Design, synthesis, and biological activity of novel polycyclic aza-amide FKBP12 ligands

Journal of Medicinal Chemistry

Volumn 49, Issue 3, 2006, Pages 1202-1206

  Hudack Jr , Raymond A ^a   Barta, Nancy S ^a   Guo, Chuangxing ^a   Deal, Judith ^a   Dong, Liming ^a   Fay, Lorraine K ^a   Caprathe, Bradley ^a   Chatterjee, Arindam ^a   Vanderpool, Darin ^a   Bigge, Christopher ^a   Showalter, Richard ^a   Bender, Steve ^a   Augelli Szafran, Corinne E ^a   Lunney, Elizabeth ^a   Hou, Xinjun ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; BINDING PROTEIN; FKBP12 LIGAND; HETEROCYCLIC COMPOUND; NEUROIMMUNOPHILIN; POLYCYCLIC HYDROCARBON; TACROLIMUS; UNCLASSIFIED DRUG;

ARTICLE; COGNITIVE DEFECT; DIABETIC NEUROPATHY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; NERVE DEGENERATION; NERVE FIBER GROWTH; NERVE REGENERATION; OPTIC NERVE DISEASE; PARKINSON DISEASE; PERIPHERAL NERVE INJURY; STRUCTURE ACTIVITY RELATION;

AMIDES; AZA COMPOUNDS; BINDING SITES; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HYDROGEN BONDING; ISOQUINOLINES; LIGANDS; NEUROPROTECTIVE AGENTS; STRUCTURE-ACTIVITY RELATIONSHIP; TACROLIMUS; TACROLIMUS BINDING PROTEIN 1A;

EID: 32344442309     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049161u     Document Type: Article

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