Hepatic sugar phosphate levels reflect gluconeogenesis in lung cancer: simultaneous turnover measurements and 31P magnetic resonance spectroscopy in vivo

Clinical Science

Volumn 98, Issue 2, 2000, Pages 167-174

  Leij Halfwerk, Susanne ^a   Dagnelie, Pieter C ^a,b   Van Den Berg, J Willem O ^a   Paul Wilson, J H ^a   Sijens, Paul E ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

31P magnetic resonance spectroscopy; Alanine; Gluconeogenesis; Liver; Lung cancer; Stable isotope tracers; Weight loss

Indexed keywords

ALANINE; GLUCOSE; ORGANOPHOSPHATE; PHOSPHORUS 31; SUGAR PHOSPHATE; TRACER; TRITIUM;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION FUNCTION; DIET RESTRICTION; GLUCONEOGENESIS; GLUCOSE INFUSION; HUMAN; LIVER METABOLISM; LUNG CANCER; LUNG NON SMALL CELL CANCER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; WEIGHT REDUCTION;

EID: 0033956111     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0980167     Document Type: Article

References (45)

1. 1 Costa, G., Lane, W. W., Vincent, R. G., Siebold, J. A., Aragon, M. and Bewley, P. T. (1980) Weight loss and cachexia in lung cancer. Nutr. Cancer 2, 98-103
2. 2 DeWys, W. D., Begg, C., Lavin, P. T. et al. (1980) Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am. J. Med. 69, 491-497
3. 3 Stanley, K. E. (1980) Prognostic factors for survival in patients with inoperable lung cancer. J. Natl. Cancer Inst. 65, 25-32
4. 4 Richards, E. W., Long, C. L., Nelson, K. M., Tohver, O. K., Pinkston, J. A., Navari, R. M. and Blakemore, W. S. (1993) Protein turnover in advanced lung cancer patients. Metab. Clin. Exp. 42, 291-296
5. 5 Heber, D., Chlebowski, R. T., Ishibashi, D. E., Herrold, J. N. and Block, J.B. (1982) Abnormalities in glucose and protein metabolism in noncachectic lung cancer patients. Cancer Res. 42, 4815-4819
6. 6 Waterhouse, C., Jeanpretre, N. and Keilson, J. (1979) Gluconeogenesis from alanine in patients with progressive malignant disease. Cancer Res. 39, 1968-1972
7. 7 Kern, K. A. and Norton, J. A. (1988) Cancer cachexia. J. Parenter. Enteral Nutr. 12, 286-298
8. 31P magnetic resonance spectroscopy study. Cancer Res. 54, 6383-6386
9. 9 Gutman, A., Thilo, E. and Biran, S. (1969) Enzymes of gluconeogenesis in tumor-bearing rats. Isr. J. Med. Sci. 5, 998-1001
10. 10 Herzfeld, A. and Greengard, O. (1977) The effect of lymphoma and other neoplasms on hepatic and plasma enzymes of the host rat. Cancer Res. 37, 231-238
11. 11 Roh, M. S., Ekman, L., Jeevanandam, M. and Brennan, M. F. (1984) Gluconeogenesis in tumor-influenced hepatocytes. Surgery 96, 427-434
12. 12 Argiles, J. M. and Lopez-Soriano, F. J. (1991) The energy state of tumor-bearing rats. J. Biol. Chem. 266, 2978-2982
13. 31P magnetic resonance spectroscopy study. Br. J. Cancer 67, 1303-1309
14. 14 Schneeberger, A. L., Thompson, R. T., Driedger, A. A., Finley, R. J. and Inculet, R. I. (1989) Effect of cancer on the in vivo energy state of rat liver and skeletal muscle. Cancer Res. 49, 1160-1164
15. 15 Noguchi, Y., Vydelingum, N. A. and Brennan, M. F. (1989) The reversal of increased gluconeogenesis in the tumor-bearing rat by tumor removal and food intake. Surgery 106, 423-430
16. 16 Hammond, K. D. and Balinsky, D. (1978) Activities of key gluconeogenic enzymes and glycogen synthase in rat and human livers, hepatomas, and hepatoma cell cultures. Cancer Res. 38, 1317-1322
17. 31P MR spectroscopy. NMR Biomed. 15, 535-544
18. 31P magnetic resonance spectroscopy. NMR Biomed. 3, 17-22
19. 19 Halfwerk, S., Dagnelie, P. C., Van den Berg, J. W. O., Hordijk-Luijk, C. H. K., Wattimena, J. L. D., Swart, G. R. and Wilson, J. H. P. (1997) Increased rates of gluconeogenesis from alanine in weight-losing lung cancer patients. Clin. Nutr. 16, 10 (abstract no. O35)
20. 20 Stumvoll, M., Meyer, C., Perriello, G., Kreider, M., Welle, S. and Gerich, J. (1998) Human kidney and liver gluconeogenesis: evidence for organ substrate selectivity. Am. J. Physiol. 274, E817-E826
21. 21 Jahoor, F., Herndon, D. N. and Wolfe, R. R. (1986) Role of insulin and glucagon in the response of glucose and alanine kinetics in burn-injured patients. J. Clin. Invest. 78, 807-814
22. 22 Varma, R., Varma, R. S., Allen, W. S. and Wardi, A. H. (1973) Gas chromatographic determination of neutral sugars from glycoproteins and acid mucopolysaccharides as aldononitrile acetates. J. Chromatogr. 86, 205-210
23. 23 Chaves Das Neves, H. J. and Vasconcelos, A. M. (1987) Capillary gas chromatography of amino acids, including asparagine and glutamine: sensitive gas chromatographic-mass spectrometric and selected ion monitoring gas chromatographic-mass spectrometric detection of the N,O(S). J. Chromatogr. 392, 249-258
24. 24 Martineau, A., Lecavalier, L., Falardeau, P. and Chiasson, J. L. (1985) Simultaneous determination of glucose turnover, alanine turnover, and gluconeogenesis in human using a double stable-isotope-labeled tracer infusion and gas chromatography-mass spectrometry analysis. Anal. Biochem. 151, 495-503
25. 25 Wolfe, R. R. (1992) Radioactive and Stable Isotope Tracers in Medicine: Principles and Practice of Kinetic Analysis, Wiley-Liss, New York
26. 31P chemical shift imaging of the human liver. Magn. Reson. Imaging 13, 621-628
27. 31P MR spectroscopy assessed liver metabolite concentrations from different institutions. Magn. Reson. Imaging 16, 205-211
28. 28 Leij-Halfwerk, S., Dagnelie, P. C., Van den Berg, J. W. O., Hordijk-Luijk, C. H. K., Wattimena, J. L. D. and Wilson, J. H. P. (1999) Increased rates of gluconeogenesis from alanine in lung cancer patients and the relation with weight loss. Gastroenterology 116, A2561 (abstract no. G2462)
29. 31P MRS. Invest. Radiol. 24, 980-984
30. 30 Jalan, R., Taylor-Robinson, S. D. and Hodgson, H. J. (1996) In vivo hepatic magnetic resonance spectroscopy: clinical or research tool? J. Hepatol. 25, 414-424
31. 13C NMR. Science 254, 573-576
32. 32 Petersen, K. F., Krssak, M., Navarro, V. et al. (1999) Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis. Am. J. Physiol. 276, E529-E535
33. 31P MRS study of patients with liver cirrhosis: progress towards a non-invasive assessment of disease severity. NMR Biomed. 6, 168-172
34. 34 Jalan, R., Sargentoni, J., Coutts, G. A., Bell, J. D., Rolles, K., Burroughs, A. K. and Taylor Robinson, S. D. (1996) Hepatic phosphorus-31 magnetic resonance spectroscopy in primary biliary cirrhosis and its relation to prognostic models. Gut 39, 141-146
35. 31P nuclear magnetic resonance spectroscopy study. Biochim. Biophys. Acta 1272, 113-118
36. 31P magnetic resonance spectroscopy and electron microscopy of the cirrhotic liver. Liver 17, 198-209
37. 31P magnetic resonance spectroscopy in chronic alcohol abusers. Gastroenterology 108, 776-788
38. 31P magnetic resonance spectroscopy of focal hepatic malignancies. NMR Biomed. 5, 114-120
39. 31P magnetic resonance spectroscopy of human liver in elderly patients: changes according to nutritional status and inflammatory state. Metab. Clin. Exp. 45, 1059-1061
40. 13C NMR study of hepatic pyruvate carboxylase activity in tumor rats. Biochem. Biophys. Res. Commun. 179, 366-371
41. 41 McGraw, C. A., Vawter, G. F. and Hug, G. (1986) Phosphoenolpyruvate carboxykinase activity in human liver. Forensic Sci. Int. 30, 143-154
42. 42 Tsuburaya, A., Blumberg, D., Burt, M. and Brennan, M. F. (1995) Energy depletion in the liver and in isolated hepatocytes of tumor-bearing animals. J. Surg. Res. 59, 421-427
43. 31P NMR any answers? Contrib. Nephrol. 63, 53-59
44. 31P-MRS in the rat. Biochim. Biophys. Acta 1335, 290-304
45. 1H-NMR investigation in vitro of normal and abnormal human liver. Biochim. Biophys. Acta 1225, 71-77