Clinical review: Renal tubular acidosis - A physicochemical approach

Critical Care

Volumn 9, Issue 6, 2005, Pages 573-580

  Ring, Troels ^a   Frische, Sebastian ^b   Nielsen, Søren ^b  

^a AALBORG UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; CARBON DIOXIDE; CARBONATE DEHYDRATASE; CHLORIDE ION; COTRANSPORTER; ELECTROLYTE; POTASSIUM ION; PROTON; SODIUM ION;

ACID BASE BALANCE; CARBON DIOXIDE TENSION; DIAGNOSTIC TEST; DIFFERENTIAL DIAGNOSIS; EXPERIMENTAL STUDY; HUMAN; HYPERKALEMIA; IONIZATION; KIDNEY DISTAL TUBULE; KIDNEY TUBULE ACIDOSIS; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON TRANSPORT; REGULATORY MECHANISM; REVIEW; THEORY; URINARY EXCRETION;

ACID-BASE EQUILIBRIUM; ACIDOSIS, RENAL TUBULAR; CHEMISTRY, CLINICAL; HUMANS;

EID: 31744451420     PISSN: 13648535     EISSN: None     Source Type: Journal    
DOI: 10.1186/cc3802     Document Type: Review

References (72)

1. Corey HE: Stewart and beyond: New models of acid-base balance. Kidney Int 2003, 64:777-787.
2. Laing CM, Toye AM, Caposso G, Unwin RJ: Renal tubular acidosis: developments in our understanding of the molecular basis. Int J Biochem Cell Biol 2005, 37:1151-1161.
3. Lemann J Jr, Bushinsky DA, Hamm LL: Bone buffering of acid and base in humans. Am J Physiol 2003, 285:F811-F832.
4. Cohen RM, Feldman GM, Fernandez PC: The balance of acid, base and charge in health and disease. Kidney Int 1997, 52: 287-293.
5. Cheema-Dhadli S, Lin S-H, Halperin ML: Mechanisms used to dispose of progressively increasing alkali loads in rats. Am J Physiol 2002, 282:F1049-F1055.
6. Brown JC, Packer RK, Knepper MA: Role of organic anions in renal response to dietary acid and base loads. Am J Physiol 1989, 257:170-F176.
7. Kamel KS, Briceno LF, Sanchez MI, Brenes L, Yorgin P, Kooh SW, Balfe JW, Halperin ML: A new classification for renal defects in net acid excretion. Am J Kidney Dis 1997, 29:136-146.
8. Burbea Z-H, Gullans SR, Ben-Yaakov S: ΔAlkalinity: a simple method to measure cellular net acid-base fluxes. Am J Physiol 1987, 253:C525-C534.
9. Osther PJ, Engel K, Kildeberg P: Renal response to acute acid loading. Scand J Urol Nephrol 2004, 38:62-68.
10. Atkinson DE, Bourke E: Metabolic aspects of the regulation of systemic pH. Am J Physiol 1987, 252:F947-F956.
11. Nagami GT: Renal ammonia production and excretion. In The Kidney, Physiology and Pathophysiology, 3rd ed. Edited by Seldin DW, Giebisch G. Philadelphia: Lippincott Williams & Wilkins; 2000:1995-2013.
12. Hosch M, Muser J, Hulter HN, Krapf R: Ureagenesis: evidence for a lack of hepatic regulation of acid-base equilibrium in humans. Am J Physiol 2004, 286:F94-F99.
13. Gennari FJ, Maddox DA: Renal regulation of acid-base homeostasis: integrated response. In The Kidney, Physiology and Pathophysiology, 3rd ed. Edited by Seldin DW, Giebisch G. Philadelphia: Lippincott Williams & Wilkins; 2000:2015-2053.
14. Kurtz I, Dass PD, Cramer S: The importance of renal ammonia metabolism to whole body acid-base balance: a reanalysis of the pathophysiology of renal tubular acidosis. Miner Electrolyte Metab 1990, 16:331-340.
15. Weiner ID: The Rh gene family and renal ammonium transport. Curr Opin Nephrol Hypertens 2004, 13:533-540.
16. Frank AE, Weiner ID: Effects of ammonia on acid-base transport by the B-type intercalated cell. J Am Soc Nephrol 2001, 12:1607-1614.
17. Frank AE, Wingo CS, Andrews PM, Ageloff S, Knepper MA, Weiner ID: Mechanisms through which ammonia regulates cortical collecting duct net proton secretion. Am J Physiol 2002, 282:F1120-F1128.
18. Stewart PA: Modern quantitative acid-base chemistry. Can J Physiol Pharmacol 1983, 61:1444-1461.
19. Stewart PA: How to understand acid-base. A Quantitative acid-base primer for biology and medicine. London: Edward Arnold; 1981.
20. Stewart PA: Independent and dependent variables of acid-base control. Respir Physiol 1978, 33:9-26.
21. Corey HE: Bench-to-bedside review: fundamental principles of acid-base physiology. Crit Care 2004, 8:184-192.
22. Lindinger MI, Heigenhauser GJF, McKelvie RS, Jones NL: Blood ion regulation during repeated maximal exercise and recovery in humans. Am J Physiol 1992, 262:R126-R136.
23. Ring T, Andersen PT, Knudsen F, Nielsen FB: Salicylate-induced hyperventilation [letter]. Lancet 1985, i:1450.
24. Geers C, Gros G: Carbon dioxide transport and carbonic anhydrase in blood and muscle. Phys Rev 2000, 80:681-715.
25. Kim S, Lee JW, Park J, Na KY, Joo KW, Ahn C, Kim S, Lee JS, Kim GH, Kim J, et al.: The urine-blood PCO2 gradient as a diagnostic index of H+-ATPase defect in distal renal tubular acidosis. Kidney Int 2004, 66:761-767.
26. Purkerson JM, Schwartz GJ: Expression of membrane-associated carbonic anhydrase isoforms IV, IX, XII, and XIV in the rabbit: induction of CA IV and IX during maturation. Am J Physiol 2005, 288:R1256-R1263.
27. Wooten EW: Analytic calculation of physiological acid-base parameters in plasma. J Appl Physiol 1999, 86:326-334.
28. Staempfli HR, Constable PD: Experimental determination of net protein charge and Atot and Ka of nonvolatile buffers in human plasma. Am J Physiol 2003, 95:620-630.
29. Gowrishankar M, Chen CB, Mallie JP, Halperin ML: What is the impact of potassium excretion on the intracellular fluid volume: importance of urine anions. Kidney Int 1996, 50:1490-1495.
30. Kellum JA: Determinants of blood pH in health and disease. Crit Care 2000, 4:6-14.
31. Soriano JR: Renal tubular acidosis: the clinical entity. J Am Soc Nephrol 2002, 13:2160-2170.
32. Kellum JA: Metabolic acidosis in the critically ill: lessons from physical chemistry. Kidney Int 1998, Suppl 66:s-81-s-86.
33. Constable PD: Hyperchloremic acidosis: the classic example of strong ion acidosis. Anesth Surg 2003, 96:919-922.
34. Weinstein AM: Mathematical models of renal fluid and electrolyte transport: acknowledging our uncertainty. Am J Physiol 2003, 284:F871-884.
35. Petrovic S, Barone S, Weinstein AM, Soleimani M: Activation of the apical Na+/H+ exchanger NHE3 by formate: basis of enhanced fluid and electrolyte reabsorption by formate in the kidney. Am J Physiol 2004, 287:F336-F346.
36. Wang Z, Wang T, Petrovic S, Tuo B, Riederer B, Lorenz JN, Seidler U, Aronson PS, Soleimani M: Renal and intestinal transport defects in Slc26a6-null mice. Am J Physiol 2005, 288:C957-C965.
37. Guo P, Weinstein AM, Weinbaum S: A dual-pathway ultrastructural model for the tight junction of rat proximal tubule epithelium. Am J Physiol 2003, 285:F241-F257.
38. Igarashi T, Sekine T, Inatomi J, Seki G: Unravelling the molecular pathogenesis of isolated proximal renal tubular acidosis. J Am Soc Nephrol 2002, 13:2171-2177.
39. Warth R, Barrière H, Meneton P, Bloch M, Thomas J, Tauc M, Heitzmann D, Romeo E, Verrey F, Mengual R, et al.: Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport. Proc Natl Acad Sci USA 2004, 101:8215-8220.
40. Pushkin A, Abuladze N, Gross E, Newman D, Tatishchev S, Lee I, Fedotoff O, Bondar G, Azimov R, Nguyen M, et al.: Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells. J Physiol 2004, 559:55-65.
41. Skinner R: Chronic ifosfamide nephrotoxicity in children. Med Pediatr Oncol 2003, 41:190-197.
42. Hemstreet BA: Antimicrobial-associated renal tubular acidosis. Ann Pharmacother 2004, 38:1031-1038.
43. Zhou Y, Zhao J, Bouyer P, Boron WF: Evidence from renal proximal tubules that HCO3- and solute transport are acutely regulated not by pH but by basolateral HCO3- and CO2. Proc Natl Acad Sci USA 2005, 102:3875-3880.
44. Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP: Renal vacuolar H+-ATPase. Physiol Rev 2004, 84: 1263-1314.
45. Devonald MAJ, Karet FE: Renal epithelial traffic jams and one-way streets. J Am Soc Nephrol 2004, 15:1370-1381.
46. Karet FE: Inherited diatal renal tubular acidosis. J Am Soc Nephrol 2002, 13:2178-2184.
47. Paroutis P, Touret N, Grinstein S: The pH of the secretory pathway: measurement, determinants, and regulation. Physiology 2004, 19:207-215.
48. Jentsch TJ: Chloride transport in the kidney: lessons from human disease and knockout mice. J Am Soc Nephrol 2005, 16:1549-1561.
49. Boettger T, Hübner CA, Maier H, Rust MB, Beck FX, Jentsch TJ: Deafness and renal tubular acidosis in mice lacking the K-Cl cotransporter Kcc4. Nature 2002, 416:874-878.
50. Watanabe S, Tsuruoko S, Vijayakumar S, Fischer G, Zhang Y, Fujimura A, Al-Awqati Q, Schwartz GJ: Cyclosporin A produces distal renal tubular acidosis by blocking peptidyl prolyl cis-trans isomerase activity of cyclophilin. Am J Physiol 2005, 288:F40-F47.
51. Schwartz GJ, Tsuruoka S, Vijayakumar S, Petrovic S, Mian A, Al-Awqati Q: Acid incubation reverses the polarity of intercalated cell transporters, and effect mediated by hensin. J Clin Invest 2002, 109:89-99.
52. Goldman RD, Koren G: Amphotericin B nephrotoxicity in children. J Pediatr Hematol Oncol 2004, 26:421-426.
53. Shah GN, Bonapace G, Hu PY, Strisciuglio P, Sly WS: Carbonic anhydrase II deficiency syndrome (osteopetrosis with renal tubular acidosis and brain calcification): novel mutations in CA2 indentified by direct sequencing expand the opportunity for genotype-phenotype correlation. Hum Mutat 2004, 24:272.
54. Pushkin A, Abuladze N, Gross E, Newman D, Tatishchev S, Lee I, Fedotoff O, Bondar G, Azimov R, Ngyuen M, et al.: Molecular mechanisms of kNBC1-carbonic anhydrase II interaction in proximal tubule cells. J Physiol 2004, 559:55-65.
55. Alvarez BV, Vilas GL, Casey JR: Matabolon disruption: a mechanism that regulates bicarbonate transport. EMBO J 2005, 24: 2499-2511.
56. Gamba G: Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension. Am J Physiol 2005, 288:F245-F252.
57. Kahle KT, Wilson FH, Lifton RP: Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switch. Trends Endocrinol Metab 2005, 20:1-6.
58. DuBose TD, Good DW: Chronic hyperkalemia impairs ammonium transport and accumulation in the inner medulla of the rat. J Clin Invest 1992, 90:1443-1449.
59. Xu BE, Stippec S, Chu PY, Lazrak A, Li XJ, Lee BH, English JM, Ortega B, Huang CL, Cobb MH: WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci USA 2005, 102:10315-10320.
60. Halperin ML, Richarson RMA, Bear RA, Magner PO, Kamel K, Ethier J: Urine ammonium: the key to the diagnosis of diatal renal tubular acidosis. Nephron 1988, 50:1-4.
61. DuBose TD, Caflisch CR: Validation of the difference in urine and blood carbon dioxide tension during bicarbonate loading as an index of distal nephron acidification in experimental models of distal renal tubular acidosis. J Clin Invest 1985, 75: 1116-1123.
62. Smulders YM, Frissen PHJ, Slaats EH, Silberbusch J: Renal tubular acidosis. Pathophysiology and diagnosis. Arch Intern Med 1996, 156:1629-1636.
63. Sebastian A, McSherry E, Morris RC Jr: Impaired renal conservation of sodium and chloride during sustained correction of systemic acidosis in patients with type 1, classic renal tubular acidosis. J Clin Invest 1976, 58:454-469.
64. Frische S, Kwon T-H, Frøkiær J, Madsen KM, Nielsen S: Regulated expression of pendrin in rat kidney in response to chronic NH4Cl or NaHCO3 loading. Am J Physiol 2003, 284: F584-F593.
65. Wall SM, Kim YH, Stanley L, Glapion DM, Everett LA, Green ED, Verlander JW: NaCl restriction upregulates renal Slc26a4 through subcellular redistribution. Role in Cl- conservation. Hypertension 2004, 44:982-987.
66. Quentin F, Chambrey R, Trinh-Trang-Tan MM, Fysekidis M, Cambillau M, Paillard M, Aronson PS, Eladari D: The Cl-/HCO3-exchanger pendrin in the rat kidney is regulated in response to chronic alterations in chloride balance. Am J Physiol 2004, 287:F1179-F1188.
67. Li S, Sato S, Yang X, Preisig PA, Alpern RJ: Pyk2 activation is integral to acid stimulation of sodium/hydrogen exchanger 3. J Clin Invest 2004, 114:1782-1789.
68. Gluck SL: Acid sensing in renal epithelial cells. J Clin Invest 2004, 114:1696-1699.
69. Putman, CT, Jones NL, Heigenhauser GJF: Effects of short-term training on plasma acid-base balance during incremental exercise in man. J Physiol 2003, 550:585-603.
70. Truskett TM: The subtleties of water in small spaces. Proc Natl Acad Sci USA 2003, 100:10139-10140.
71. Ikizler TA, Sezer MT, Flakoll PJ, Hariacher S, Kanagasundaram NS, Gritter N, Knights S, Shyr Y, Paganini E, Hakim RM, et al.: Urea space and total body water measurements by stable isotopes in patients with acute renal failure. Kidney Int 2004, 65:725-732.
72. Wooten EW: Calculation of physiological acid-base parameters in multicompartmental systems with application to human blood. J Appl Physiol 2003, 95:2333-2344.