Synthesis and biological activity of novel 4,4-difluorobenzazepine derivatives as non-peptide antagonists of the arginine vasopressin V 1A receptor

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 6, 2006, Pages 1827-1837

  Shimada, Yoshiaki ^a   Taniguchi, Nobuaki ^a   Matsuhisa, Akira ^a   Akane, Hiroaki ^a   Kawano, Noriyuki ^a   Suzuki, Takeshi ^a   Tobe, Takahiko ^a   Kakefuda, Akio ^a   Yatsu, Takeyuki ^a   Tahara, Atsuo ^a   Tomura, Yuichi ^a   Kusayama, Toshiyuki ^a   Wada, Koh Ichi ^a   Tsukada, Junko ^a   Orita, Masaya ^a   Tsunoda, Takashi ^a   Tanaka, Akihiro ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

2 Methylfuran 3 carbonyl group; Arginine vasopressin; V1A receptor selective antagonist; YM218

Indexed keywords

2 METHYLFURAN; 4,4 DIFLUOROBENZAZEPINE DERIVATIVES; [4' [(4,4 DIFLUORO 5 2 OXOETHYLIDENE 2 4 PIPERIDINOPIPERIDINO) 2,3,4,5 TETRAHYDRO 1H 1 BENZAPIN 1 YL] CARBONYL]PHENYL 2 METHYLFURAN 3 CARBOXAMIDE; [4' [(4,4 DIFLUORO 5 CARBAMOYLMETHYLIDENE 2,3,4,5 TETRAHYDRO 1H 1 BENZAZAPIN 1 YL)CARBONYL]PHENYL]CARBOXAMIDE; ARGININE VASOPRESSIN 5 1A RECEPTOR; ARGIPRESSIN RECEPTOR; BENZAZEPINE DERIVATIVE; UNCLASSIFIED DRUG; VASOPRESSIN RECEPTOR ANTAGONIST;

ARTICLE; BIOLOGICAL ACTIVITY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG EFFECT; DRUG POTENTIATION; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; NONHUMAN; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZAZEPINES; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; FLUORINE; HUMANS; MALE; MOLECULAR STRUCTURE; PEPTIDES; RATS; RECEPTORS, VASOPRESSIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 32044456400     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.10.035     Document Type: Article

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