Synthesis and Structure-Activity Relationships of 5,6,7,8-Tetrahydro-4H-thieno[3,2-b]azepine Derivatives: Novel Arginine Vasopressin Antagonists

Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2004, Pages 101-109

  Cho, Hidetsura ^a   Murakami, Kengo ^a   Nakanishi, Hiroyuki ^a   Fujisawa, Akitaka ^a   Isoshima, Hirotaka ^a   Niwa, Misako ^a   Hayakawa, Kazuhide ^a   Hase, Yasunori ^a   Uchida, Itsuo ^a   Watanabe, Hidenori ^a   Wakitani, Korekiyo ^a   Aisaka, Kazuo ^a  

^a JAPAN TOBACCO INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARGIPRESSIN; AZEPINE DERIVATIVE; HETEROCYCLIC COMPOUND; JTV 605; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; CELL MEMBRANE; CHO CELL; CONTROLLED STUDY; DIURESIS; DRUG ACTIVITY; DRUG BINDING; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYPERTENSION; KIDNEY; LIVER; MALE; NONHUMAN; PHYSICAL CHEMISTRY; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THROMBOCYTE MEMBRANE;

ANIMALS; ARGININE VASOPRESSIN; AZEPINES; BENZAMIDES; BINDING, COMPETITIVE; BLOOD PLATELETS; CHO CELLS; CRICETINAE; HUMANS; HYPERTENSION; KIDNEY; LIVER; MALE; MEMBRANES; MODELS, MOLECULAR; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, VASOPRESSIN; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 9144262488     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030287l     Document Type: Article

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