Selective ET(A) antagonists. 5. Discovery and structure-activity relationships of phenoxyphenylacetic acid derivatives

Journal of Medicinal Chemistry

Volumn 43, Issue 5, 2000, Pages 900-910

  Astles, Peter C ^b   Brown, Thomas J ^b   Halley, Frank ^b   Handscombe, Caroline M ^b   Harris, Neil V ^b   Majid, Tahir N ^b   McCarthy, Clive ^b   McLay, Lain M ^b   Morley, Andrew ^b   Porter, Barry ^a,b   Roach, Alan G ^b   Sargent, Carol ^b   Smith, Christopher ^b   Walsh, Roger J A ^b  

^a Pharmagene Plc   (United Kingdom)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 [5 (1,3 BENZODIOXOL 5 YLMETHOXY) 2 CYANOPHENOXY] 2 (2 METHYLPHENYL)ACETIC ACID; ENDOTHELIN A RECEPTOR ANTAGONIST; PHENYLACETIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AORTA; ARTICLE; DRUG BIOAVAILABILITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; AORTA; BINDING, COMPETITIVE; BIOLOGICAL AVAILABILITY; CELL LINE; CEREBELLUM; DECEREBRATE STATE; ENDOTHELIN-1; MODELS, MOLECULAR; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PHENYLACETATES; PYRIDINES; RADIOLIGAND ASSAY; RATS; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034624831     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990378b     Document Type: Article

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