Evaluation of fluorine-18-labeled alkylating agents as potential synthons for the labeling of oligonucleotides

Applied Radiation and Isotopes

Volumn 58, Issue 4, 2003, Pages 469-476

  De Vries, Erik F J ^a   Vroegh, Joke ^a   Elsinga, Philip H ^a   Vaalburg, Willem ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Fluorine 18; Labeling; Nucleoside; Oligonucleotide; Positron emission tomography

Indexed keywords

AGENTS; ALKYLATION; MONOMERS; OLIGOMERS;

SYNTHONS;

NUCLEIC ACIDS;

5' O THIOMONOPHOSPHATE; ADENOSINE 5' O (2 FLUOROETHYL)THIOPHOSPHATE F 18; ADENOSINE 5' O (3 FLUORO 2 HYDROXYPROPYL)THIOPHOSPHATE F 18; ADENOSINE 5' O (4 FLUOROPHENACYL)THIOPHOSPHATE F 18; ADENOSINE 5' O [3 (FLUOROMETHYL)BENZYL]THIOPHOSPHATE F 18; ADENOSINE 5' O [4 (FLUOROMETHYL)BENZYL]THIOPHOSPHATE F 18; ADENOSINE 5' O [N (4 FLUOROBENZYL)ACETAMIDE]THIOPHOSPHATE F 18; ALKYLATING AGENT; ANTISENSE OLIGONUCLEOTIDE; MONOMER; PHOSPHATE; PHOSPHOROTHIOIC ACID DERIVATIVE; TRACER; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; COST; DRUG SCREENING; DRUG SYNTHESIS; ISOTOPE LABELING; MODEL; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOCHEMISTRY;

EID: 0037379993     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8043(03)00022-8     Document Type: Article

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