A functional network of intramolecular cross-reacting epitopes delays the elicitation of neutralizing antibodies to Trypanosoma cruzi trans-sialidase

Journal of Infectious Diseases

Volumn 186, Issue 3, 2002, Pages 397-404

  Pitcovsky, Tamara A ^a   Buscaglia, Carlos A ^a   Mucci, Juan ^a   Campetella, Oscar ^a  

^a INSTITUTO DE INVESTIGACIONES BIOTECNOLÓGICAS   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; NEUTRALIZING ANTIBODY; PARASITE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; CROSS REACTION; EPITOPE MAPPING; FEMALE; MOUSE; NONHUMAN; PARASITE VIRULENCE; PRIORITY JOURNAL; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, PROTOZOAN; CHAGAS DISEASE; DNA, PROTOZOAN; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; ESCHERICHIA COLI; FEMALE; GLYCOPROTEINS; HUMANS; MICE; MICE, INBRED C3H; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEURAMINIDASE; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRYPANOSOMA CRUZI;

EID: 0036681847     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/341463     Document Type: Article

References (35)

1. The mechanisms of Trypanosoma cruzi invasion of mammalian cells
2. Functional diversity in the trans-sialidase and mucin families in Trypanosoma cruzi
3. A superfamily of Trypanosoma cruzi surface antigens
4. Enzymically inactive members of the trans-sialidase family from Trypanosoma cruzi display β-galactose binding activity
5. The surface glycoproteins of Trypanosoma cruzi encode a superfamily of variant T cell epitopes
6. Infection by Trypanosoma cruzi: Identification of a parasite ligand and its host cell receptor
7. FL-160 proteins of Trypanosoma cruzi are expressed from a multigene family and contain two distinct epitopes that mimic nervous tissues
8. The surface trans-sialidase family of Trypanosoma cruzi
9. Structural and functional properties of Trypanosoma trans-sialidase
10. A novel cell surface trans-sialidase of Trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells
11. Mucin-like glycoproteins linked to the membrane by glycosylphosphatidylinositol anchor are the major acceptors of sialic acid in a reaction catalyzed by trans-sialidase in metacyclic forms of Trypanosoma cruzi
12. Mucin-like molecules form a negatively charged coat that protects Trypanosoma cruzi trypomastigotes from killing by human anti-alpha-galactosyl antibodies
13. Trypanosoma cruzi trans-sialidase potentiates T cell activation through antigen-presenting cells: Role of IL-6 and Bruton's tyrosine kinase
14. Trans-sialidase from Trypanosoma cruzi induces apoptosis in cells from the immune system in vivo
15. Thymocyte depletion in Trypanosoma cruzi infection is mediated by trans-sialidase-induced apoptosis on nurse cell complex
16. Mice infected with Trypanosoma cruzi produce antibodies against the enzymatic domain of trans-sialidase that inhibit its activity
17. Antibodies inhibiting Trypanosoma cruzi trans-sialidase activity in sera from human infections
18. Sera from chronic Chagasic patients and rodents infected with Trypanosoma cruzi inhibit trans-sialidase by recognizing its amino-terminal and catalytic domain
19. Identification of a Trypanosoma cruzi antigen that is shed during the acute phase of Chagas' disease
20. Multiple overlapping epitopes in the repetitive unit of the shed acute-phase antigen from Trypanosoma cruzi enhance its immunogenic properties
21. Structural basis of sialyltransferase activity in trypanosomal sialidases
22. Epitope mapping of trans-sialidase from Trypanosoma cruzi reveals the presence of several cross-reactive determinants
23. The repetitive domain of Trypanosoma cruzi trans-sialidase enhances the immune response against the catalytic domain
24. Tandem amino acid repeats from Trypanosoma cruzi shed antigens increase the half-life of proteins in blood
25. Trypanosoma rangeli sialidase: Cloning, expression and similarity to T. cruzi trans-sialidase
26. Serum neuraminidase activity and hematological alterations in acute human Chagas' disease
27. SAPA/trans-sialidase and cruzipain: Two antigens from Trypanosoma cruzi contain immunodominant but enzymatically inactive domains
28. Refocusing neutralizing antibody response by targeted dampening of an immunodominant epitope
29. Immunogenicity and protective efficacy of the alpha C protein of group B Streptococci are inversely related to the number of repeats
30. Subversion of the immune system by pathogens
31. On the function of repetitive domains in protein antigens of Plasmodium and other eukaryotic parasites
32. Repetitive proteins and genes of malaria
33. Diversity in repeat-containing surface proteins of Leishmania major
34. Identification of immunodominant epitopes in Trypanosoma cruzi trypomastigote surface antigen-1 protein that mask protective epitopes
35. Crossreactive antigens between life cycle stages of Plasmodium falciparum