SCOPUS 정보 검색 플랫폼

Volumn , Issue 9, 2004, Pages 1509-1521

Catalytic direct asymmetric Michael reactions: Addition of unmodified ketone and aldehyde donors to alkylidene malonates and nitro olefins

(5) Betancort, Juan M a Sakthivel, Kandasamy a Thayumanavan, Rajeswari a Tanaka, Fujie a Barbas III, Carlos F a

a SCRIPPS RESEARCH INSTITUTE (United States)

Author keywords

Asymmetric catalysis; Enamines; Ketones; Michael additions; Organocatalysis

Indexed keywords

ALDEHYDES; KETONES; OLEFINS;

CARBONYL DONORS; ENANTIOSELECTIVITY;

CATALYST ACTIVITY;

ALDEHYDE; ALKENE DERIVATIVE; CARBONYL DERIVATIVE; KETONE; MALONIC ACID;

ARTICLE; CATALYSIS; CATALYST; ENANTIOSELECTIVITY; MICHAEL ADDITION;

EID: 3142613216 PISSN: 00397881 EISSN: None Source Type: Journal
DOI: 10.1055/s-2004-822392 Document Type: Article

Times cited : (207)

References (96)

1
- 0003445429
- Springer: Berlin
- (a) Comprehensive Asymmetric Catalysis, Vol. I-III; Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: Berlin, 1999.
- (1999) Comprehensive Asymmetric Catalysis , vol.1-3
- Jacobsen, E.N.¹ Pfaltz, A.² Yamamoto, H.³

2
- 0003400107
- Wiley: New York
- (b) Noyori, R. Asymmetric Catalysis in Organic Synthesis; Wiley: New York, 1994.
- (1994) Asymmetric Catalysis in Organic Synthesis
- Noyori, R.¹

3
- 84891580093
- Wiley-VCH: Weinheim
- (c) Ojima, I. Catalytic Asymmetric Synthesis; Wiley-VCH: Weinheim, 1993.
- (1993) Catalytic Asymmetric Synthesis
- Ojima, I.¹

4
- 0035886887
- (a) For an excellent review, see: Dalko, P. I.; Moisan, L. Angew. Chem. Int. Ed. 2001, 40, 3726.
- (2001) Angew. Chem. Int. Ed. , vol.40 , pp. 3726
- Dalko, P.I.¹ Moisan, L.²

5
- 0037170944
- (b) See also: Jarvo, E. R.; Miller, S. J. Tetrahedron 2002, 58, 2481.
- (2002) Tetrahedron , vol.58 , pp. 2481
- Jarvo, E.R.¹ Miller, S.J.²

6
- 0003573894
- Pergamon Press: Oxford
- Perlmutter, P. Conjugate Addition Reactions in Organic Synthesis; Pergamon Press: Oxford, 1992.
- (1992) Conjugate Addition Reactions in Organic Synthesis
- Perlmutter, P.¹

7
- 3142537123
- For recent reviews on catalytic asymmetric 1,4-addition, see: (a) Krause, N.; Hoffmann-Roder, A. Synthesis 2001, 171. (b) Sibi, M. P.; Manyem, S. Tetrahedron 2000, 56, 8033. (c) Tomioka, K.; Nagaoka, Y. In Comprehensive Asymmetric Catalysis, Vol. III; Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: Berlin, 1999, 1105-1120. (d) Yamaguchi, M. In Comprehensive Asymmetric Catalysis, Vol. III; Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: Berlin, 1999, 1121-1139. (e) Kanai, M.; Shibasaki, M. In Catalytic Asymmetric Synthesis, 2nd ed.; Ojima, I., Ed.; Wiley: New York, 2000, 569. (f) Berner, O. E.; Tedeschi, L.; Enders, D. Eur. J. Org. Chem. 2002, 1788.
- (2001) Synthesis , vol.171
- Krause, N.¹ Hoffmann-Roder, A.²

8
- 0034612973
- For recent reviews on catalytic asymmetric 1,4-addition, see: (a) Krause, N.; Hoffmann-Roder, A. Synthesis 2001, 171. (b) Sibi, M. P.; Manyem, S. Tetrahedron 2000, 56, 8033. (c) Tomioka, K.; Nagaoka, Y. In Comprehensive Asymmetric Catalysis, Vol. III; Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: Berlin, 1999, 1105-1120. (d) Yamaguchi, M. In Comprehensive Asymmetric Catalysis, Vol. III; Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: Berlin, 1999, 1121-1139. (e) Kanai, M.; Shibasaki, M. In Catalytic Asymmetric Synthesis, 2nd ed.; Ojima, I., Ed.; Wiley: New York, 2000, 569. (f) Berner, O. E.; Tedeschi, L.; Enders, D. Eur. J. Org. Chem. 2002, 1788.
- (2000) Tetrahedron , vol.56 , pp. 8033
- Sibi, M.P.¹ Manyem, S.²

9
- 0000679263
- Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: Berlin
- For recent reviews on catalytic asymmetric 1,4-addition, see: (a) Krause, N.; Hoffmann-Roder, A. Synthesis 2001, 171. (b) Sibi, M. P.; Manyem, S. Tetrahedron 2000, 56, 8033. (c) Tomioka, K.; Nagaoka, Y. In Comprehensive Asymmetric Catalysis, Vol. III; Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: Berlin, 1999, 1105-1120. (d) Yamaguchi, M. In Comprehensive Asymmetric Catalysis, Vol. III; Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: Berlin, 1999, 1121-1139. (e) Kanai, M.; Shibasaki, M. In Catalytic Asymmetric Synthesis, 2nd ed.; Ojima, I., Ed.; Wiley: New York, 2000, 569. (f) Berner, O. E.; Tedeschi, L.; Enders, D. Eur. J. Org. Chem. 2002, 1788.
- (1999) Comprehensive Asymmetric Catalysis , vol.3 , pp. 1105-1120
- Tomioka, K.¹ Nagaoka, Y.²

10
- 0000957502
- Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: Berlin
- For recent reviews on catalytic asymmetric 1,4-addition, see: (a) Krause, N.; Hoffmann-Roder, A. Synthesis 2001, 171. (b) Sibi, M. P.; Manyem, S. Tetrahedron 2000, 56, 8033. (c) Tomioka, K.; Nagaoka, Y. In Comprehensive Asymmetric Catalysis, Vol. III; Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: Berlin, 1999, 1105-1120. (d) Yamaguchi, M. In Comprehensive Asymmetric Catalysis, Vol. III; Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: Berlin, 1999, 1121-1139. (e) Kanai, M.; Shibasaki, M. In Catalytic Asymmetric Synthesis, 2nd ed.; Ojima, I., Ed.; Wiley: New York, 2000, 569. (f) Berner, O. E.; Tedeschi, L.; Enders, D. Eur. J. Org. Chem. 2002, 1788.
- (1999) Comprehensive Asymmetric Catalysis , vol.3 , pp. 1121-1139
- Yamaguchi, M.¹

11
- 0003105323
- Ojima, I., Ed.; Wiley: New York
- For recent reviews on catalytic asymmetric 1,4-addition, see: (a) Krause, N.; Hoffmann-Roder, A. Synthesis 2001, 171. (b) Sibi, M. P.; Manyem, S. Tetrahedron 2000, 56, 8033. (c) Tomioka, K.; Nagaoka, Y. In Comprehensive Asymmetric Catalysis, Vol. III; Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: Berlin, 1999, 1105-1120. (d) Yamaguchi, M. In Comprehensive Asymmetric Catalysis, Vol. III; Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: Berlin, 1999, 1121-1139. (e) Kanai, M.; Shibasaki, M. In Catalytic Asymmetric Synthesis, 2nd ed.; Ojima, I., Ed.; Wiley: New York, 2000, 569. (f) Berner, O. E.; Tedeschi, L.; Enders, D. Eur. J. Org. Chem. 2002, 1788.
- (2000) Catalytic Asymmetric Synthesis, 2nd Ed. , pp. 569
- Kanai, M.¹ Shibasaki, M.²

12
- 2242472314
- For recent reviews on catalytic asymmetric 1,4-addition, see: (a) Krause, N.; Hoffmann-Roder, A. Synthesis 2001, 171. (b) Sibi, M. P.; Manyem, S. Tetrahedron 2000, 56, 8033. (c) Tomioka, K.; Nagaoka, Y. In Comprehensive Asymmetric Catalysis, Vol. III; Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: Berlin, 1999, 1105-1120. (d) Yamaguchi, M. In Comprehensive Asymmetric Catalysis, Vol. III; Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: Berlin, 1999, 1121-1139. (e) Kanai, M.; Shibasaki, M. In Catalytic Asymmetric Synthesis, 2nd ed.; Ojima, I., Ed.; Wiley: New York, 2000, 569. (f) Berner, O. E.; Tedeschi, L.; Enders, D. Eur. J. Org. Chem. 2002, 1788.
- (2002) Eur. J. Org. Chem. , pp. 1788
- Berner, O.E.¹ Tedeschi, L.² Enders, D.³

13
- 0001392528
- (a) Kim, Y. S.; Matsunaga, S.; Das, J.; Sekine, A.; Ohshima, T.; Shibasaki, M. J. Am. Chem. Soc. 2000, 122, 6506.
- (2000) J. Am. Chem. Soc. , vol.122 , pp. 6506
- Kim, Y.S.¹ Matsunaga, S.² Das, J.³ Sekine, A.⁴ Ohshima, T.⁵ Shibasaki, M.⁶

14
- 33748240969
- (b) Arai, T.; Sasai, H.; Aoe, K.; Okamura, K.; Date, T.; Shibasaki, M. Angew. Chem., Int. Ed. Engl. 1996, 35, 104.
- (1996) Angew. Chem., Int. Ed. Engl. , vol.35 , pp. 104
- Arai, T.¹ Sasai, H.² Aoe, K.³ Okamura, K.⁴ Date, T.⁵ Shibasaki, M.⁶

15
- 0000497004
- (c) Hanessian, S.; Pham, V. Org. Lett. 2000, 2, 2975.
- (2000) Org. Lett. , vol.2 , pp. 2975
- Hanessian, S.¹ Pham, V.²

16
- 0343967492
- (d) Yamaguchi, M.; Shiraishi, T.; Hirama, M. J. Org. Chem. 1996, 61, 3520.
- (1996) J. Org. Chem. , vol.61 , pp. 3520
- Yamaguchi, M.¹ Shiraishi, T.² Hirama, M.³

17
- 0033520797
- (e) Ji, J.; Barnes, D. M.; Zhang, J.; King, S. A.; Wittenberger, S. J.; Morton, H. E. J. Am. Chem. Soc. 1999, 121, 10215.
- (1999) J. Am. Chem. Soc. , vol.121 , pp. 10215
- Ji, J.¹ Barnes, D.M.² Zhang, J.³ King, S.A.⁴ Wittenberger, S.J.⁵ Morton, H.E.⁶

18
- 0030603064
- (a) Yasuda, K.; Shindo, M.; Koga, K. Tetrahedron Lett. 1996, 37, 6343.
- (1996) Tetrahedron Lett. , vol.37 , pp. 6343
- Yasuda, K.¹ Shindo, M.² Koga, K.³

19
- 0001645987
- (b) Enders, D.; Demir, A. S.; Rendenbach, B. E. M. Chem. Ber. 1987, 120, 1731.
- (1987) Chem. Ber. , vol.120 , pp. 1731
- Enders, D.¹ Demir, A.S.² Rendenbach, B.E.M.³

20
- 0026099316
- (c) Martens, J.; Lubben, S. Tetrahedron 1991, 47, 1205.
- (1991) Tetrahedron , vol.47 , pp. 1205
- Martens, J.¹ Lubben, S.²

21
- 0348248914
- (d) Blarer, S. J.; Seebach, D. Chem. Ber. 1983, 116, 2250.
- (1983) Chem. Ber. , vol.116 , pp. 2250
- Blarer, S.J.¹ Seebach, D.²

22
- 33947482604
- For a seminal reference, see: Stork, G.; Brizzolara, A.; Landesman, H.; Szmuszkovicz, J.; Terrell, R. J. Am. Chem. Soc. 1963, 85, 207.
- (1963) J. Am. Chem. Soc. , vol.85 , pp. 207
- Stork, G.¹ Brizzolara, A.² Landesman, H.³ Szmuszkovicz, J.⁴ Terrell, R.⁵

23
- 0026418434
- For a general discussion of atom economy in organic synthesis, see: (a) Trost, B. M. Science 1991, 254, 1471. (b) Trost, B. M. Angew. Chem., Int. Ed. Engl. 1995, 34, 259.
- (1991) Science , vol.254 , pp. 1471
- Trost, B.M.¹

24
- 33750309194
- For a general discussion of atom economy in organic synthesis, see: (a) Trost, B. M. Science 1991, 254, 1471. (b) Trost, B. M. Angew. Chem., Int. Ed. Engl. 1995, 34, 259.
- (1995) Angew. Chem., Int. Ed. Engl. , vol.34 , pp. 259
- Trost, B.M.¹

25
- 3042625080
- For previous work on Aldol reaction, see the following: (a) Mase, N.; Tanaka, F.; Barbas, C. F. III. Angew. Chem. Int. Ed. 2004, 43, 2420. (b) Cordova, A.; Notz, W.; Barbas, C. F. III. J. Org. Chem. 2002, 67, 301. (c) Sakthivel, K.; Notz, W.; Bui, T.; Barbas, C. F. III. J. Am. Chem. Soc. 2001, 123, 5260. (d) List, B.; Lerner, R.; Barbas, C. F. III. J. Am. Chem. Soc. 2000, 122, 2395.
- (2004) Angew. Chem. Int. Ed. , vol.43 , pp. 2420
- Mase, N.¹ Tanaka, F.² Barbas III, C.F.³

26
- 0037059471
- For previous work on Aldol reaction, see the following: (a) Mase, N.; Tanaka, F.; Barbas, C. F. III. Angew. Chem. Int. Ed. 2004, 43, 2420. (b) Cordova, A.; Notz, W.; Barbas, C. F. III. J. Org. Chem. 2002, 67, 301. (c) Sakthivel, K.; Notz, W.; Bui, T.; Barbas, C. F. III. J. Am. Chem. Soc. 2001, 123, 5260. (d) List, B.; Lerner, R.; Barbas, C. F. III. J. Am. Chem. Soc. 2000, 122, 2395.
- (2002) J. Org. Chem. , vol.67 , pp. 301
- Cordova, A.¹ Notz, W.² Barbas III, C.F.³

27
- 0034812506
- For previous work on Aldol reaction, see the following: (a) Mase, N.; Tanaka, F.; Barbas, C. F. III. Angew. Chem. Int. Ed. 2004, 43, 2420. (b) Cordova, A.; Notz, W.; Barbas, C. F. III. J. Org. Chem. 2002, 67, 301. (c) Sakthivel, K.; Notz, W.; Bui, T.; Barbas, C. F. III. J. Am. Chem. Soc. 2001, 123, 5260. (d) List, B.; Lerner, R.; Barbas, C. F. III. J. Am. Chem. Soc. 2000, 122, 2395.
- (2001) J. Am. Chem. Soc. , vol.123 , pp. 5260
- Sakthivel, K.¹ Notz, W.² Bui, T.³ Barbas III, C.F.⁴

28
- 0034654216
- For previous work on Aldol reaction, see the following: (a) Mase, N.; Tanaka, F.; Barbas, C. F. III. Angew. Chem. Int. Ed. 2004, 43, 2420. (b) Cordova, A.; Notz, W.; Barbas, C. F. III. J. Org. Chem. 2002, 67, 301. (c) Sakthivel, K.; Notz, W.; Bui, T.; Barbas, C. F. III. J. Am. Chem. Soc. 2001, 123, 5260. (d) List, B.; Lerner, R.; Barbas, C. F. III. J. Am. Chem. Soc. 2000, 122, 2395.
- (2000) J. Am. Chem. Soc. , vol.122 , pp. 2395
- List, B.¹ Lerner, R.² Barbas III, C.F.³

29
- 0142091320
- For previous work on Mannich reactions, see the following: (a) Chowdari, N. S.; Ramachary, D. B.; Barbas, C. F. III. Synlett 2003, 12, 1906. (b) Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2003, 44, 1923. (c) Notz, W.; Tanaka, F.; Watanabe, S.-I.; Chowdari, N. S.; Turner, J. M.; Thayumanavan, R.; Barbas, C. F. III. J. Org. Chem. 2003, 68, 9624. (d) Watanabe, S.; Cordova, A.; Tanaka, F.; Barbas, C. F. III. Org. Lett. 2002, 4, 4519. (e) Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2002, 43, 7749. (f) Cordova, A.; Notz, W.; Zhong, G.; Betancort, J. M.; Barbas, C. F. III. J. Am. Chem. Soc. 2002, 124, 1866. (g) Cordova, A.; Watanabe, S.; Tanaka, F.; Notz, W.; Barbas, C. F. III. J. Am. Chem. Soc. 2002, 124, 1866. (h) Notz, W.; Sakthivel, K.; Bui, T.; Zhong, G.; Barbas, C. F. III. Tetrahedron Lett. 2001, 42, 199.
- (2003) Synlett , vol.12 , pp. 1906
- Chowdari, N.S.¹ Ramachary, D.B.² Barbas III, C.F.³

30
- 0037463462
- For previous work on Mannich reactions, see the following: (a) Chowdari, N. S.; Ramachary, D. B.; Barbas, C. F. III. Synlett 2003, 12, 1906. (b) Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2003, 44, 1923. (c) Notz, W.; Tanaka, F.; Watanabe, S.-I.; Chowdari, N. S.; Turner, J. M.; Thayumanavan, R.; Barbas, C. F. III. J. Org. Chem. 2003, 68, 9624. (d) Watanabe, S.; Cordova, A.; Tanaka, F.; Barbas, C. F. III. Org. Lett. 2002, 4, 4519. (e) Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2002, 43, 7749. (f) Cordova, A.; Notz, W.; Zhong, G.; Betancort, J. M.; Barbas, C. F. III. J. Am. Chem. Soc. 2002, 124, 1866. (g) Cordova, A.; Watanabe, S.; Tanaka, F.; Notz, W.; Barbas, C. F. III. J. Am. Chem. Soc. 2002, 124, 1866. (h) Notz, W.; Sakthivel, K.; Bui, T.; Zhong, G.; Barbas, C. F. III. Tetrahedron Lett. 2001, 42, 199.
- (2003) Tetrahedron Lett. , vol.44 , pp. 1923
- Cordova, A.¹ Barbas III, C.F.²

31
- 0345529038
- For previous work on Mannich reactions, see the following: (a) Chowdari, N. S.; Ramachary, D. B.; Barbas, C. F. III. Synlett 2003, 12, 1906. (b) Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2003, 44, 1923. (c) Notz, W.; Tanaka, F.; Watanabe, S.-I.; Chowdari, N. S.; Turner, J. M.; Thayumanavan, R.; Barbas, C. F. III. J. Org. Chem. 2003, 68, 9624. (d) Watanabe, S.; Cordova, A.; Tanaka, F.; Barbas, C. F. III. Org. Lett. 2002, 4, 4519. (e) Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2002, 43, 7749. (f) Cordova, A.; Notz, W.; Zhong, G.; Betancort, J. M.; Barbas, C. F. III. J. Am. Chem. Soc. 2002, 124, 1866. (g) Cordova, A.; Watanabe, S.; Tanaka, F.; Notz, W.; Barbas, C. F. III. J. Am. Chem. Soc. 2002, 124, 1866. (h) Notz, W.; Sakthivel, K.; Bui, T.; Zhong, G.; Barbas, C. F. III. Tetrahedron Lett. 2001, 42, 199.
- (2003) J. Org. Chem. , vol.68 , pp. 9624
- Notz, W.¹ Tanaka, F.² Watanabe, S.-I.³ Chowdari, N.S.⁴ Turner, J.M.⁵ Thayumanavan, R.⁶ Barbas III, C.F.⁷

32
- 0037069710
- For previous work on Mannich reactions, see the following: (a) Chowdari, N. S.; Ramachary, D. B.; Barbas, C. F. III. Synlett 2003, 12, 1906. (b) Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2003, 44, 1923. (c) Notz, W.; Tanaka, F.; Watanabe, S.-I.; Chowdari, N. S.; Turner, J. M.; Thayumanavan, R.; Barbas, C. F. III. J. Org. Chem. 2003, 68, 9624. (d) Watanabe, S.; Cordova, A.; Tanaka, F.; Barbas, C. F. III. Org. Lett. 2002, 4, 4519. (e) Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2002, 43, 7749. (f) Cordova, A.; Notz, W.; Zhong, G.; Betancort, J. M.; Barbas, C. F. III. J. Am. Chem. Soc. 2002, 124, 1866. (g) Cordova, A.; Watanabe, S.; Tanaka, F.; Notz, W.; Barbas, C. F. III. J. Am. Chem. Soc. 2002, 124, 1866. (h) Notz, W.; Sakthivel, K.; Bui, T.; Zhong, G.; Barbas, C. F. III. Tetrahedron Lett. 2001, 42, 199.
- (2002) Org. Lett. , vol.4 , pp. 4519
- Watanabe, S.¹ Cordova, A.² Tanaka, F.³ Barbas III, C.F.⁴

33
- 0037152299
- For previous work on Mannich reactions, see the following: (a) Chowdari, N. S.; Ramachary, D. B.; Barbas, C. F. III. Synlett 2003, 12, 1906. (b) Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2003, 44, 1923. (c) Notz, W.; Tanaka, F.; Watanabe, S.-I.; Chowdari, N. S.; Turner, J. M.; Thayumanavan, R.; Barbas, C. F. III. J. Org. Chem. 2003, 68, 9624. (d) Watanabe, S.; Cordova, A.; Tanaka, F.; Barbas, C. F. III. Org. Lett. 2002, 4, 4519. (e) Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2002, 43, 7749. (f) Cordova, A.; Notz, W.; Zhong, G.; Betancort, J. M.; Barbas, C. F. III. J. Am. Chem. Soc. 2002, 124, 1866. (g) Cordova, A.; Watanabe, S.; Tanaka, F.; Notz, W.; Barbas, C. F. III. J. Am. Chem. Soc. 2002, 124, 1866. (h) Notz, W.; Sakthivel, K.; Bui, T.; Zhong, G.; Barbas, C. F. III. Tetrahedron Lett. 2001, 42, 199.
- (2002) Tetrahedron Lett. , vol.43 , pp. 7749
- Cordova, A.¹ Barbas III, C.F.²

34
- 0037028990
- For previous work on Mannich reactions, see the following: (a) Chowdari, N. S.; Ramachary, D. B.; Barbas, C. F. III. Synlett 2003, 12, 1906. (b) Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2003, 44, 1923. (c) Notz, W.; Tanaka, F.; Watanabe, S.-I.; Chowdari, N. S.; Turner, J. M.; Thayumanavan, R.; Barbas, C. F. III. J. Org. Chem. 2003, 68, 9624. (d) Watanabe, S.; Cordova, A.; Tanaka, F.; Barbas, C. F. III. Org. Lett. 2002, 4, 4519. (e) Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2002, 43, 7749. (f) Cordova, A.; Notz, W.; Zhong, G.; Betancort, J. M.; Barbas, C. F. III. J. Am. Chem. Soc. 2002, 124, 1866. (g) Cordova, A.; Watanabe, S.; Tanaka, F.; Notz, W.; Barbas, C. F. III. J. Am. Chem. Soc. 2002, 124, 1866. (h) Notz, W.; Sakthivel, K.; Bui, T.; Zhong, G.; Barbas, C. F. III. Tetrahedron Lett. 2001, 42, 199.
- (2002) J. Am. Chem. Soc. , vol.124 , pp. 1866
- Cordova, A.¹ Notz, W.² Zhong, G.³ Betancort, J.M.⁴ Barbas III, C.F.⁵

35
- 0037028990
- For previous work on Mannich reactions, see the following: (a) Chowdari, N. S.; Ramachary, D. B.; Barbas, C. F. III. Synlett 2003, 12, 1906. (b) Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2003, 44, 1923. (c) Notz, W.; Tanaka, F.; Watanabe, S.-I.; Chowdari, N. S.; Turner, J. M.; Thayumanavan, R.; Barbas, C. F. III. J. Org. Chem. 2003, 68, 9624. (d) Watanabe, S.; Cordova, A.; Tanaka, F.; Barbas, C. F. III. Org. Lett. 2002, 4, 4519. (e) Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2002, 43, 7749. (f) Cordova, A.; Notz, W.; Zhong, G.; Betancort, J. M.; Barbas, C. F. III. J. Am. Chem. Soc. 2002, 124, 1866. (g) Cordova, A.; Watanabe, S.; Tanaka, F.; Notz, W.; Barbas, C. F. III. J. Am. Chem. Soc. 2002, 124, 1866. (h) Notz, W.; Sakthivel, K.; Bui, T.; Zhong, G.; Barbas, C. F. III. Tetrahedron Lett. 2001, 42, 199.
- (2002) J. Am. Chem. Soc. , vol.124 , pp. 1866
- Cordova, A.¹ Watanabe, S.² Tanaka, F.³ Notz, W.⁴ Barbas III, C.F.⁵

36
- 0035825097
- For previous work on Mannich reactions, see the following: (a) Chowdari, N. S.; Ramachary, D. B.; Barbas, C. F. III. Synlett 2003, 12, 1906. (b) Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2003, 44, 1923. (c) Notz, W.; Tanaka, F.; Watanabe, S.-I.; Chowdari, N. S.; Turner, J. M.; Thayumanavan, R.; Barbas, C. F. III. J. Org. Chem. 2003, 68, 9624. (d) Watanabe, S.; Cordova, A.; Tanaka, F.; Barbas, C. F. III. Org. Lett. 2002, 4, 4519. (e) Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2002, 43, 7749. (f) Cordova, A.; Notz, W.; Zhong, G.; Betancort, J. M.; Barbas, C. F. III. J. Am. Chem. Soc. 2002, 124, 1866. (g) Cordova, A.; Watanabe, S.; Tanaka, F.; Notz, W.; Barbas, C. F. III. J. Am. Chem. Soc. 2002, 124, 1866. (h) Notz, W.; Sakthivel, K.; Bui, T.; Zhong, G.; Barbas, C. F. III. Tetrahedron Lett. 2001, 42, 199.
- (2001) Tetrahedron Lett. , vol.42 , pp. 199
- Notz, W.¹ Sakthivel, K.² Bui, T.³ Zhong, G.⁴ Barbas III, C.F.⁵

37
- 0034596452
- For previous work on Robinson annulations, see: Bui, T.; Barbas, C. F. III. Tetrahedron Lett. 2000, 41, 6951.
- (2000) Tetrahedron Lett. , vol.41 , pp. 6951
- Bui, T.¹ Barbas III, C.F.²

38
- 0037140856
- For previous work on Diels - Alder reactions, see the following: (a) Thayumanavan, R.; Dhevalapally, B.; Sakthivel, K.; Tanaka, F.; Barbas, C. F. III. Tetrahedron Lett. 2002, 43, 3817. (b) Ramachary, D. B.; Chowdari, N. S.; Barbas, C. F. III. Tetrahedron Lett. 2002, 43, 6743.
- (2002) Tetrahedron Lett. , vol.43 , pp. 3817
- Thayumanavan, R.¹ Dhevalapally, B.² Sakthivel, K.³ Tanaka, F.⁴ Barbas III, C.F.⁵

39
- 0037119742
- For previous work on Diels - Alder reactions, see the following: (a) Thayumanavan, R.; Dhevalapally, B.; Sakthivel, K.; Tanaka, F.; Barbas, C. F. III. Tetrahedron Lett. 2002, 43, 3817. (b) Ramachary, D. B.; Chowdari, N. S.; Barbas, C. F. III. Tetrahedron Lett. 2002, 43, 6743.
- (2002) Tetrahedron Lett. , vol.43 , pp. 6743
- Ramachary, D.B.¹ Chowdari, N.S.² Barbas III, C.F.³

40
- 0142059749
- For previous work on multicomponent reactions, see the following: (a) Ramachary, D. B.; Chowdari, N. S.; Barbas, C. F. III. Synlett 2003, 12, 1910. (b) Chowdari, N. S.; Ramachary, D. B.; Barbas, C. F. III. Org. Lett. 2003, 5, 1685. (c) Chowdari, N. S.; Ramachary, D. B.; Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2002, 43, 9591.
- (2003) Synlett , vol.12 , pp. 1910
- Ramachary, D.B.¹ Chowdari, N.S.² Barbas III, C.F.³

41
- 0042655108
- For previous work on multicomponent reactions, see the following: (a) Ramachary, D. B.; Chowdari, N. S.; Barbas, C. F. III. Synlett 2003, 12, 1910. (b) Chowdari, N. S.; Ramachary, D. B.; Barbas, C. F. III. Org. Lett. 2003, 5, 1685. (c) Chowdari, N. S.; Ramachary, D. B.; Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2002, 43, 9591.
- (2003) Org. Lett. , vol.5 , pp. 1685
- Chowdari, N.S.¹ Ramachary, D.B.² Barbas III, C.F.³

42
- 0037164621
- For previous work on multicomponent reactions, see the following: (a) Ramachary, D. B.; Chowdari, N. S.; Barbas, C. F. III. Synlett 2003, 12, 1910. (b) Chowdari, N. S.; Ramachary, D. B.; Barbas, C. F. III. Org. Lett. 2003, 5, 1685. (c) Chowdari, N. S.; Ramachary, D. B.; Cordova, A.; Barbas, C. F. III. Tetrahedron Lett. 2002, 43, 9591.
- (2002) Tetrahedron Lett. , vol.43 , pp. 9591
- Chowdari, N.S.¹ Ramachary, D.B.² Cordova, A.³ Barbas III, C.F.⁴

43
- 0002462320
- For leading references on Aldol reactions, see the following: (a) Bogevig, A.; Kumaragurubaran, N.; Jorgensen, K. A. Chem. Commun. 2002, 620. (b) Northrup, A. B.; MacMillan, D. W. C. J. Am. Chem. Soc. 2002, 124, 6798.
- (2002) Chem. Commun. , pp. 620
- Bogevig, A.¹ Kumaragurubaran, N.² Jorgensen, K.A.³

44
- 0037134880
- For leading references on Aldol reactions, see the following: (a) Bogevig, A.; Kumaragurubaran, N.; Jorgensen, K. A. Chem. Commun. 2002, 620. (b) Northrup, A. B.; MacMillan, D. W. C. J. Am. Chem. Soc. 2002, 124, 6798.
- (2002) J. Am. Chem. Soc. , vol.124 , pp. 6798
- Northrup, A.B.¹ MacMillan, D.W.C.²

45
- 0037028550
- For leading references on Mannich reactions, see: List, B.; Pojarliev, P.; Biller, W. T.; Martin, H. J. J. Am. Chem. Soc. 2002, 124, 827.
- (2002) J. Am. Chem. Soc. , vol.124 , pp. 827
- List, B.¹ Pojarliev, P.² Biller, W.T.³ Martin, H.J.⁴

46
- 0242323633
- For leading references on Michael reactions, see the following: (a) Mailand, N.; Hansen, T.; Jørgensen, K. A. Angew. Chem. Int. Ed. 2003, 42, 4955. (b) Enders, D.; Seki, A. Synlett 2002, 26. (c) Halland, N.; Hazell, R. G.; Jorgensen, K. A. J. Org. Chem. 2002, 67, 8331. (d) Horstmann, T. E.; Guerin, D. J.; Miller, S. J. Angew. Chem. Int. Ed. 2000, 39, 3635.
- (2003) Angew. Chem. Int. Ed. , vol.42 , pp. 4955
- Mailand, N.¹ Hansen, T.² Jørgensen, K.A.³

47
- 0036138062
- For leading references on Michael reactions, see the following: (a) Mailand, N.; Hansen, T.; Jørgensen, K. A. Angew. Chem. Int. Ed. 2003, 42, 4955. (b) Enders, D.; Seki, A. Synlett 2002, 26. (c) Halland, N.; Hazell, R. G.; Jorgensen, K. A. J. Org. Chem. 2002, 67, 8331. (d) Horstmann, T. E.; Guerin, D. J.; Miller, S. J. Angew. Chem. Int. Ed. 2000, 39, 3635.
- (2002) Synlett , pp. 26
- Enders, D.¹ Seki, A.²

48
- 0037195702
- For leading references on Michael reactions, see the following: (a) Mailand, N.; Hansen, T.; Jørgensen, K. A. Angew. Chem. Int. Ed. 2003, 42, 4955. (b) Enders, D.; Seki, A. Synlett 2002, 26. (c) Halland, N.; Hazell, R. G.; Jorgensen, K. A. J. Org. Chem. 2002, 67, 8331. (d) Horstmann, T. E.; Guerin, D. J.; Miller, S. J. Angew. Chem. Int. Ed. 2000, 39, 3635.
- (2002) J. Org. Chem. , vol.67 , pp. 8331
- Halland, N.¹ Hazell, R.G.² Jorgensen, K.A.³

49
- 0034675660
- For leading references on Michael reactions, see the following: (a) Mailand, N.; Hansen, T.; Jørgensen, K. A. Angew. Chem. Int. Ed. 2003, 42, 4955. (b) Enders, D.; Seki, A. Synlett 2002, 26. (c) Halland, N.; Hazell, R. G.; Jorgensen, K. A. J. Org. Chem. 2002, 67, 8331. (d) Horstmann, T. E.; Guerin, D. J.; Miller, S. J. Angew. Chem. Int. Ed. 2000, 39, 3635.
- (2000) Angew. Chem. Int. Ed. , vol.39 , pp. 3635
- Horstmann, T.E.¹ Guerin, D.J.² Miller, S.J.³

50
- 0037139610
- For leading references on Diels - Alder reactions, see the following: (a) Northrup, A. B.; MacMillan, D. W. C. J. Am. Chem. Soc. 2002, 124, 2458. (b) Ahrendt, K. A.; Borths, C. J.; MacMillan, D. W. C. J. Am. Chem. Soc. 2000, 122, 4243.
- (2002) J. Am. Chem. Soc. , vol.124 , pp. 2458
- Northrup, A.B.¹ MacMillan, D.W.C.²

51
- 0034600250
- For leading references on Diels - Alder reactions, see the following: (a) Northrup, A. B.; MacMillan, D. W. C. J. Am. Chem. Soc. 2002, 124, 2458. (b) Ahrendt, K. A.; Borths, C. J.; MacMillan, D. W. C. J. Am. Chem. Soc. 2000, 122, 4243.
- (2000) J. Am. Chem. Soc. , vol.122 , pp. 4243
- Ahrendt, K.A.¹ Borths, C.J.² MacMillan, D.W.C.³

52
- 0036260164
- For leading references on α-aminations, see the following: (a) Bogevig, A.; Juhl, K.; Kumaragurubaran, N.; Zhuang, W.; Jorgensen, K. A. Angew. Chem. Int. Ed. 2002, 41, 1790. (b) List, B. J. Am. Chem. Soc. 2602, 124, 5656.
- (2002) Angew. Chem. Int. Ed. , vol.41 , pp. 1790
- Bogevig, A.¹ Juhl, K.² Kumaragurubaran, N.³ Zhuang, W.⁴ Jorgensen, K.A.⁵

53
- 0037157154
- For leading references on α-aminations, see the following: (a) Bogevig, A.; Juhl, K.; Kumaragurubaran, N.; Zhuang, W.; Jorgensen, K. A. Angew. Chem. Int. Ed. 2002, 41, 1790. (b) List, B. J. Am. Chem. Soc. 2002, 124, 5656.
- (2002) J. Am. Chem. Soc. , vol.124 , pp. 5656
- List, B.¹

54
- 0141522552
- For leading references on α-oxidation reactions, see the following: (a) Zhong, G. Angew. Chem. Int. Ed. 2003, 42, 4247. (b) Brown, S. P.; Brochu, M. P.; Sinz, C. J.; MacMillan, D. W. C. J. Am. Chem. Soc. 2003, 125, 10808.
- (2003) Angew. Chem. Int. Ed. , vol.42 , pp. 4247
- Zhong, G.¹

55
- 0041733541
- For leading references on α-oxidation reactions, see the following: (a) Zhong, G. Angew. Chem. Int. Ed. 2003, 42, 4247. (b) Brown, S. P.; Brochu, M. P.; Sinz, C. J.; MacMillan, D. W. C. J. Am. Chem. Soc. 2003, 125, 10808.
- (2003) J. Am. Chem. Soc. , vol.125 , pp. 10808
- Brown, S.P.¹ Brochu, M.P.² Sinz, C.J.³ MacMillan, D.W.C.⁴

56
- 1842863015
- For leading references on α-chlorination reactions, see the following: (a) Halland, N.; Braunton, A.; Bachmann, S.; Marigo, M.; Jorgensen, K. A. J. Am. Chem. Soc. 2004, 126, 4790. (b) Brochu, M. P.; Brown, S. P.; MacMillan, D. W. C. J. Am. Chem. Soc. 2004, 126, 4108.
- (2004) J. Am. Chem. Soc. , vol.126 , pp. 4790
- Halland, N.¹ Braunton, A.² Bachmann, S.³ Marigo, M.⁴ Jorgensen, K.A.⁵

57
- 1842450587
- For leading references on α-chlorination reactions, see the following: (a) Halland, N.; Braunton, A.; Bachmann, S.; Marigo, M.; Jorgensen, K. A. J. Am. Chem. Soc. 2004, 126, 4790. (b) Brochu, M. P.; Brown, S. P.; MacMillan, D. W. C. J. Am. Chem. Soc. 2004, 126, 4108.
- (2004) J. Am. Chem. Soc. , vol.126 , pp. 4108
- Brochu, M.P.¹ Brown, S.P.² MacMillan, D.W.C.³

58
- 0034638388
- For leading references on 1,3-dipolar cycloadditions, see: Jan, W. S.; Wiener, J. J. M.; MacMillan, D. W. C. J. Am. Chem. Soc. 2000, 122, 9874.
- (2000) J. Am. Chem. Soc. , vol.122 , pp. 9874
- Jan, W.S.¹ Wiener, J.J.M.² MacMillan, D.W.C.³

59
- 0035796953
- Portions of this work have been communicated: (a) Betancort, J. M.; Sakthivel, K.; Thayumanavan, R.; Barbas, C. F. III. Tetrahedron Lett. 2001, 42, 4441. (b) Betancort, J. M.; Barbas, C. F. III. Org. Lett. 2001, 3, 3737.
- (2001) Tetrahedron Lett. , vol.42 , pp. 4441
- Betancort, J.M.¹ Sakthivel, K.² Thayumanavan, R.³ Barbas III, C.F.⁴

60
- 0035891780
- Portions of this work have been communicated: (a) Betancort, J. M.; Sakthivel, K.; Thayumanavan, R.; Barbas, C. F. III. Tetrahedron Lett. 2001, 42, 4441. (b) Betancort, J. M.; Barbas, C. F. III. Org. Lett. 2001, 3, 3737.
- (2001) Org. Lett. , vol.3 , pp. 3737
- Betancort, J.M.¹ Barbas III, C.F.²

61
- 0000688857
- (a) Herrman, K.; Wynberg, H. J. Org. Chem. 1979, 44, 2238.
- (1979) J. Org. Chem. , vol.44 , pp. 2238
- Herrman, K.¹ Wynberg, H.²

62
- 0027483074
- (b) Latvala, A.; Stanchev, S.; Linden, A.; Hesse, M. Tetrahedron: Asymmetry 1993, 4, 173.
- (1993) Tetrahedron: Asymmetry , vol.4 , pp. 173
- Latvala, A.¹ Stanchev, S.² Linden, A.³ Hesse, M.⁴

63
- 0025327884
- Diamines were prepared according to the method of Asami: Asami, M. Bull Chem. Soc. Jpn. 1990, 63, 721.
- (1990) Bull Chem. Soc. Jpn. , vol.63 , pp. 721
- Asami, M.¹

64
- 0034908567
- The use of amines as catalysts for the asymmetric aldol reaction see refs 9c, 11 and: Saito, S.; Nakadai, M.; Yamamoto, H. Synlett 2001, 8, 1245.
- (2001) Synlett , vol.8 , pp. 1245
- Saito, S.¹ Nakadai, M.² Yamamoto, H.³

65
- 0141563562
- (a) Andrey, O.; Alexakis, A.; Bernardinelli, G. Org. Lett. 2003, 5, 2559.
- (2003) Org. Lett. , vol.5 , pp. 2559
- Andrey, O.¹ Alexakis, A.² Bernardinelli, G.³

66
- 0141425514
- (b) Andrey, O.; Vidonne, A.; Alexakis, A. Tetrahedron Lett. 2003, 44, 7901.
- (2003) Tetrahedron Lett. , vol.44 , pp. 7901
- Andrey, O.¹ Vidonne, A.² Alexakis, A.³

67
- 0000220483
- (c) Alexakis, A.; Andrey, O. Org. Lett. 2002, 4, 3611.
- (2002) Org. Lett. , vol.4 , pp. 3611
- Alexakis, A.¹ Andrey, O.²

68
- 3142573229
- note
- In this case we opted for the preparation of the dibenzyl derivatives since the aryl group provided a better chromophore for chiral-phase HPLC determination of the enantiomeric excess.

69
- 0034748990
- For a non-stereoselective version employing L-proline as catalyst, see: List, B.; Castello, C. Synlett 2001, 11, 1687.
- (2001) Synlett , vol.11 , pp. 1687
- List, B.¹ Castello, C.²

70
- 85077854948
- (a) Krapcho, A. P. Synthesis 1982, 805.
- (1982) Synthesis , vol.805
- Krapcho, A.P.¹

71
- 0000946458
- (b) Tomioka, K.; Yasuda, K.; Koga, K. Tetrahedron Lett. 1986, 27, 4611.
- (1986) Tetrahedron Lett. , vol.27 , pp. 4611
- Tomioka, K.¹ Yasuda, K.² Koga, K.³

72
- 0041724370
- Helmchen, G.; Hoffmann, R. W.; Mulzer, J.; Schaumann, E., Eds.; Thieme: Stuttgart
- For a review on stereoselective additions to nitroalkenes, see: Pyne, S. G. In Stereoselective Synthesis, Methods of Organic Chemistry (Houben-Weyl), E21 ed., Vol. IV; Helmchen, G.; Hoffmann, R. W.; Mulzer, J.; Schaumann, E., Eds.; Thieme: Stuttgart, 1996, 2161-2176.
- (1996) Stereoselective Synthesis, Methods of Organic Chemistry (Houben-Weyl), E21 Ed. , vol.4 , pp. 2161-2176
- Pyne, S.G.¹

73
- 0003527998
- Wiley-VCH: New York
- See, for example: Ono, N. The Nitro Group in Organic Synthesis; Wiley-VCH: New York, 2001.
- (2001) The Nitro Group in Organic Synthesis
- Ono, N.¹

74
- 0035795031
- For Alexakis's later studies employing chiral diamines, see ref. 26c. For a recent example of addition of naked aldehydes to electron-deficient olefins in a non-enantioselective manner, see: (a) Hagiwara, H.; Okabe, T.; Hakoda, K.; Hoshi, T.; Ono, H.; Kamat, V. P.; Suzuki, T.; Ando, M. Tetrahedron Lett. 2001, 42, 2705. (b) Hagiwara, H.; Komatsubara, N.; Ono, H.; Okabe, T.; Hoshi, T.; Suzuki, T.; Ando, M.; Kato, M. J. Chem. Soc., Perkin Trans. 1 2001, 316.
- (2001) Tetrahedron Lett. , vol.42 , pp. 2705
- Hagiwara, H.¹ Okabe, T.² Hakoda, K.³ Hoshi, T.⁴ Ono, H.⁵ Kamat, V.P.⁶ Suzuki, T.⁷ Ando, M.⁸

75
- 0035819731
- For Alexakis's later studies employing chiral diamines, see ref. 26c. For a recent example of addition of naked aldehydes to electron-deficient olefins in a non-enantioselective manner, see: (a) Hagiwara, H.; Okabe, T.; Hakoda, K.; Hoshi, T.; Ono, H.; Kamat, V. P.; Suzuki, T.; Ando, M. Tetrahedron Lett. 2001, 42, 2705. (b) Hagiwara, H.; Komatsubara, N.; Ono, H.; Okabe, T.; Hoshi, T.; Suzuki, T.; Ando, M.; Kato, M. J. Chem. Soc., Perkin Trans. 1 2001, 316.
- (2001) J. Chem. Soc., Perkin Trans. 1 , pp. 316
- Hagiwara, H.¹ Komatsubara, N.² Ono, H.³ Okabe, T.⁴ Hoshi, T.⁵ Suzuki, T.⁶ Ando, M.⁷ Kato, M.⁸

76
- 0033775563
- (a) O'Hagan, D. Nat. Prod. Rep. 2000, 17, 435.
- (2000) Nat. Prod. Rep. , vol.17 , pp. 435
- O'Hagan, D.¹

77
- 0004175604
- Brossi, A., Ed.; Academic Press: New York, Chap. 6
- (b) Numata, A.; Ibuka, T. In The Alkaloids, Vol. 31; Brossi, A., Ed.; Academic Press: New York, 1987, Chap. 6.
- (1987) The Alkaloids , vol.31
- Numata, A.¹ Ibuka, T.²

78
- 3142609424
- Brossi, A., Ed.; Academic Press: New York
- (c) Massiot, G.; Delaude, C. In The Alkaloids, Vol. 27; Brossi, A., Ed.; Academic Press: New York, 1986, Chap. 3.
- (1986) The Alkaloids , vol.27 , pp. 3
- Massiot, G.¹ Delaude, C.²

79
- 0035939112
- (a) Ling, R.; Ekhato, I. V.; Rubin, J. R.; Wustrow, D. J. Tetrahedron 2001, 57, 6579.
- (2001) Tetrahedron , vol.57 , pp. 6579
- Ling, R.¹ Ekhato, I.V.² Rubin, J.R.³ Wustrow, D.J.⁴

80
- 0033516457
- (b) Karlsson, S.; Han, F.; Hogberg, H.-E.; Caldirola, P. Tetrahedron: Asymmetry 1999, 10, 2605.
- (1999) Tetrahedron: Asymmetry , vol.10 , pp. 2605
- Karlsson, S.¹ Han, F.² Hogberg, H.-E.³ Caldirola, P.⁴

81
- 0029055877
- and references cited therein
- (c) Denmark, S. E.; Marcin, L. R. J. Org. Chem. 1995, 60, 3221; and references cited therein.
- (1995) J. Org. Chem. , vol.60 , pp. 3221
- Denmark, S.E.¹ Marcin, L.R.²

82
- 3142573228
- note
- When (S)-1-(2-pyrrolidinylmethyl)pyrrolidine and 2,4-pentanedione are mixed in equimolar amounts in DMSO, enamine formation is detected through UV spectroscopy. Furthermore, while pyrrolidine itself promotes the Michael reaction, the N-methyl derivative, which lacks the secondary amine is ineffective as catalyst. Alexakis et al. have also reported detection of enamine intermediates by GC-MS. See ref. 26c.

83
- 79958222806
- (a) Seebach, D.; Golinski, J. Helv. Chim. Acta 1981, 64, 1413.
- (1981) Helv. Chim. Acta , vol.64 , pp. 1413
- Seebach, D.¹ Golinski, J.²

84
- 0000353461
- (b) Blarer, S. J.; Schweizer, W. B.; Seebach, D. Helv. Chim. Acta 1982, 65, 1637.
- (1982) Helv. Chim. Acta , vol.65 , pp. 1637
- Blarer, S.J.¹ Schweizer, W.B.² Seebach, D.³

85
- 0000933767
- (c) Blarer, S. J.; Seebach, D. Chem. Ber. 1983, 116, 3086.
- (1983) Chem. Ber. , vol.116 , pp. 3086
- Blarer, S.J.¹ Seebach, D.²

86
- 0003091207
- (d) Haner, R.; Laube, T.; Seebach, D. Chimia 1984, 38, 255.
- (1984) Chimia , vol.38 , pp. 255
- Haner, R.¹ Laube, T.² Seebach, D.³

87
- 84986346889
- (e) Seebach, D.; Beck, A. K.; Golinski, J.; Hay, J. N.; Laube, T. Helv. Chim. Acta 1985, 68, 162.
- (1985) Helv. Chim. Acta , vol.68 , pp. 162
- Seebach, D.¹ Beck, A.K.² Golinski, J.³ Hay, J.N.⁴ Laube, T.⁵

88
- 84986364598
- (f) Seebach, D.; Brook, M. A. Helv. Chim. Acta 1985, 68, 319.
- (1985) Helv. Chim. Acta , vol.68 , pp. 319
- Seebach, D.¹ Brook, M.A.²

89
- 84987467086
- For theoretical studies of the reaction of chiral enamines to electrophilic olefins, see: (a) Sevin, A.; Masure, D.; Giessner-Prettre, C.; Pfau, M. Helv. Chim. Acta 1990, 73, 552. (b) Lucero, M. J.; Houk, K. N. J. Am. Chem. Soc. 1997, 119, 826; and references cited therein.
- (1990) Helv. Chim. Acta , vol.73 , pp. 552
- Sevin, A.¹ Masure, D.² Giessner-Prettre, C.³ Pfau, M.⁴

90
- 0031040549
- and references cited therein
- For theoretical studies of the reaction of chiral enamines to electrophilic olefins, see: (a) Sevin, A.; Masure, D.; Giessner-Prettre, C.; Pfau, M. Helv. Chim. Acta 1990, 73, 552. (b) Lucero, M. J.; Houk, K. N. J. Am. Chem. Soc. 1997, 119, 826; and references cited therein.
- (1997) J. Am. Chem. Soc. , vol.119 , pp. 826
- Lucero, M.J.¹ Houk, K.N.²

91
- 0001645987
- Enders, D.; Demir, A. S.; Rendenbach, B. E. M. Chem. Ber. 1987, 120, 1731.
- (1987) Chem. Ber. , vol.120 , pp. 1731
- Enders, D.¹ Demir, A.S.² Rendenbach, B.E.M.³

92
- 0343967492
- Yamaguchi, M.; Shiraishi, T.; Hirama, M. J. Org. Chem. 1996, 61, 3520.
- (1996) J. Org. Chem. , vol.61 , pp. 3520
- Yamaguchi, M.¹ Shiraishi, T.² Hirama, M.³

93
- 0348248914
- Blarer, S. J.; Seebach, D. Chem Ber. 1983, 116, 2250.
- (1983) Chem Ber. , vol.116 , pp. 2250
- Blarer, S.J.¹ Seebach, D.²

94
- 0024608611
- Schionato, A.; Paganelli, S.; Botteghi, C.; Chelucci, G. J. Mol. Catal. 1989, 50, 11.
- (1989) J. Mol. Catal. , vol.50 , pp. 11
- Schionato, A.¹ Paganelli, S.² Botteghi, C.³ Chelucci, G.⁴

95
- 33845279307
- Yamamoto, Y.; Nishii, S. J. Org. Chem. 1988, 53, 3597.
- (1988) J. Org. Chem. , vol.53 , pp. 3597
- Yamamoto, Y.¹ Nishii, S.²

96
- 0000353461
- Blarer, S. J.; Schweizer, W. B.; Seebach, D. Helv. Chim. Acta 1982, 65, 1637.
- (1982) Helv. Chim. Acta , vol.65 , pp. 1637
- Blarer, S.J.¹ Schweizer, W.B.² Seebach, D.³

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.