Modulating GABA modulators

British Journal of Pharmacology

Volumn 147, Issue 3, 2006, Pages 237-238

  Paronis, Carol A ^a  

^a MCLEAN HOSPITAL   (United States)

Author keywords

Benzodiazepine; Drug interactions; GABA A; Neuroactive steroid

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; ALFAXALONE; BENZODIAZEPINE; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; DIAZEPAM; FLUMAZENIL; LIGAND; MIDAZOLAM; NEUROSTEROID; STEROID;

BINDING SITE; DRUG ACTIVITY; DRUG BINDING; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; GABAERGIC SYSTEM; LIGAND BINDING; MEDICAL RESEARCH; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; REGULATORY MECHANISM; REVIEW;

ANIMALS; BENZODIAZEPINES; DRUG INTERACTIONS; GABA MODULATORS; HUMANS; RECEPTORS, GABA-A;

EID: 32244440381     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706552     Document Type: Review

References (11)

1. A receptors. Eur. J. Pharmacol., 325, 1-7.
2. A receptor activity by alphaxolone. Br. J. Pharmacol., 90, 491-500.
3. HAEFELY, W., MARTIN, J.R. & SCHOCH, P. (1984). Pharmacological profile of two benzodiazepine partial agonists: Ro16-6028 and Ro17-1812. Clin. Neuropharm., 7S1, 670-671.
4. A receptor function. Mol. Pharm., 46, 977-985.
5. KLEPNER, C.A., LIPPA, A.S., BENSON, D.I., SANO, M.L. & BEER, B. (1979). Resolution of two biochemically and pharmacologically distinct benzodiazepine receptors. Pharmacol. Biochem. Behav., 11, 457-462.
6. A modulators triazolam and pregnanolone in rhesus monkeys. Psychopharmacology, 158, 289-296.
7. A receptor agonists in rhesus monkeys. Psychopharmacology, 178, 400-409.
8. MCMAHON, L.R. & FRANCE, C.P. (2005b). Different behavioral effects of low efficacy positive GABAA modulators in combination with benzodiazepines and a neuroactive steroid in rhesus monkeys. Br. J. Pharmacol., 147, 260-268 (this issue).
9. A receptors. Mol. Pharmacol., 65, 1191-1197.
10. 36Cl ion flux. Mol. Pharm., 59, 1108-1118.
11. Visser, S.A.G., Huntjens, D.R.H., Van der Graff, P.H., Peletier, L.A. & Danhof, M. (2003). Mechanism-based modeling of the pharmacodynamic interaction of alphaxolone and midazolam in rats. J. Pharmacol Expt. Ther., 307, 765-775.