Anti-fibrotic effects of theophylline on lung fibroblasts

Biochemical and Biophysical Research Communications

Volumn 341, Issue 3, 2006, Pages 684-690

  Yano, Yukihiro ^a   Yoshida, Mitsuhiro ^a   Hoshino, Shigenori ^a   Inoue, Koji ^a   Kida, Hiroshi ^a   Yanagita, Masahiko ^a   Takimoto, Takayuki ^a   Hirata, Haruhiko ^a   Kijima, Takashi ^a   Kumagai, Toru ^a   Osaki, Tadashi ^a   Tachibana, Isao ^a   Kawase, Ichiro ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Airway remodeling; Asthma; cAMP; Collagen; COPD; Fibroblast; PKA; TGF ; Theophylline

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; DEXAMETHASONE; MESSENGER RNA; THEOPHYLLINE; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INHIBITION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CELL LINE; COLLAGEN TYPE I; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DEXAMETHASONE; FIBROBLASTS; FIBROSIS; GENE EXPRESSION; HUMANS; LUNG; PROTEIN KINASE INHIBITORS; RNA, MESSENGER; THEOPHYLLINE; TRANSFORMING GROWTH FACTOR BETA;

EID: 31744445706     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.01.018     Document Type: Article

References (36)

1. M.J. Finney, J.A. Karlsson, and C.G. Persson Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation Br. J. Pharmacol. 85 1985 29 36
2. K.F. Rabe, H. Magnussen, and G. Dent Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants Eur. Respir. J. 8 1995 637 642
3. G.E. D'Alonzo Theophylline revisited Allergy Asthma Proc. 17 1996 335 339
4. P.J. Barnes Theophylline: new perspectives for an old drug Am. J. Respir. Crit. Care Med. 167 2003 813 818
5. M. Kobayashi, Y. Nasuhara, T. Betsuyaku, E. Shibuya, Y. Tanino, M. Tanino, K. Takamura, K. Nagai, T. Hosokawa, and M. Nishimura Effect of low-dose theophylline on airway inflammation in COPD Respirology 9 2004 249 254
6. K. Yasui, K. Agematsu, K. Shinozaki, S. Hokibara, H. Nagumo, T. Nakazawa, and A. Komiyama Theophylline induces neutrophil apoptosis through adenosine A2A receptor antagonism J. Leukoc. Biol. 67 2000 529 535
7. P.J. Barnes, I.M. Adcock, and K. Ito Histone acetylation and deacetylation: importance in inflammatory lung diseases Eur. Respir. J. 25 2005 552 563
8. P.K. Jeffery Remodeling in asthma and chronic obstructive lung disease Am. J. Respir. Crit. Care Med. 164 2001 S28 S38
9. J. Bousquet, P.K. Jeffery, W.W. Busse, M. Johnson, and A.M. Vignola Asthma. From bronchoconstriction to airways inflammation and remodeling Am. J. Respir. Crit. Care Med. 161 2000 1720 1745
10. S. Gabbrielli, S. Di Lollo, N. Stanflin, and P. Romagnoli Myofibroblast and elastic and collagen fiber hyperplasia in the bronchial mucosa: a possible basis for the progressive irreversibility of airway obstruction in chronic asthma Pathologica 86 1994 157 160
11. A.E. Redington Fibrosis and airway remodelling Clin. Exp. Allergy 30 Suppl. 1 2000 42 45
12. V.M. Antonio, C. Pascal, C. Giuseppina, M. Anna, P. Elisabetta, R. Aroldo, l.R.M. Antionio, B. Vincenzo, B. Giovanni, and B. Jean Transforming Growth Factor-beta expression in mucosal biopsies in asthma and chronic bronchitis Am. J. Respir. Crit. Care Med. 156 1997 591 599
13. K. Inoue, M. Yoshida, T. Arai, S. Hoshino, Y. Yano, M. Yanagita, H. Kida, T. Takimoto, H. Hirata, T. Kumagai, T. Osaki, T. Kijima, I. Tachibana, and I. Kawase IL-10 inhibits transforming growth factor-b-induction of type I collagen mRNA expression via both JNK and p38 pathways in human lung fibroblasts EXCLI J. 4 2005 49 60
14. U. Bolkenius, D. Hahn, A.M. Gressner, K. Breitkopf, S. Dooley, and L. Wickert Glucocorticoids decrease the bioavailability of TGF-beta which leads to a reduced TGF-beta signaling in hepatic stellate cells Biochem. Biophys. Res. Commun. 325 2004 1264 1270
15. E. Cazes, J. Giron-Michel, S. Baouz, C. Doucet, F. Cagnoni, S. Oddera, M. Korner, G. Dasic, R. Testi, B. Azzarone, and G.W. Canonica Novel anti-inflammatory effects of the inhaled corticosteroid fluticasone propionate during lung myofibroblastic differentiation J. Immunol. 167 2001 5329 5337
16. K.R. Cutroneo, and K.M. Sterling Jr. How do glucocorticoids compare to oligo decoys as inhibitors of collagen synthesis and potential toxicity of these therapeutics? J. Cell Biochem. 92 2004 6 15
17. N. Meisler, K.A. Keefer, H.P. Ehrlich, D.R. Yager, J. Myers-Parrelli, and K.R. Cutroneo Dexamethasone abrogates the fibrogenic effect of transforming growth factor-beta in rat granuloma and granulation tissue fibroblasts J. Invest. Dermatol. 108 1997 285 289
18. A. Desmouliere, and G. Gabbiani Myofibroblast differentiation during fibrosis Exp. Nephrol. 3 1995 134 139
19. A. Desmouliere Factors influencing myofibroblast differentiation during wound healing and fibrosis Cell Biol. Int. 19 1995 471 476
20. C. Kuhn, and J.A. McDonald The roles of the myofibroblast in idiopathic pulmonary fibrosis. Ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis Am. J. Pathol. 138 1991 1257 1265
21. J.E. Kolodsick, M. Peters-Golden, J. Larios, G.B. Toews, V.J. Thannickal, and B.B. Moore Prostaglandin E2 inhibits fibroblast to myofibroblast transition via E. prostanoid receptor 2 signaling and cyclic adenosine monophosphate elevation Am. J. Respir. Cell Mol. Biol. 29 2003 537 544
22. T. Pan, R.J. Mason, J.Y. Westcott, and J.M. Shannon Rat alveolar type II cells inhibit lung fibroblast proliferation in vitro Am. J. Respir. Cell Mol. Biol. 25 2001 353 361
23. T. Tsuruda, J. Kato, K. Kitamura, M. Kawamoto, K. Kuwasako, T. Imamura, Y. Koiwaya, T. Tsuji, K. Kangawa, and T. Eto An autocrine or a paracrine role of adrenomedullin in modulating cardiac fibroblast growth Cardiovasc. Res. 43 1999 958 967
24. T.F. Li, M.J. Zuscik, A.M. Ionescu, X. Zhang, R.N. Rosier, E.M. Schwarz, H. Drissi, and R.J. O'Keefe PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling Exp. Cell Res. 300 2004 159 169
25. J.S. Swaney, D.M. Roth, E.R. Olson, J.E. Naugle, J.G. Meszaros, and P.A. Insel Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase Proc. Natl. Acad. Sci. USA 102 2005 437 442
26. J.L. Bos Epac: a new cAMP target and new avenues in cAMP research Nat. Rev. Mol. Cell Biol. 4 2003 733 738
27. M. Yoshida, J. Sakuma, S. Hayashi, K. Abe, I. Saito, S. Harada, M. Sakatani, S. Yamamoto, N. Matsumoto, and Y. Kaneda A histologically distinctive interstitial pneumonia induced by overexpression of the interleukin 6, transforming growth factor beta 1, or platelet-derived growth factor B gene Proc. Natl. Acad. Sci. USA 92 1995 9570 9574
28. P.J. Sime, Z. Xing, F.L. Graham, K.G. Csaky, and J. Gauldie Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung J. Clin. Invest. 100 1997 768 776
29. J.H. Li, H.J. Zhu, X.R. Huang, K.N. Lai, R.J. Johnson, and H.Y. Lan Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation J. Am. Soc. Nephrol. 13 2002 1464 1472
30. A. Nakao, M. Fujii, R. Matsumura, K. Kumano, Y. Saito, K. Miyazono, and I. Iwamoto Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice J. Clin. Invest. 104 1999 5 11
31. S.L. Lin, R.H. Chen, Y.M. Chen, W.C. Chiang, C.F. Lai, K.D. Wu, and T.J. Tsai Pentoxifylline attenuates tubulointerstitial fibrosis by blocking smad3/4-activated transcription and profibrogenic effects of connective tissue growth factor J. Am. Soc. Nephrol. 16 2005 2702 2713
32. M. Schiller, F. Verrecchia, and A. Mauviel Cyclic adenosine 3′,5′-monophosphate-elevating agents inhibit transforming growth factor-beta-induced SMAD3/4-dependent transcription via a protein kinase A-dependent mechanism Oncogene 22 2003 8881 8890
33. A. Chen, and B.H. Davis UV irradiation activates JNK and increases alphaI(I) collagen gene expression in rat hepatic stellate cells J. Biol. Chem. 274 1999 158 164
34. M. Varela-Rey, C. Montiel-Duarte, J.A. Oses-Prieto, M.J. Lopez-Zabalza, J.P. Jaffrezou, M. Rojkind, and M.J. Iraburu p38 MAPK mediates the regulation of alpha1(I) procollagen mRNA levels by TNF-alpha and TGF-beta in a cell line of rat hepatic stellate cells(1) FEBS Lett. 528 2002 133 138
35. Y. Hirota, T. Tsukazaki, A. Yonekura, Y. Miyazaki, M. Osaki, H. Shindo, and S. Yamashita Activation of specific MEK-ERK cascade is necessary for TGFbeta signaling and crosstalk with PKA and PKC pathways in cultured rat articular chondrocytes Osteoarthritis Cartilage 8 2000 241 247
36. J.J. Mascali, P. Cvietusa, J. Negri, and L. Borish Anti-inflammatory effects of theophylline: modulation of cytokine production Ann. Allergy Asthma Immunol. 77 1996 34 38