Role of IL-10 in invasive aspergillosis: Increased resistance of IL-10 gene knockout mice to lethal systemic aspergillosis

Clinical and Experimental Immunology

Volumn 122, Issue 2, 2000, Pages 186-191

  Clemons, K V ^a,b,f   Grunig, G ^a,b,c,d   Sobel, R A ^a,b,e   Mirels, L F ^a,b   Rennick, D M ^a,b,c   Stevens, D A ^a,b  

^a CALIFORNIA INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e STANFORD UNIVERSITY   (United States)

^f SANTA CLARA VALLEY MEDICAL CENTER   (United States)

Author keywords

Aspergillosis; Cytokines; Host resistance; IL 10

Indexed keywords

GENE PRODUCT; INTERLEUKIN 10;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; BODY BURDEN; BRAIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HOST SUSCEPTIBILITY; IMMUNE RESPONSE; KIDNEY; MACROPHAGE; MOUSE; MYCOSIS; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; STRAIN DIFFERENCE; SYSTEMIC DISEASE; TH2 CELL; TISSUE INJURY;

ANIMALS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; BRAIN; COLONY COUNT, MICROBIAL; FEMALE; INTERLEUKIN-10; KIDNEY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; TH1 CELLS; TH2 CELLS; TIME FACTORS;

EID: 0033732650     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2000.01382.x     Document Type: Article

References (38)

1. Interleukin-10 and its receptor
2. Interleukin-10
3. Immunosuppressive and anti-inflammatory properties of interleukin-10
4. Interleukin-10. Actions and therapeutic potential
5. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice
6. Importance of interleukin-10 in genetic susceptibility of mice to Coccidioides immitis
7. Regulatory role of exogenous IL-10 in the development of immune response versus Cryptococcus neoformans
8. Interleukin-4 and -10 exacerbate candidiasis in mice
9. Neutralization of IL-10 up-regulates nitric oxide production and protects susceptible mice from challenge with Candida albicans
10. Purified capsular polysaccharide of Cryptococcus neoformans induces interleukin-10 secretion by human monocytes
11. IL-10 exerts suppressive and enhancing effects on antifungal activity of mononuclear phagocytes against Aspergillus fumigatus
12. Cytokine- and T helper-dependent lung mucosal immunity in mice with invasive pulmonary aspergillosis
13. Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis
14. Aspergillus fumigatus conidia induce a Th1-type cytokine response
15. Efficacy of oral saperconazole in systemic murine aspergillosis
16. Studies with IL-10(-/-) mice: An overview
17. Interleukin-10 gene knock-out mice: A model of chronic inflammation
18. Acquired immunity in experimental murine aspergillosis is mediated by macrophages
19. Comparison of the antimicrobial activity of deactivated human macrophages challenged with Aspergillus fumigatus and Listeria monocytogenes
20. Interferon-gamma and tumor necrosis factor-alpha protect mice from invasive aspergillosis
21. Th1 and Th2 cytokines in mice with invasive aspergillosis
22. Experimental models in antifungal chemotherapy
23. Maturity as a critical determinant of resistance to fungal infections: Studies in murine blastomycosis
24. Paracoccidioidomycosis: An update
25. Blockade of endogenous TNF-alpha exacerbates primary and secondary pulmonary histoplasmosis by differential mechanisms
26. Interleukin-4 and interleukin-10 inhibit nitric oxide-dependent macrophage killing of Candida albicans
27. Effects of interleukin-10 on human peripheral blood mononuclear cell responses to Cryptococcus neoformans, Candida albicans, and lipopolysaccharide
28. Epidemiology of invasive aspergillosis in European cancer centres. EORTC Invasive Fungal Infections Cooperative Group
29. Aspergillus wound infection following laparostomy
30. Antifungal and surgical treatment of invasive aspergillosis: Review of 2,121 published cases
31. Invasive aspergillosis in patients with AIDS
32. Cure of chronic invasive sinus aspergillosis with oral saperconazole
33. Cyclosporine and itraconazole interaction in heart and lung transplant recipients
34. Brain abscess following marrow transplantation: Experience at the Fred Hutchinson Cancer Research Center, 1984-92
35. 10 Year review of invasive aspergillosis detected at necropsy
36. AIDS-related visceral aspergillosis: An under diagnosed disease during life?
37. The neuropathology of organ transplantation: Comparison and contrast in 500 patients
38. Therapeutic outcome in invasive aspergillosis