Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing

Journal of Biological Chemistry

Volumn 279, Issue 27, 2004, Pages 27841-27844

  Rossner, Steffen ^a,c   Fuchsbrunner, Katrin ^a   Lange Dohna, Christine ^a   Hartlage Rübsamen, Maike ^a   Bigl, Volker ^a   Betz, Andrea ^b   Reim, Kerstin ^b   Brose, Nils ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^c Paul Flechsig Inst for Brain Res   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; DISEASES; ESTERS; METABOLISM; PATIENT TREATMENT; PROTEINS;

AMYLOID PRECURSOR PROTEIN (APP); MESSENGER PATHWAYS;

BIOTECHNOLOGY;

2 [1 (3 DIMETHYLAMINOPROPYL) 5 METHOXY 1H INDOL 3 YL] 3 (1H INDOL 3 YL)MALEIMIDE; ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; DIACYLGLYCEROL; PHORBOL 13 ACETATE 12 MYRISTATE; PLASMID DNA; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; DEGENERATIVE DISEASE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; MEMBRANE VESICLE; MOUSE; MUNC13 1 GENE; MUTANT; NEUROBLASTOMA CELL; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; SENILE PLAQUE; TISSUE SPECIFICITY;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANIMALS, NEWBORN; ASPARTIC ENDOPEPTIDASES; BLOTTING, WESTERN; BRAIN; CELL LINE, TUMOR; CELL MOVEMENT; DIGLYCERIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; GENE DELETION; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; NERVE TISSUE PROTEINS; PEPTIDES; PHORBOL ESTERS; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; SYNAPSES; TETRADECANOYLPHORBOL ACETATE; TRANSFECTION;

ANIMALIA;

EID: 3142615475     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C400122200     Document Type: Article

References (22)

1. Golde, T. E., Estus, S., Younkin, L. H., Selkoe, D. J., and Younkin, S. G. (1992) Science 255, 728-730
2. Seubert, P., Oltersdorf, T., Lee, M. G., Barbour, R., Blomquist, C., Davis, D. L., Bryant, K., Fritz, L. C., Galasko, D., Thal, L. J., Lieberburg, I., and Schenk, D. B. (1993) Nature 361, 260-263
3. Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lile, J., Jarosinski, M. A., Biere, A. L., Curran, E., Burgess, T., Louis, J. C., Collins, F., Treanor, J., Rogers, G., and Citron, M. (1999) Science 286, 735-741
4. Haass, C., Koo, E. H., Mellon, A., Hung, A. Y., and Selkoe, D. J. (1992) Nature 357, 500-503
5. Weidemann, A., König, G., Bunke, D., Fischer, P., Salbaum, J. M., Masters, C., and Beyreuther, K. (1989) Cell 57, 115-126
6. Buxbaum, J. D., Gandy, S. E., Cicchetti, P., Ehrlich, M. E., Czernik, A. J., Fracasso, R. P., Ramabhadran, T. V., Unterbeck, A. J., and Greengard, P. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 6003-6006
7. Buxbaum, J. D., Koo, E. H., and Greengard, P. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 9195-9198
8. Caporaso, G. L., Gandy, S. E., Buxbaum, J. D., Ramabhadran, T. V., and Greengard, P. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 3055-3059
9. Slack, B. E., Nitsch, R. M., Livneh, E., Kunz, G. M., Eldar, H., and Wurtman, R. J. (1993) J. Biol. Chem. 268, 21097-21101
10. Skovronsky, D. M., Moore, D. B., Milla, M. E., Doms, R. W., and Lee, V. M. (2000) J. Biol. Chem. 275, 2568-2575
11. Betz, A., Ashrey, U., Rickmann, M., Augustin, I., Neher, E., Südhof, T. C., Rettig, J., and Brose, N. (1998) Neuron 21, 123-136
12. Brose, N., Hofmann, K., Hata, Y., and Südhof, T. C. (1995) J. Biol. Chem. 270, 25273-25280
13. Augustin, I., Rosenmund, C., Südhof, T. C., and Brose, N. (1999) Nature 400, 457-461
14. Augustin, I., Korte, S., Rickmann, M., Kretzschmar, H. A., Südhof, T. C., Herms, J. W., and Brose, N. (2001) J. Neurosci. 21, 10-17
15. Rhee, J. S., Betz, A., Pyott, S., Reim, K., Varoqueaux, F., Augustin, I., Hesse, D., Südhof, T. C., Takahashi, M., Rosenmund, C., and Brose, N. (2002) Cell 108, 121-133
16. Rossner, S., Beck, M. T. Stahl, T., Mendla, K., Schliebs, R., and Bigl, V. (2000) Eur. J. Neurosci. 12, 3191-3200
17. Brückner, G., and Grosche, J. (2001) Exp. Brain Res. 137, 83-93
18. Brose, N., and Rosenmund, C. (2002) J. Cell Sci. 115, 4399-4411
19. Xu, H., Greengard, P., and Gandy, S. (1995) J. Biol. Chem. 270, 23243-23245
20. Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., Jasionowski, M., Haass, C., and Fahrenholz, F. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3922-3927
21. Sheu, L., Pasyk, E. A., Ji, J., Huang, X., Gao, X., Varoqueaux, F., Brose, N., and Gaisano, H. Y. (2003) J. Biol. Chem. 278, 27556-27563
22. Betz, A., Thakur, P., Junge, H. J., Ashery, U., Rhee, J. S., Scheuss, V., Rosenmund, C., Rettig, J., and Brose, N. (2001) Neuron 30, 183-196