The αvβ5 integrin functions as an endocytic receptor for vitronectin

Journal of Cell Science

Volumn 111, Issue 4, 1998, Pages 425-433

  Memmo, Loretta M ^a   McKeown Longo, Paula ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

(v) 5 integrin; Endocytosis; Vitronectin

Indexed keywords

CLATHRIN; INTEGRIN; POTASSIUM; VITRONECTIN; VITRONECTIN RECEPTOR; WORTMANNIN; ALPHAVBETA5 INTEGRIN; ANDROSTANE DERIVATIVE; BETA INTEGRIN; BETA3 INTEGRIN; BETA5 INTEGRIN; ENZYME INHIBITOR; FIBRINOGEN RECEPTOR; LEUKOCYTE ANTIGEN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE;

ARTICLE; COATED PIT; CYTOPLASM VESICLE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INTERNALIZATION; LYSOSOME; POTASSIUM DEPLETION; PRIORITY JOURNAL; SKIN FIBROBLAST; CELL ADHESION; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; ENDOCYTOSIS; ENDOSOME; FIBROBLAST; METABOLISM; PHYSIOLOGY; SKIN;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANTIGENS, CD; CELL ADHESION; CELLS, CULTURED; COATED PITS, CELL-MEMBRANE; ENDOCYTOSIS; ENDOSOMES; ENZYME INHIBITORS; FIBROBLASTS; HUMANS; INTEGRIN BETA CHAINS; INTEGRIN BETA3; INTEGRINS; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; LYSOSOMES; MEMBRANE GLYCOPROTEINS; PLATELET MEMBRANE GLYCOPROTEINS; POTASSIUM; RECEPTORS, VITRONECTIN; SKIN; VITRONECTIN;

EID: 0031886616     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Altankot, G. and Grinned, F. (1993). Depletion of intracellular potassium disrupts coaled pits and reversibly inhibits cell polarization during fibroblast spreading. J. Cell Biol. 120. 1444-1459.
2. Barnes, D. W. and Reing. J. (1985) Human spreading factor: Synthesis and response by Hep G2 hepatoma cells in culture J. Cell Physiol. 125, 207-214.
3. 5 integrin and interferes with Hela cell spreading. Mol. Cell. Biol. 15, 711-722.
4. Bittorf, S. V., Williams, E. C. and Mosher, D. F. (1993). Alteration of vitronectin: Characterization of changes induced by treatment with urea. J. Biol. Chem. 268, 24838-24846.
5. 5. J. Clin. Invest. 96, 1987-2001
6. 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157-1164.
7. Ciambrone, G. J. (1992). Vitronectin regulates the synthesis and localization of urokinase-type plasminogen activator in HT-1080 cells. J. Biol. Chem. 267, 13617-13622.
8. Ciambrone, G. J. and McKeown-Longo, P. J. (1990). Plasminogen activator inhibitor type I stabilizes vitronectin-dependent adhesions in HT-1080 cells. J. Cell Biol. 111, 2183-2195.
9. Dahlback, B. and Podack, E. R. (1985). Characterization of human S-protein, an inhibitor of the membrane attack complex of complement. Demonstration of a free reactive thiol group. Biochemistry 24, 2368-2374.
10. Deng, G., Royle, G., Seiffert, D. and Loskutoff, D. J. (1995). The PAI-I vitronectin interaction: Two cats in a bag? Thromb. Haemost. 71, 66-70.
11. 3prevents maturation of blood vessels during embryonic neovascularization. J. Cell Sci. 108, 2655-2661.
12. Dvorak, H. F. (1979). Induction of a fibrin-gel investment: An early event in line 10 hepatocarcinoma growth mediated by tumor-secreted products. J. Immunol. 122, 166.
13. Gladson, C. L., Seegmiller, J. E., Smith, J. W., Klier, J. and Cheresh, D. A. (1990). Glioblastoma cells synthesize and secrete the adhesive protein vitronectin. J. Exp. Neurol. 49, 339-345.
14. Gladson, C. L., Wilcox, J. N., Sanders, L., Gillespie, G. Y. and Cheresh, D. A. (1995). Cerebral microenvironment influences expression of the vitronectin gene in astrocytic tumors. J. Cell Sci. 108, 947-956.
15. 5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway. J. Virol. 69, 5951-5958.
16. Hekman. C. M. and Loskutoff, D. J. (1985). Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants. J. Biol. Chem. 260. 11581-11587.
17. 5-directed cell motility but not adhesion on vitronectin. J. Cell Biol. 127, 859-866.
18. Larkin, J. M., Brown, M. S., Goldstein. J. L. and Anderson. R. G. W. (1983). Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts. Cell 33, 273-285.
19. 5 dependent cytoskeletal associations and focal adhesion kinase phosphorylation. J. Cell Biol. 134, 1323-1332.
20. McKeown-Longo, P. J. and Panetti, T. S. (1993). Receptor mediated endocytosis of vitronectin by fibroblast monolayers. In Biology of Vitronectins and their Receptors (ed. K. T. Preissner, S. Rosenblatt, C. Kost, J. Wegerhoff and D. F. Mosher). pp. 111-118. Elsevier Science Publishers. B.V.
21. McKeown-Longo, P. J. and Scalise-Panetti, T. (1996). Structure and function of vitronectin. Trends Glyosci. Glycotechnol. 8, 327-340.
22. Naski, M. C., Lawrence, D. A., Mosher, D. F., Podor, T. J. and Ginsburg, D. (1993). Kinetics of inactivation of α-thrombin by plasminogen inhibitor-1. J. Biol. Chem. 268, 12367-12372.
23. 2-macroglobulin receptor/low density lipoprotein receptor-related protein. J. Biol. Chem. 269, 25668-25676.
24. 2-macroglobulin receptor/LDL receptor-related protein binds urokinase-plasminogen activator inhibitor type-1 complex. J. Biol. Chem. 267, 14543-14546.
25. Okada, T., Sakuma, L., Fukui, Y., Hazeki, O. and Ui, M. (1994). Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase J. Biol. Chem. 269, 3563-3567.
26. Panetti, T. S. and McKeown-Longo. P. J. (1993a). Receptor mediated endocytosis of vitronectin is regulated by its conformational state. J. Biol. Chem. 268. 11988-11993.
27. 5 integrin receptor regulates receptor-mediated endocytosis of vitronectin. J. Biol. Chem. 268. 11492-11495.
28. 5 integrin receptor-mediated endocytosis of vitronectin is protein kinase C-dependent. J. Biol. Chem. 270. 18593-18597.
29. 5 monoclonal antibodies. J. Cell Sci. 105, 101-111.
30. 5. J. Biol. Chem. 272, 2736-2743.
31. Preissner, K. T. (1991). Structure and biological role of vitronectin. Annu. Rev. Cell Biol. 7, 275-310.
32. Seiffert, D. (1997). The glycosaminoglycan binding site governs ligand binding (to the somatomedin βdomain of vitronectin. J. Biol. Chem. 272. 9971-9978.
33. Seiffert, D., Ciambrone, G., Wagner, N. V., Binder, B. R. and Loskutoff. D. J. (1994). The somatomedin B domain of vitronectin. J. Biol. Chem. 269. 2659-2666.
34. Seiffert, D. and Loskutoff, D. J. (1991). Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin. J. Biol. Chem. 266, 2824-2830.
35. Seiffert, D. and Loskutoff, D. J. (1996). Type 1 plasminogen activator inhibitor induces multimerization of plasma vitronectin. J. Biol. Chem. 271, 29644-29651.
36. n within platelet α-granules. Blood 88, 552-560.
37. Seiffert, D., and Smith, J. W. (1997). The cell adhesion domain in plasma vitronectin is cryptic. J. Biol. Chem. 272, 13705-13710.
38. Seiffert, D., Wagner, N. N. and Loskutoff, D. J. (1990). Serum-derived vitronectin influences the pericellular distribution of type 1 plasminogen activator inhibitor. J. Cell Biol. 111, 1283-1291.
39. Shpetner, H., Joly, M., Hartley, D. and Corvera, S. (1996) Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin. J. Cell Biol. 132, 595-605.
40. Small, J. V. and Celis, J. E. (1978). Filament arrangements in negatively stained cells: the organization of actin. J. Cell Biol. 16. 308-325.
41. Spiro, D. J., Boll, W., Kirchhausen, T. and Wessling-Resnick. M. (1996). Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro. Mol. Biol. Cell 7, 355-367.
42. 3 binding to vitronectin. Nature 383, 441-443.
43. Stockmann, A., Hess, S., Declerck, P., Timpl, R. and Preissner, K. T. (1993). Multimeric vitronectin: Identification and characterization of conformation-dependent self-association of the adhesive protein. J. Biol. Chem. 268, 22874-22882.
44. Tomasini, B. R. and Mosher, D. F. (1998). Conformational states of vitronectin: Preferential expression of an antigenic epitope when vitronectin is covalently and noncovalently complexed with thrombin-antithrombin III or treated with urea. Blood 72. 903-912.
45. Waltz, D. A. and Chapman, H. A. (1994). Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy. J. Biol. Chem. 269. 14746-14750.
46. 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface. J. Cell Biol. 113, 919-929.
47. 5 selectively promotes adenovirus mediated cell membrane permeabilization. J. Cell Biol. 127, 257-264.
48. 5 promote adenovirus internalization but not virus attachment. Cell 73, 309-319.
49. Wilcox, S. A., Reho, T., Higgins, P. J., Tominna-Sebald. E. and McKeown-Longo, P. J. (1996). Localization of urokinase to focal adhesions by human fibrosarcoma cells synthesizing recombinant vitronectin. Biochem. Cell Biol. 74, 899-910.
50. Wilkins-Port, C. E. and McKeown-Longo, P. (1996). Heparan sulfate proteoglycans function in the binding and degradation of vitronectin by fibroblast monolayers. Biochem. Cell Biol. 74, 887-897.
51. Woods, A., Smith, C. G., Rees, D. A. and Wilson, G. (1983) . Stages in specialization of fibroblast adhesion and deposition of extracellular matrix. Eur. J. Cell Biol. 32. 108-116.
52. Yano, H., Nakanishi, S., Kimura, K., Hanai, N., Saitoh, Y., Fukui, Y., Nonomura, Y. and Matsuda, Y. (1993). Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J. Biol. Chem. 268, 25846-25856.
53. Yatohgo, T., Izumi, M., Kashiwagi, H. and Hayashi, M. (1988). Novel purification of vitronectin from human plasma by heparin affinity chromatography. Cell Struct. Funct. 13, 281-292.
54. Yebra, M., Filardo, E. J., Bayna, E. M., Kawahara, E., Becker, J.C. and Cheresh, D. A. (1995). Induction of carcinoma cell migration on vitronectin by NF-kB-dependent gene expression Mol. Biol. Cell 6, 841-850.