Down-regulation of TGF-β receptors in human colorectal cancer: Implications for cancer development

British Journal of Cancer

Volumn 80, Issue 1-2, 1999, Pages 194-205

  Matsushita, M ^a   Matsuzaki, K ^a   Date, M ^a   Watanabe, T ^a   Shibano, K ^a   Nakagawa, T ^a   Yanagitani, S ^a   Amoh, Y ^a   Takemoto, H ^a   Ogata, N ^a   Yamamoto, C ^a   Kubota, Y ^a   Seki, T ^a   Inokuchi, H ^b   Nishizawa, M ^a   Takada, H ^a   Sawamura, T ^a   Okamura, A ^a   Inoue, K ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b Dept of Respiratory Medicine Saiseikai Noe Hospital   (Japan)

Author keywords

Colorectal adenoma; Colorectal cancer; Smad; TGF ; TGF receptor

Indexed keywords

MESSENGER RNA; PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANGIOGENESIS; ARTICLE; CANCER GROWTH; CLINICAL ARTICLE; COLON ADENOMA; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; EPITHELIUM CELL; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTERSTITIUM; MESENCHYME CELL; NORTHERN BLOTTING; PRIORITY JOURNAL; STROMA;

ADENOMA; ADULT; AGED; BLOTTING, NORTHERN; COLORECTAL NEOPLASMS; DOWN-REGULATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA;

EID: 0032920840     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690339     Document Type: Article

References (46)

1. Attisano L, Wrana JL, López-Casillas F and Massagué J (1994) TGF-β receptors and actions. BBA 1222: 71-80
2. Avery A, Paraskeva C, Hall P, Flanders KC, Sporn M and Moorghen M (1993) TGF-β expression in the human colon: differential immunostaining along crypt epithelium. Br J Cancer 68: 137-139
3. Bae HW, Geiser AG, Kim DH, Chung MT, Burmester JK, Sporn MB, Roberts AB and Kim SJ (1995) Characterization of the promoter region of the human transforming growth factor-β type II receptor gene. J Biol Chem 270: 29460-29468
4. Barnard JA, Beauchamp RD, Coffey RJ and Moses HL (1989) Regulation of intestinal epithelial cell growth by transforming growth factor type β. Proc Natl Acad Sci USA 86: 1578-1582
5. Barnard JA, Lyons RM and Moses HL (1990) The cell biology of transforming growth factor β. Biochem Biophys Acta 1032: 79-87
6. Barnard JA, Warwick GJ and Gold LI (1993) Localization of transforming growth factor β isoforms in the normal murine small intestine and colon. Gastroenterology 105: 67-73
7. 1 promoter by v-src gene products is mediated through the AP-1 complex. Mol Cell Biol 10: 4978-4983
8. 1 and its type II receptor in control of epidermal homeostasis in transgenic mice. Genes Dev 9: 945-955
9. Date M, Matsuzaki K, Matsushita M, Sakitani K, Shibano K, Okajima A, Yamamoto C, Ogata N, Okumura T, Seki T, Kubota Y, Kan M, McKeehan WL and Inoue K (1998) Differential expression of transforming growth factor-β and its receptors in hepatocytes and nonparenchymal cells of rat liver after CC14 administration. J Hepatol 28: 572-581
10. Edwards DR, Murphy G, Reynolds JJ, Whitham SE, Docherty AJP, Angel P and Heath JK (1987) Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J 6: 1899-1904
11. Fráter-Schröder M, Müller G, Birchmeier W and Böhlen P (1986) Transforming growth factor-beta inhibits endothelial cell proliferation. Biochem Biophys Res Commun 137: 295-302
12. Franzen P, ten Dijke P, Yamashita H, Schulz P, Heldin C-H and Miyazono K (1993) Cloning of a TGF-β type I receptor that forms a heteromeric complex with the TGF-β type II receptor. Cell 75: 681-692
13. He WW, Gustafson ML, Hirose S and Donahoe PK (1993) Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-β type II receptor family. Den Dyn 196: 133-142
14. Heinmark RL, Twardzik DR and Schwartz SM (1986) Inhibition of endothelial regeneration by type-beta transforming growth factor from platelets. Science 233: 1078-1080
15. 1. Exp Cell Res 181: 442-453
16. Hutter RVP and Sobin LH (1986) A universal staging system for cancer of the colon and rectum. Arch Pathol Lab Med 110: 367-368
17. Ignotz RA and Massagué J (1986) Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem 261: 4337-4345
18. Kim DH, Chang JH, Lee KH, Lee HY and Kim SJ (1997) Mechanism of E1A-induced transforming growth factor-β (TGF-β) resistance in mouse keratinocytes involves repression of TGF-β type II transcription. J Biol Chem 272: 688-694
19. Koyama S and Podolsky DK (1989) Differential expression of transforming growth factors α and β in rat intestinal epithelial cells. J Clin Invest 83: 1768-1773
20. Kurokawa M, Lynch K and Podolsky DK (1987) Effects of growth factors on an intestinal epithelial cell line: transforming growth factor β inhibits proliferation and stimulates differentiation. Biochem Biophys Res Commun 142: 775-782
21. Laiho M, Saksela O, Andreasen PA and Keski-Oja J (1986) Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblast by transforming growth factor-β. J Cell Biol 103: 2403-2410
22. Lin HY, Wang X-F, Ng-Eaton E, Weinberg RA and Lodish HF (1992) Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell 68: 775-785
23. Madri JA, Pratt BM and Tucker AM (1988) Phenotypic modulation of endothelial cells by transforming growth factor-β depends upon the composition and organization of the extracellular matrix. J Cell Biol 106: 1375-1384
24. Manning AM, Williams AC, Game SM and Paraskeva C (1991) Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor β (TGF-β): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-β. Oncogene 6: 1471-1476
25. Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B, Brattain M and Willson JKV (1995) Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 268: 1336-1338
26. Massagué J, Hata A and Liu F (1997) TGF-β signalling through the Smad pathway. Trends Cell Biol 7: 187-192
27. Mathew LS and Vale WW (1991) Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell 65: 973-982
28. Matsuzaki K, Xu J, Wang F, McKeehan WL, Krummen L and Kan M (1993) A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor β, or bone morphogenic factor. J Biol Chem 268: 12719-12723
29. Matsuzaki K, Kan M and McKeeham WL (1996) Ligand-dependent and independent interactions in assembly of a pentameric transforming growth factor beta receptor complex. In Vitro Cell Dev Biol 32: 345-360
30. Muto T, Bussey HJR and Morson BC (1975) The evolution of cancer of the colon and rectum. Cancer 36: 2251-2270
31. Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Isisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K and ten Dijke P (1997) TGF-β receptor-mediated signaling through Smad2, Smad3 and Smad4. EMBO J 16: 5353-5362
32. S716 knockout mice. Cancer Res 57: 1644-1649
33. 1. Nucleic Acids Res 18: 3059
34. Roberts AB, Anzano MA, Wakefield LM, Roche NS, Stern DF and Sporn MB (1985) Type β: transforming growth factor: a bifunctional regulator of cellular growth. Proc Natl Acad Sci USA 82: 119-123
35. Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine UI, Liotta LA, Falanga V, Kehrl JH and Fauci AS (1986) Transforming growth factor type β rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 83: 4167-4171
36. Serra R and Moses HL (1996) Tumor suppressor genes in the TGF-β signaling pathway? Nature Med 2: 390-391
37. Sporn MB and Roberts AB (1988) Peptide growth factors are multifunctional. Nature 332: 217-219
38. Sporn MB and Roberts AB (1992) Transforming growth factor-β: recent progress and new challenges. J Cell Biol 119: 1017-1021
39. Takaku K, Oshima M, Miyoshi H, Matsui M, Michael FS and Makoto MT (1998) Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 92: 645-656
40. ten Dijke P, Ichijo H, Franzén P, Schulz P, Saras J, Toyoshima H, Heldin C-H and Miyazono K (1993) Activin receptor-like kinases: a novel subclass of cell-surface receptors with preedicted serine/threonine kinase activity. Oncogene 8: 2879-2887
41. ten Dijke P, Yamashita H, Ichijo H, Franzén P, Laiho M, Miyazono K and Heldin C-H (1994) Characterization of type I receptors for transforming growth factor-β and activin. Science 204: 101-104
42. 1 in patients with colorectal cancer: association with disease progression. Gasrtoenterology 110: 375-382
43. Wang J, Han W, Zborowska E, Liang J, Wang X, Willson JKV, Sun L and Brattain MG (1996) Reduced expression of transforming growth factor β type I receptor contributes to the malignancy of human colon carcinoma cells. J Biol Chem 271: 17366-17371
44. Xu J, Matsuzaki K, McKeehan K, Wang F, Kan M and McKeehan WL (1994) Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly (A) addition. Proc Natl Acad Sci USA 91: 7957-7961
45. Xu J, McKeehan K, Matsuzaki K and McKeehan WL (1995) Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. J Biol Chem 270: 6308-6313
46. Zhang T, Nanney LB, Peeler MO, Williams CS, Lamps L, Heppner KJ, DuBois RN and Beauchamp D (1997) Decreased transforming growth factor β type II receptor expression in intenstinal adenomas from Min/+ mice is associated with increased cyclin D1 and cyclin-dependent kinase 4 expression. Cancer Res 57: 1638-1643