The human Ca2+-activated K+ channel, IK, can be blocked by the tricyclic antihistamine promethazine

Neuropharmacology

Volumn 50, Issue 4, 2006, Pages 458-467

  Wittekindt, Oliver H ^a   Schmitz, Alexander ^b   Lehmann Horn, Frank ^a   Hänsel, Wolfram ^b   Grissmer, Stephan ^a  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

IK channel; Neuroleptic; Potassium channel; Promethazine

Indexed keywords

ANTIHISTAMINIC AGENT; CALCIUM ACTIVATED POTASSIUM CHANNEL; PHENOTHIAZINE DERIVATIVE; PROMETHAZINE; TRIMETHYL[1 METHYL 2 (10H PHENOTHIAZIN 10 YL)ETHYL]AMMONIUM; UNCLASSIFIED DRUG; CALCIUM; HISTAMINE H1 RECEPTOR ANTAGONIST; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE POTENTIAL; CELL PH; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; DRUG POTENCY; ELECTRIC FIELD; EMBRYO; EXCISION; EXTRACELLULAR MATRIX; GENETIC PROCEDURES; HUMAN; HUMAN CELL; IC 50; PATCH CLAMP; PRIORITY JOURNAL; WHOLE CELL; CELL LINE; CELL MEMBRANE; DRUG ANTAGONISM; KIDNEY; PH; PHYSIOLOGY;

CALCIUM; CELL LINE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; HISTAMINE H1 ANTAGONISTS; HUMANS; HYDROGEN-ION CONCENTRATION; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; KIDNEY; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; PROMETHAZINE;

EID: 32144461587     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2005.10.005     Document Type: Article

References (42)

1. L. Amaral, J.E. Kristiansen, M. Viveiros, and J. Atouguia Activity of phenothiazines against antibiotic-resistant Mycobacterium tuberculosis: a review supporting further studies that may elucidate the potential use of thioridazine as anti-tuberculosis therapy J. Antimicrob. Chemother. 47 2001 505 511
2. + channels J. Neurosci. 22 2002 6499 6506
3. +-ATPase activity Mol. Pharmacol. 44 1993 129 141
4. C. Carignani, and M. Corsi Inhibition of SK3 channels in the TE671 human medulloblastoma cell line by desipramine and imipramine Eur. J. Pharmacol. 448 2002 139 142
5. W.J. Cook, L.J. Walter, and M.R. Walter Drug binding by calmodulin: crystal structure of a calmodulin-trifluoperazine complex Biochemistry 33 1994 15259 15265
6. W.A. Daniel Mechanisms of cellular distribution of psychotropic drugs. Significance for drug action and interactions Prog. Neuropsychopharmacol. Biol. Psychiatry 27 2003 65 73
7. B. Del Carlo, M. Pellegrini, and M. Pellegrino Calmodulin antagonists do not inhibit IK(Ca) channels of human erythrocytes Biochim. Biophys. Acta 1558 2002 133 141
8. E. Delpon, J. Tamargo, and J. Sanchez-Chapula Effects of imipramine on the transient outward current in rabbit atrial single cells Br. J. Pharmacol. 106 1992 464 469
9. D.C. Devor, A.K. Singh, L.C. Lambert, A. DeLuca, R.A. Frizzell, and R.J. Bridges Bicarbonate and chloride secretion in Calu-3 human airway epithelial cells J. Gen. Physiol. 113 1999 743 760
10. J.C. Dreixler, J. Bian, Y. Cao, M.T. Roberts, J.D. Roizen, and K.M. Houamed Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds Eur. J. Pharmacol. 401 2000 1 7
11. Ca channel, IKCa1 J. Biol. Chem. 274 1999 5746 5754
12. B.J. Forrest, and J. Mattai The displacement of phenothiazines from phospholipid binding sites by cholesterol Biochem. Biophys. Res. Commun. 114 1983 1001 1005
13. N. Galeotti, C. Ghelardini, and A. Bartolini The role of potassium channels in antihistamine analgesia Neuropharmacology 38 1999 1893 1901
14. G. Isenberg, and J. Tamargo Effect of imipramine on calcium and potassium currents in isolated bovine ventricular myocytes Eur. J. Pharmacol. 108 1985 121 131
15. Y. Ito, S. Sato, M. Son, H. Kume, K. Takagi, and K. Yamaki Bioelectric toxicity caused by chlorpromazine in human lung epithelial cells Toxicol. Appl. Pharmacol. 183 2002 198 206
16. S.H. Jo, J.B. Youm, C.O. Lee, Y.E. Earm, and W.K. Ho Blockade of the HERG human cardiac K(+) channel by the antidepressant drug amitriptyline Br. J. Pharmacol. 129 2000 1474 1480
17. + channel HIK1 J. Biol. Chem. 279 2004 15531 15540
18. J.H. Jonkman, H.G. Westenberg, N.V. Rijntjes, K.E. van der, and S.F. Lindeboom Whole body distribution of the quaternary ammonium compound thiazinamium (N-methylpromethazine) and promethazine in monkey and mice Arzneimittelforschung 33 1983 223 228
19. C.N. Karson, J.E. Newton, R. Livingston, J.B. Jolly, T.B. Cooper, J. Sprigg, and R.A. Komoroski Human brain fluoxetine concentrations J. Neuropsychiatry Clin. Neurosci. 5 1993 322 329
20. 2+)-activated potassium channels J. Neurosci. 19 1999 8830 8838
21. Ca channel in human t lymphocytes. Roles in proliferation and volume regulation J. Biol. Chem. 274 1999 14838 14849
22. + channels by various antidepressant drugs Neuropsychopharmacology 29 2004 1841 1851
23. + current: an external open channel blocker preventing fast inactivation Biophys. J. 75 1998 2845 2857
24. C. Li, and W.B. Gefter Acute pulmonary edema induced by overdosage of phenothiazines Chest 101 1992 102 104
25. T. Muller Electron microscopic demonstration of intracelluar promethazine accumulation sites by a precipitation technique: application to the cerebellar cortex of the mouse J. Histochem. Cytochem. 44 1996 531 535
26. + channel J. Gen. Physiol. 92 1988 569 586
27. J. Neyton, and C. Miller Potassium blocks barium permeation through a calcium-activated potassium channel J. Gen. Physiol. 92 1988 549 567
28. H. Ochiai, M. Kashiwagi, T. Usui, Y. Oyama, Y. Tokita, and T. Ishikawa Torsade De pointes with T wave alternans in a patient receiving moderate dose of chlorpromazine: report of a case Kokyu To Junkan 38 1990 819 822
29. N. Ogata, and T. Narahashi Block of sodium channels by psychotropic drugs in single guinea-pig cardiac myocytes Br. J. Pharmacol. 97 1989 905 913
30. + current by chlorpromazine and 4-aminopyridine in neurones of the rat dorsal root ganglia Br. J. Pharmacol. 109 1993 1239 1246
31. N. Ogata, M. Yoshii, and T. Narahashi Psychotropic drugs block voltage-gated ion channels in neuroblastoma cells Brain Res. 476 1989 140 144
32. v1.3 Mol. Pharmacol. 50 1996 1625 1634
33. 2+/calmodulin Nature 410 2001 1120 1124
34. L.C. Strenkoski-Nix, J. Ermer, S. DeCleene, W. Cevallos, and P.R. Mayer Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects Am. J. Health Syst. Pharm. 57 2000 1499 1505
35. C. Studenik, R. Lemmens-Gruber, and P. Heistracher Proarrhythmic effects of antidepressants and neuroleptic drugs on isolated, spontaneously beating guinea-pig Purkinje fibers Eur. J. Pharm. Sci. 7 1999 113 118
36. v1.3 channels Biochem. Pharmacol. 65 2003 551 561
37. G.C. Terstappen, G. Pula, C. Carignani, M.X. Chen, and R. Roncarati Pharmacological characterisation of the human small conductance calcium-activated potassium channel HSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines Neuropharmacology 40 2001 772 783
38. A.G. Teschemacher, E.P. Seward, J.C. Hancox, and H.J. Witchel Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline Br. J. Pharmacol. 128 1999 479 485
39. D. Thomas, K. Wu, S. Kathofer, H.A. Katus, W. Schoels, J. Kiehn, and C.A. Karle The antipsychotic drug chlorpromazine inhibits HERG potassium channels Br. J. Pharmacol. 139 2003 567 574
40. 2+-calmodulin Nat. Struct. Biol. 1 1994 795 801
41. J.P. Warner, T.R. Barnes, and J.A. Henry Electrocardiographic changes in patients receiving neuroleptic medication Acta Psychiatr. Scand. 93 1996 311 313
42. A.M. Woodhull Ionic blockage of sodium channels in nerve J. Gen. Physiol. 61 1973 687 708