Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate

Journal of Biological Chemistry

Volumn 279, Issue 28, 2004, Pages 29427-29435

  Guo, Qing ^a   Shen, Yuequan ^a   Zhukovskaya, Natalia L ^a   Florián, Jan ^b   Tang, Wei Jen ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CELLS; CONFORMATIONS; MUTAGENESIS; PATHOLOGY; SUBSTRATES;

CALMODULIN; MUTATIONAL ANALYSIS;

PROTEINS;

ADENYLATE CYCLASE; ADENYLATE CYCLASE TOXIN; ANTHRAX TOXIN; CALCIUM ION; CYCLIC AMP; EDEMA FACTOR; GUANOSINE TRIPHOSPHATE; PYROPHOSPHATE; UNCLASSIFIED DRUG; YTTERBIUM;

ANTHRAX; ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CYCLIZATION; ENZYME ACTIVE SITE; ENZYME INHIBITOR INTERACTION; INHIBITION KINETICS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY;

ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; CALCIUM; CALMODULIN; CYCLIC AMP; DIPHOSPHATES; GUANOSINE TRIPHOSPHATE; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PROTEIN CONFORMATION;

ANTHRAX; BACTERIA (MICROORGANISMS);

EID: 3142662017     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M402689200     Document Type: Article

References (40)

1. Linder, J. U., and Schultz, J. E. (2003) Cell. Signal. 15, 1081-1089
2. Sunahara, R. K., Dessauer, C. W., and Gilman, A. G. (1996) Annu. Rev. Pharmacol. Toxicol. 36, 461-480
3. Yahr, T. L., Vallis, A. J., Hancock, M. K., Barbieri, J. T., and Frank, D. W. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13899-13904
4. Ladant, D., and Ullmann, A. (1999) Trends Microbiol. 7, 172-176
5. Shen, Y., Lee, Y. S., Soelaiman, S., Bergson, P., Lu, D., Chen, A., Beckingham, K., Grabarek, Z., Mrksich, M., and Tang, W. J. (2002) EMBO J. 21, 6721-6732
6. Drum, C. L., Yan, S. Z., Bard, J., Shen, Y., Lu, D., Soelaiman, S., Grabarek, Z., Bohm, A., and Tang, W.-J. (2002) Nature 415, 396-402
7. Tesmer, J. J., Sunahara, R. K., Gilman, A. G., and Sprang, S. R. (1997) Science 278, 1907-1916
8. Mock, M., and Fouet, A. (2001) Annu. Rev. Microbiol. 55, 647-671
9. Mourez, M., Lacy, D. B., Cunningham, K., Legmann, R., Sellman, B. R., Mogridge, J., and Collier, R. J. (2002) Trends Microbiol. 10, 287-293
10. Elliott, J. L., Mogridge, J., and Collier, R. J. (2000) Biochemistry 39, 6706-6713
11. Drum, C. L., Yan, S. Z., Sarac, R., Mabuchi, Y., Beckingham, K., Bohm, A., Grabarek, Z., and Tang, W. J. (2000) J. Biol. Chem. 275, 36334-36340
12. Hoeflich, K. P., and Ikura, M. (2002) Cell 108, 739-742
13. Ulmer, T. S., Soelaiman, S., Li, S., Klee, C. B., Tang, W. J., and Bax, A. (2003) J. Biol. Chem. 278, 29261-29266
14. Dessauer, C. W., and Gilman, A. G. (1997) J. Biol. Chem. 272, 27787-27795
15. Tesmer, J. J., Sunahara, R. K., Johnson, R. A., Gosselin, G., Gilman, A. G., and Sprang, S. R. (1999) Science 285, 756-760
16. Shen, Y., Guo, Q., Zhukovskaya, N. L., Drum, C. L., Bohm, A., and Tang, W. J. (2004) Biochem. Biophys. Res. Commun. 317, 309-314
17. Munier, H., Bouhss, A., Krin, E., Danchin, A., Gilles, A. M., Glaser, P., and Barzu, O. (1992) J. Biol. Chem. 267, 9816-9820
18. Steitz, T. A., and Steitz, J. A. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 6498-6502
19. Ling, H., Boudsocq, F., Woodgate, R., and Yang, W. (2001) Cell 107, 91-102
20. Doublie, S., Tabor, S., Long, A. M., Richardson, C. C., and Ellenberger, T. (1998) Nature 391, 251-258
21. Huang, H., Chopra, R., Verdine, G. L., and Harrison, S. C. (1998) Science 282, 1669-1675
22. Franklin, M. C., Wang, J., and Steitz, T. A. (2001) Cell 105, 657-667
23. Sawaya, M. R., Prasad, R., Wilson, S. H., Kraut, J., and Pelletier, H. (1997) Biochemistry 36, 11205-11215
24. Pelletier, H., Sawaya, M. R., Kumar, A., Wilson, S. H., and Kraut, J. (1994) Science 264, 1891-1903
25. Drum, C. L., Shen, Y., Rice, P. A., Bohm, A., and Tang, W. J. (2001) Acta Crystallogr. Sect. D Biol. Crystallogr. 57, 1881-1884
26. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
27. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D Biol. Crystallogr. 54, 905-921
28. Farndale, R. W., Allan, L. M., and Martin, B. R. (1992) in Signal Transduction, a Practical Approach (Milligan, G., ed) pp. 75-103, Oxford Press, Oxford
29. Gerlt, J. A., Coderre, J. A., and Wolin, M. S. (1980) J. Biol. Chem. 255, 331-334
30. Eckstein, F., Romaniuk, P. J., Heideman, W., and Storm, D. R. (1981) J. Biol. Chem. 256, 9118-9120
31. Brautigam, C. A., Aschheim, K., and Steitz, T. A. (1999) Chem. Biol. 6, 901-908
32. Florián, J., Goodman, M. F., and Warshel, A. (2003) J. Am. Chem. Soc. 125, 8163-8177
33. Florián, J., and Warshel, A. (1998) J. Phys. Chem. B 102, 719-734
34. Tesmer, J. J., Dessauer, C. W., Sunahara, R. K., Murray, L. D., Johnson, R. A., Gilman, A. G., and Sprang, S. R. (2000) Biochemistry 39, 14464-14471
35. Dessauer, C. W., Tesmer, J. J., Sprang, S. R., and Gilman, A. G. (1999) Trends Pharmacol. Sci. 20, 205-210
36. Benkovic, S. J., and Hammes-Schiffer, S. (2003) Science 301, 1196-1202
37. Garcia-Viloca, M., Gao, J., Karplus, M., and Truhlar, D. G. (2004) Science 303, 186-195
38. Kraut, D. A., Carroll, K. S., and Herschlag, D. (2003) Annu. Rev. Biochem. 72, 517-571
39. Shen, Y., Zhukovskaya, N. L., Zimmer, M. I., Soelaiman, S., Bergson, P., Wang, C. R., Gibbs, C. S., and Tang, W. J. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 3242-3247
40. Soelaiman, S., Wei, B. Q., Bergson, P., Lee, Y. S., Shen, Y., Mrksich, M., Shoichet, B. K., and Tang, W. J. (2003) J. Biol. Chem. 278, 25990-25997