Gene expression profiling of seizure disorders

Neurochemical Research

Volumn 29, Issue 6, 2004, Pages 1083-1092

  Elliott, Robert C ^a   Lowenstein, Daniel H ^b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Epilepsy; Gene expression; Hippocampus; Microarrays; Seizure

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; GLUTAMATE RECEPTOR; KAINIC ACID; PENTETRAZOLE; PILOCARPINE;

BRAIN DEVELOPMENT; BRAIN NERVE CELL; BRAIN REGION; CELL FUNCTION; CELL SURVIVAL; DNA MICROARRAY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE TARGETING; GENOME ANALYSIS; HUMAN; MEDICAL RESEARCH; MOLECULAR DYNAMICS; NERVE CELL STIMULATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEIZURE; ANIMAL; DISEASE MODEL; EPILEPSY; GENE EXPRESSION REGULATION; GENETICS; METHODOLOGY;

ANIMALS; DISEASE MODELS, ANIMAL; EPILEPSY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 3142733426     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:NERE.0000023595.12396.1b     Document Type: Review

References (97)

1. Coulter, D. A., McIntyre, D. C., and Loscher, W. 2002. Animal models of limbic epilepsies: what can they tell us? Brain Pathol. 12(2):240-256.
2. White, H. S. 2002. Animal models of epileptogenesis. Neurology. 59(9 Suppl 5):S7-S14.
3. Goddard, G. V., McIntyre, D. C., and Leech, C. K. 1969. A permanent change in brain function resulting from daily electrical stimulation. Exp. Neurol. 25(3):295-330.
4. Racine, R. J. 1972. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 32(3):281-294.
5. Racine, R. 1978. Kindling: the first decade. Neurosurgery. 3(2):234-252.
6. Wasterlain, C. G., Morin, A. M., and Jonec, V. 1982. Kindling: a pharmacological approach. Electroencephalogr. Clin. Neurophysiol. Suppl. 36:264-273.
7. Sloviter, R. S. and Damiano, B. P. 1981. Sustained electrical stimulation of the perforant path duplicates kainate-induced electrophysiological effects and hippocampal damage in rats. Neurosci. Lett. 24(3):279-284.
8. Sloviter, R. S. 1983. "Epileptic" brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies. Brain Res. Bull. 10(5):675-697.
9. Swinyard, E. A. 1969. Laboratory evaluation of antiepileptic drugs. Review of laboratory methods. Epilepsia 10(2):107-119.
10. Squires, R. F., Saederup, E., Crawley, J. N., Skolnick, P., and Paul, S. M. 1984. Convulsant potencies of tetrazoles are highly correlated with actions on GABA/benzodiazepine/picrotoxin receptor complexes in brain. Life Sci. 35(14):1439-1444.
11. Campbell, K. A., Bank, B., and Milgram, N. W. 1984. Epileptogenic effects of electrolytic lesions in the hippocampus: role of iron deposition. Exp. Neurol. 86(3):506-514.
12. Pico, R. M. and Gall, C. M. 1994. Hippocampal epileptogenesis produced by electrolytic iron deposition in the rat dentate gyms. Epilepsy Res. 19:27-36.
13. Nadler, J. V. 1981. Minireview. Kainic acid as a tool for the study of temporal lobe epilepsy. Life Sci. 29(20):2031-2042.
14. Cavalheiro, E. A. 1995. The pilocarpine model of epilepsy. Ital. J. Neurol. Sci. 16:33-37.
15. Ben-Ari, Y. and Cossart, R. 2000. Kainate, a double agent that generates seizures: two decades of progress. Trends Neurosci. 23(11):580-587.
16. Margerison, J. H. and Corsellis, J. A. 1966. Epilepsy and the temporal lobes. A clinical, electroencephalographic and neuropathological study of the brain in epilepsy, with particular reference to the temporal lobes. Brain 89(3):499-530.
17. Lowenstein, D. H. 2001. Structural reorganization of hippocampal networks caused by seizure activity. Int. Rev. Neurobiol. 45:209-236.
18. Sutula, T., Cascino, G., Cavazos, J., Parada, I., and Ramirez, L. 1989. Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Ann. Neurol. 26(3):321-330.
19. Houser, C. R., Miyashiro, J. E., Swartz, B. E., Walsh, G. O., Rich, J. R., and Delgado-Escueta, A. V. 1990. Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy. J. Neurosci. 10(1):267-282.
20. Isokawa, M., Levesque, M. F., Babb, T. L., and Engel, J., Jr. 1993. Single mossy fiber axonal systems of human dentate granule cells studied in hippocampal slices from patients with temporal lobe epilepsy. J. Neurosci. 13(4):1511-1522.
21. Franck, J., Pokorny, J., Kunkel, D. D., and Schwartzkroin, P. A. 1995. Physiologic and morphologic characteristics of granule cell circuitry in human epileptic hippocampus. Epilepsia. 36: 543-558.
22. Tauck, D. and Nadler, J. 1985. Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. J. Neurosci. 5(4):1016-1022.
23. Sloviter, R. S. 1992. Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats. Neurosci. Lett. 137:91-96.
24. Wuarin, J. and Dudek, F. 1996. Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate-treated epileptic rats. J. Neurosci. 16: 4438-4448.
25. Ben-Ari, Y. 1985. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 14(2):375-403.
26. Cronin, J. and Dudek, F. E. 1988. Chronic seizures and collateral sprouting of dentate mossy fibers after kainic acid treatment in rats. Brain Res. 474(1):181-184.
27. Mello, L. E., Cavalheiro, E. A., Tan, A. M., Kupfer, W. R., Pretorius, J. K., Babb, T. L., and Finch, D. M. 1993. Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting. Epilepsia 34(6):985-995.
28. Sonnenberg, J. L., Mitchelmore, C., Macgregor-Leon, P. F., Hempstead, J., Morgan, J. I., and Curran, T. 1989. Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain. J. Neurosci. Res. 24(1):72-80.
29. Kaminska, B., Filipkowski, R. K., Zurkowska, G., Lason, W., Przewlocki, R., and Kaczmarek, L. 1994. Dynamic changes in the composition of the AP-1 transcription factor DNA-binding activity in rat brain following kainate-induced seizures and cell death. Eur. J. Neurosci. 6:1558-1566.
30. Hope, B. T., KeIz, M. B., Duman, R. S., and Nestler, E. J. 1994. Chronic electroconvulsive seizure (ECS) treatment results in expression of a long-lasting AP-1 complex in brain with altered composition and characteristics. J. Neurosci. 14(7):4318-4328.
31. Pennypacker, K. P., Thai, L., Hong, J-S., and McMillian, M. K. 1994. Prolonged expression of AP-1 transcription factors in the rat hippocampus after systemic kainate treatment. J. Neurosci. 14(7):3998-1006.
32. McNamara, J. O., Peper, A. M., and Patrone, V. 1980. Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors. Proc. Natl. Acad. Sci. USA 77(5):3029-3032.
33. Valdes, F., Dasheiff, R. M., Birmingham, F., Crutcher, K. A., and McNamara, J. O. 1982. Benzodiazepine receptor increases after repeated seizures: evidence for localization to dentate granule cells. Proc. Natl. Acad. Sci. USA 79(1):193-197.
34. Shin, C., Pedersen, H. B., and McNamara, J. O. 1985. Gamma-aminobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study. J.Neurosci. 5(10):2696-2701.
35. Hong, J. S., Wood, P. L., Gillin, J. C., Yang, H. Y., and Costa, E. 1980. Changes of hippocampal metenkephalin content after recurrent motor seizures. Nature 285(5762):231-232.
36. Lason, W., Przewlocka, B., Stala, L., and Przewlocki, R. 1983. Changes in hippocampal immunoreactive dynorphin and neoendorphin content following intra-amygdalar kainic acid-induced seizures. Neuropeptides 3(5):399-104.
37. White, J. D. and Gall, C. M. 1986. Increased enkephalin gene expression in the hippocampus following seizures. NIDA Res. Monogr. 75:393-396.
38. Pitkanen, A., Beal, M. F., Sirvio, J., Swartz, K. J., Mannisto, P.T., and Riekkinen, P. J. 1989. Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrazol-kindled rats. Neuropeptides 14(3):197-207.
39. Gall, C., Lauterborn, J., Isackson, P., and White, J. 1990. Seizures, neuropeptide regulation, and mRNA expression in the hippocampus. Prog. Brain Res. 83:371-390.
40. McGinty, J. F., Kanamatsu, T., Obie, J., and Hong, J. S. 1986. Modulation of opioid peptide metabolism by seizures: differentiation of opioid subclasses. NIDA Res. Monogr. 71:89-101.
41. Morgan, J. I., Cohen, D. R., Hempstead, J. L., and Curran, T. 1987. Mapping patterns of c-fos expression in the central nervous system after seizure. Science 237(4811):192-197.
42. Sonnenberg, J. L., Macgregor-Leon, P. F., Curran, T., and Morgan, J. I. 1989. Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure. Neuron 3:359-365.
43. Dragunow, M., Yamada, N., Bilkey, D. K., and Lawlor, P. 1992. Induction of immediate-early gene proteins in dentate granule cells and somatostatin interneurons after hippocampal seizures. Mol. Brain Res. 13(1-2):119-126.
44. Gass, P., Herdegen, T., Bravo, R., and Kiessling, M. 1992. Induction of immediate early gene encoded proteins in the rat hippocampus after bicuculline-induced seizures: differential expression of KROX-24, Fos and Jun proteins. Neuroscience 48(2):315-324.
45. Elliott, R. C. and Gall, C. M. 2000. Changes in activating protein 1 (AP-1) composition correspond with the biphasic profile of nerve growth factor mRNA expression in rat hippocampus after hilus lesion-induced seizures. J. Neurosci. 20(6):2142-2149.
46. Sonnenberg, J. L., Rauscher III, F. J., Morgan, J. I., and Curran, T. 1989. Regulation of proenkephalin by Fos and Jun. Science. 246:1622-1625.
47. Gonzalez-Martin, C., de Diego, I., Crespo, D., and Fairen, A. 1992. Transient c-fos expression accompanies naturally occurring cell death in the developing interhemispheric cortex of the rat. Brain Res. Dev. Brain Res. 68(1):83-95.
48. Smeyne, R. J., Vendrell, M., Hayward, M., Baker, S. T., Miao, G. G., Schilling, K., Robertson, L. M., Curran, T., and Morgan, J. I. 1993. Continuous c-fos expression precedes programmed cell death in vivo. Nature 363(6425):166-169.
49. Kasof, G. M., Mandelzys, A., Maika, S. D., Hammer, R. E., Curran, T., and Morgan, J. I. 1995. Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats. J. Neurosci. 15(6):4238-1249.
50. Kaczmarek, L. 1992. Expression of c-fos and other genes encoding transcription factors in long-term potentiation. Behav. Neural Biol. 57(3):263-266.
51. Nikolaev, E., Kaminska, B., Tischmeyer, W., Matthies, H., and Kaczmarek, L. 1992. Induction of expression of genes encoding transcription factors in the rat brain elicited by behavioral training. Brain Res. Bull. 28:479-184.
52. Abraham, W. C., Mason, S. E., Demmer, J., Williams, J. M., Richardson, C. L., Tate, W. P., Lawlor, P. A., and Dragunow, M. 1993. Correlations between immediate early gene induction and the persistence of long-term potentiation. Neuroscience 56(3): 717-727.
53. Dragunow, M. 1996. A role for immediate-early transcription factors in learning and memory. Behav. Genet. 26(3):293-299.
54. Gall, C. M. and Isackson, P. J. 1989. Limbic seizures increase neuronal production of messenger RNA for nerve growth factor. Science 245:758-761.
55. Lauterborn, J. C., Isackson, P. J., and Gall, C. M. 1994. Seizure-induced increases in NGF mRNA exhibit different time courses across forebrain regions and are biphasic in hippocampus. Exp. Neurol. 125:22-40.
56. Isackson, P. J., Huntsman, M. M., Murray, K. D., and Gall, C. M. 1991. BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction different from NGF. Neuron 6:937-948.
57. Dugich-Djordjevic, M. M., Tocco, G., Lapchak, P. A., Pasinetti, G. M., Najm, I., Baudry, M., and Hefti, F. 1992. Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid. Neuroscience 47(2):303-315.
58. Humpel, C., Wetmore, C., and Olson, L. 1993. Regulation of brain-derived neurotrophic factor messenger RNA and protein at the cellular level in pentylenetetrazol-induced epileptic seizures. Neuroscience 53(4):909-918.
59. Gall, C., Lauterborn, J., Bundman, M., Murray, K., and Isackson, P. 1991. Seizures and the regulation of neurotrophic factor and neuropeptide gene expression in brain. Epilepsy Res. Suppl. 4:225-245.
60. Rocamora, N., Palacios, J. M., and Mengod, G. 1992. Limbic seizures induce a differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor and neurotrophin- 3, in the rat hippocampus. Brain Res. Mol. Brain Res. 13(1-2):27-33.
61. Merlio, J., Ernfors, P., Kokaia, Z., Middlemas, D., Bengzon, J., Kokaia, M., Smith, M., Siesjo, B., Hunter, T., Lindvall, O., and Persson, H. 1993. Increased production of the TrkB protein tyrosine kinase receptor after brain insults. Neuron 10(2):151-164.
62. Binder, D. K., Routbort, M. J., and McNamara, J. O. 1999. Immunohistochemical evidence of seizure-induced activation of trk receptors in the mossy fiber pathway of adult rat hippocampus. J. Neurosci. 19(11):4616-4626.
63. Roux, P. P., Colicos, M. A., Barker, P. A., and Kennedy, T. E. 1999. p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure. J. Neurosci. 19(16):6887-6896.
64. Kokaia, Z., Bengzon, J., Metsis, M., Kokaia, M., Persson, H., and Lindvall, O. 1993. Coexpression of neurotrophins and their receptors in neurons of the central nervous system. Proc. Natl. Acad. Sci. USA 90(14):6711-6715.
65. Kokaia, M., Ernfors, P., Kokaia, Z., Elmer, E., Jaenisch, R., and Lindvall, O. 1995. Suppressed epileptogenesis in BDNF mutant mice. Exp. Neurol. 133(2):215-224.
66. Larmet, Y., Reibel, S., Carnahan, J., Nawa, H., Marescaux, C., and Depaulis, A. 1995. Protective effects of brain-derived neurotrophic factor on the development of hippocampal kindling in the rat. Neuroreport 6(14):1937-1941.
67. Croll, S. D., Suri, C., Compton, D. L., Simmons, M. V., Yancopoulos, G. D., Lindsay, R. M., Wiegand, S. J., Rudge, J. S., and Scharfman, H. E. 1999. Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience 93(4):1491-1506.
68. Kang, H. and Schuman, E. 1995. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 267(5204):1658-1662.
69. Levine, E., Dreyfus, C., Black, I., and Plummer, M. 1995. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Proc. Natl. Acad. Sci. USA 92(17):8074-8077.
70. Qian, Z., Gilbert, M. E., Colicos, M. A., Kandel, E. R., and Kuhl, D. 1993. Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation. Nature 361(6411):453-457.
71. Yamagata, K., Andreasson, K. I., Kaufmann, W. E., Barnes, C. A., and Worley, P. F. 1993. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11(2):371-86.
72. Yamagata, K., Sanders, L. K., Kaufmann, W. E., Yee, W., Barnes, C. A., Nathans, D., and Worley, P. F. 1994. rheb, a growth factor-and synaptic activity-regulated gene, encodes a novel Ras-related protein. J. Biol. Chem. 269(23):16333-16339.
73. Lyford, G. L., Yamagata, K., Kaufmann, W. E., Barnes, C. A., Sanders, L. K., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Lanahan, A. A., and Worley, P. F. 1995. Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron 14(2): 433-445.
74. Nedivi, E., Hevroni, D., Naot, D., Israeli, D., and Citri, Y. 1993. Numerous candidate plasticity-related genes revealed by differential cDNA cloning. Nature 363:718-721.
75. Naeve, G. S., Ramakrishnan, M., Kramer, R., Hevroni, D., Citri, Y., and Theill, L. E. 1997. Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis. Proc. Natl. Acad. Sci. USA 94(6):2648-2653.
76. Hevroni, D., Rattner, A., Bundman, M., Lederfein, D., Gabarah, A., Mangelus, M., Silverman, M. A., Kedar, H., Naor, C., Kornuc, M., Hanoch, T., Seger, R., Theill, L. E., Nedivi, E., Richter-Levin, G., and Citri, Y. 1998. Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms. J. Mol. Neurosci. 10(2):75-98.
77. Adams, M. D., Kelley, J. M., Gocayne, J. D., Dubnick, M., Polymeropoulos, M. H., Xiao, H., Merril, C. R., Wu, A., Olde, B., Moreno, R. F., and et al. 1991. Complementary DNA sequencing: expressed sequence tags and human genome project. Science 252(5013):1651-1656.
78. Adams, M. D., Dubnick, M., Kerlavage, A. R., Moreno, R., Kelley, J. M., Utterback, T. R., Nagle, J. W., Fields, C., and Venter. J. C. 1992. Sequence identification of 2,375 human brain genes. Nature 355(6361):632-634.
79. Sutcliffe, J. G. 2001. Open-system approaches to gene expression in the CNS. J. Neurosci. 21(21):8306-8309.
80. Velculescu, V. E., Zhang, L., Vogelstein, B., and Kinzler, K. W. 1995. Serial analysis of gene expression. Science 270(5235): 484-487.
81. Hendriksen, H., Datson, N. A., Ghijsen, W. E., van Vliet, E. A., da Silva, F. H., Gorter, J. A., and Vreugdenhil, E. 2001. Altered hippocampal gene expression prior to the onset of spontaneous seizures in the rat post-status epilepticus model. Eur. J. Neurosci. 14(9): 1475-1484.
82. 1999. The Chipping Forecast. Nat. Genet. 21(Suppl.):1-60.
83. Sandberg, R., Yasuda, R., Pankratz, D. G., Carter, T. A., Del Rio, J. A., Wodicka, L., Mayford, M., Lockhart, D. J., and Barlow, C. 2000. Regional and strain-specific gene expression mapping in the adult mouse brain. Proc. Natl. Acad. Sci. USA 97(20):11038-11043.
84. Zirlinger, M., Kreiman, G., and Anderson, D. J. 2001. Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei. Proc. Natl. Acad. Sci. USA 98(9):5270-5275.
85. Zhao, X., Lein, E. S., He, A., Smith, S. C., Aston, C., and Gage, F. H. 2001. Transcriptional profiling reveals strict boundaries between hippocampal subrogions. J. Comp. Neurol. 441(3):187-196.
86. Lee, C. K., Klopp, R. G., Weindruch, R., and Prolla, T. A. 1999. Gene expression profile of aging and its retardation by caloric restriction. Science 285(5432):1390-1393.
87. Rampon, C., Jiang, C. H., Dong, H., Tang, Y. P., Lockhart, D. J., Schultz, P. G., Tsien, J. Z., and Hu, Y. 2000. Effects of environmental enrichment on gene expression in the brain. Proc. Natl. Acad. Sci. USA 97(23):12880-12884.
88. Mody, M., Cao, Y., Cui, Z., Tay, K. Y., Shyong, A., Shimizu, E., Pham, K., Schultz, P., Welsh, D., and Tsien, .T. Z. 2001. Genome-wide gene expression profiles of the developing mouse hippocampus. Proc. Natl. Acad. Sci. USA 98(15):8862-8867.
89. Elliott, R. C., Miles, M. F., and Lowenstein, D. H. 2003. Overlapping microarray profiles of dentate gyrus gene expression during development- and epilepsy-associated neurogenesis and axon outgrowth. J. Neurosci. 23(6):2218-2227.
90. Serafini, T. 1999. Of neurons and gene chips. Curr. Opin. Neurobiol. 9(5):641-644.
91. Cao, Y. and Dulac, C. 2001. Profiling brain transcription: neurons learn a lesson from yeast. Curr. Opin. Neurobiol. 11(5): 615-620.
92. Lockhart, D. J. and Barlow, C. 2001. Expressing what's on your mind: DNA arrays and the brain. Nat. Rev. Neurosci. 2(1):63-68.
93. Amaral, D. G. 1978. A Golgi study of cell types in the hilar region of the hippocampus in the rat. J. Comp. Neurol. 182(4 Pt 2): 851-914.
94. Freund, T. F. and Buzsaki, G. 1996. Interneurons of the hippocampus. Hippocampus 6(4):347-170.
95. Luo, L., Salunga, R. C., Guo, H., Burner, A., Joy, K. C., Galindo, J. E., Xiao, H., Rogers, K. E., Wan, J. S., Jackson, M. R., and Erlander, M. G. 1999. Gene expression profiles of laser-captured adjacent neuronal subtypes. Nat. Med. 5(1):117-122.
96. Brady, G. 2000. Expression profiling of single mammalian cells-small is beautiful. Yeast. 17(3):211-217.
97. Eberwine, J., Kacharmina, J. E., Andrews, C., Miyashiro, K., McIntosh, T., Becker, K., Barrett, T., Hinkle, D., Dent, G., and Marciano, P. 2001. mRNA expression analysis of tissue sections and single cells. J. Neurosci. 21(21):8310-8314.