Role of protease-activated receptor 1 in tumor metastasis promoted by tissue factor

Thrombosis and Haemostasis

Volumn 86, Issue 5, 2001, Pages 1210-1214

  Bromberg, M E ^a   Bailly, M A ^a   Konigsberg, W H ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Factor VIIa; Melanoma; Metastasis; Protease activated receptor; Tissue factor

Indexed keywords

BLOOD CLOTTING FACTOR 7A; COMPLEMENTARY DNA; GLYCOPROTEIN; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; THROMBOPLASTIN; PROTEASE-ACTIVATED RECEPTOR 1; THROMBIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING; CYTOPLASM; FEMALE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MELANOMA; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; TUMOR; TUMOR CELL; TUMOR CELL LINE; ANIMAL; CELL CULTURE; DISEASE MODEL; DRUG POTENTIATION; GENETICS; LUNG TUMOR; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; TRANSPLANTATION;

ANIMAL; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; FEMALE; HUMAN; LUNG NEOPLASMS; MELANOMA; MICE; MICE, SCID; NEOPLASM METASTASIS; RECEPTORS, THROMBIN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THROMBOPLASTIN; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035164461     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1616053     Document Type: Article

References (31)

1. Tissue factor and hemostasis
2. Tissue factor controls the balance of angiogenic and anti-angiogenic properties of tumor cells in mice
3. Tissue factor promotes metastasis by a pathway independent of blood coagulation
4. Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis
5. Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor
6. Role of tissue factor in metastasis: Function of the cytoplasmic and extracellular domains of the molecule
7. Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis
8. Tissue factor-initiated thrombin generation activates the thrombin receptor on malignant melanoma cells
9. Role of platelets, thrombin, integrin IIb-IIIa, fibronectin and Von Willebrand factor on tumor adhesion in vitro and metastasis in vivo
10. Protease-activated receptor-1 (PAR-1) is required and rate limiting for thrombin-enhanced experimental pulmonary metastasis
11. Inhibition of murine melanoma experimental metastasis by recombinant disulfatohirudin, a highly specific thrombin inhibitor
12. Thrombin signalling and protease-activated receptors
13. Solid tumor cells express functional "tethered ligand" thrombin receptor
14. Presence of the seven transmembrane thrombin receptor on human tumour cells: Effect of activation on tumour adhesion to platelets and tumour tyrosine phosphorylation
15. Trypsin stimulates integrin αβ-dependent adhesion to fibronectin and proliferation of gastric carcinoma cells through activation of proteinase-activated receptor-2
16. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2
17. Thrombin receptor overexpression in malignant and physiological invasion processes
18. Role of thrombin receptor in breast cancer invasiveness
19. 2+ oscillations in Madin-Darby canine kidney cells only when proteolytically active
20. Factor VIIa-induced p44/42 mitogen-activated protein kinase activation requires the proteolytic activity of factor VIIa and is independent of the tissue factor cytoplasmic domain
21. Coagulation factors VIIa and Xa induce cell signaling leading to up-regulation of the egr-1 gene
22. Factor VIIa and thrombin induce the expression of Cyr61 and connective tissue growth factor, extracellular matrix signaling proteins that could act as possible downstream mediators in factor VIIa-tissue factor-induced signal transduction
23. Exclusion of known protease activated receptors in factor VIIa-induced signal transduction
24. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
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26. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug section markers and a complementary helper-free packaging cell line
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28. Thrombin responses in human endothelial cells
29. The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase
30. The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism
31. A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280