Combined treatment with neurotrophin-3 and LSD facilitates behavioral recovery from double-hemisection spinal injury in neonatal rats

Journal of Neurotrauma

Volumn 23, Issue 1, 2006, Pages 66-74

  Arvanian, Victor L ^b   Manuzon, Honeyleen ^a,b   Davenport, Michael ^a   Bushell, Georgia ^a   Mendell, Lorne M ^b   Robinson, John K ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b Stony Brook University   (United States)

Author keywords

5 HT receptor; Behavior; LSD; NT 3; Rat; Spinal cord injury

Indexed keywords

LYSERGIDE; NEUROTROPHIN 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; HINDLIMB; IN VITRO STUDY; INJURY SEVERITY; MALE; MOTONEURON; NEWBORN; NONHUMAN; OPEN FIELD BEHAVIOR; PERINATAL PERIOD; RAT; REARING; SPINAL CORD HEMISECTION; SPINAL CORD INJURY; SPINAL CORD TRANSSECTION; SWIMMING; TREATMENT OUTCOME;

ANIMALS; ANIMALS, NEWBORN; DENERVATION; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; GAIT DISORDERS, NEUROLOGIC; INJECTIONS, SPINAL; LUMBAR VERTEBRAE; LYSERGIC ACID DIETHYLAMIDE; MALE; MOTOR ACTIVITY; MOTOR NEURONS; NEURAL PATHWAYS; NEUROTROPHIN 3; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN AGONISTS; SPINAL CORD; SPINAL CORD INJURIES; TREATMENT OUTCOME;

EID: 31944442262     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2006.23.66     Document Type: Article

References (39)

1. AGHAJANIAN, G.K., and MAREK, G.J. (1999). Serotonin and hallucinogens. Neuropsychopharmacology. 21, 16S-23S.
2. AGHAJANIAN, G.K., and MAREK, G.J. (2000). Serotonin model of schizophrenia: emerging role of glutamate mechanisms. Brain Res. Brain Res. Rev. 31, 302-312.
3. ANTRI, M., MOUFFLE, C., ORSAL, D., and BARTHE, J.Y. (2003). 5-HT1A receptors are involved in short- and long-term processes responsible for 5-HT-induced locomotor function recovery in chronic spinal rat. Eur. J. Neurosci. 18, 1963-1972.
4. + block extends the action of NT-3 on synaptic transmission in neonatal rat motoneurons. J. Neurophysiol. 86, 123-129.
5. ARVANIAN, V.L., HORNER, P.J., GAGE, F.H., and MENDELL L.M. (2003). Chronic neurotrophin-3 strengthens synaptic connections to motoneurons in the neonatal rat. J. Neurosci. 23, 8706-8712.
6. 2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA/kainate responses in maturing rat motoneurons. J. Neurophysiol. 92, 2394-2404.
7. 2A,2C receptor agonist DOB on NMDA-evoked responses in the rat medial prefrontal cortex. Eur. J. Neurosci. 11, 2917-2934.
8. ARVANOV, V.L., SEEBACH, B.S., and MENDELL, L.M. (2000). NT-3 evokes an LTP-like facilitation of AMPA/Kainate receptor-mediated synaptic transmission in the neonatal rat spinal cord. J. Neurophysiol. 84, 752-758.
9. BERNSTEIN, D.R., and STELZNER, D.J. (1983). Plasticity of the corticospinal tract following midthoracic spinal injury in the postnatal rat. J. Comp. Neurol. 221, 382-400.
10. BREGMAN, B.S., and GOLDBERGER, M.E. (1983). Infant lesion effect. I. Development of motor behavior following neonatal spinal cord damage in cats. Dev. Brain Res. 9, 1-15.
11. BREGMAN, B., McATEE, M., DAI, H., and KUHN, P. (1997). Neurotrophic factors increase axonal growth after spinal cord injury and transplantation in the adult rat. Exp. Neurobiol. 148, 475-494.
12. BREGMAN, B.S., COUMANS, J.V., DAI, H.N., et al. (2002). Transplants and neurotrophic factors increase regeneration and recovery of function after spinal cord injury. Prog Brain Res. 137, 257-73.
13. 2+ block of NMDA-receptor channels as a mechanism of modulation. Nature 356, 521-3.
14. CLARAC, F., VINAY, L., CAZALETS, J.R., FADY, J.C., and JAMON, M. (1998). Role of gravity in the development of posture and locomotion in the neonatal rat. Brain Res. Brain Res. Rev. 28, 35-43.
15. COUMANS, J., LIN, T., DAI, H., et al. (2001). Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins. J. Neurosci. 21, 9334-9344.
16. EDGERTON, V.R., LEON, R.D., HARKEMA, S.J., et al. (2001) Retraining the injured spinal cord. J. Physiol. 533, 15-22.
17. FRIEDMAN, B., KLEINFELD, D., IP, N., et al. (1995). BDNF and NT-4/5 exert neurotrophic influences on adult injured spinal cord motor neurons. J. Neurosci. 15, 1044-1056.
18. HAINS, B.C., JOHNSON, K.M., McADOO, D.J., EATON, M.J., and HULSEBOSCH, C.E. (2001). Engraftment of serotonergic precursors enhances locomotor function and attenuates chronic central pain behavior following spinal hemisection injury in the rat. Exp. Neurol. 171, 361-378.
19. HOUWELING, D., LANKHORST, A., GISPEN, W., BAR, P., and JOOSTEN, E. (1998). Collagen containing neurotrophin-3 (NT-3) attracts regrowing injured corticospinal axons in the adult rat spinal cord and promotes partial functional recovery. Exp. Neurol. 153, 49-59.
20. KIM, D., ADIPUDI, V., SHIBAYAMA, M., et al. (1999). Direct agonists for serotonin receptors enhance locomotor function in rats that received neural transplants after neonatal spinal transection. J. Neurosci. 9, 6213-24.
21. LOY, D.N., MAGNUSON, D.S., ZHANG, Y.P., et al. (2002). Functional redundancy of ventral spinal locomotor pathways. J. Neurosci. 22, 315-323.
22. LU, P., YANG, H., JONES, L.L., FILBIN, M.T., and TUSZYNSKI, M.H. (2004). Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury. J. Neurosci. 24, 6402-6409.
23. MANUZON, H., MOTIN, V., ARVANIAN, V., ROBINSON, J.K., and MENDELL, L.M. (2002). Evaluation of spontaneous and (NT-3 + LSD)-facilitated recovery from double-hemisection spinal cord injury (SCI). Neurosci. Abstr. 28.
24. McTIGUE, D., HORNER, P., STOKES, B., and GAGE, F. (1998). Neurotrophin-3 and brain derived neurotrophic factor induce oligodendrocyte and myelination of regenerating axons in the contused adult rat spinal cord. J. Neurosci. 18, 5354-5365.
25. MENDELL, L.M., JOHNSON, R.D., and MUNSON, J.B. (1999). Neurotrophin action on the recovery of the monosynaptic reflex after peripheral axotomy in the cat. J. Neurosci. 19, 3162-3170.
26. MEYENBURG, J., BROSAMLE, C., METZ, G., and SCHWAB, M. (1998). Regeneration and sprouting of chronically injured corticospinal tract fibers in adult rats promoted by NT-3 and the mAB IN-1, which neutralizes myelin- associated neurite growth inhibitors. Exp. Neurol. 154, 583-594.
27. MOTIN, V., MANUZON, H., HORNER, P., GAGE, F.H., MENDELL, L.M., and ARVANIAN V.L. (2002). LSD potentiates effects of neurotrophin-3 (NT-3) in strengthening spinal synapses and can reveal connections of descending fibers surviving partial spinal cord injury. Neurosci. Abstr. 28.
28. NOVIKOVA, L., NOVIKOV, L., and KELLERTH, J. (2000). Survival effects of BDNF and NT-3 on axotomized rubrospinal neurons depend on the temporal pattern of neurotrophin administration. Eur. J. Neurosci. 12, 776-780.
29. NOVIKOVA, L., NOVIKOV, L., and KELLERTH, J. (2002). Differential effects of neurotrophins on neuronal survival and axonal regeneration after spinal cord injury in adult rats. J. Comp. Neurol. 452, 255-263.
30. PINCO, M., and LEV-TOV, A. (1994). Synaptic transmission between ventrolateral funiculus axons and lumbar motoneurons in the isolated spinal cord of the neonatal rat. J. Neurophysiol. 72, 2406-2419.
31. PRIESTLEY, J., RAMER, M., KING, V., McMAHON, S., and BROWN, R. (2002). Stimulating regeneration in the damaged spinal cord. J. Physiol. (Paris) 96, 123-133.
32. SAYER, F., OUDEGA, M., and HAAG, T. (2002). Neurotrophins reduce degeneration of injured ascending sensory and corticospinal motor axons in adult rat spinal cord. Exp. Neurol. 175, 282-296.
33. SEEBACH, B.S., ARVANOV, V.L., and MENDELL, L.M. (1999). Effects of BDNF and NT-3 on development of Ia/motoneuron functional connectivity in neonatal rats. J. Neurophysiol. 81, 2398-2405.
34. TUSZYNSKI, M., GRILL, R., JONES, L., et al. (2003). NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection. Exp. Neurol. 181, 47-56.
35. VAN HARTESVELDT, C., MOORE, B., and HARTMAN, B.K. (1986). Transient midline raphe glial structure in the developing rat. J. Comp. Neurol. 253, 174-84.
36. WHITE, D. (2000). Neurotrophin-3 antisense oligonucleotide attenuates nerve injury-induced A beta-fibre sprouting. Brain Res. 885, 79-86.
37. WINTER, J.C., HELSLEY, S., FIORELLA, D., and RABIN, R.A. (1999). The acute effects of monoamine reuptake inhibitors on the stimulus effects of hallucinogens. Pharmacol. Biochem. Behav. 63, 507-513.
38. YE, J., and HOULE, J. (1997). Treatment of the chronically injured spinal cord with neurotrophic factors can promote axonal regeneration from suspraspinal neurons. Exp. Neurol. 143, 70-81.
39. ZHANG, Y., DIJKHUIZEN, P., ANDERSON, P., LIEBERMAN, R., and VERHAAGEN, J. (1998). NT-3 delivered by an adenoviral vector induces injured dorsal root axons to regenerate into the spinal cord of adult rats. J. Neurosci. Res. 54, 554-562.