SMAD4/DPC4 expression and prognosis in human colorectal cancer

Anticancer Research

Volumn 26, Issue 1 B, 2006, Pages 507-510

  Isaksson Mettävainio, Martin ^a   Palmqvist, Richard ^a   Forssell, Johan ^a   Stenling, Roger ^a   Öberg, Åke ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Colorectal cancer; DPC4; Immunohistochemistry; SMAD4

Indexed keywords

FORMALDEHYDE; PARAFFIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CELL NUCLEUS; CHROMOSOME 18; CLINICAL FEATURE; COLORECTAL CANCER; CORRELATION ANALYSIS; EVALUATION; FEMALE; GENE; GENE EXPRESSION; GENE INACTIVATION; GENE LOCUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SMAD4 GENE; SWEDEN; UNIVARIATE ANALYSIS;

AGED; AGED, 80 AND OVER; CELL NUCLEUS; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 32144453528     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Tomlinson I, Ilyas M and Novelli M: Molecular genetics of colon cancer. Cancer Metastasis Rev 16: 67-79, 1997.
2. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AM and Bos JL: Genetic alterations during colorectal-tumor development. N Engl J Med 319: 525-532, 1988.
3. Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH and Kern SE: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271: 350-353, 1996.
4. Derynck R and Feng XH: TGF-beta receptor signaling. Biochim Biophys Acta 1333: F105-150, 1997.
5. Engel ME, Datta PK and Moses HL: Signal transduction by transforming growth factor-beta: a cooperative paradigm with extensive negative regulation. J Cell Biochem Suppl 30-31: 111-122, 1998.
6. Markowitz SD and Roberts AB: Tumor suppressor activity of the TGF-beta pathway in human cancers. Cytokine Growth Factor Rev 7: 93-102, 1996.
7. Manning AM, Williams AC, Game SM and Paraskeva C: Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta. Oncogene 6: 1471-1476, 1991.
8. Matsushita M, Matsuzaki K, Date M, Watanabe T, Shibano K, Nakagawa T, Yanagitani S, Amoh Y, Takemoto H, Ogata N, Yamamoto C, Kubota Y, Seki T, Inokuchi H, Nishizawa M, Takada H, Sawamura T, Okamura A and Inoue K: Downregulation of TGF-beta receptors in human colorectal cancer: implications for cancer development. Br J Cancer 80: 194-205, 1999.
9. Miyaki M, Iijima T, Konishi M, Sakai K, Ishii A, Yasuno M, Hishima T, Koike M, Shitara N, Iwama T, Utsunomiya J, Kuroki T and Mori T: Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. Oncogene 18: 3098-3103, 1999.
10. Salovaara R, Roth S, Loukola A, Launonen V, Sistonen P, Avizienyte E, Kristo P, Jarvinen H, Souchelnytskyi S, Sarlomo-Rikala M and Aaltonen LA: Frequent loss of SMAD4/DPC4 protein in colorectal cancers. Gut 51: 56-59, 2002.
11. Calonge MJ and Massague J: Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells. J Biol Chem 274: 33637-33643, 1999.
12. Moses HL, Coffey RJ Jr, Leof EB, Lyons RM and Keski-Oja J: Transforming growth factor beta regulation of cell proliferation. J Cell Physiol Suppl 5: 1-7, 1987.
13. Howe JR, Roth S, Ringold JC, Summers RW, Jarvinen HJ, Sistonen P, Tomlinson IP, Houlston RS, Bevan S, Mitros FA, Stone EM and Aaltonen LA: Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science 280: 1086-1088, 1998.
14. Thiagalingam S, Lengauer C, Leach FS, Schutte M, Hahn SA, Overhauser J, Willson JK, Markowitz S, Hamilton SR, Kern SE, Kinzler KW and Vogelstein B: Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nat Genet 13: 343-346, 1996.
15. Takagi Y, Kohmura H, Futamura M, Kida H, Tanemura H, Shimokawa K and Saji S: Somatic alterations of the DPC4 gene in human colorectal cancers in vivo. Gastroenterology 111: 1369-1372, 1996.
16. Fink SP, Swinler SE, Lutterbaugh JD, Massague J, Thiagalingam S, Kinzler KW, Vogelstein B, Willson JK and Markowitz S: Transforming growth factor-beta-induced growth inhibition in a Smad4 mutant colon adenoma cell line. Cancer Res 61: 256-260, 2001.
17. Wilentz RE, Su GH, Dai JL, Sparks AB, Argani P, Sohn TA, Yeo CJ, Kern SE and Hruban RH: Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas: a new marker of DPC4 inactivation. Am J Pathol 156: 37-43, 2000.
18. Ogunbiyi OA, Goodfellow PJ, Herfarth K, Gagliardi G, Swanson PE, Birnbaum EH, Read TE, Fleshman JW, Kodner IJ and Moley JF: Confirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator. J Clin Oncol 16: 427-433, 1998.
19. Lanza G, Matteuzzi M, Gafa R, Orvieto E, Maestri I, Santini A and del Senno L: Chromosome 18q allelic loss and prognosis in stage II and III colon cancer. Int J Cancer 79: 390-395, 1998.
20. Diep CB, Thorstensen L, Meling GI, Skovlund E, Rognum TO and Lothe RA: Genetic tumor markers with prognostic impact in Dukes' stages B and C colorectal cancer patients. J Clin Oncol 21: 820-829, 2003.
21. Cohn KH, Ornstein DL, Wang F, LaPaix FD, Phipps K, Edelsberg C, Zuna R, Mott LA and Dunn JL: The significance of allelic deletions and aneuploidy in colorectal carcinoma. Results of a 5-year follow-up study. Cancer 79: 233-244, 1997.
22. Jen J, Kim H, Piantadosi S, Liu ZF, Levitt RC, Sistonen P, Kinzler KW, Vogelstein B and Hamilton SR: Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med 331: 213-221, 1994.
23. Laurent-Puig P, Olschwang S, Delattre O, Remvikos Y, Asselain B, Melot T, Validire P, Muleris M, Girodet J, Salmon RJ et al: Survival and acquired genetic alterations in colorectal cancer. Gastroenterology 102: 1136-1141, 1992.
24. Alazzouzi H, Alhopuro P, Salovaara R, Sammalkorpi H, Jarvinen H, Mecklin JP, Hemminki A, Schwartz S Jr, Aaltonen LA and Arango D: SMAD4 as a prognostic marker in colorectal cancer. Clin Cancer Res 11: 2606-2611, 2005.