Activation of microsomal glutathione S-transferase and inhibition of cytochrome P450 1A1 activity as a model system for detecting protein alkylation by thiourea-containing compounds in rat liver microsomes

Chemical Research in Toxicology

Volumn 12, Issue 5, 1999, Pages 396-402

  Onderwater, Rob C A ^a   Commandeur, Jan N M ^a   Menge, Wiro M P B ^a   Vermeulen, Nico P E ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DITHIOTHREITOL; ETHOXYRESORUFIN DEETHYLASE; GLUTATHIONE TRANSFERASE; PHENYLTHIOUREA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOUREA DERIVATIVE; UNSPECIFIC MONOOXYGENASE;

ALKYLATION; ANIMAL EXPERIMENT; ARTICLE; DRUG METABOLISM; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING;

ALKYLATION; ANIMALS; CYTOCHROME P-450 CYP1A1; ENZYME ACTIVATION; GLUTATHIONE TRANSFERASE; MALE; MICROSOMES, LIVER; MODELS, BIOLOGICAL; OXIDATION-REDUCTION; PROTEINS; RATS; RATS, WISTAR; THIOCHOLINE; THIOUREA;

ANIMALIA;

EID: 0032789797     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx980198p     Document Type: Article

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