A concise synthesis of AG5473/5507 utilizing N-acyliminium ion chemistry

Tetrahedron Letters

Volumn 41, Issue 28, 2000, Pages 5307-5311

  Guo, Chuangxing ^a   Reich, Siegfried ^a   Showalter, Rich ^a   Villafranca, Ernie ^a   Dong, Liming ^a  

^a AGOURON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AG 5473; AG 5507; IMMUNOSUPPRESSIVE AGENT; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CYCLIZATION; IMMUNOSUPPRESSIVE TREATMENT; NERVE REGENERATION; SYNTHESIS;

EID: 0034622362     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00846-7     Document Type: Article

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19. Although the stereochemistry of 6 was assigned by NOE experiments on 14β (major), it is not crucial for our synthesis of the targets.
20. Resolution of the two enantiomers of the amines similar to 18 is being actively pursued.