Alpha-1 adrenoceptor agonists generate a "fast" NMDA receptor-independent motor rhythm in the neonatal rat spinal cord

Journal of Neurophysiology

Volumn 92, Issue 2, 2004, Pages 997-1010

  Gabbay, H ^a   Lev Tov, A ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; METHOXAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PRAZOSIN; YOHIMBINE;

ALPHA ADRENERGIC STIMULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARTICLE; BACK; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FAST MOTOR RHYTHM; LOCOMOTION; LUMBAR SPINE; MAMMAL; MOTONEURON; MOTOR ACTIVITY; NERVE EXCITABILITY; NERVE TRANSECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RHYTHM; SLOW MOTOR RHYTHM; SPINAL CORD STIMULATION;

2-AMINO-5-PHOSPHONOVALERATE; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ELECTRIC IMPEDANCE; ELECTRIC STIMULATION; EXCITATORY AMINO ACID ANTAGONISTS; LUMBOSACRAL REGION; METHOXAMINE; MOTOR ACTIVITY; MOTOR NEURONS; NOREPINEPHRINE; PERIODICITY; PRAZOSIN; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, N-METHYL-D-ASPARTATE; SACROCOCCYGEAL REGION; SPINAL CORD; YOHIMBINE;

EID: 3142683684     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00205.2004     Document Type: Article

References (52)

1. Barbeau H and Rossignol S. Initiation and modulation of the locomotor pattern in the adult chronic spinal cat by noradrenergic, serotonergic and dopaminergic drugs. Brain Res 546: 250-260, 1991.
2. Bennett DJ, Gorassini M, Fouad K, Sanelli L, Han Y, and Cheng J. Spasticity in rats with sacral spinal cord injury. J Neurotrauma 16: 69-84, 1999.
3. Bonnot A, Whelan PJ, Mentis GZ, and O'Donovan MJ. Spatiotemporal pattern of motoneuron activation in the rostral lumbar and the sacral segments during locomotor-like activity in the neonatal mouse spinal cord. J Neurosci 22: 1-6, 2002a.
4. Bonnot A, Whelan PJ, Mentis GZ, and O'Donovan MJ. Locomotor-like activity generated by the neonatal mouse spinal cord. Brain Res Brain Res Rev 40: 141-151, 2002b.
5. Cazalets JR and Bertrand S. Coupling between lumbar and sacral motor networks in the neonatal rat spinal cord. Eur J Neurosci 12: 2993-3002, 2000.
6. Chau C, Barbeau H, and Rossignol S. Effects of intrathecal α1-and α2-noradrenergic agonists and noradrenaline on locomotion in chronic spinal cats. J Neurophysiol 79: 2941-2963, 1998.
7. Clark FM and Proudfit HK. The projection of locus coeruleus neurons to the spinal cord in the rat determined by anterograde tracing combined with immunocytochemistry. Brain Res 538: 231-245, 1991a.
8. Clark FM and Proudfit HK. The projection of noradrenergic neurons in the A7 catecholamine cell group to the spinal cord in the rat demonstrated by anterograde tracing combined with immunocytochemistry. Brain Res 547: 279-288, 1991b.
9. Cook WM, Timm RM, and Hyman DE. Swimming ability in three Costa Rican dry forest rodents Rev Biol Trop 49: 1177-1181, 2001.
10. Delvolvé I, Gabbay H, and Lev-Tov A. The motor output and behavior produced by rhythmogenic sacrocaudal networks in spinal cords of neonatal rats. J Neurophysiol 85: 2100-2110, 2001.
11. Eide AL, Glover J, Kjaerulff O, and Kiehn O. Characterization of commissural interneurons in the lumbar region of the neonatal rat spinal cord. J Comp Neurol 403: 332-345, 1999.
12. Forssberg H and Grillner S. The locomotion of the acute spinal cat injected with clonidine iv. Brain Res 50: 184-186, 1973.
13. Fuxe K, Tinner B, Bjelke B, Agnati LF, Verhofstad A, Steinbusch HGW, Goldstein M, and Kalia M. Monoaminergic and peptidergic innervation of the intermedio-lateral horn of the spinal cord. 1. Distribution patterns of nerve terminal networks. Eur J Neurosci 2: 430-450, 1990.
14. Gabbay H, Delvolvé I, and Lev-Tov A. Pattern generation in caudal-lumbar and sacrococcygeal segments of the neonatal rat spinal cord. J Neurophysiol 88: 732-739, 2002.
15. Grillner S and Zangger P. On the central generation of locomotion in the low spinal cat. Exp Brain Res 34: 241-261, 1979.
16. Grzanna R and Fritschy J-M. Efferent projections of different subpopulations of central noradrenaline neurons. Prog Brain Res 88: 89-101, 1991.
17. Hochman S and Schmidt BJ. Whole cell recordings of lumbar motoneurons during locomotor-like activity in the in vitro neonatal rat spinal cord. J Neurophysiol 79: 743-752, 1998.
18. Hounsgaard J and Kiehn O. Serotonin-induced bistability of turtle motoneurons caused by a nifedipine-sensitive calcium plateau potential. J Physiol 414: 265-282, 1989.
19. Hounsgaard J and Kiehn O. Calcium spikes and calcium plateaux evoked by differential polarization in dendrites of turtle motoneurons in vitro. J Physiol 468: 245-259, 1993.
20. Hultborn H, Conway BA, Gossard JP, Brownstone R, Fedirchuk B, Schomburg ED, Enriquez-Denton M, and Perreault MC. How do we approach the locomotor network in the mammalian spinal cord? Ann NY Acad Sci 860: 70-82, 1998.
21. Jankowska E, Jukes MG, Lund S, and Lundberg A. The effect of DOPA on the spinal cord. VI. Half-center organization of interneurons transmitting effects from the flexor reflex afferents. Acta Physiol. Scand 70: 389-402, 1967.
22. Jiang Z, Carlin KP, and Brownstone RM. An in vitro functionally mature mouse spinal cord preparation for the study of spinal motor networks. Brain Res 816: 493-499, 1999a.
23. Jiang Z, Rempel J, Li J, Sawchuk MA, Carlin KP, and Brownstone RM. Development of L-type calcium channels and a nifedipine-sensitive motor activity in the postnatal mouse spinal cord. Eur J Neurosci 11: 3481-3487, 1999b.
24. Kiehn O, Hultborn H, and Conway BA. Spinal locomotor activity in acutely spinalized cats induced by intrathecal application of noradrenaline. Neurosci Lett 143: 243-246, 1992.
25. Kiehn O, Johnson BR, and Raastad M. Plateau properties in mammalian spinal interneurons during transmitter-induced locomotor activity. Neuroscience. 75: 263-73, 1996.
26. Kiehn O and Kjaerulff O. Spatiotemporal characteristics of 5-HT and dopamine-induced rhythmic hindlimb activity in the in vitro neonatal rat. J Neurophysiol 75: 1472-1482, 1996.
27. Kiehn O, Sillar KT, Kjaerulff O, and McDearmid JR. Effects of noradrenaline on locomotor rhythm-generating networks in the isolated neonatal rat spinal cord. J Neurophysiol 82: 741-6, 1999.
28. Kjaerulff O and Kiehn O. Crossed rhythmic synaptic input to motoneurons during selective activation of the contralateral spinal locomotor network. J Neurosci 17: 9433-9447, 1997.
29. Kremer E and Lev-Tov A. Localization of the spinal network associated with generation of hindlimb locomotion in the neonatal rat and organization of its transverse coupling system. J Neurophysiol 77: 1155-1170, 1997.
30. Lee RH and Heckman CJ. Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic a1 agonist methoxamine. J Neurophysiol 81: 2164-2174, 1999.
31. Lev-Tov A and Delvolvé I. Pattern generation in non-limb moving segments of the mammalian spinal cord. Brain Res Bull 53: 671-675, 2000.
32. Lev-Tov A, Delvolvé I, and Kremer E. Sacrocaudal afferents induce rhythmic efferent bursting in isolated spinal cords of neonatal rats. J Neurophysiol 83: 888-894, 2000.
33. Martin WJ, Gupta NK, Loo CM, Rohde DS, and Basbaum AI. Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing. Pain 80: 57-65, 1999.
34. Morin D, Bonnot A, Ballion B, and Viala D. Alpha1-adrenergic receptor-induced slow rhythmicity in nonrespiratory cervical motoneurons of neonatal rat spinal cord. Eur J Neurosci 12: 2950-2966, 2000.
35. Parkis MA, Bayliss DA, and Berger AJ. Actions of norepinephrine on rat hypoglossal motoneurons. J Neurophysiol 74: 1911-1919, 1995.
36. 2+ channels. Brain Res Brain Res Rev 40: 223-229, 2002.
37. Rajaofetra N, Poulat P, Marlier L, Geffard M, and Privat A. Pre- and postnatal development of noradrenergic projections to the rat spinal cord: an immunocytochemical study. Brain Res Dev Brain Res 67: 237-246, 1992.
38. Rossignol S, Chau C, Brustein E, Giroux N, Bouyer L, Barbeau H, and Reader TA. Pharmacological activation and modulation of the central pattern generator for locomotion in the cat. Ann NY Acad Sci 860: 346-59, 1998.
39. Russo RE and Hounsgaard J. Plateau-generating neurons in the dorsal horn in an in vitro preparation of the turtle spinal cord. J Physiol 493: 39-54, 1996.
40. Smith JC, Feldman JL, and Schmidt BJ. Neural mechanisms generating locomotion studied in mammalian brain stem-spinal cord in vitro. FASEB J. 2: 2283-2288, 1988.
41. Sqalli Houssaini Y and Cazalets JR. Noradrenergic control of locomotor networks in the in vitro spinal cord of the neonatal rat. Brain Res 852: 100-109, 2000.
42. Stokke MF, Nissen UV, Glover JC, and Kiehn O. Projection patterns of commissural interneurons in the lumbar spinal cord of the neonatal rat. J Comp Neurol 446: 349-359, 2002.
43. Strauss I, and Lev-Tov A. Neural pathways between sacrocaudal afferents and lumbar pattern generators in neonatal rats. J Neurophysiol 89: 773-784, 2003.
44. Tanaka H, Takahashi S, Miyamoto A, Oki J, Cho K, and Okuno A. Developmental changes in the noradrenergic innervations of spinal motoneurons in neonatal rats. Pediatr Neurol 14: 21-7, 1996.
45. Tresch MC and Kiehn O. Coding of locomotor phase in populations of neurons in rostral and caudal segments of the neonatal rat lumbar spinal cord. J Neurophysiol 82: 3563-3574, 1999.
46. Viala D and Buser P. The effects of Dopa and 5HTP on rhythmic efferent discharges in hindlimb nerves in the rabbit. Brain Res 12: 437-443, 1969.
47. Wada N and Shikaki N. Neuronal pathways for spinal reflexes activated by group I and group II muscle afferents in the spinal segment (Col) innervating the tail in the low spinalized cat. Exp Brain Res 125: 129-138, 1999.
48. Walker C, Vierck CJJ, and Ritz LA. Balance in the cat: role of the tail and effects of sacrocaudal transection. Behav Brain Res 91: 41-47, 1998.
49. Westlund KN, Bowker RM, Ziegler MG, and Coulter JD. Descending noradrenergic projections and their spinal terminations. Prog Brain Res 57: 219-238, 1982.
50. Whelan P, Bonnot A, and O'Donovan MJ. Properties of rhythmic activity generated by the isolated spinal cord of the neonatal mouse. J Neurophysiol 84: 2821-33, 2000.
51. White SR, Fung SJ, and Barnes CD. Norepinephrine effects on spinal motoneurons. Prog Brain Res 88: 343-350, 1991.
52. Zar JH. Biostatistical Analysis. Englewood Cliffs, NJ: Prentice-Hall, 1984.