The lipophilicity behavior of three catechol-O-methyltransferase (COMT) inhibitors and simple analogues

Helvetica Chimica Acta

Volumn 89, Issue 1, 2006, Pages 144-152

  Novaroli, Laura ^a   Doulakas, Geraldine Bouchard ^a   Reist, Marianne ^a   Rolando, Barbara ^b   Fruttero, Roberta ^b   Gasco, Alberto ^b   Carrupt, Pierre Alain ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITIVES; CHEMICAL COMPOUNDS; IONIZATION; PHARMACOKINETICS; PHYSICAL CHEMISTRY; SOLVENTS;

CATECHOL-O-METHYLTRANSFERASE (COMT); INHIBITORS ENTACAPONE; LIPOPHILICITY; NITECAPONE;

ENZYME KINETICS;

2 NITROPHENOL; 2,4 DINITROPHENOL; 2,5 DINITROPHENOL; 3 NITROPHENOL; 4 NITROCATECHOL; 4 NITROPHENOL; CATECHOL; CATECHOL METHYLTRANSFERASE INHIBITOR; ENTACAPONE; NITECAPONE; PHENOL; PHENOL DERIVATIVE; TOLCAPONE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; CYCLIC POTENTIOMETRY; DRUG PENETRATION; DRUG STRUCTURE; HYDROGEN BOND; IONIZATION; LIPOPHILICITY; MOLECULAR INTERACTION; PARKINSON DISEASE; PARTITION COEFFICIENT; PH; PHYSICAL CHEMISTRY; PKA; PRIORITY JOURNAL;

EID: 31344468545     PISSN: 0018019X     EISSN: None     Source Type: Journal    
DOI: 10.1002/hlca.200690007     Document Type: Article

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