Oxidized low-density lipoprotein increases the production of intracellular reactive oxygen species in endothelial cells: Inhibitory effect of lacidipine

Journal of Hypertension

Volumn 16, Issue 12 SUPPL., 1998, Pages 1913-1919

  Cominacini, Luciano ^a,c   Garbin, Ulisse ^a   Pasini, Anna Fratta ^a   Davoli, Anna ^a   Campagnola, Mario ^a   Pastorino, Antonio M ^b   Gaviraghi, Giovanni ^b   Lo Cascio, Vincenzo ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b GLAXOSMITHKLINE   (United States)

^c OSPEDALE POLICLINICO   (Italy)

Author keywords

2'7' dichlorofluorescin; Human umbilical vein endothelial cells; Lacidipine; Oxidized low density lipoprotein; Reactive oxygen species

Indexed keywords

CALCIUM ANTAGONIST; CELL ADHESION MOLECULE; COPPER ION; FLUORESCENT DYE; LACIDIPINE; OXIDIZED LOW DENSITY LIPOPROTEIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR;

CONFERENCE PAPER; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0032421731     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199816121-00010     Document Type: Conference Paper

References (48)

1. Avogaro P, Bittolo Bon G, Cazzolato G. Presence of a modified low density lipoprotein in humans. Arteriosclerosis 1988; 8:79-87.
2. Boyd HC, Gown AM, Wolfbauer G, Chait A. Direct evidence for a protein recognized by a monoclonal antibody against oxidatively modified LDL in atherosclerotic lesions from a Watanabe heritable hyperlipidemic rabbit. Am J Pathol 1989; 135:815-824.
3. Steinberg D, Parthasarathy SS, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modification of low-density lipoprotein that increases its atherogenicity. New Engl J Med 1989; 320:915-924.
4. Rosenfeld ME. Oxidized LDL affects multiple atherogenic cellular responses. Circulation 1991: 83:2137-2140.
5. Wiklund O, Mattson L, Bjornheden T, Camejo G, Bonders G. Uptake and degradation of low density lipoproteins in atherosclerotic rabbit aorta: role of local LDL modification. J Lipid Res 1991; 32:55-62.
6. Jeng JR, Chang CH, Shieh SM, Chiu HC. Oxidized low-density lipoprotein enhances monocyte-endothelial cell binding against shear-stress-induced detachment. Biochim Biophys Acta 1993; 1178:221-227.
7. Cominacini L, Garbin U, Fratta Pasini A, Davoli A, Campagnola M, Contessi GB, et al. Antioxidants inhibit the expression of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 induced by oxidized LDL on human umbilical vein endothelial cells. Free Rad Biol Med 1997; 22:117-127.
8. Cominacini L, Garbin U, Fratta Pasini A, Paulon T, Davoli A, Campagnola M, et al. Lacidipine inhibits the activation of the transcription factor NF-kappa B and the expression of adhesion molecules induced by pro-oxidant signals on endothelial cells. J Hypertens 1997; 15:1633-1639.
9. Khan BV, Parthasarathy SS, Alexander RW, Medford RM. Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells. J Clin Invest 1995; 95:262-270.
10. Neish AS, Williams AJ, Palmer HJ, Whitley MZ, Collins T. Functional analysis of the human vascular cell adhesion molecule-1 promoter. J Exp Med 1992; 176:1583-1593.
11. Voraberger G, Schafer R, Strotowa C. Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5′-regulatory region. J Immunol 1991; 147:2777-2786.
12. Iademarco MF, McQuillan JJ, Rosen GD, Dean DC. Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1). J Biol Chem 1992; 267:16323-16329.
13. Schreck R, Rieber P, Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kB transcription factor and HIV-1. EMBO J 1991; 10:2247-2258.
14. Lander HR. An essential role for free radicals and derived species in signal transduction. FASEB J 1997; 11:118-124.
15. Ohba M, Shibanuma M, Kuroki T, Nose K. Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells. J Cell Biol 1994; 126:1079-1088.
16. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 1994; 74:1141-1148.
17. 2 for platelet-derived growth factor signal transduction. Science 1995; 270:296-299.
18. Lo YY, Cruz TF. Involvement of reactive oxigen species in cytokine and growth factor induction of c-fos expression in chondrocytes. J Biol Chem 1995; 270:11 727-11 730.
19. 2-generating NADH oxidase in human lung fibroblasts by transforming growth factor 1. J Biol Chem 1995; 270:30 334-30 338.
20. Van Amsterdam FTM, Roveri A, Maiorino M, Ratti E, Ursini F. Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity. Free Rad Biol Med 1992; 12:183-187.
21. Bauskin A, Alkalay I, Ben-Neriah Y. Redox regulation of a protein tyrosine kinase in the endoplasmic reticulum. Cell 1991; 66:685-696.
22. Henkel T, Mackleidt T, Alkalay I, Kronke M, Ben-Neriah Y, Baeuerle PA. Rapid proteolysis of IkB-alpha is necessary for activation of transcription factor NF-kB. Nature 1993; 365:182-185.
23. Havel RJ, Eder MA, Bragdon JM. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 1955; 34:1345-1353.
24. Cominacini L, Garbin U, Davoli A, Micciolo R, Bosello O, Gaviraghi G. A simple test for predisposition to LDL oxidation based on the fluorescence development during copper-catalyzed oxidative modification. J Lipid Res 1991; 32:349-358.
25. Cominacini L, Garbin U, De Santis A, Campagnola M, Davoli A, Fratta Pasini A. Mechanisms involved in the in vitro modification of low density lipoprotein by human umbilical vein endothelial cells and copper ions. J Lipid Med 1996; 13:19-33.
26. Smith PK, Krohn RI, Hermanson GT, Mallia A, Garttner FH, Provenzano AC. Measurement of protein using bicinchoninic acid. Anal Biochem 1985; 105:293-299.
27. Haberland ME, Fogelman AM. Scavenger receptor-mediated recognition of maleyl bovine plasma albumin and the demaleylated protein in human monocyte macrophages. Proc Natl Acad Sci USA 1985; 82: 2693-2697.
28. Habeeb AF. Determination of free aminogroups in proteins by trinitrobenzenesulfonic acid. Anal Biochem 1966; 14:328-336.
29. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. J Clin Invest 1973; 52:2745-2752.
30. Smith CW, Marlin SD, Rothlein R, Toman C, Anderson DC. Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophilis in vitro. J Clin Invest 1989; 83:2008-2017.
31. Landegren U. Measurement of cell numbers by means of the endogenous enzyme hexosaminidase: application to detection of lymphokines and cell surface antigens. J Immunol Meth 1984; 67:379-385.
32. 2 in cultured endothelial cells. Arch Biochem Biophys 1993; 302:348-355.
33. Zulueta JJ, Sawhney R, Feng SY, Cote CC, Hassoun PM. Intracellular generation of reactive oxigen species in endothelial cells exposed to anoxiareoxygenation. Am J Physiol 1997; 272:L897-L902.
34. Corsetti JP, Weidner CH, Cianci J, Sparks E. The labeling of lipoproteins for studies of cellular binding with a fluorescent lipophilic dye. Anal Biochem 1991; 195:122-128.
35. Basu SK, Goldstein JL, Anderson RGW, Brown MS. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc Natl Acad Sci USA 1976; 73:3178-3182.
36. Cominacini L, Garbin U, Pastorino AM, Campagnola M, Fratta Pasini A, Davoli A, et al. Effects of troglitazone on in vitro oxidation of LDL and HDL induced by copper ions and endothelial cells. Diabetologia 1997; 40:165-172.
37. Carlos TM, Schwartz BR, Kovach NL, Yee E, Rosa M, Osborn L, Chi-Rosso G, et al. Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells. Blood 1990; 76:965-970.
38. Rollins BJ, Yoshimura T, Leonard EJ, Pober JS. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant MCP-1/JE. Am J Pathol 1990; 136:1229-1233.
39. Osborn L. Leukocyte adhesion to endothelium in inflammation. Cell 1990; 62:3-6.
40. Parhami F, Fang ZT, Fogelman AM, Andalibi A, Territo MC, Berliner JA. Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate. J Clin Invest 1993; 92:471-478.
41. Hahne M, Jager U, Isenmann S, Hallmann R, Vestweber D. Five tumor necrosis factor-inducible cell adhesion mechanisms on the surface of mouse endothelioma cells mediate the binding of leukocytes. J Cell Biol 1993; 121:655-664.
42. Sawamura T, Kume N, Aoyama T, Morlwaki H, Hoshikawa H, Alba Y, et al. An endothelial receptor for oxidized low-density lipoprotein. Nature 1997; 386:73-77.
43. Fialkow L, Chan CK, Gristein S, Downey GP. Regulation of tyrosine phosphorilation in neutrophilis by the NADPH oxidase. Role of reactive oxygen intermediates. J Biol Chem 1993; 269:13 725-13 728.
44. Schreck R, Meier B, Mannel DM, Droge W, Baeuerle PA. Dithiocarbamates as potent inhibitors of nuclear factor kB activation in intact cells. J Exp Med 1992; 175:1181-1194.
45. Weber C, Erl W, Pietsch A, Strobel M, Loms Ziegler-Heitbrock HW, Weber PC. Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-KB mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulate to generate radicals. Arterioscler Thromb 1994; 14:1665-1673.
46. Smith WL, Marnett LJ, De Witt DL. Prostaglandin and thromboxane biosynthesis. Pharmacol Ther 199; 49:153-179.
47. Droge W, Schulze-Hostoff K, Milm S, Galtar D, Schenk H, Eck HP, et al. Functions of glutathione and glutathione disulfide in immunology and immunopathology. Faseb J 1994; 8:1131-1138.
48. Lander HM, Milbank AJ, Taurus JM, Hajjar DP, Hempstead BL, Schwartz GD, et al. Redox regulation of cell signalling. Nature 1996; 381:380-381.