Generation of a Snail1 (Snai1) conditional null allele

Genesis (United States)

Volumn 44, Issue 1, 2006, Pages 7-11

  Murray, Stephen A ^a   Carver, Ethan A ^a,b   Gridley, Thomas ^a  

^a JACKSON LABORATORY   (United States)

^b UNIVERSITY OF TENNESSEE AT CHATTANOOGA   (United States)

Author keywords

Conditional inactivation; Cre loxP; Gene targeting

Indexed keywords

ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; DNA FLANKING REGION; EMBRYO DEVELOPMENT; EPITHELIUM CELL; EXON; GASTRULATION; GENE; GENE TARGETING; MULTIGENE FAMILY; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; SNAIL; SNAIL1 GENE; TRANSCRIPTION REGULATION;

ANIMALIA; GASTROPODA; VERTEBRATA;

EID: 32344434185     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/gene.20178     Document Type: Article

References (18)

1. Barrallo-Gimeno A, Nieto MA. 2005. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 132:3151-3161.
2. Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, Garcia De Herreros A. 2000. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2:84-89.
3. Bolos V, Peinado H, Perez-Moreno MA, Fraga MF, Esteller M, Cano A. 2003. The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci 116:499-511.
4. Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, Portillo F, Nieto MA. 2000. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2:76-83.
5. Carver EA, Jiang R, Lan Y, Oram KF, Gridley T. 2001. The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol Cell Biol 21:8184-8188.
6. Dymecki SM. 1996. A modular set of Flp, FRT and lacZ fusion vectors for manipulating genes by site-specific recombination. Gene 171:197-201.
7. Farley FW, Soriano P, Steffen LS, Dymecki SM. 2000. Widespread recombinase expression using FLPeR (flipper) mice, genesis 28:106-110.
8. Hay ED. 1995. An overview of epithelio-mesenchymal transformation. Acta Anat (Basel) 154:8-20.
9. Ikenouchi J, Matsuda M, Furuse M, Tsukita S. 2003. Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J Cell Sci 116:1959-1967.
10. Jiang R, Lan Y, Norton CR, Sundberg JP, Gridley T. 1998. The Slug gene is not essential for mesoderm or neural crest development in mice. Dev Biol 198:277-285.
11. Kalluri R, Neilson EG. 2003. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112:1776-1784.
12. Nieto MA, Bennett MF, Sargent MG, Wilkinson DG. 1992. Cloning and developmental expression of Sna, a murine homologue of the Drosophila snail gene. Development 116:227-237.
13. Person AD, Klewer SE, Runyan RB. 2005. Cell biology of cardiac cushion development. Int Rev Cytol 243:287-335.
14. Shook D, Keller R. 2003. Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development. Mech Dev 120:1351-1383.
15. Smith DE, Franco del Amo F, Gridley T. 1992. Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development. Development 116:1033-1039.
16. Swiatek PJ, Gridley T. 1993. Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes Dev 7:2071-2084.
17. Tallquist MD, Soriano P. 2000. Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function, genesis 26:113-115.
18. Thiery JP. 2003. Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15:740-746.