Multiple-mutation at a potential ligand-binding region decreased allergenicity of a mite allergen Der f 2 without disrupting global structure

FEBS Letters

Volumn 579, Issue 9, 2005, Pages 1988-1994

  Nakazawa, Takuya ^a   Takai, Toshiro ^a   Hatanaka, Hideki ^b   Mizuuchi, Eri ^a,c   Nagamune, Teruyuki ^c   Okumura, Ko ^a   Ogawa, Hideoki ^a  

^a JUNTENDO UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Der f 2; House dust mite; IgE epitope; MD 2 related lipid recognition proteins; Potential ligand binding cavity; Recombinant allergen; Tertiary structure

Indexed keywords

HOUSE DUST ALLERGEN; HOUSE DUST ALLERGEN DERMATOPHAGOIDES FARINAE 2; IMMUNOGLOBULIN E; MD 2 RELATED LIPID RECOGNITION PROTEIN; MUTANT PROTEIN; NIEMANN PICK TYPE 2 DISEASE PROTEIN; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG; VACCINE;

ALLERGENICITY; ARTICLE; BINDING SITE; CIRCULAR DICHROISM; CONTROLLED STUDY; DERMATOPHAGOIDES FARINAE; GENE DISRUPTION; GENE MUTATION; HUMAN; LIGAND BINDING; MITE; POPULATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN STRUCTURE;

EID: 15544382364     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.01.088     Document Type: Article

References (37)

1. T.A. Platts-Mills, and M.D. Chapman Dust mites: immunology, allergic disease, and environmental control J. Allergy Clin. Immunol. 80 1987 755 775
2. W.R. Thomas, W.A. Smith, B.J. Hales, K.L. Mills, and R.M. O'Brien Characterization and immunobiology of house dust mite allergens Int. Arch. Allergy Immunol. 129 2002 1 18
3. T. Yuuki, Y. Okumura, T. Ando, H. Yamakawa, M. Suko, M. Haida, and H. Okudaira Cloning and sequencing of cDNA corresponding to mite major allergen Der fII Arerugi 39 1990 557 561
4. T. Takai, T. Yuuki, Y. Okumura, A. Mori, and H. Okudaira Determination of the N- and C-terminal sequences required to bind human IgE of the major house dust mite allergen Der f 2 and epitope mapping for monoclonal antibodies Mol. Immunol. 34 1997 255 261
5. T. Takai, A. Mori, T. Yuuki, H. Okudaira, and Y. Okumura Non-anaphylactic combination of partially deleted fragments of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy Mol. Immunol. 36 1999 1055 1065
6. T. Takai, T. Yokota, M. Yasue, C. Nishiyama, T. Yuuki, A. Mori, H. Okudaira, and Y. Okumura Engineering of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy Nat. Biotechnol. 15 1997 754 758
7. T. Takai, S. Ichikawa, T. Yokota, H. Hatanaka, F. Inagaki, and Y. Okumura Unlocking the allergenic structure of the major house dust mite allergen Der f 2 by elimination of key intramolecular interactions FEBS Lett. 484 2000 102 107
8. W.R. Thomas, and K.Y. Chua The major mite allergen Der p 2 - a secretion of the male mite reproductive tract? Clin. Exp. Allergy 25 1995 667 669
9. C. Kirchhoff, C. Osterhoff, and L. Young Molecular cloning and characterization of HE1, a major secretory protein of the human epididymis Biol. Reprod. 54 1996 847 856
10. S. Naureckiene, D.E. Sleat, H. Lackland, A. Fensom, M.T. Vanier, R. Wattiaux, M. Jadot, and P. Lobel Identification of HE1 as the second gene of Niemann-Pick C disease Science 290 2000 2298 2301
11. R. Shimazu, S. Akashi, H. Ogata, Y. Nagai, K. Fukudome, K. Miyake, and M. Kimoto MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4 J. Exp. Med. 189 1999 1777 1782
12. N. Inohara, and G. Nunez ML - a conserved domain involved in innate immunity and lipid metabolism Trends Biochem. Sci. 27 2002 219 221
13. N. Okamura, S. Kiuchi, M. Tamba, T. Kashima, S. Hiramoto, T. Baba, F. Dacheux, J.L. Dacheux, Y. Sugita, and Y.Z. Jin A porcine homolog of the major secretory protein of human epididymis, HE1, specifically binds cholesterol Biochim. Biophys. Acta 1438 1999 377 387
14. S. Viriyakosol, P.S. Tobias, R.L. Kitchens, and T.N. Kirkland MD-2 binds to bacterial lipopolysaccharide J. Biol. Chem. 276 2001 38044 38051
15. R. Valenta The future of antigen-specific immunotherapy of allergy Nat. Rev. Immunol. 2 2002 446 453
16. S. Flicker, and R. Valenta Renaissance of the blocking antibody concept in type I allergy Int. Arch. Allergy Immunol. 132 2003 13 24
17. J. Holm, M. Gajhede, M. Ferreras, A. Henriksen, H. Ipsen, J.N. Larsen, L. Lund, H. Jacobi, A. Millner, P.A. Wurtzen, and M.D. Spangfort Allergy vaccine engineering: epitope modulation of recombinant Bet v 1 reduces IgE binding but retains protein folding pattern for induction of protective blocking-antibody responses J. Immunol. 173 2004 5258 5267
18. T. Takai, S. Ichikawa, H. Hatanaka, F. Inagaki, and Y. Okumura Effects of proline mutations in the major house dust mite allergen Der f 2 on IgE-binding and histamine-releasing activity Eur. J. Biochem. 267 2000 6650 6656
19. T. Takai, R. Mineki, T. Nakazawa, M. Takaoka, H. Yasueda, K. Murayama, K. Okumura, and H. Ogawa Maturation of the activities of recombinant mite allergens Der p 1 and Der f 1, and its implication in the blockade of proteolytic activity FEBS Lett. 531 2002 265 272
20. T. Yuuki, Y. Okumura, T. Ando, H. Yamakawa, M. Suko, M. Haida, and H. Okudaira Cloning and expression of cDNA coding for the major house dust mite allerge nDer fII in Escherichia coli Agric. Biol. Chem. 55 1991 1233 1238
21. H. Nishi, S. Nishimura, M. Higashiura, N. Ikeya, H. Ohta, T. Tsuji, M. Nishimura, S. Ohnishi, and H. Higashi A new method for histamine release from purified peripheral blood basophils using monoclonal antibody-coated magnetic beads J. Immunol. Methods 240 2000 39 46
22. M.A. Marti-Renom, A.C. Stuart, A. Fiser, R. Sanchez, F. Melo, and A. Sali Comparative protein structure modeling of genes and genomes Annu. Rev. Biophys. Biomol. Struct. 29 2000 291 325
23. Ichikawa, S., Hatanaka, H., Takai, T., Nishiyama, C., Yuuki, T., Ogura, K., Okumura, Y. and Inagaki, F. (2000) Tertiary structure of mite allergen Der f 2 and recognition by antibodies. In: Proceedings of the 39th Annual Meeting of the Nuclear Magnetic Society of Japan, pp. 168-169
24. P.J. Kraulis MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures J. Appl. Crystallogr. 24 1991 946 950
25. E.A. Merrit, and M.E.P. Murphy Raster3D version 2.0. A program for photorealistic molecular graphics Acta Crystallogr. D50 1994 869 873
26. S. Ichikawa, H. Hatanaka, T. Yuuki, N. Iwamoto, S. Kojima, C. Nishiyama, K. Ogura, Y. Okumura, and F. Inagaki Solution structure of Der f 2, the major mite allergen for atopic diseases J. Biol. Chem. 273 1998 356 360
27. D.C. Ko, J. Binkley, A. Sidow, and M.P. Scott The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels Proc. Natl. Acad. Sci. USA 100 2003 2518 2525
28. A. Visintin, E. Latz, B.G. Monks, T. Espevik, and D.T. Golenbock Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction J. Biol. Chem. 278 2003 48313 48320
29. F. Re, and J.L. Strominger Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness J. Immunol. 171 2003 5272 5276
30. K. Kawasaki, H. Nogawa, and M. Nishijima Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies, and for conferring LPS and taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis J. Immunol. 170 2003 413 420
31. A. Gruber, M. Mancek, H. Wagner, C.J. Kirschning, and R. Jerala Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular LPS recognition J. Biol. Chem. 279 2004 28475 28482
32. S. Korematsu, Y. Tanaka, S. Hosoi, S. Koyanagi, T. Yokota, B. Mikami, and N. Minato C8/119S mutation of major mite allergen Derf-2 leads to degenerate secondary structure and molecular polymerization and induces potent and exclusive Th1 cell differentiation J. Immunol. 165 2000 2895 2902
33. M. Yasue, T. Yokota, M. Fukada, T. Takai, M. Suko, H. Okudaira, and Y. Okumura Hyposensitization to allergic reaction in rDer f 2-sensitized mice by the intranasal administration of a mutant of rDer f 2, C8/119S Clin. Exp. Immunol. 113 1998 1 9
34. M.H. Loveless Immunological studies of pollinosis: I. The presence of 2 antibodies related to the same pollen-allergen in the serum of treated hay fever patients J. Immunol. 38 1940 25 50
35. R. Bhattacharyya, and P. Chakrabarti Stereospecific interactions of proline residues in protein structures and complexes J. Mol. Biol. 331 2003 925 940
36. U. Derewenda, J. Li, Z. Derewenda, Z. Dauter, G.A. Mueller, G.S. Rule, and D.C. Benjamin The crystal structure of a major dust mite allergen Der p 2, and its biological implications J. Mol. Biol. 318 2002 189 197
37. N. Friedland, H.L. Liou, P. Lobel, and A.M. Stock Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease Proc. Natl. Acad. Sci. USA 100 2003 2512 2517