Molecular mechanism of allergy-related gene regulation and hematopoietic cell development by transcription factors

Bioscience, Biotechnology and Biochemistry

Volumn 70, Issue 1, 2006, Pages 1-9

  Nishiyama, Chiharu ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Allergy; GATA 1; High affinity receptor for IgE (Fc RI); PU.1; Single nucleotide polymorphism (SNP)

Indexed keywords

DISEASE CONTROL; FUNCTIONS; GENES;

GATA-1; HIGH-AFFINITY RECEPTOR FOR IGE (FCΕRI); PU.1; SINGLE NUCLEOTIDE POLYMORPHISM (SNP);

ALLERGIES;

IMMUNOGLOBULIN E RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HEMATOPOIETIC SYSTEM; HUMAN; HYPERSENSITIVITY; IMMUNOLOGY; METABOLISM; REVIEW;

ANIMALS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; HEMATOPOIETIC SYSTEM; HUMANS; HYPERSENSITIVITY; RECEPTORS, IGE; TRANSCRIPTION FACTORS;

EID: 31444449798     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.70.1     Document Type: Review

References (63)

1. Dombrowicz, D., Flamand, V., Brigman, K. K., Koller, B. H., and Kinet, J.-P., Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor α chain gene. Cell, 75, 969-976 (1993).
2. Nishiyama, C., Hasegawa, M., Nishiyama, M., Takahashi, K., Akizawa, Y., Yokota, T., Okumura, K., Ogawa, H., and Ra, C., Regulation of human FcεRI α-chain gene expression by multiple transcription factors. J. Immunol., 168, 4546-4552 (2002).
3. Nishiyama, C., Yokota, T., Okumura, K., and Ra, C., The transcription factors Elf-1 and GATA-1 bind to cell-specific enhancer elements of human high-affinity IgE receptor α-chain gene. J. Immunol., 163, 623-630 (1999).
4. Nishiyama, C., Takahashi, K., Nishiyama, M., Okumura, K., Ra, C., Ohtake, Y., and Yokota, T., Splice isoforms of transcription factor Elf-1 affecting its regulatory function in transcription: molecular cloning of rat Elf-1. Biosci. Biotechnol. Biochem., 64, 2601-2607 (2000).
5. Rekhtman, N., Radparvar, F., Evans, T., and Skoultchi, A. I., Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Genes Dev., 13, 1398-1411 (1999).
6. Nerlov, C., Querfurth, E., Kulessa, H., and Graf, T., GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription. Blood, 95, 2543-2551 (2000).
7. Zhang, P., Behre, G., Pan, J., Iwama, A., Wara-Aswapati, N., Rodomska, H. S., Auron, P. E., Tenen, D. G., and Sun, Z., Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. Proc. Natl. Acad. Sci. U.S.A., 96, 8705-8710 (1999).
8. Walsh, J. C., DeKoter, R. P., Lee, H.-J., Smith, E. D., Lancki, D. W., Gurish, M. F., Friend, D. S., Stevens, R. L., Anastasi, J., and Singh, H., Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates. Immunity, 17, 665-676 (2002).
9. Terada, N., Konno, A., Terada, Y., Fukuda, S., Yamashita, T., Abe, T., Shimada, H., Ishida, K., Yoshimura, K., Tanaka, Y., Ra, C., Ishikawa, K., and Togawa, K., IL-4 upregulates FcεRI α-chain messenger RNA in eosinophils. J. Allergy Clin. Immunol., 96, 1161-1169 (1995).
10. Toru, H., Ra, C., Nonoyama, S., Suzuki, K., Yata, J., and Nakahata, T., Induction of the high-affinity IgE receptor (FcεRI) on human mast cells by IL-4. Int. Immunol., 8, 1367-1373 (1996).
11. Pawankar, R., Okuda, M., Yssel, H., Okumura, K., and Ra, C., Nasal mast cells in perennial allergic rhinitics exhibit increased expression of the FcεRI, CD40L, IL-4, and IL-13, and can induce IgE synthesis in B cells. J. Clin. Invest., 99, 1492-1499 (1997).
12. Xia, H.-Z., Du, Z., Craig, S., Klisch, G., Noben-Trauth, N., Kochan, J. P., Huff, T. H., Irani, A.-M. A., and Schwartz, L. B., Effect of recombinant human IL-4 on tryptase, chymase, and Fcε receptor type I expression in recombinant human stem cell factor-dependent fetal liver-derived human mast cells. J. Immunol., 159, 2911-2921 (1997).
13. Bischoff, S. C., Selige, G., Lorentz, A., Sebald, W., Raab, R., and Manns, M. P., IL-4 enhances proliferation and mediator release in mature human mast cells. Proc. Natl. Acad. Sci. U.S.A., 96, 8080-8085 (1999).
14. Gosset, P., Lamblin-Degros, C., Tillie-Leblond, I., Charbonnier, A.-S., Joseph, M., Wallaert, B., Kochan, J. P., and Tonnel, A.-B., Modulation of high-affinity IgE receptor expression in blood monocytes: opposite effect of IL-4 and glucocorticoids. J. Allergy Clin. Immunol., 107, 114-122 (2001).
15. Ryan, J. J., DeSimone, S., Klish, G., Shelburne, C., McReynolds, L. J., Han, K., Kovacs, R., Mirmonsef, P., and Huff, T. F., IL-4 inhibits mouse mast cell FcεRI expression through a STAT6-dependent mechanism. J. Immunol., 161, 6915-6923 (1998).
16. Nishiyama, C., Hasegawa, M., Nishiyama, M., Takahashi, K., Yokota, T., Okumura, K., and Ra, C., Cloning of full-length genomic DNA encoding human FcεRI α-chain and its transcriptional regulation. Biochem. Biophys. Res. Commun., 284, 1056-1064 (2001).
17. Hasegawa, M., Nishiyama, C., Nishiyama, M., Akizawa, Y., Takahashi, K., Ito, T., Furukawa, S., Ra, C., Okumura, K., and Ogawa, H., Regulation of the human FcεRI α-chain distal promoter. J. Immunol., 170, 3732-3738 (2003).
18. Kraft, S., Wessendorf, J. H. M., Hanau, D., and Bieber, T., Regulation of the high affinity receptor for IgE on human epidermal Langerhans cells. J. Immunol., 161, 1000-1006 (1998).
19. Smith, S. J., Ying, S., Meng, Q., Sullivan, M. H. F., Barkans, J., Kon, O. M., Sihra, B., Larche, M., Levi-Schaffer, F., and Kay, A. B., Blood eosinophils from atopic donors express messenger RNA for the α, β, and γ subunits of the high-affinity IgE receptor (FcεRI) and intracellular, but not cell surface, α subunit protein. J. Allergy Clin. Immunol., 105, 309-317 (2000).
20. Dombrowicz, D., Lin, S., Flamand, V., Brini, A. T., Koller, B. H., and Kinet, J.-P., Allergy-associated FcRβ is a molecular amplifier of IgE- and IgG-mediated in vivo responses. Immunity, 8, 517-529 (1998).
21. Donnadieu, E., Jouvin, M.-H., and Kinet, J.-P., A second amplifier function for the allergy-associated FcεRI-β subunit. Immunity, 12, 515-523 (2000).
22. Sandford, A. J., Shirakawa, T., Moffatt, M. F., Daniels, S. E., Ra, C., Faux, J. A., Young, R. P., Nakamura, Y., Lathrop, G. M., Cookson, W. O. C. M., and Hopkin, J. M., Localisation of atopy and β subunit of high-affinity IgE receptor (FcεRI) on chromosome 11q. Lancet, 341, 332-334 (1993).
23. Maeda, K., Nishiyama, C., Tokura, T., Akizawa, Y., Nishiyama, M., Ogawa, H., Okumura, K., and Ra, C., Regulation of cell type-specific mouse FcεRI β-chain gene expression by GATA-1 via four GATA motifs in the promoter. J. Immunol., 170, 334-340 (2003).
24. Akizawa, Y., Nishiyama, C., Hasegawa, M., Maeda, K., Nakahata, T., Okumura, K., Ra, C., and Ogawa, H., Regulation of human FcεRI β chain gene expression by Oct-1. Int. Immunol., 15, 549-556 (2003).
25. Takahashi, K., Nishiyama, C., Hasegawa, M., Akizawa, Y., and Ra, C., Regulation of the human high affinity IgE receptor β-chain gene expression via an intronic element. J. Immunol., 171, 2478-2484 (2003).
26. Takahashi, S., Onodera, K., Motobashi, H., Suwabe, N., Hayashi, N., Yanai, N., Nabesima, Y., and Yamamoto, M., Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene. J. Biol. Chem., 272, 12611-12615 (1997).
27. Nishiyama, C., Ito, T., Nishiyama, M., Masaki, S., Maeda, K., Nakano, N., Ng, W., Fukuyama, K., Yamamoto, M., Okumura, K., and Ogawa, H., GATA-1 is required for expression of FcεRI on mast cells: analysis of mast cells derived from GATA-1 knockdown mouse bone marrow. Int. Immunol., 17, 847-856 (2005).
28. Shirakawa, T., Li, A., Dubowitz, M., Dekker, J. W., Shaw, A. E., Faux, J. A., Ra, C., Cookson, W. O. C. M., and Hopkin, J. M., Association between atopy and variants of the β subunit of the high-affinity immunoglobulin E receptor. Nat. Genet., 7, 125-130 (1994).
29. Hill, M. R., and Cookson, W. O. C. M., A new variant of the β subunit of the high-affinity receptor for immunoglobulin E (FcεRI-β E237G): associations with measures of atopy and bronchial hyper-responsiveness. Hum. Mol. Genet., 5, 959-962 (1996).
30. Duffy, D. L., Healey, S. C., Chenevix-Trench, G., and Martin, N. G., Atopy in Australia. Nat. Genet., 10, 260 (1995).
31. Shirakawa, T., Mao, X.-Q., Sasaki, S., Enomoto, T., Kawai, M., Morimoto, K., and Hopkin, J., Association between atopic asthma and a coding variant of FcεRIβ in a Japanese population. Hum. Mol. Genet., 5, 1129-1130 (1996).
32. Laprise, C., Boulet, L. P., Morissette, J., Winstall, E., and Raymond, V., Evidence for association and linkage between atopy, airway hyper-responsiveness, and the beta subunit Glu237Gly variant of the high-affinity receptor for immunoglobulin E in the French-Canadian population. Immunogenetics, 51, 695-702 (2000).
33. Nagata, H., Mutoh, H., Kumahara, K., Arimoto, Y., Tomemori, T., Sakurai, D., Arase, K., Ohno, K., Yamakoshi, T., Nakano, K., Okawa, T., Numata, T., and Konno, A., Association between nasal allergy and a coding variant of the FcεRIβ gene Glu237Gly in a Japanese population. Hum. Genet., 109, 262-266 (2001).
34. Ishizawa, M., Shibasaki, M., Yokouchi, Y., Noguchi, E., Arinami, T., Yamakawa-Kobayashi, K., Matsui, A., and Hamaguchi, H., No association between atopic asthma and a coding variant of FcεRIβ in a Japanese population. J. Hum. Genet., 44, 308-311 (1999).
35. Takabayashi, A., Ihara, K., Sasaki, Y., Nishima, S., Izuhara, K., Hamasaki, N., and Hara, T., Childhood atopic asthma: positive association with a polymorphism of IL-4 receptor α gene but not with that of IL-4 promoter or Fcε receptor I β gene. Exp. Clin. Immunogenet., 17, 63-70 (2000).
36. Furumoto, Y., Hiraoka, S., Kawamoto, K., Masaki, S., Kitamura, T., Okumura, K., and Ra, C., Polymorphisms in FcεRI β chain do not affect IgE-mediated mast cell activation. Biochem. Biophys. Res. Commun., 273, 765-771 (2000).
37. Donnadieu, E., Cookson, W. O., Jouvin, M.-H., and Kinet, J.-P., Allergy-associated polymorphisms of the FcεRIβ subunit do not impact its two amplification functions. J. Immunol., 165, 3917-3922 (2000).
38. Nishiyama, C., Akizawa, Y., Nishiyama, M., Tokura, T., Kawada, H., Mitsuishi, K., Hasegawa, M., Ito, T., Nakano, N., Okamoto, A., Takagi, A., Yagita, H., Okumura, K., and Ogawa, H., Polymorphisms in the FcεRIβ promoter region affecting transcription activity: a possible promoter-dependent mechanism for association between FcεRIβ and atopy. J. Immunol., 173, 6458-6464 (2004).
39. Asai, K., Kitaura, J., Kawakami, Y., Yamagata, N., Tsai, M., Carbone, D. P., Liu, F.-T., Galli, S. J., and Kawakami, T., Regulation of mast cell survival by IgE. Immunity, 14, 791-800 (2001).
40. Kalesnikoff, J., Huber, M., Lam, V., Damen, J. E., Zhang, J., Siraganian, R. P., and Krystal, G., Monomeric IgE stimulates signaling pathways in mast cells and leads to cytokine production and cell survival. Immunity, 14, 801-811 (2001).
41. Cookson, W. O. C. M., Ubhi, B., Lawrence, R., Abecasis, G. R., Walley, A. J., Cox, H. E., Coleman, R., Leaves, N. I., Trembath, R. C., Moffatt, M. F., and Harper, J. I., Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci. Nat. Genet., 27, 372-373 (2001).
42. Hasegawa, M., Nishiyama, C., Nishiyama, M., Akizawa, Y., Mitsuishi, K., Ito, T., Kawada, H., Furukawa, S., Ra, C., Okumura, K., and Ogawa, H., A novel -66T/C polymorphism in FcεRI α-chain promoter affecting the transcription activity: possible relationship to allergic diseases. J. Immunol., 171, 1927-1933 (2003).
43. McKercher, S. R., Torbett, B. E., Anderson, K. L., Henkel, G. W., Vestal, D. J., Baribault, H., Klemsz, M., Feeney, A. J., Wu, G. E., Paige, C. J., and Maki, R. A., Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J., 15, 5647-5648 (1996).
44. Scott, E. W., Simon, M. C., Anastasi, J., and Singh, H., Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science, 265, 1573-1577 (1994).
45. Scott, E. W., Fisher, R. C., Olson, M. C., Kehrli, E. W., Simon, M. C., and Singh, H., PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity, 6, 437-447 (1997).
46. Anderson, K. L., Perkin, H., Surh, C. D., Venturini, S., Maki, R. A., and Torbett, B. E., Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells. J. Immunol., 164, 1855-1861 (2000).
47. Guerriero, A., Langmuir, P. B., Spain, L. M., and Scott, E. W., PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells. Blood, 95, 879-885 (2000).
48. DeKoter, R. P., and Singh, H., Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science, 288, 1439-1441 (2000).
49. Dahl, R., Walsh, J. C., Lancki, D., Laslo, P., Iyer, S. R., Singh, H., and Simon, M. C., Regulation of macrophages and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor. Nat. Immunol., 4, 1029-1036 (2003).
50. Galson, D. L., Hensold, J. O., Bishop, T. R., Schalling, M., D'Andrea, A. D., Jones, C., Auron, P. E., and Housman, D. E., Mouse β-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription facto Spi-1/PU.1, and is restricted in expression to hematopoietic cells and testis. Mol. Cell. Biol., 13, 2929-2941 (1993).
51. Nishiyama, C., Nishiyama, M., Ito, T., Masaki, S., Maeda, K., Masuoka, N., Yamane, H., Kitamura, T., Ogawa, H., and Okumura, K., Overproduction of PU.1 in mast cell progenitors: its effect on monocyte- and mast cell-specific gene expression. Biochem. Biophys. Res. Commun., 313, 516-521 (2004).
52. Ito, T., Nishiyama, C., Nishiyama, M., Matsuda, H., Maeda, K., Akizawa, Y., Tsuboi, R., Okumura, K., and Ogawa, H., Mast cells acquire monocyte-specific gene expression and monocyte-like morphology by overproduction of PU.1. J. Immunol., 174, 376-383 (2005).
53. Nishiyama, C., Nishiyama, M., Ito, T., Masaki, S., Masuoka, N., Yamane, H., Kitamura, T., Ogawa, H., and Okumura, K., Functional analysis of PU.1 domains in monocyte-specific gene regulation. FEBS Lett., 561, 63-68 (2004).
54. Nishiyama, C., Yuuki, T., Takai, T., Okumura, Y., and Okudaira, H., Determination of three disulfide bonds in a major house dust mite allergen, Der f II. Int. Arch. Allergy Immunol., 101, 159-166 (1993).
55. Nishiyama, C., Yuuki, T., Usui, Y., Iwamoto, N., Okumura, Y., and Okudaira, H., Effects of amino acid variations in recombinant Der f II on its human IgE and mouse IgG recognition. Int. Arch. Allergy Immunol., 105, 62-69 (1994).
56. Nishiyama, C., Fukada, M., Usui, Y., Iwamoto, N., Yuuki, T., Okumura, Y., and Okudaira, H., Analysis of IgE-epitope of Der f 2, a major mite allergen, by in vitro mutagenesis. Mol. Immunol., 32, 1021-1029 (1995).
57. Nishiyama, C., Yasuhara, T., Yuuki, T., and Okumura, Y., Cloning and expression in Escherichia coli of cDNA encoding house dust mite allergen Der f 3, serine protease from Dermatophagoides farinae. FEBS Lett., 377, 62-66 (1995).
58. Iwamoto, N., Nishiyama, C., Yasuhara, T., Saito, A., Yuuki, T., Okumura, Y., and Okudaira, H., Direct expression of Der f 2, a major house dust mite allergen, in Escherichia coli. Int. Arch. Allergy Immunol., 109, 356-361 (1996).
59. Takai, T., Yokota, T., Yasue, M., Nishiyama, C., Yuuki, T., Mori, A., Okudaira, H., and Okumura, Y., Engineering of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy. Nat. Biotechnol., 15, 754-758 (1997).
60. Ichikawa, S., Hatanaka, H., Yuuki, T., Iwamoto, N., Kojima, S., Nishiyama, C., Ogura, K., Okumura, Y., and Inagaki, F., Solution structure of Der f 2, the major mite allergen for atopic diseases. J. Biol. Chem., 273, 356-360 (1998).
61. Nishiyama, C., Hatanaka, H., Ichikawa, S., Fukada, M., Akagawa-Chihara, M., Yuuki, T., Yokota, T., Inagaki, F., and Okumura, Y., Analysis of human IgE epitope of Der f 2 with anti-Der f 2 mouse monoclonal antibodies. Mol. Immunol., 36, 53-60 (1999).
62. Nakazawa, T., Takai, T., Hatanaka, H., Mizuuchi, E., Nagamune, T., Okumura, K., and Ogawa, H., Multiple-mutation at a potential ligand-binding region decreased allergenicity of a mite allergen Der f 2 without disrupting global structure. FEBS Lett., 579, 1988-1994 (2005).
63. Ichikawa, S., Takai, T., Inoue, T., Yuuki, T., Okumura, Y., Ogura, K., Inagaki, F., and Hatanaka, H., NMR study on the major mite allergen Der f 2: its refined tertiary structure, epitopes for monoclonal antibodies and characteristics shared by ML protein group members. J. Biochem., 137, 255-263 (2005).