Role of γ-glutamyl cysteine synthetase (γ-GCS) gene expression as marker of drug sensitivity in acute myeloid leukemias

Clinica Chimica Acta

Volumn 365, Issue 1-2, 2006, Pages 342-345

  Carnicer, Maria José ^a   Bernardini, Sergio ^a   Bellincampi, Lorenza ^a   Noguera, Nelida Inés ^a   Nuccetelli, Marzia ^a   Ammatuna, Emanuele ^a   Breccia, Massimo ^b   Lo Coco, Francesco ^a   Federici, Giorgio ^a,c  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

glutamyl cysteine synthetase; Acute myeloid leukemia; Acute promyelocytic leukemia; Glutathione transferase P1 1

Indexed keywords

GLUTAMATE CYSTEINE LIGASE; MESSENGER RNA;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; FEMALE; GENE EXPRESSION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACUTE DISEASE; ANTINEOPLASTIC AGENTS; GENE EXPRESSION; GLUTAMATE-CYSTEINE LIGASE; HUMANS; LEUKEMIA, MYELOID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 32044437367     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2005.09.012     Document Type: Article

References (15)

1. H. Shen, L. Kauvar, and K.D. Tew Importance of glutathione and associated enzymes in drug response Oncol Res 9 1997 295 302
2. Y. Sagara, R. Dargusch, D. Chambers, J. Davis, D. Schubert, and P. Maher Cellular mechanisms of resistance to chronic oxidative stress Free Radic Biol Med 24 1998 1375 1389
3. M. O'Brien, G.D. Kruh, and K.D. Tew The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance J Pharmacol Exp Ther 294 2000 480 487
4. T. Iida, H. Kijima, and Y. Urata Hammerhead ribozyme against gamma-glutamylcysteine synthetase sensitizes human colonic cancer cells to cisplatin by down-regulating both the glutathione synthesis and the expression of multidrug resistance proteins Cancer Gene Ther 8 2001 803 814
5. J. Dai, R.S. Weinberg, S. Waxman, and Y. Jing Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system Blood 93 1999 268 277
6. K. Davison, S. Cote, S. Mader, and W.H. Miller Glutathione depletion overcomes resistance to arsenic trioxide in arsenic-resistant cell lines Leukemia 17 2003 931 940
7. J.D. Hayes, and R.C. Strange Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress Free Radic Res 22 1995 193 207
8. M. Vignetti, P. Fazi, and M. Sborgia Cytoreduction rate after hydroxyurea pre-treatment is an independent prognostic factor for complete remission in adult acute myeloid leukemia Hematol J 2004 S37
9. F. Mandelli, D. Diverio, and G. Avvisati Molecular remission in PML/RAR-positive acute promyelocytic leucemia by combined all-trans retinoic acid and idarubicin (AIDA) therapy Blood 90 1997 1014 1021
10. J. Bennet, D. Catovsky, and M. Daniel Proposed revised criteria for the acute myeloid leukemias: a report of the French-American-British Cooperative Group Ann Intern Med 103 4 1985 620 625
11. Livak KJ. Comparative Ct method. ABI Prism 7700 sequence detection system. User Bulletin no. 2. PE Applied Biosystems; 1997.
12. P. Mantymaa, T. Guttorm, and T. Siitonen Cellular redox state and its relationship to the inhibition of clonal cell growth and the induction of apoptosis during all-trans retinoic acid exposure in acute myeloblastic leukemia cells Haematologica 85 2000 238 245
13. A.C. Wild, and R.T. Mulcahy Regulation of γ-glutamylcysteine synthetase subunit gene expression: insight into trascriptional control of antioxidant defenses Free Radic Res 32 2000 281 301
14. K.R. Sekhar, M.J. Meredith, and L.D. Kerr Expression of glutathione and γ-glutamylcysteine synthetase mRNA is Jun dependent Biochem Biophys Res Commun 234 1997 588 593
15. A.C. Wild, J.J. Gipp, and R.T. Mulcahy Overlapping antioxidant responsive element and PMA response element sequences mediate basal and g-naphthoflavone-induced expression of the human γ-glutamylcysteine synthetase catalytic subunit gene Biochem J 332 1998 373 381