ALDH2 and CYP2E1 genotypes, urinary acetaldehyde excretion and the health consequences in moderate alcohol consumers

Journal of Human Genetics

Volumn 51, Issue 2, 2006, Pages 104-111

  Yamada, Yuichi ^a   Imai, Tsunehiko ^b   Ishizaki, Masao ^a   Honda, Ryumon ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Blood pressure; Cytochrome P450 2E1 (CYP2E1); Esophageal cancer; Fasting serum glucose; Low Km aldehyde dehydrogenase (ALDH2); Moderate alcohol consumption; Serum lipid peroxides; Urinary acetaldehyde

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALDEHYDE DEHYDROGENASE; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450 2E1; GAMMA GLUTAMYLTRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID PEROXIDE;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD PRESSURE; CHOLESTEROL BLOOD LEVEL; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GENETIC ASSOCIATION; GENOTYPE; HEALTH HAZARD; HEALTH STATUS; HUMAN; MAJOR CLINICAL STUDY; MALE; POPULATION GENETICS; URINARY EXCRETION;

ACETALDEHYDE; ADULT; ALCOHOL DRINKING; ALDEHYDE DEHYDROGENASE; ASPARTATE AMINOTRANSFERASES; BLOOD PRESSURE; CHOLESTEROL, HDL; CYTOCHROME P-450 CYP2E1; GAMMA-GLUTAMYLTRANSFERASE; GENOTYPE; HUMANS; JAPAN; MALE; MIDDLE AGED; PEROXIDASES;

EID: 31544482462     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-005-0330-0     Document Type: Article

References (38)

1. Amamoto K, Okamura T, Tamaki S, Kita Y, Tsuji Y, Kadowaki T, Nakamura Y, Ueshima H (2002) Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population. Hypertens Res 25:857-864
2. Araki K, Fukase O, Yamamoto A, Fujiwara T, Kurayama H, Yamaguchi H, Inagaki H, Okochi T (1994) Relationship between serum lipid peroxide level (serum TBA level) and smoking, alcohol drinking, food frequency, serum vitamin C and E in subjects of a human dock (in Japanese). Jpn J Publ Health 41:311-322
3. Bush TL (1990) The epidemiology of cardiovascular disease in postmenopausal women. Ann N Y Acad Sci 592:45-55
4. Enomoto N, Takase S, Yasuhara M, Takada A (1991) Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes. Alcohol Clin Exp Res 15:141-144
5. Gorodeski GI (1994) Impact of the menopause on the epidemiology and risk factors of coronary artery heart disease in women. Exp Gerontol 29:357-375
6. Harada S, Agarwal DP, Goedde HW (1981) Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese. Lancet ii:982
7. Hayashi SI, Watanabe J, Kawajiri K (1991) Genetic polymorphisms in 5′-flanking region change transcriptional regulation of the human cytochrome P450 IIE1 gene. J Biochem 110:559-565
8. Imai T, Omoto M, Kanegae T, Tsukamoto S (2002) Changes of bound ethanol and acetaldehyde levels in urine of the habit drinkers (in Japanese). Jpn J Alcohol Stud Drug Depend 37:386-387
9. Itoh T, Matsumoto M, Nakamura M, Okada A, Shirahashi N, Hougaku H, Hashimoto H, Sakaguchi M, Handa N, Takeshita T, Morimoto K, Hori M (1997) Effects of daily alcohol intake on the blood pressure differ depending on an individual's sensitivity to alcohol: oriental flushing as a sign to stop drinking for health reasons. J Hypertens 15:1211-1217
10. Kamino K, Nagasaka K, Imagawa M, Yamamoto H, Yoneda H, Ueki A, Kitamura S, Namekata K, Miki T, Ohta S (2000) Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population. Biochem Biophys Res Commun 273:192-196
11. Kim JM, Stewart R, Shin IS, Jung JS, Yoon JS (2004) Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population. Neurobiol Aging 25:295-301
12. Kuriyama S, Suzuki Y, Atsumi Y, Tomonari H, Matsuoka K, Houjou T, Shoji R, Hosoya T (1998) Aldehyde dehydrogenase 2 (ALDH2) gene polymorphism in NIDDM patients with chronic renal failure (in Japanese). Jpn J Nephrol 40:344-348
13. Lieber CS (1980) Alcohol, protein metabolism and liver injury. Gastroenterol 79:373-390
14. Mizoi Y, Ijiri I, Tatsuno Y, Kijima T, Fujiwara S, Adachi J, Hishida S (1979) Relationship between facial flushing and blood acetaldehyde levels after alcohol intake. Pharmacol Biochem Behav 10:301-311
15. Murata C, Suzuki Y, Muramatsu T, Taniyama M, Atsumi Y, Matsuoka K, Watanabe T, Okazaki I (2000) Inactive aldehyde dehydrogenase 2 worsens glycemic control in patients with type 2 diabetes mellitus who drink low to moderate amounts of alcohol. Alcohol Clin Exp Res 24:5S-11S
16. Noborisaka Y, Ishida M, Ishizaki M, Nakaishi H, Tsuritani I, Honda R, Yamada Y (1998) A cross-sectional observation on the association of menopause with coronary risk factors in Japanese female workers. J Occup Health 40:207-211
17. Ohsawa I, Kamino K, Nagasaka K, Ando F, Niino N, Shimokata H, Ohta S (2003) Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females. J Hum Genet 48:404-409
18. Ohsawa I, Nishimaki K, Yasuda C, Kamino K, Ohta S (2003) Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells. J Neurochem 84:1110-1117
19. Okayama A, Ueshima H, Yamakawa M, Kita Y (1994) Low Km aldehyde dehydrogenase deficiency does not influence the elevation of blood pressure by alcohol. J Hum Hypertens 8:205-208
20. Shimmura T, Nakazaki M, Nishino H, Nakagawa H, Naruse Y, Kagamimori S (1995) Glutathione peroxidase activities in blood and serum lipid peroxide level (TBARS level) in healthy drinkers (in Japanese). Annu Rep Toyama Inst Health 18:181-184
21. Sun F, Tsuritani I, Honda R, Ma Z-Y, Yamada Y (1999) Association of genetic polymorphisms with excessive alcohol consumption in Japanese men. Hum Genet 105:295-300
22. Suzuki Y, Muramatsu T, Taniyama M, Atsumi Y, Kawaguchi R, Higuchi S, Hosokawa K, Asahina T (1996) Association of aldehyde dehydrogenase with inheritance of NIDDM. Diabetologia 39:1115-1118
23. Leu(UUR) mutation at position 3243. Diabetes Care 19:1423-1425
24. Suzuki Y, Taniyama M, Muramatsu T, Higuchi S, Ohta S, Atsumi Y, Matsuoka K (2004) ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes. Alcohol Clin Exp Res 28:111S-116S
25. Takagi S, Baba S, Iwai N, Fukuda M, Katsuya T, Higaki J, Mannami T, Goto Y, Ogihara T (2001) The aldehyde dehydrogenase 2 gene is a risk factor for hypertension in Japanese but does not alter the sensitivity to pressor effects of alcohol: The Suita Study. Hypertens Res 24:365-370
26. Takagi S, Iwai N, Yamauchi R, Kojima S, Yasuno S, Baba T, Terashima M, Tsutsumi Y, Suzuki S, Morii I, Hanai S, Ono K, Baba S, Tomoike H, Kawamura A, Monogi H, Goto Y (2002) Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men. Hypertens Res 25:677-681
27. Takeshita T (1999) Genetic factors which regulate alcohol drinking behavior and their effects on health. Jpn J Hyg 54:450-458
28. Tanaka H, Ikai E, Yamada Y (1997) Genetic polymorphisms in alcohol metabolizing enzymes as related to sensitivity to alcohol-induced health effects. Environ Health Prev Med 1:193-200
29. Tsuritani I, Ikai E, Date T, Suzuki Y, Ishizaki M, Yamada Y (1995) Polymorphism in ALDH2-genotype in Japanese men and the alcohol-blood pressure relationship. Am J Hypertens 8:1053-1059
30. Vasdev S, Mian T, Longerich L, Prabhakaran V, Parai S (1995) N-acetyl cysteine attenuates ethanol induced hypertension in rats. Artery 21:312-336
31. Vasdev S, Wadhawan S, Ford CA, Parai S, Longerich L, Gadag V (1999) Dietary vitamin B6 supplementation prevents ethanol-induced hypertension in rats. Nutr Metab Cardiovasc Dis 9:55-63
32. Yamada Y, Sun F, Tsuritani I, Honda R (2002) Genetic differences in ethanol metabolizing enzymes and blood pressure in Japanese alcohol consumers. J Hum Hypertens 16:479-486
33. Yamada Y, Noborisaka Y, Ishizaki M, Tsuritani I, Honda R (2004) Low fasting serum insulin in Japanese alcohol consumers does not imply improved coronary risk factors. Environ Health Prev Med 9:243-250
34. Yin SJ, Chou FJ, Chao SF, Tsai SF, Liao CS, Wang SL, Wu CW, Lee SC (1993) Alcohol and aldehyde dehydrogenases in human esophagus: comparison with the stomach enzyme activities. Alcohol Clin Exp Res 17:376-381
35. Yokoyama A, Muramatsu T, Ohmori T, Higuchi S, Hayashida M, Ishii H (1996) Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males. Cancer Epidemiol Biomark Prev 5:99-102
36. Yokoyama A, Muramatsu T, Ohmori T, Yokoyama T, Okuyama K, Takahashi H, Hasegawa Y, Higuchi S, Maruyama K, Shirakura K, Ishii H (1998) Alcohol-related cancers and aldehyde dehydrogenase-2 in Japapnese alcoholics. Carcinogenesis 19:1383-1387
37. Yokoyama A, Muramatsu T, Ohmori T, Yokoyama T, Matsushita S, Higuchi S, Maruyama K, Ishii H (2001) Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics. Carcinogenesis 22:433-439
38. Yokoyama A, Kato H, Yokoyama T, Tsujinaka T, Muto M, Omori T, Haneda T, Kumagai Y, Igaki H, Yokoyama M, Watanabe H, Fukuda H, Yoshizumi H (2002) Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma. Carcinogenesis 23:1851-1859