Positive and negative regulation of angiogenesis: From cell biology to the clinic

Vascular Medicine

Volumn 1, Issue 4, 1996, Pages 259-266

  Pepper, Michael S ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Anti angiogenesis; Blood vessel; Ischemia; Therapeutic angiogenesis; Tumor; Vascular endothelial growth factor

Indexed keywords

VASCULOTROPIN;

ANGIOGENESIS; CYTOLOGY; HUMAN; ISCHEMIA; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW;

EID: 0030444794     PISSN: 1358863X     EISSN: None     Source Type: Journal    
DOI: 10.1177/1358863X9600100404     Document Type: Review

References (83)

1. Evans HM. On the development of the aortae, cardinal and umbilical veins, and the other blood vessels of vertebrate embryos from capillaries. Anat Rec 1909; 3: 498-518.
2. Folkman J. Clinical applications of research on angiogenesis. New Engl J Med 1995; 333: 1757-1763.
3. Risau W, Flamme I. Vasculogenesis. Ann Rev Cell Dev Biol 1995; 11: 73-91.
4. Dieterlen-Lievre F, Godin I, Pardenaud L. Ontogeny of hematopoiesis in the avian embryo: a general paradigm. Curr Top Microbiol Immunol 1996; 212: 119-128.
5. Wilting J, Brand-Saberi B, Kurz H, Christ B. Development of the embryonic vascular system. Cell Mol Biol Res 1995; 41: 219-232.
6. Folkman J. Tumor angiogenesis. Adv Cancer Res 1974; 19: 331-358.
7. Holmgren L, O'Reilly MS, Folkman J. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Med 1995; 1: 149-153.
8. O'Reilly MS, Holmgren L, Chen C, Folkman J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nature Med 1996; 2: 689-692.
9. Clark ER, Clark EL. Microscopic observations on the growth of blood capillaries in the living mammal. Am J Anat 1939; 64: 251-301.
10. Ausprunk DH, Folkman J. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res 1977; 14: 53-65.
11. Paku S, Paweletz N. First steps in tumor-related angiogenesis. Lab Invest 1991; 65: 334-346.
12. Brooks PC. Cell adhesion molecules and angiogenesis. Cancer Metastasis Rev 1996; 15: 187-194.
13. Pepper MS, Montesano R, Mandriota S, Orci L, Vassalli J-D. Angiogenesis: a paradigm for balanced extracellular proteolysis during cell migration and morphogenesis. Enzyme Protein 1996; 49: 138-162.
14. Bouck N. Tumor angiogenesis: the role of oncogenes and tumor suppressor genes. Cancer Cells 1990; 2: 179-185.
15. Liotta LA, Steeg PS, Stetler-Stevenson WG. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 1991; 64: 327-366.
16. Pepper MS, Mandriota S, Vassalli J-D, Orci L, Montesano R. Angiogenesis regulating cytokines: activities and interactions. Curr Top Microbiol Immunol 1996; 213/II: 31-67.
17. Ferrara N, Houck K, Jackeman L, Leung DW. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev 1992; 13: 18-35.
18. Christofori G. The role of fibroblast growth factors in tumour progression and angiogenesis. In. Bicknell R, Lewis CE, Ferrara N eds. Tumour angiogenesis. Oxford: Oxford University Press, 1996 (in press).
19. Montesano R, Vassalli J-D, Baird A, Guillemin R, Orci L. Basic fibroblast growth factor induces angiogenesis in vitro. Proc Natl Acad Sci USA 1986; 83: 7297-7301.
20. Pepper MS, Ferrara N, Orci L, Montesano R. Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem Biophys Res Commun 1992; 189: 824-831.
21. Klagsbrun M, D'Amore PA. Regulators of angiogenesis. Annu Rev Physiol 1991; 53: 217-239.
22. Leek RD, Harris AL, Lewis CE. Cytokine networks in solid human tumors: regulation of angiogenesis. J Leukoc Biol 1994; 56: 423-435.
23. Risau W. What, if anything, is an angiogenic factor? Cancer Metastasis Rev 1996; 15: 149-151.
24. Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992; 359: 843-845.
25. Goldberg MA, Schneider TJ. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J Biol Chem 1994; 269: 4355-4359.
26. Ikeda E, Achen MG, Breier G, Risau W. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J Biol Chem 1995; 270: 19761-19766.
27. Höckel M, Schlenger K, Doctrow S, Kissel T, Vaupel P. Therapeutic angiogenesis. Arch Surg 1993; 128: 423-429.
28. Symes JF, Sniderman AD. Angiogenesis: potential therapy for ischaemic disease. Current Opin Lipidol 1994; 5: 305-312.
29. Simons M, Ware JA. Food for starving hearts. Nature Med 1996; 2: 519-520.
30. Yanagisawa-Miwa A, Uchida Y, Nakamura F et al. Salvage of infarcted myocardium by angiogenic action of basic fibroblast growth factor. Science 1992; 257: 1401-1403.
31. Battler A, Scheinowitz M, Bor A et al. Intracoronary injection of basic fibroblast growth factor enhances angiogenesis in infarcted swine myocardium. J Am Coll Cardiol 1993; 22: 2001-2006.
32. Banai S, Jaklitsch MT, Shou M et al. Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs. Circulation 1994; 89: 2183-2189.
33. Harada K, Grossman W, Friedman M et al. Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts. J Clin Invest 1994; 94: 623-630.
34. Harada K, Friedman M, Lopez JJ et al. Vascular endothelial growth factor administration in chronic myocardial ischemia. Am J Physiol 1996; 270: H1791-H1802.
35. Unger EF, Banai S, Shou M et al. Basic fibroblast growth factor enhances myocardial collateral flow in a canine model. Am J Physiol 1994; 266: H1588-H1595.
36. Pearlman JD, Hibberd MG, Chuang ML et al. Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angiogenesis. Nature Med 1995; 1: 1085-1089.
37. Landau C, Jacobs AK, Haudenschild CC. Intrapericardial basic fibroblast growth factor induces myocardial angiogenesis in a rabbit model of chronic ischemia. Am Heart J 1995; 129: 924-931.
38. Lazarous DF, Scheinowitz M, Shou M et al. Effects of chronic systemic administration of basic fibroblast growth factor on collateral development in the canine heart. Circulation 1995; 91: 145-153.
39. Uchida Y, Yanagisawa-Miwa A, Nakamura F et al. Angiogenic therapy of acute myocardial infarction by intrapericardial injection of basic fibroblast growth factor and heparin sulfate: an experimental study. Am Heart J 1995; 130: 1182-1188.
40. Giordano FJ, Ping P, McKirnan D et al. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nature Med 1996; 2: 534-539.
41. Baffour R, Berman J, Garb JL, Rhee SW, Kaufman J, Friedmann P. Enhanced angiogenesis and growth of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a rabbit model of acute lower limb ischemia. J Vasc Surg 1992; 16: 181-191.
42. Chleboun JO, Martins RN, Mitchell CA, Chirila TV. bFGF enhances the development of the collateral circulation after acute arterial occlusion. Biochem Biophys Res Commun 1992; 185: 510-516.
43. Pu L-Q, Sniderman AD, Brassard R et al. Enhanced revascularization of the ischemic limb by angiogenic therapy. Circulation 1993; 88: 208-215.
44. Martins RN, Chleboun JO, Sellers P, Sleigh M, Muir J. The role of PDGF-BB on the development of the collateral circulation after acute arterial occlusion. Growth Factors 1994; 10: 299-306.
45. Takeshita S, Zheng LP, Brogi E et al. Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J Clin Invest 1994; 93: 662-670.
46. Takeshita S, Rossow ST, Kearney M et al. Time course of increased cellular proliferation in collateral arteries after administration of vascular endothelial growth factor in a rabbit model of lower limb vascular insufficiency. Am J Pathol 1995; 147: 1649-1660.
47. Bauters C, Asahara T, Zheng LP et al. Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor. Circulation 1995; 91: 2802-2809.
48. Bauters C, Asahara T, Zheng LP et al. Site-specific therapeutic angiogenesis after systemic administration of vascular endothelial growth factor. J Vasc Surg 1995; 21: 314-325.
49. Yang HT, Deschenes MR, Ogilvie RW, Terjung RL. Basic fibroblast growth factor increases collateral blood flow in rats with femoral arterial ligation. Cir Res 1996; 79: 62-69.
50. Asahara T, Bauters C, Zheng LP et al. Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo. Circulation 1995; 92 (suppl II): II365-II371.
51. Isner JM, Walsh K, Symes J et al. Arterial gene therapy for therapeutic angiogenesis in patients with peripheral vascular disease. Circulation 1995; 91: 2687-2692.
52. 165 in patient with ischaemic limb. Lancet 1996; 348: 370-374.
53. Höckel M, Burke JF. Angiotropin treatment prevents flap necrosis and enhances dermal regeneration in rabbits. Arch Surg 1989; 124: 693-698.
54. Khouri RK, Brown DM, Leal-Khouri SM, Tark KC, Shaw WW. The effect of basic fibroblast growth factor on the neovascularization process: skin flap survival and staged flap transfers. Br J Plast Surg 1991; 44: 585-588.
55. Ishiguro N, Yabe Y, Shimizu T, Iwata H, Miura T. Basic fibroblast growth factor has a beneficial effect on the viability of random skin flaps in rats. Ann Plast Surg 1994; 32: 356-360.
56. Puumala M, Anderson RE, Meyer FB. Intraventricular infusion of HBGF-2 promotes cerebral angiogenesis in Wistar rats. Brain Res 1990; 534: 283-286.
57. Lyons MK, Anderson RE, Meyer FB. Basic fibroblast growth factor promotes in vivo cerebral angiogenesis in chronic forebrain ischemia. Brain Res 1991; 558: 315-320.
58. Yamada K, Kinoshita A, Kohmura E et al. Basic fibroblast growth factor prevents thalamic degeneration after cortical infarction. J Cereb Blood Flow Metab 1991; 11: 472-478.
59. Cuevas P, Gimenez-Gallego G, Carceller F, Cuevas B, Crespo A. Single topical application of recombinant human basic fibroblast growth factor (rbFGF) promotes neovascularization in rat cerebral cortex. Surg Neurol 1993; 39: 380-384.
60. Nakata N, Kato H, Kogure K. Protective effects of basic fibroblast growth factor against hippocampal neuronal damage following cerebral ischemia in the gerbil. Brain Res 1993; 605: 354-356.
61. Fan T-P, Jagger R, Bicknell R. Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targetting of gene therapy. Trends Pharmacol Sci 1995; 16: 57-66.
62. Dvorak HF, Brown LF, Detmar M, Dvorak AM. Vascular Permeability Factor/Vascular Endothelial Growth Factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995; 146: 1029-1039.
63. Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, Ferrara N. Inhibition of vascular endothelial growth factor induced angiogenesis suppresses tumor growth in vivo. Nature 1993; 362: 841-844.
64. Kondo S, Asano M, Suzuki H. Significance of vascular endothelial growth factor/vascular permeability factor for solid tumor growth, and its inhibition by the antibody. Biochem Biophys Res Commun 1993; 194: 1234-1241.
65. Millauer B, Shawver LK, Plate KH, Risau W, Ullrich A. Glioblastoma growth inhibited in vivo by a dominant negative Flk-1 mutant. Nature 1994; 367: 576-579.
66. Millauer B, Longhi MP, Plate KH et al. Dominant negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo. Cancer Res 1996; 56: 1615-1620.
67. 121. Cancer Res 1995; 55: 5296-5310.
68. Warren RS, Yuan H, Matli MR, Gillett NA, Ferrara N. Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J Clin Invest 1995; 95: 1789-1797.
69. Saleh M, Stacker SA, Wilks AF. Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence. Cancer Res 1996; 56: 393-401.
70. Melynk O, Shuman MA, Kim KJ. Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth. Cancer Res 1996; 56: 921-924.
71. Ramakrishnan S, Olson TA, Bautch VL, Mohanraj D. Vascular endothelial growth factor-toxin conjugate specifically inhibits KDR/flk-1-positive endothelial cell proliferation in vitro and angiogenesis in vivo. Cancer Res 1996; 56: 1324-1330.
72. Sidkey YA, Borden EC. Inhibition of angiogenesis by interferons: effects of tumor- and lymphocyte-induced vascular responses. Cancer Res 1987; 47: 5155-5161.
73. Majewski S, Szmurlo A, Marczak M, Jablonska S, Bollag W. Synergistic effect of retinoids and interferon α on tumor-induced angiogenesis: anti-angiogenic effect on HPV-harboring tumor cell lines. Int J Cancer 1994; 57: 81-85.
74. Pepper MS, Vassalli J-D, Wilks JW, Schweigerer L, Orci L, Montesano R. Modulation of bovine microvascular endothelial cell proteolytic properties by inhibitors of angiogenesis. J Cell Biochem 1994; 55: 419-434.
75. Singh RK, Gutman M, Bucana CD, Sanchez R, Llansa N, Fidler IJ. Interferons α and β down-regulate the expression of basic fibroblast growth factor in human carcinomas. Proc Natl Acad Sci USA 1995; 92: 4562-4566.
76. Chodak GW, Hospelhorn V, Judge SM, Mayforth R, Koeppen H, Sasse J. Increased levels of fibroblast growth factor-like activity in urine from patients with bladder or kidney cancer. Cancer Res 1988; 48: 2083-2088.
77. Nguyen M, Watanabe H, Budson AE, Richie JP, Folkman J. Elevated levels of the angiogenic peptide basic fibroblast growth factor in urine of bladder cancer patients. J Natl Cancer Inst 1993; 85: 241-242.
78. Nguyen M, Watanabe H, Budson AE, Richie JP, Hayes DF, Folkman J. Elevated levels of the angiogenic peptide, basic fibroblast growth factor, in urine of patients with a wide spectrum of cancers. J Natl Cancer Inst 1994; 86: 356-361.
79. Kondo S, Asano M, Matsuo K, Ohmori I, Suzuki H. Vascular endothelial growth factor/vascular permeability factor is detectable in the sera of tumor-bearing mice and cancer patients. Biochim Biophys Acta 1994; 1221: 211-214.
80. Meyer GE, Yu E, Siegal JA, Petteway JC, Blumenstein BA, Brawer MK. Serum basic fibroblast growth factor in men with and without prostate carcinoma. Cancer 1995; 76: 2304-2311.
81. Chow N-H, Chang C-J, Yeh T-M, Chan S-H, Tzai T-S, Lin J S-N. Implications of urinary basic fibroblast growth factor excretion in patients with urothelial carcinoma. Clin Sci 1996; 90: 127-133.
82. Jacot JL, Laver NM, Glover JP, Lazarous DF, Unger EF, Robinson WG. Histological evaluation of the canine retinal vasculature following chronic systemic administration of basic fibroblast growth factor. J Anat 1996; 188: 349-354.
83. Coffin JD, Florkiewicz RZ, Neumann J et al. Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) in transgenic mice. Mol Biol Cell 1995; 6: 1861-1873.