Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines

Journal of Medicinal Chemistry

Volumn 47, Issue 15, 2004, Pages 3823-3842

  Mewshaw, Richard E ^a   Zhou, Dahui ^a   Zhou, Ping ^a   Shi, Xiaojie ^a   Hornby, Geoffrey ^a   Spangler, Taylor ^a   Scerni, Rosemary ^a   Smith, Deborah ^a   Schechter, Lee E ^a   Andree, Terrance H ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 METHOXYPHENOXYETHYL)BENZYLCARBAMIC ACID TERT BUTYL ESTER; 2 (5 FLUORO 1H INDOL 3 YL)ETHANOL; 3 (5 FLUORO 1H INDOL 3 YL)ETHYLBROMIDE; 3 INDOLYLBUTYLAMINE; 3 INDOLYLBUTYRAMIDE; 3 INDOLYLPROPIONAMIDE; 3 INDOLYLPROPYLAMINE; 5 FLUOROINDOLYL 3 PROPYLAMINE; 5 FLUOROINDOLYL 3 PROPYLAZIDE; 5 FLUOROINDOLYL 3 PROPYLBROMIDE; [2 (2 METHOXYPHENOXY)ETHYL]BENZYLAMINE; [2 (6 FLUOROCHROMAN 8 YLOXY)ETHYL][2 (5 FLUORO 1H INDOL 3 YL)ETHYL]AMINE; [2 (6 FLUOROCHROMAN 8 YLOXY)ETHYL][3 (5 FLUORO 1H INDOL 3 YL)PROPYL]AMINE; [3 (1H INDOL 3 YL)PROPYL][2 (2 METHOXYPHENOXY)ETHYL]AMINE; [3 (1H INDOL 3 YL)PROPYL][2 (NAPHTHALEN 1 YLOXY)ETHYL]AMINE; [3 (5 FLUORO 1H INDOL 3 YL)PROPYL][2 (2 METHOXYPHENOXY)ETHYL]BENZYLAMINE; [3 (5 FLUORO 1H INDOL 3 YL)PROPYL][2 (5,6,7,8 TETRAHYDRONAPHTHALEN 1 YLOXY)ETHYL]AMINE; [4 (1H INDOL 3 YL)BUTYL][2 (2 METHOXYPHENOXY)ETHYL]AMINE; ALIPHATIC AMINE; ANTIDEPRESSANT AGENT; BENZYL [3 (1H INDOL 3YL)PROPYL][2 (2 METHOXYPHENOXY)ETHYL]AMINE; BENZYL [4 (1H INDOL 3 YL)BUTYL][2 (2 METHOXYPHENOXY)ETHYL]AMINE; HALOGEN; INDOLE; INDOLE DERIVATIVE; PIPERIDINE DERIVATIVE; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING ASSAY; COMPETITIVE INHIBITION; CONFORMATIONAL TRANSITION; DEPRESSION; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PHARMACOPHORE; PSYCHOPHARMACOLOGY; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TECHNIQUE;

AMINES; ANIMALS; ANTIDEPRESSIVE AGENTS; CARRIER PROTEINS; CELL LINE; CEREBRAL CORTEX; CRICETINAE; HUMANS; INDOLES; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; NERVE TISSUE PROTEINS; RATS; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, ADRENERGIC, ALPHA-1; SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3142579793     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0304010     Document Type: Article

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