Activation of specific MEK-ERK cascade is necessary for TGFβ signaling and crosstalk with PKA and PKC pathways in cultured rat articular chondrocytes

Osteoarthritis and Cartilage

Volumn 8, Issue 4, 2000, Pages 241-247

  Hirota, Y ^a   Tsukazaki, T ^a   Yonekura, A ^a   Miyazaki, Y ^a   Osaki, M ^a   Shindo, H ^a   Yamashita, S ^b  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

Articular chondrocytes; MAPK; TGF

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN KINASE C; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; ENZYME ACTIVATION; NONHUMAN; OSTEOARTHRITIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0033854959     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.1999.0297     Document Type: Article

References (30)

1. Chang SC, Hoang B, Thomas JT, Vukicevic S, Luyten FP, Ryba NJ. Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-β superfamily predominantly expressed in long bones during human embryonic development. J Biol Chem. 269:1994;28227-28234.
2. Saltis J. TGF-β: receptors and cell cycle arrest. Mol Cell Endocrinol. 116:1996;227-232.
3. Moses HL, Serra R. Regulation of differentiation by TGF-β Curr Opin Genet Dev. 6:1996;581-586.
4. Solloway MJ, Robertson EJ. Early embryonic lethality in Bmp5; Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development. 126:1999;1753-1768.
5. Hoodless PA, Wrana JL. Mechanism and function of signaling by the TGFβ superfamily. Curr Top Microbiol Immunol. 228:1998;235-272.
6. van Osch GJ, van den Berg WB, Hunziker EB, Hauselmann HJ. Differential effects of IGF-1 and TGF β-2 on the assembly of proteoglycans in pericellular and territorial matrix by cultured bovine articular chondrocytes. Osteoarthritis Cartilage. 6:1998;187-195.
7. Demoor FM, Redini F, Boittin M, Pujol JP. Expression of decorin and biglycan by rabbit articular chondrocytes. Effects of cytokines and phenotypic modulation. Biochim Biophys Acta. 1398:1998;179-191.
8. Campbell IK, Wojta J, Novak U, Hamilton JA. Cytokine modulation of plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocytes. Down-regulation by tumor necrosis factor α and up-regulation by transforming growth factor-β basic fibroblast growth factor. Biochim Biophys Acta. 1226:1994;277-285.
9. Moldovan F, Pelletier JP, Hambor J, Cloutier JM, Martel PJ. Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilagein situ : in vitro mimicking effect by transforming growth factor β Arthritis Rheum. 40:1997;1653-1661.
10. Glansbeek HL, van BH, Vitters EL, van der Kraan. Stimulation of articular cartilage repair in established arthritis by local administration of transforming growth factor-β into murine knee joints. Lab Invest. 78:1998;133-142.
11. Bradham DM, Horton WJ. In vivo cartilage formation from growth factor modulated articular chondrocytes. Clin Orthop. 00:1998;239-249.
12. Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL. SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor. Cell. 95:1998;779-791.
13. Visser JA, Themmen AP. Downstream factors in transforming growth factor-β family signaling. Mol Cell Endocrinol. 146:1998;7-17.
14. Hocevar BA, Brown TL, Howe PH. TGFβ induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J. 18:1999;1345-1356.
15. Tsukazaki T, Usa T, Matsumoto T, Enomoto H, Ohtsuru A, Namba H. Effect of transforming growth factor β on the insulin-like growth factor-I autocrine/paracrine axis in cultured rat articular chondrocytes. Exp Cell Res. 215:1994;9-16.
16. Osaki M, Tsukazaki T, Yonekura A, Miyazaki Y, Iwasaki K, Shindo H. Regulation of c-fos gene induction and mitogenic effect of transforming growth factor β in rat articular chondrocyte. Endocr J. 46:1999;253-261.
17. Yonekura A, Osaki M, Hirota Y, Tsukazaki T, Miyazaki Y, Matsumoto T. Transforming growth factor-β stimulates articular chondrocyte cell growth through p44/42 MAP kinase activation. Endocr J. 46:1999;545-553.
18. Forrer P, Tamaskovic R, Jaussi R. Enzyme-linked immunosorbent assay for measurement of JNK, ERK, and p38 kinase activities. Biol Chem. 379:1998;1101-1111.
19. Minden A, Lin A, McMahon M, Lange-Carter C, Derijard B, Davis RJ. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science. 266:1994;1719-1723.
20. Yan M, Dai T, Deak JC, Kyriakis JM, Zon LI, Woodgett JR. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature. 372:1994;798-800.
21. Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N. Identification of a member of the MAPKKK family as a potential mediator of TGFβ signal transduction. Science. 270:1995;2008-2011.
22. Atfi A, Djelloul S, Chastre E, Davis R, Gespach C. Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor β-mediated signaling. J Biol Chem. 272:1997;1429-1432.
23. Tsukazaki T, Ohtsuru A, Namba H, Oda J, Matsumoto T, Osaki M. Parathyroid hormone-related protein (PTHrP) action in rat articular chondrocyte: comparison of PTH(1-34), PTHrP(1-34), PTHrP(1-141), PTHrP(100-114) and antisense oligonucleotides against PTHrP. J Endocriol. 150:1996;359-368.
24. Chapekar MS, Huggett AC, Thorgeirsson SS. Growth modulatory effects of a liver-derived growth inhibitor, transforming growth factor β1, and recombinant tumor necrosis factor α, in normal and neoplastic cells. Exp Cell Res. 185:1989;247-257.
25. Stolz DB, Michalopoulos GK. Synergistic enhancement of EGF, but not HGF, stimulated hepatocyte motility by TGFβ1 in vitro. J Cell Physiol. 170:1997;57-68.
26. Atfi A, Buisine M, Mazars A, Gespach C. Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor β through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway. J Biol Chem. 272:1997;24731-24734.
27. Wrana JL, Attisano L, Carcamo J, Zentella A, Doody J, Laiho M. TGFβ signals through a heteromeric protein kinase receptor complex. Cell. 71:1992;1003-1014.
28. Zhang Y, Feng XH, Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription. Nature. 394:1998;909-913.
29. Cook SJ, McCormick F. Inhibition by cAMP of Ras-dependent activation of Raf. Science. 262:1993;1069-1072.
30. Wu J, Dent P, Jelinek T, Wolfman A, Weber MJ, Sturgill TW. Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate. Science. 262:1993;1065-1069.