Perfluorocarbon emulsion improves oxygenation of the cat primary visual cortex

Journal of Applied Physiology

Volumn 86, Issue 5, 1999, Pages 1497-1504

  Padnick, Lissa B ^a   Linsenmeier, R A ^a,b   Goldstick, Thomas K ^a,b  

^a Northwestern University   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Brain; Tissue oxygen tension

Indexed keywords

FLUOROCARBON;

ARTICLE; BRAIN OXYGEN TENSION; DRUG EFFICACY; EMULSION; GAS TRANSPORT; MATHEMATICAL ANALYSIS; PRIORITY JOURNAL; VISUAL CORTEX;

EID: 0032895272     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.86.5.1497     Document Type: Article

References (38)

1. Batra, S., B. P. Peters, J. D. Symons, D. Y. Hazard, U. del Balzo, J. D. Bradley, P. E. Keipert, and S. F. Flaim. Perflubron emulsion increases tissue oxygenation in a canine model of hemodilution (Abstract). Artif. Cells Blood Substit. Immobil. Biotechnol. 24: 307, 1996.
2. Bek, T., and T. Ledet. Vascular occlusion in diabetic retinopathy. Acta Ophthalmol. Scand. 74: 36-40, 1996.
3. Bill, A. Ocular circulation. In: Physiology of the Eye: Clinical Application (6th ed.), edited by R. A. Moses. St. Louis, MO: Mosby, 1975, p. 210-231.
4. Biro, G. P. Central hemodynamics and blood flow distribution during infusion of perflubron emulsion or its vehicle: effects in anesthetized dogs. Artif. Cells Blood Substit. Immobil. Biotechnol. 22: 1343-1353, 1994.
5. Braun, R. D., R. A. Linsenmeier, and T. K. Goldstick. New perfluorocarbon emulsion improves tissue oxygenation in the cat retina. J. Appl. Physiol. 72: 1960-1968, 1992.
6. Brizel, D. M., R. Dodge, and M. W. Dewhirst. The effect of the perflubron emulsion Oxygent™ on the calibration characteristics of polarographic oxygen electrodes. Radiother. Oncol. 33: 262-265, 1994.
7. 2 gradients and countercurrent exchange in the cat vitreous humor near retinal arterioles and venules. Microvasc. Res. 45: 134-148, 1993.
8. Chakrabarti, S. Mathematical Analysis of the Enhancement of Oxygen Transport by a Perfluorocarbon Emulsion for Blood Flowing in Oxygenator Tubes (MS thesis). Evanston, IL: Northwestern University, 1995.
9. Clark, L. C., Jr., R. B. Spokane, R. E. Hoffmann, S. Ranjan, H. M. Homan, A. C. Maloney, S. J. Jacobs, T. L. Stroup, and P. E. Winston. Polarographic cerebral oxygen availability, fluorocarbon blood levels and efficacy of oxygen transport by emulsions. Artif. Cells Blood Substit. Immobil. Biotechnol. 16: 375-393, 1988.
10. Eckstein, E. C., J. F. Koleski, and C. M. Waters. Concentration profiles of 1 and 2.5 μm beads during blood flow: hematocrit effects. ASAIO Trans. 35: 188-190, 1989.
11. 2 extraction following hemodilution with dextran or Fluosol-DA. J. Crit. Care 3: 14-18, 1988.
12. Goldstick, T. K. Oxygen transport. In: Engineering Principles in Physiology, edited by J. H. U. Brown and D. S. Gann. New York: Academic, 1973, vol. 2, p. 257-282.
13. Guo, J., J. A. White, and H. H. Batjer. Intravenous perflubron emulsion administration improves the recovery of auditory evoked potentials after temporary brain stem ischemia in dogs. Neurosurg. 36: 350-357, 1995.
14. Hochmuth, R. M., R. N. Marple, and S. P. Sutera. Capillary blood flow. I. Erythrocyte deformation in glass capillaries. Microvasc. Res. 2: 409-419, 1970.
15. Jensen, P. S., and M. R. Glucksberg. Regional variation in capillary hemodynamics in the cat retina. Invest. Ophthalmol. Vis. Sci. 39: 407-415, 1998.
16. 2-Hb affinity of rabbit and cat blood. Pflügers Arch. 408: 451-457, 1987.
17. Kline, R. A., W. Negendank, L. McCoy, and R. Berguer. Beneficial effects of isovolemic hemodilution using a perfluorocarbon emulsion in a stroke model. Am. J. Surg. 162: 103-106, 1991.
18. Lübbers, D. W. Oxygen delivery and microcirculation in the brain. In: Microcirculation in Circulatory Disorders, edited by H. Manube, B. W. Zweifach, and K. Mossemer. New York: Springer-Verlag, 1988, p. 33-50.
19. Maas, A. I. R., W. Fleckenstein, D. A. de Jong, and H. van Santbrink. Monitoring cerebral oxygenation: experimental studies and preliminary clinical results of continuous monitoring of cerebrospinal fluid and brain tissue oxygen tensions. Acta Neurochir. Suppl. (Wien) 59: 50-57, 1993.
20. Mattrey, R. F., P. L. Hilpert, C. D. Long, D. M. Long, R. M. Mitten, and T. Peterson. Hemodynamic effects of intravenous lecithin-based perfluorocarbon emulsions in dogs. Crit. Care Med. 17: 652-656, 1989.
21. 2 supply. J. Appl. Physiol. 31: 751-759, 1971.
22. Nair, P. K., J. D. Hellums, and J. S. Olson. Prediction of oxygen transport rates in blood flowing in large capillaries. Microvasc. Res. 38: 269-285, 1989.
23. 2. Microvasc. Res. 9: 158-165, 1975.
24. Padnick, L. B., and R. A. Linsenmeier. Properties of the flash visual evoked potential recorded in the cat primary visual cortex. Vision Res. In press.
25. Padnick, L. B., R. A. Linsenmeier, and T. K. Goldstick. Oxygenation of the cat primary visual cortex. J. Appl. Physiol. 86: 1490-1496, 1999.
26. Peerless, S. J., R. Ishikawa, I. G. Hunter, and M. J. Peerless. Protective effect of Fluosol-DA in acute cerebral ischemia. Stroke 12: 528-563, 1981.
27. Purves, M. J. The Physiology of the Cerebral Circulation. London: Cambridge University Press, 1972.
28. Records, R. E. Physiology of the Human Eye and Visual System. Hagerstown, MD: Harper & Row, 1979.
29. Riess, J. Fluorocarbon-based in vivo oxygen transport and delivery systems. Vox Sang. 61: 225-239, 1991.
30. Schneiderman, G., and T. K. Goldstick. Oxygen electrode design criteria and performance characteristics: recessed cathode. J. Appl. Physiol. 45: 145-154, 1978.
31. Sutherland, G. R., J. K. Farrar, and S. J. Peerless. The effect of Fluosol-DA on oxygen availability in focal cerebral ischemia. Stroke 15: 829-835, 1984.
32. Szeto, S. Radial Segregation of Perfluorocarbon Droplets in Ghost Cell Suspensions Flowing Through a Capillary Tube (MS thesis). Evanston, IL: Northwestern University, 1997.
33. 2 in brain cortex of unanaesthetized rabbits. Adv. Exp. Med. Biol. 411: 403-409, 1996.
34. Vslef, S. N., and T. K. Goldstick. Enhanced oxygen delivery induced by perfluorocarbon emulsions in capillary tube oxygenators. ASAIO J. 40: M643-M648, 1994.
35. Villringer, A., A. Them, U. Lindauer, K. Einhaupl, and U. Dirnagl. Capillary perfusion of the rat brain cortex. An in vivo confocal microscopy study. Circ. Res. 75: 55-62, 1994.
36. 2 of cat cerebral cortex. Stroke 1: 194-200, 1970.
37. Zander, R. Oxygen solubility in normal human blood. In: Advances in Physiological Sciences: Oxygen Transport to Tissue, edited by A. G. B. Kovach, E. Dóra, M. Kessler, and I. A. Silver. Budapest, Hungary: Akademiai Kiado, 1981, vol. 25, p. 331-332.
38. Zuck, T. F., and J. G. Riess. Current status of injectable oxygen carriers. Crit. Rev. Clin. Lab. Sci. 31: 295-324, 1994.