Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from Bosentan

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 17, 1997, Pages 2223-2228

  Neidhart, Werner ^a   Breu, Volker ^a   Burri, Kaspar ^a   Clozel, Martine ^a   Hirth, Georges ^a   Klinkhammer, Uwe ^a   Giller, Thomas ^a   Ramuz, Henri ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 PYRIDYLCARBAMIC ACID 2 [[5 (2 METHOXYPHENOXY) 6 [[(4 ISOPROPYLPHENYL)SULFONYL]AMINO] 2 MORPHOLINO 4 PYRIMIDINYL]OXY]ETHYL ESTER; BOSENTAN; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BIOAVAILABILITY; DOG; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALIA; CANIS FAMILIARIS;

EID: 0030984174     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00400-9     Document Type: Article

References (13)

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