Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 2

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 14, 2003, Pages 2393-2397

  Takeuchi, Kumiko ^a   Kohn, Todd J ^a   Honigschmidt, Nicholas A ^a   Rocco, Vincent P ^a   Spinazze, Patrick G ^a   Koch, Daniel J ^a   Atkinson, Steven T ^a   Hertel, Larry W ^a   Nelson, David L ^a   Wainscott, D Bradley ^a   Ahmad, Laura J ^a   Shaw, Janice ^a   Threlkeld, Penny G ^a   Wong, David T ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; NEW DRUG; PIPERIDINE DERIVATIVE; SEROTONIN 1A ANTAGONIST; SEROTONIN RECEPTOR; SEROTONIN UPTAKE INHIBITOR;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; IN VITRO STUDY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

EID: 12444276294     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00392-5     Document Type: Article

References (14)

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13. 1H NMR.
14. 1H NMR, COSY, ROESY or 1D TOCSY, and eHSQC experiments. Details of the stereoselective synthesis of each isomer will be reported elsewhere.