BECK, L., BAISCH, F., GAFFNEY, F. A., BUCKEY, J. C., ARBEILLE, PH., PATAT, F., TEN HARKEL, A. D. J., HILLEBRECHT, A., SCHULZ, H., KAREMAKER, J. M., MEYER, M. & BLOMQVIST, C. G. (1992). Cardiovascular responses to lower body negative pressure before, during, and after ten days head-down tilt bedrest. In Head-down Tilt Bedrest. HDT '88 - An International Collaborative Effort in Integrated Systems Physiology, ed. SALTIN, B., BAISCH, F., BECK, L., BLOMQVIST, C. G. & KAREMAKER, J. M. Acta Physiologica Scandinavica 144, suppl. 604, 43-52.
5. BOOMSMA, F., ALBERTS, G., VAN EIJK, L., MAN IN'T VELD, A. J. & SCHALEKAMP, M. A. D. H. (1993). Optimal collection and storage conditions for catecholamine measurements in human plasma and urine. Clinical Chemistry 39, 2503-2508.
6. BUCKEY, J. C. JR, GAFFNEY, F. A., LANE, L. D., LEVINE, B. D., WATENPAUGH, D. E., WRIGHT, S. J., YANCEY, C. W. JR, MEYER, D. M. & BLOMQVIST, C. G. (1996a). Central venous pressure in space. Journal of Applied Physiology 81, 19-25.
7. BUCKEY, J. C. JR, LANE, L. D., LEVINE, B. D., WATENPAUGH, D. E., WRIGHT, S. J., MOORE, W. E., GAFFNEY, F. A. & BLOMQVIST, C. G. (1996b). Orthostatic intolerance after spaceflight. Journal of Applied Physiology 81, 7-18.
8. CONVERTINO, V. A., DOERR, D. F., LUDWIG, D. A. & VERNIKOS, J. (1994). Effect of simulated microgravity on cardiopulmonary baroreflex control of forearm vascular resistance. American Journal of Physiology 266, R1962-1969.
9. CONVERTINO, V. A., LUDWIG, D. A., GRAY, B. D. & VERNIKOS, J. (1998). Effects of exposure to simulated microgravity on neuronal catecholamine release and blood pressure responses to norepinephrine and angiotensin. Clinical Autonomic Research 8, 101-110.
10. COX, J. F., TAHVANAINEN, K. U. O., KUUSELA, T. A., LEVINE, B. D., COOKE, W. H., MANO, T., IWASE, S., SAITO, M., SUGIYAMA, Y., ERTL, A. C., BIAGGIONI, L, DIEDRICH, A., ROBERTSON, R. M., ZUCKERMAN, J. H., LANE, L. D., RAY, C. A., WHITE, R. J., PAWELCZYK, J. A., BUCKEY, J. C. JR, BAISCH, F. J., BLOMQVIST, C. G., ROBERTSON, D. & ECKBERG, D. L. (2002). Influence of microgravity on astronauts' sympathetic and vagal responses to Valsalva's manoeuvre. Journal of Physiology 538, 309-320.
11. ERTL, A. C. & NEUROLAB AUTONOMIC TEAM INVESTIGATORS (1998). Sympathetic response to orthostatic stress is preserved in space. Circulation 98 (suppl. S), I-471.
12. ESLER, M. (1993). Clinical application of noradrenaline spillover methodology: delineation of regional human sympathetic nervous responses. Pharmacology and Toxicology 73, 243-253.
13. ESLER, M., JENNINGS. G., LAMBERT, G., MEREDITH, I., HORNE, M. & EISENHOFER, G. (1990). Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions. Physiological Reviews 70, 963-985.
14. FAGIUS, J. & WALLIN, B. G. (1993). Long-term variability and reproducibility of resting human muscle nerve sympathetic activity at rest, as reassessed after a decade. Clinical Autonomic Research 3, 201-205.
15. FRITSCH-YELLE, J. M., WHITSON, P. A., BONDAR, R. L. & BROWN, T. E. (1996). Subnormal norepinephrine release relates to presyncope in astronauts after spaceflight. Journal of Applied Physiology 81, 2134-2141.
16. GOLDSTEIN, D. S., VERNIKOS, J., HOLMES, C. & CONVERTINO, V. A. (1995). Catecholaminergic effects of prolonged head-down bed rest. Journal of Applied Physiology 78, 1023-1029.
17. JACOB, G., COSTA, F., SHANNON, J. R., ROBERTSON, R. M., WATHEN,M., STEIN, M., BIAGGIONI, I, ERTL, A., BLACK, B. & ROBERTSON, D. (2000). The neuropathic postural tachycardia syndrome. New England Journal of Medicine 343, 1008-1014.
18. JACOB, G., ERTL, A. C., SHANNON, J. R., FURLAN, R., ROBERTSON, R. M. & ROBERTSON, D. (1998). Effect of standing on neurohumoral responses and plasma volume in healthy subjects. Journal of Applied Physiology 84, 914-921.
19. JOHNSON, P. C., DRISCOLL, T. B. & LEBLANC, A. D. (1977). Blood volume changes. In Biomedical Results from Skylab, ed. JOHNSTON, R. S. & DIETLEIN, L. F., pp. 235-241. National Aeronautics and Space Administration, Washington, DC, USA.
20. JOHNSON, R. L., HOFFLER, G. W., NICOGOSSIAN, A. E., BERGMAN, S. A. JR & JACKSON, M. M. (1977). Lower body negative pressure: third manned Skylab mission. In Biomedical Results from Skylab, ed. JOHNSTON, R. S. & DIETLEIN, L. F., pp. 284-312. National Aeronautics and Space Administration, Washington, DC, USA.
21. KAMIYA, A., IWASE, S., SUGIYAMA, Y., MANO, T. & SUDOH, M. (2000). Vasomotor sympathetic nerve activity in men during bed rest and on orthostasis after bed rest. Aviation, Space, and Environmental Medicine 71, 142-149.
22. KVETŇANSKÝ, R., NOSKOV, V. B., BLAZICEK, P., GHARIB, C., POPOVA, I. A., GAUQUELIN, G., MACHO, L., GUELL, A. & GRIGORIEV, A. I. (1991). Activity of the sympathoadrenal system in cosmonauts during 25-day space flight on Station Mir. Acta Astronautica 23, 109-116.
23. LEACH, C. S., ALFREY, C. P., SUKI, W. N., LEONARD, J. L., RAMBAUT,P. C., INNERS, L. D., SMITH, S. M., LANE, H. W. & KRAUHS, J. M. (1996). Regulation of body fluid compartments during short-term spaceflight. Journal of Applied Physiology 81, 105-116.
24. LEACH, C. S., ALTCHULER, S. I. & CINTRON-TREVINO, N. M. (1983). The endocrine and metabolic responses to space flight. Medicine and Science in Sports and Exercise 15, 432-440.
25. LEACH, C. S. & RAMBAUT, P. C. (1977). Biochemical responses of the Skylab crewmen: an overview. In Biomedical Results from Skylab, ed. JOHNSTON, R. S. & DIETLEIN, L. S., pp. 204-215. National Aeronautics and Space Administration, Washington, DC, USA.
26. LEVINE, B. D., PAWELCZYK, J. A., ERTL, A. C., COX, J. F., ZUCKERMAN, J. H., DIEDRICH, A., BIAGGIONI, I., RAY, C. A., SMITH, M. L., IWASE, S., SAITO, M., SUGIYAMA, Y., MANO, T., ZHANG, R., IWASAKI, K., LANE, L. D., BUCKEY, J. C. JR, COOKE, W. H., BAISCH, F. J., ROBERTSON, D., ECKBERG, D. L. & BLOMQVIST, C. G. (2002). Human muscle sympathetic neural and haemodynamnic responses to tilt following spaceflight. Journal of Physiology 538, 331-340.
27. LEVINE, B. D., ZUCKERMAN, J. H. & PAWELCZYK, J. A. (1997). Cardiac atrophy after bed-rest deconditioning: a nonneural mechanism for orthostatic intolerance. Circulation 96, 517-525.
28. MANO, T., IWASE, S. & KAMIYA, A. (1998). Sympathetic nerve responses in humans to short and long term simulation of microgravity. Journal of Gravitational Physiology 5, 93-96.
29. MEREDITH, I. T., EISENHOFER, G., LAMBERT, G. W., JENNINGS, G. L., THOMPSON, J. & ESLER, M. D. (1992). Plasma norepinephrine responses to head-up tilt are misleading in autonomic failure. Hypertension 19, 628-633.
30. NORSK, P., DRUMMER, C., RÖCKER, L., STROLLO, F., CHRISTENSEN, N. J., WARBERG, J., BIE, P., STADEAGER, C., JOHANSEN, L. B., HEER, M., GUNGA, H.-C. & GERZER, R. (1995). Renal and endocrine responses in humans to isotonic saline infusion during microgravity. Journal of Applied Physiology 78, 2253-2259.
31. PAWELCZYK, J. A., ZUCKERMAN, J. H., BLOMQVIST, C. G. & LEVINE, B. D. (2001). Regulation of muscle sympathetic nerve activity after bed rest deconditioning. American Journal of Physiology 280, H2230-2239.
32. PRISK, G. K., GUY, H. J. B., ELLIOTT, A. R., DEUTSCHMAN, R. A. III & WEST, J. B. (1993). Pulmonary diffusing capacity, capillary blood volume, and cardiac output during sustained microgravity. Journal of Applied Physiology 75, 15-26.
33. ROBERTSON, D., CONVERTINO, V. A. & VERNIKOS, J. (1994). The sympathetic nervous system and the physiological consequences of spaceflight: a hypothesis. American Journal of the Medical Sciences 308, 126-132.
34. ROBERTSON, D., JOHNSON, G. A., ROBERTSON, R. M., NIES, A. S., SHAND, D. G. & OATES, J. A. (1979). Comparative assessment of stimuli that release neuronal and adrenomedullary catecholamines in man. Circulation 59, 637-642.
35. RUMMEL, J. A., MICHEL, E. L., SAWIN, C. F. & BUDERER, M. C. (1976). Medical experiment M-171: results from the second manned Skylab mission. Aviation, Space, and Environmental Medicine 47, 1056-1060.
36. SHANNON, J. R., FLATTEM, N. L., JORDAN, J., JACOB, G., BLACK, B. K., BIAGGIONI, L, BLAKELY, R. D. & ROBERTSON, D. (2000). Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. New England Journal of Medicine 342, 541-549.
37. SHOEMAKER, J. K., HOGEMAN, C. S., LEUENBERGER, U. A., HERR, M. D., GRAY, K., SILBER, D. H. & SINOWAY, L. I. (1998). Sympathetic discharge and vascular resistance after bed rest. Journal of Applied Physiology 84, 612-617.
38. SHOEMAKER, J. K., HOGEMAN, C. S. & SINOWAY, L. I. (1999). Contributions of MSNA and stroke volume to orthostatic intolerance following bed rest. American Journal of Physiology 277, R1084-1090.
39. SHORTT, T. L. & RAY, C. A. (1997). Sympathetic and vascular responses to head-down neck flexion in humans. American Journal of Physiology 272, H1780-1784.
40. VERNIKOS, J., LUDWIG, D. A., ERTL, A. C., WADE, C. E., KELL, L. & O'HARA, D. (1996). Effect of standing or walking on physiological changes induced by head down bed rest: implications for spaceflight. Aviation, Space, and Environmental Medicine 67, 1069-1079.
41. WALLIN, B. G. (1988). Relationship between sympathetic nerve traffic and plasma concentrations of noradrenaline in man. Pharmacology & Toxicology 63 (suppl. 1), 9-11.
42. WALLIN, B. G. & ECKBERG, D. L. (1982). Sympathetic transients caused by abrupt alterations of carotid baroreceptor activity in humans. American Journal of Physiology 242, H185-190.
43. WALLIN, B. G., ESLER, M., DORWARD, P., ELSENHOFER, G., FERRIER,C., WESTERMAN, R. & JENNINGS, G. (1992). Simultaneous measurements of cardiac noradrenaline spillover and sympathetic outflow to skeletal muscle in humans. Journal of Physiology 453, 45-58.
44. WATENPAUGH, D. E., BUCKEY, J. C., LANE, L. D., GAFFNEY, F. A., LEVINE, B. D., MOORE, W. E., WRIGHT, S. J. & BLOMQVIST, C. G. (2001). Effects of spaceflight on human calf hemodynamics. Journal of Applied Physiology 90, 1552-1558.
45. WATENPAUGH, D. E. & HARGENS, A. R. (1995). The cardiovascular system in microgravity. In Handbook of Physiology, section 4, Environmental Physiology, Vol. 1, ed. FREGLY, M. J. & BLATTEIS, C. M., pp. 631-674. Oxford University Press, New York, NY, USA.
46. WHITSON, P. A., CHARLES, J. B., WILLIAMS, W. J. & CINTRÓN, N. M. (1995). Changes in sympathoadrenal response to standing in humans after spaceflight. Journal of Applied Physiology 79, 428-433.
47. YOUNG, L. R., OMAN, C. M., MERFELD, D., WATT, D., ROY, S., DELUCA, C., BALKWILL, D., CHRISTIE, J., GROLEAU, N., JACKSON, D. K., LAW, G., MODESTINO, S. & MAYER, W. (1993). Spatial orientation and posture during and following weightlessness: human experiments on Spacelab Life Sciences 1. Journal of Vestibular Research 3, 231-239.