Inactive aldehyde dehydrogenase 2 worsens glycemic control in patients with type 2 diabetes mellitus who drink low to moderate amounts of alcohol

Alcoholism: Clinical and Experimental Research

Volumn 24, Issue 4 SUPPL., 2000, Pages

  Murata, Chisato ^a   Suzuki, Yoshihiko ^a   Muramatsu, Taro ^b   Taniyama, Matsuo ^c   Atsumi, Yoshihito ^a   Matsuoka, Kempei ^a   Watanabe, Tetsu ^d   Okazaki, Isao ^d  

^a SAISEIKAI CENTRAL HOSPITAL   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c SHOWA UNIVERSITY   (Japan)

^d TOKAI UNIVERSITY   (Japan)

Author keywords

Aldehyde Dehydrogenase 2; Diabetic Complication; Drinking Habit; Glycemic Control; Hemoglobin A1c; Type 2 Diabetes Mellitus

Indexed keywords

ALCOHOL; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; GLUCOSE; HEMOGLOBIN A1C; INSULIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; CONFERENCE PAPER; ENZYME POLYMORPHISM; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; HYPERINSULINEMIA; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

EID: 0034015350     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2000.tb00003.x     Document Type: Conference Paper

References (30)

1. Bell DSH (1996) Alcohol and the NIDDM patient. Diabetes Care 19: 509-515.
2. Ben G, Gnidi L, Maran A, Gigante A, Duner E, Iori E, Tiengo A, Avogaro A (1991) Effects of chronic alcohol intake on carbohydrate and lipid metabolism in subjects with type II (non-insulin-dependent) diabetes. Am J Med 90:70-76.
3. Christiansen C, Thomsen C, Rasmussen O, Hauerslev C, Balle M, Hansen C, Hermansen K (1994) Effect of alcohol on glucose, insulin, free fatty acid and triacylglycerol responses to a light meal in non-insulin-dependent diabetic subjects. Br J Nutr 71:449-454.
4. Flario L, Mohammad AK, Paresh D (1988) Ethanol and its novel metabolites inhibit insulin action on adipocytes. Diabetes 37:912-915.
5. Fujishima M, Kiyohara Y, Kato I, Ohmura T, Iwamoto H, Nakayama K, Ohmori S, Yoshitake T (1996) Diabetes and cardiovascular disease in a prospective population survey in Japan. Diabetes (Suppl 3) 45:S14-S16.
6. Gin H, Morlat P, Ragnaud JM, Aubertin J (1992) Short-term effect of red wine (consumed during meals) on insulin requirement and glucose tolerance in diabetic patients. Diabetes Care 15:546-548.
7. Higuchi S, Muramatsu T, Shigemori K, Saito M, Kono H, Dufour MC, Harford TC (1992) The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese. J Stud Alcohol 53:170-175.
8. Hodge AM, Dowse GK, Collins VR, Zimmet Z (1993) Abnormal glucose tolerance and alcohol consumption in three populations at high risk of non-insulin-dependent diabetes mellitus. Am J Epidemiol 137:178-189.
9. Holley DC, Bagby GJ, Curry D (1981) Ethanol-insulin interrelationships in the rat studied in vitro and in vivo: Evidence for direct ethanol inhibition of biphasic glucose-induced insulin secretion. Metabolism 30:894-899.
10. Iso H, Kitamura A, Shimamoto T, Sankai T, Naito Y, Sato S, Kiyama M, Iida M, Komachi Y (1995) Alcohol intake and the risk of cardiovascular disease in middle-aged Japanese men. Stroke 26:767-773.
11. Jerntorp P, Ohlin H, Aimer LO (1986b) Aldehyde dehydrogenase activity and large vessel disease in diabetes mellitus. A preliminary study. Diabetes 35:291-294.
12. Jerntorp P, Ohlin H, Sundkvist G, Almer LO (1986a) Effects of chlorpropamide and alcohol on aldehyde dehydrogenase activity and blood acetaldehyde concentration. Diabetes Res 3:369-372.
13. Kirchhoff M, Torp-Pedersen C, Hougaard K, Jacobsen TJ, Sjoel A, Munch K, Tingleff J, Joergensen T, Schroll M, Olsen ME (1994) Casual blood pressure in a general Danish population: Relation to age, sex, weight, height, diabetes, serum lipid and consumption of coffee, tobacco and alcohol. J Clin Epidemiol 47:469-474.
14. Koivisto VA, Haapa E, Tulokas S, Pelkonen R, Toivonen M (1993) Alcohol with a meal has no adverse effects on postprandial glucose homeostasis in diabetic patients. Diabetes Care 16:1612-1614.
15. Kuriyama S, Suzuki Y, Atsumi Y, Tomonari H, Matsuoka K, Houjou T, Shoji R, Hosoya T (1998) Aldehyde dehydrogenase 2 (ALDH2) gene polymorphism in NIDDM patients with chronic renal failure. Nippon Jinzo Gakkai Shi 40:344-348.
16. Lieber CS (1997) Cytochrome P-4502E1: Its physiological and pathological role. Physiol Rev 77:517-544.
17. Marchand LL, Wilkens LR, Kolonel LN, Hankin JH, Lyu L-C (1997) Association of sedentary lifestyle, obesity, smoking, alcohol use, and diabetes with the risk of colorectal cancer. Cancer Res 57:4787-4794.
18. McMonagle J, Felig P (1975) Effects of ethanol ingestion on glucose tolerance and insulin secretion in normal and diabetic subjects. Metabolism 24:625-632.
19. Moss SE, Klein R, Klein BEK (1994) The association of alcohol consumption with the incidence and progression of diabetic retinopathy. Ophthalmology 101:1962-1968.
20. Nikkilae EA, Taskinen M-R (1975) Ethanol-induced alterations of glucose tolerance, postglucose hypoglycemia, and insulin secretion in normal, obese, and diabetic subjects. Diabetes 24:933-943.
21. Ohlin H, Helander A, Tottmar O, Jerntorp P, Almer LO (1987) Aldehyde dehydrogenase activity and vascular disease in type II diabetes - A comparison between 2 different assays for activity. Diabetes Res 6:91-94.
22. Ohmura T, Ueda K, Kiyohara Y, Kato I, Iwamoto H, Nakayama K, Nomiyama K, Ohmori S, Yoshitake T, Shinkawa A, Hasuo Y, Fujishima M (1994) The association of the insulin resistance syndrome with impaired glucose tolerance and NIDDM in the Japanese general population: The Hisayama study. Diabetologia 37:897-904.
23. Phillips GB, Safrit HF (1971) Alcoholic diabetes: Induction of glucose intolerance with alcohol. JAMA 217:1513-1519.
24. Rimm EB, Chan J, Stampfer MJ, Colditz GA, Willett WC (1995) Prospective study of cigarette smoking, alcohol use, and the risk of diabetes in men. Br Med J 310:555-559.
25. Suzuki Y, Muramatsu T, Taniyama M, Atsumi Y, Kawaguchi R, Higuchi S, Hosokawa K, Asahina T, Murata C, Matsuoka K (1996a) Association of aldehyde dehydrogenase with inheritance of NIDDM. Diabetologia 39:1115-1118.
26. Suzuki Y, Muramatsu T, Taniyama M, Atsumi Y, Suematsu M, Kawaguchi R, Higuchi S, Asahina T, Murata C, Handa M, Matsuoka K (1996b) Mitochondrial aldehyde dehydrogenase in diabetes associated with mitochondrial tRNA (Leu (UUR)) mutation at position 3243. Diabetes Care 19:1423-1425.
27. Tiengo AV, Valerio A, Morinari M, Meneghel A, Lapolla A (1981) Effect of ethanol, acetaldehyde and acetate on insulin and glucagon secretion in the perfused rat pancreas. Diabetes 30:705-709.
28. Walsh CH, O'Sullivan DJ (1974) Effect of moderate alcohol intake on control of diabetes. Diabetes 23:440-442.
29. Xu D, Dhillon AS, Abelmann A, Croft K, Peters TJ, Palmer TN (1998) Alcohol-related diols cause acute insulin resistance in vivo. Metabolism 47:1180-1186.
30. Yokoyama A, Muramatsu T, Ohmori T, Higuchi S, Hayashida M, Ishii H (1996) Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males. Cancer Epidemiol Biomarkers Prev 5:99-102.