Effect of perfluorocarbons on brain oxygenation and ischemic damage in an acute subdural hematoma model in rats

Journal of Neurosurgery

Volumn 103, Issue 4, 2005, Pages 724-730

  Taek, Hyun Kwon ^b   Sun, Dong ^b   Daugherty, Wilson P ^b   Spiess, Bruce D ^b   Bullock, M Ross ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b NONE

Author keywords

Acute subdural hematoma; Brain tissue oxygenation; Cerebral ischemia; Perfluorocarbon; Rat

Indexed keywords

OXYGEN; PERFLUOROOCTYL BROMIDE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN ISCHEMIA; BRAIN OXYGEN TENSION; BRAIN PERFUSION; BRAIN TISSUE; CONTROLLED STUDY; DRUG INFUSION; EXPERIMENTAL MODEL; HISTOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBDURAL HEMATOMA;

EID: 32044470700     PISSN: 00223085     EISSN: 00223085     Source Type: Journal    
DOI: 10.3171/jns.2005.103.4.0724     Document Type: Article

References (60)

1. Adams JH, Graham DI, Gennarelli TA: Head injury in man and experimental animals: neuropathology. Acta Neurochir Suppl 32:15-30, 1983
2. Agardh CD, Zhang H, Smith ML, Siesjo BK: Free radical production and ischemic brain damage: influence of postischemic oxygen tension. Int J Dev Neurosci 9:127-138, 1991
3. Biro GP: Perfluorocarbon-based red blood cell substitutes. Transfus Med Rev 7:84-95, 1993
4. Bruzzone P, Dionigi R, Bellinzona G, Imberti R, Stocchetti N: Effects of cerebral perfusion pressure on brain tissue PO2 in patients with severe head injury. Acta Neurochir Suppl (Wien) 71:111-113, 1998
5. Bullock MR: Hyperoxia: good or bad? J Neurosurg 98:943-944, 2003
6. Bullock R, Butcher S, McCulloch J: Changes in extracellular glutamate concentration after acute subdural haematoma in the rat - evidence for an "excitotoxic" mechanism? Acta Neurochir Suppl (Wien) 51:274-276, 1990
7. Bullock R, Butcher SP, Chen MH, Kendall L, McCulloch J: Correlation of the extracellular glutamate concentration with extent of blood flow reduction after subdural hematoma in the rat. J Neurosurg 74:794-802, 1991
8. Burger R, Vince GH, Meixensberger J, Bendszus M, Roosen K: Interrelations of laser doppler flowmetry and brain tissue oxygen pressure during ischemia and reperfusion induced by an experimental mass lesion. J Neurotrauma 16:1149-1164, 1999
9. Chance B, Oshimo N, Sugamo T, Mayersky A: Basic principles of tissue oxygen determination from mitochondrial signals, in Bicher HI, Bruley DF (eds): Oxygen Transport to Tissue. New York: Plenum, 1973, pp 277-292
10. Charbel FT, Hoffman WE, Misra M, Hannigan K, Ausman JI: Cerebral interstitial tissue oxygen tension, pH, HCO3, CO2. Surg Neurol 48:414-417, 1997
11. Di X, Bullock R: Effect of the novel high-affinity glysine-site N-methyl-D-aspartate antagonist ACEA-1021 on 125I-MK-801 binding after subdural hematoma in the rat: an in vivo autoradiographic study. J Neurosurg 85:655-661, 1996
12. Dings J, Meixensberger J, Amschler J, Hamelbeck B, Roosen K: Brain tissue pO2 in relation to cerebral perfusion pressure, TCD findings and TCD-CO2-reactivity after severe head injury. Acta Neurochir (Wien) 138:425-434, 1996
13. Dings J, Meixensberger J, Jager A, Roosen K: Clinical experience with 118 brain tissue oxygen partial pressure catheter probes. Neurosurgery 43:1082-1095, 1998
14. Doppenberg EM, Rice MR, Alessandri B, Qian Y, Di X, Bullock R: Reducing hemoglobin oxygen affinity does not increase hydroxyl radicals after acute subdural hematoma in the rat. J Neurotrauma 16:123-133, 1999
15. Doppenberg EMR, Zauner A, Bullock R, Ward JD, Fatouros PP, Young HF: Correlations between brain tissue oxygen tension, carbon dioxide tension, pH, and cerebral blood flow - a better way of monitoring the severely injured brain? Surg Neurol 49:650-654, 1998
16. Duhaime AC, Gennarelli LM, Boardman C: Neuroprotection by dextromethorphan in acute experimental subdural hematoma in the rat. J Neurotrauma 13:79-84, 1996
17. Duhaime AC, Gennarelli LM, Yachnis A: Acute subdural hematoma: is the blood itself toxic? J Neurotrauma 11:669-678, 1994
18. Fujisawa H, Maxwell WL, Graham DI, Teasdale GM, Bullock R: Focal microvascular occlusion after acute subdural haematoma in the rat: a mechanism for ischaemic damage and brain swelling? Acta Neurochir Suppl (Wien) 60:193-196, 1994
19. Gennarelli TA, Spielman GM, Langfitt TW, Gildenberg PL, Harrington T, Jane JA, et al: Influence of the type of intracranial lesion on outcome from severe head injury. J Neurosurg 56:26-32, 1982
20. Geyer RP: Perfluorochemicals as oxygen transport vehicles. Biomater Artif Cells Artif Organs 16:31-49, 1988
21. Graham DI, Adams JH, Doyle D: Ischaemic brain damage in fatal non-missile head injuries. J Neurol Sci 39:213-234, 1978
22. Haitsma IK, Maas AI: Advanced monitoring in the intensive care unit: brain tissue oxygen tension. Curr Opin Crit Care 8:115-120, 2002
23. Hoffman WE, Charbel FT, Edelman G: Brain tissue oxygen, carbon dioxide, and pH in neurosurgical patients at risk for ischemia. Anesth Analg 82:582-586, 1996
24. Kiening KL, Hartl R, Unterberg AW, Schneider GH, Bardt T, Lanksch WR: Brain tissue pO2-monitoring in comatose patients: implications for therapy. Neurol Res 19:233-240, 1997
25. Kiening KL, Schneider GH, Bardt TF, Unterberg AW, Lanksch WR: Bifrontal measurements of brain tissue-PO2 in comatose patients. Acta Neurochir Suppl (Wien) 71:172-173, 1998
26. Kiening KL, Unterberg AW, Bardt TF, Schneider GH, Lanksch WR: Monitoring of cerebral oxygenation in patients with severe head injuries: brain tissue PO2 versus jugular vein oxygen saturation. J Neurosurg 85:751-757, 1996
27. König JFR, Klippel RA: The Rat Brain: A Stereotactic Atlas of the Forebrain and Lower Parts of the Brainstem. Baltimore: Williams & Wilkins, 1963
28. Kuroda Y, Bullock R: Failure of cerebral blood flow-metabolism coupling after acute subdural hematoma in the rat. Neurosurgery 31:1062-1071, 1992
29. Kuschinsky W, Paulson OB: Capillary circulation in the brain. Cerebrovasc Brain Metab Rev 4:261-286, 1992
30. Kwon TH, Chao DL, Malloy K, Sun D, Alessandri B, Bullock MR: Tempol, a novel stable nitroxide, reduces brain damage and free radical production, after acute subdural hematoma in the rat. J Neurotrauma 20:337-345, 2003
31. Maxwell WL, Irvine A, Adams JH, Graham DI, Gennarelli TA: Response of cerebral microvasculature to brain injury. J Pathol 155:327-335, 1988
32. Menzel M, Doppenberg EM, Zauner A, Soukup J, Reinert MM, Bullock R: Increased inspired oxygen concentration as a factor in improved brain tissue oxygenation and tissue lactate levels after severe human head injury. J Neurosurg 91:1-10, 1999
33. Miller JD, Bullock R, Graham DI, Chen MH, Teasdale GM: Ischemic brain damage in a model of acute subdural hematoma. Neurosurgery 27:433-439, 1990
34. Nair PK, Hellums JD, Olson JS: Prediction of oxygen transport rates in blood flowing in large capillaries. Microvasc Res 38:269-285, 1989
35. Nakajima S, Meyer JS, Amano T, Shaw T, Okabe T, Mortel KF: Cerebral vasomotor responsiveness during 100% oxygen inhalation in cerebral ischemia. Arch Neurol 40:271-276, 1983
36. Osborne KA, Shigeno T, Balarsky AM, Ford I, McCulloch J, Teadale GM, et al: Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia. J Neurol Neurosurg Psychiatry 50:402-410, 1987
37. Padnick LB, Linsenmeier RA, Goldstick TK: Perfluorocarbon emulsion improves oxygenation of the cat primary visual cortex. J Appl Physiol 86:1497-1504, 1999
38. Patel TR, Schielke GP, Hoff JT, Keep RF, Lorris Betz A: Comparison of cerebral blood flow and injury following intracerebral and subdural hematoma in the rat. Brain Res 829:125-133, 1999
39. Rockswold GL, Ford SE, Anderson DC, Bergman TA, Sherman RE: Results of a prospective randomized trial for treatment of severely brain-injured patients with hyperbaric oxygen. J Neurosurg 76:929-934, 1992
40. Sakas DE, Stranjalis G, Whittaker K, Whitwell HL: Perfluorochemical oxygen carriers: potential uses in neurosciences. Cerebrovasc Brain Metab Rev 8:209-229, 1996
41. Sakas DE, Whittaker KW, Crowell RM, Zervas NT: Perfluorocarbons: recent developments and implications for neurosurgery. J Neurosurg 85:248-254, 1996
42. Scheufler KM, Rohrborn HJ, Zentner J: Does tissue oxygen-tension reliably reflect cerebral oxygen delivery and consumption? Anesth Analg 95:1042-1048, 2002
43. Sciamanna MA, Lee CP: Ischemia/reperfusion-induced injury of forebrain mitochondria and protection by ascorbate. Arch Biochem Biophys 305:215-224, 1993
44. Seelig JM, Becker DP, Miller JD, Greenberg RP, Ward JD, Choi SC: Traumatic acute subdural hematoma: major mortality reduction in comatose patients treated within four hours. N Engl J Med 304:1511-1518, 1981
45. Siesjo BK, Siesjo P: Mechanisms of secondary brain injury. Eur J Anaesthesiol 13:247-268, 1996
46. Singhal AB, Dijkhuizen RM, Rosen BR, Lo EH: Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke. Neurology 58:945-952, 2002
47. Singhal AB, Wang X, Sumii T, Mori T, Lo EH: Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion. J Cereb Blood Flow Metab 22:861-868, 2002
48. Stowell CP, Levin J, Spiess BD, Winslow RM: Progress in the development of RBC substitutes. Transfusion 41:287-299, 2001
49. Sunami K, Takeda Y, Hashimoto M, Hirakawa M: Hyperbaric oxygen reduces infarct volume in rats by increasing oxygen supply to the ischemic periphery. Crit Care Med 28:2831-2836, 2000
50. Tajima A, Nakata H, Lin SZ, Acuff V, Fenstermacher J: Differences and similarities in albumin and red blood cell flows through cerebral microvessels. Am J Physiol 262:H1515-H1524, 1992
51. Theilen H, Schrock H, Kuschinsky W: Gross persistence of capillary plasma perfusion after middle cerebral artery occlusion in the rat brain. J Cereb Blood Flow Metab 14:1055-1061, 1994
52. Valadka AB, Gopinath SP, Contant CF, Uzura M, Robertson CS: Relationship of brain tissue PO2 to outcome after severe head injury. Crit Care Med 26:1576-1581, 1998
53. van den Brink WA: Experimental Closed Head Injury marginally impairs brain oxygenation, systemic parameters are of influence on brain oxygen values, in van den Brink WA (ed): Head Injury, from Man to Model. Delft, The Netherlands: Eburon, 2001, pp 145-161
54. van den Brink WA, van Santbrink H, Avezaat CJ, Hogesteeger C, Jansen W, Kloos LM, et al: Monitoring brain oxygen tension in severe head injury: the Rotterdam experience. Acta Neurochir Suppl (Wien) 71:190-194, 1998
55. van den Brink WA, van Santbrink H, Steyerberg EW, Avezaat CJ, Suazo JA, Hogesteeger C, et al: Brain oxygen tension in severe head injury. Neurosurgery 46:868-878, 2000
56. van Santbrink H, Maas AI, Avezaat CJ: Continuous monitoring of partial pressure of brain tissue oxygen in patients with severe head injury. Neurosurgery 38:21-31, 1996
57. Vaz R, Sarmento A, Borges N, Cruz C, Azevedo I: Ultrastructural study of brain microvessels in patients with traumatic cerebral contusions. Acta Neurochir (Wien) 139:215-220, 1997
58. Watson NA, Beards SC, Altaf N, Kassner A, Jackson A: The effect of hyperoxia on cerebral blood flow: a study in healthy volunteers using magnetic resonance phase-contrast angiography. Eur J Anaesthesiol 17:152-159, 2000
59. Wilberger JE Jr, Harris M, Diamond DL: Acute subdural hematoma: morbidity and mortality related to timing of operative intervention. J Trauma 30:733-736, 1990
60. Zauner A, Daugherty WP, Bullock MR, Warner DS: Brain oxygenation and energy metabolism: part I - biological function and pathophysiology. Neurosurgery 51:289-302, 2002