Inhibition of motile and invasive properties of ovarian cancer cells by ASODN against Rho-associated protein kinase

Cell Communication and Adhesion

Volumn 12, Issue 1-2, 2005, Pages 59-69

  Han, Zhiqiang ^a   Xu, Gang ^a   Zhou, Jianfeng ^a   Xing, Hui ^a   Wang, Shixuan ^a   Wu, Mingfu ^a   Zhang, Yongtao ^a   Lu, Yunping ^a   Ma, Ding ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Antisense oligodeoxynucleotide; Dominant active mutant; Invasion; Metastasis; Ovarian cancer; p160ROCK

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; PROTEIN P160; RHO KINASE;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; CELL ADHESION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; METASTASIS; METASTASIS INHIBITION; OVARY CANCER; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ACTINS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CYTOSKELETON; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUTATION; NEOPLASM INVASIVENESS; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; OVARIAN NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER;

EID: 31344471919     PISSN: 10615385     EISSN: 15435180     Source Type: Journal    
DOI: 10.1080/15419060500383168     Document Type: Article

References (37)

1. American Cancer Society, Inc.. (1998) Cancer Facts & Figures-1998. Atlanta: American Cancer Society, Inc.
2. Hart, I and Saini, A. (1992) Biology of tumour metastasis Lancet, 339, pp. 1453-1457. [PUBMED] [INFOTRIEVE] [CSA]
3. Aznar, S and Lacal, J. (2001) Searching new targets for anticancer drug design: The families of Ras and Rho GTPases and their effectors Prog Nucleic Acid Res Mol Biol, 67, pp. 193-234. [PUBMED] [INFOTRIEVE] [CSA]
4. Aznar, S and Lacal, J. (2001) Rho signals to cell growth and apoptosis Cancer Lett, 165, pp. 1-10. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
5. Bar-Sagi, D and Hall, A. (2000) Ras and Rho GTPases: A family reunion Cell, 103, pp. 227-238. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
6. Schmitz, A and Govek, E and Bottner, B and (2000) Rho GTPases: signaling, migration, and invasion Exp Cell Res, 261, pp. 1-12. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
7. Settleman, J. (2000) Getting in shape with Rho Nat Cell Biol, 2, pp. E7-E9. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
8. Sahai, E and Marshal, C. (2002) Rho-GTPases and cancer Nat Rev Cancer, 2, pp. 133-142. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
9. Kamai, T and Arai, K and Tsujii, T and (2001) Overexpression of RhoA mRNA is associated with advanced stage in testicular germ cell tumour BJU Int, 87, pp. 227-231. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
10. Fritz, G and Just, I and Kaina, B. (1999) Rho GTPases are over-expressed in human tumors Int J Cancer, 81, pp. 682-687. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
11. Suwa, H and Ohshio, G and Imamura, T and (1998) Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas Br J Cancer, 77, pp. 147-152. [PUBMED] [INFOTRIEVE] [CSA]
12. van Golen, K and Wu, Z and Qiao, X and (2000) RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype Cancer Res, 60, pp. 5832-5838. [PUBMED] [INFOTRIEVE] [CSA]
13. Ishizaki, T and Maekawa, M and Fujisawa, K and (1996) The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase EMBO J, 15, pp. 1885-1893. [PUBMED] [INFOTRIEVE] [CSA]
14. Matsui, T and Amano, M and Yamamoto, T and (1996) Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho EMBO J, 15, pp. 2208-2216. [PUBMED] [INFOTRIEVE] [CSA]
15. Ishizaki, T and Naito, M and Fujisawa, K and (1997) p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions FEBS Lett, 404, pp. 118-124. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
16. Nakagawa, Q and Fujisawa, K and Ishizaki, T and (1996) ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice FEBS Lett, 392, pp. 189-193. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
17. Riento, K and Ridley, A. (2003) Rocks: Multifunctional kinases in cell behaviour Nat Rev Mol Cell Biol, 4, pp. 446-456. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
18. Itoh, K and Yoshioka, K and Akedo, H and (1999) An essential part for Rho-associated kinase in the transcellular invasion of tumor cells Nat Med, 5, pp. 221-225. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
19. Suyama, E and Kawasaki, H and Kasaoka, T and (2003) Identification of genes responsible for cell migration by a library of randomized ribozymes Cancer Res, 63, pp. 119-124. [PUBMED] [INFOTRIEVE] [CSA]
20. Hall, A. (1998) Rho GTPases and the actin cytoskeleton Science, 279, pp. 509-514. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
21. Worthylake, R and Burridge, K. (2003) RhoA and ROCK promote migration by limiting membrane protrusions J Biol Chem, 278, pp. 13578-13584. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
22. Winter, C and Wang, B and Ballew, A and (2001) Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton Cell, 105, pp. 81-91. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
23. Dawe, H and Minamide, L and Bamburg, J and (2003) ADF/cofilin controls cell polarity during fibroblast migration Curr Biol, 13, pp. 252-257. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
24. Kamai, T and Arai, K and Sumi, S and (2002) The rho/rho-kinase pathway is involved in the progression of testicular germ cell tumour BJU Int, 89, pp. 449-453. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
25. Horiuchi, A and Imai, T and Wang, C and (2003) Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma Lab Invest, 83, pp. 861-870. [PUBMED] [INFOTRIEVE] [CSA]
26. Kamai, T and Yamanishi, T and Shirataki, H and (2004) Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer Clin Cancer Res, 10, pp. 4799-4805. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
27. Kamai, T and Tsujii, T and Arai, K and (2003) Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer Clin Cancer Res, 9, pp. 2632-2641. [PUBMED] [INFOTRIEVE] [CSA]
28. Lauffenburger, D and Horwitz, A. (1996) Cell migration: A physically integrated molecular process Cell, 84, pp. 359-369. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
29. Amano, M and Ito, M and Kimura, K and (1996) Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase) J Biol Chem, 271, pp. 20246-20249. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
30. Totsukawa, G and Yamakita, Y and Yamashiro, S and (2000) Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts J Cell Biol, 150, pp. 797-806. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
31. Sumi, T and Matsumoto, K and Nakamura, T. (2001) Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase J Biol Chem, 276, pp. 670-676. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
32. Ohashi, K and Nagata, K and Maekawa, M and (2000) Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop J Biol Chem, 275, pp. 3577-3582. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
33. Matsui, T and Maeda, M and Doi, Y and (1998) Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association J Cell Biol, 140, pp. 647-657. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
34. Fukata, Y and Oshiro, N and Kinoshita, N and (1999) Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility J Cell Biol, 145, pp. 347-361. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
35. Hall, A. (1994) Small GTP-binding proteins and the regulation of the actin cytoskeleton Annu. Rev. Cell Biol, 10, pp. 31-54. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
36. Hirose, M and Ishizaki, T and Watanabe, N and (1998) Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells J Cell Biol, 141, pp. 1625-1636. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
37. Van Aelst, L and D'Souza-Schorey, C. (1997) Rho GTPases and signaling networks Genes Dev, 11, pp. 2295-2322. [PUBMED] [INFOTRIEVE] [CSA]