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Volumn 42, Issue 1, 1997, Pages 1-25

Catechol-o-methyltransferase inhibitors: Clinical potential in the treatment of Parkinson's disease

Author keywords

Catechol O methyltransferase; Entacapone; Levodopa; Pharmacodynamics; Pharmacokinetics; Tolcapone

Indexed keywords

3 O METHYLDOPA; ANTIPARKINSON AGENT; CATECHOL METHYLTRANSFERASE; CATECHOL METHYLTRANSFERASE INHIBITOR; ENTACAPONE; LEVODOPA; TOLCAPONE;

EID: 0031415076     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(199709)42:1<1::AID-DDR1>3.0.CO;2-I     Document Type: Review
Times cited : (28)

References (159)
  • 1
    • 84912942590 scopus 로고
    • Prevention of cysteamine-induced duodenal ulcers in rats by COMT-inhibitor
    • Aho P, Lindén IB, Nissinen E, Pohto P (1988a): Prevention of cysteamine-induced duodenal ulcers in rats by COMT-inhibitor. Dig Dis Sci 33:905.
    • (1988) Dig Dis Sci , vol.33 , pp. 905
    • Aho, P.1    Lindén, I.B.2    Nissinen, E.3    Pohto, P.4
  • 2
    • 84912942590 scopus 로고
    • Gastric mucosal protection in the rat by OR-462, a novel COMT-inhibitor
    • Aho P, Lindén IB, Nissinen E, Pohto P (1988b): Gastric mucosal protection in the rat by OR-462, a novel COMT-inhibitor. Dig Dis Sci 33:897.
    • (1988) Dig Dis Sci , vol.33 , pp. 897
    • Aho, P.1    Lindén, I.B.2    Nissinen, E.3    Pohto, P.4
  • 3
    • 0028891614 scopus 로고
    • Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers
    • Ahtila S, Kaakkola S, Gordin A, Korpela K, Heinävaara S, Karlsson M, Wikberg T, Tuomainen P, Männistö PT (1995): Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers. Clin Neuropharmacol 18:46-57.
    • (1995) Clin Neuropharmacol , vol.18 , pp. 46-57
    • Ahtila, S.1    Kaakkola, S.2    Gordin, A.3    Korpela, K.4    Heinävaara, S.5    Karlsson, M.6    Wikberg, T.7    Tuomainen, P.8    Männistö, P.T.9
  • 4
    • 2642603678 scopus 로고
    • Effect of COMT inhibition by CGP 28014 (N-(6-hydroxy-2-pyridyl)-N'-di-N-propyl formamidine) on plasma dopa and 3OMD in humans
    • Japan (Abstract)
    • Antonin KH, Ensslin-Haasis B, Bieck PR, Dollenbacher U, Nilsson E (1991): Effect of COMT inhibition by CGP 28014 (N-(6-hydroxy-2-pyridyl)-N'-di-N-propyl formamidine) on plasma dopa and 3OMD in humans. V Clin Pharmacol Ther Yokohama, Japan (Abstract):405-408.
    • (1991) V Clin Pharmacol Ther Yokohama , pp. 405-408
    • Antonin, K.H.1    Ensslin-Haasis, B.2    Bieck, P.R.3    Dollenbacher, U.4    Nilsson, E.5
  • 7
    • 0025619387 scopus 로고
    • Effect of the new selective COMT inhibitor CGP 28014A on the formation of 3-O-methyldopa (3OMD) in plasma of healthy subjects
    • Bieck PR, Nilsson E, Antonin KH (1990): Effect of the new selective COMT inhibitor CGP 28014A on the formation of 3-O-methyldopa (3OMD) in plasma of healthy subjects. J Neural Transm Suppl 32:387-391.
    • (1990) J Neural Transm Suppl , vol.32 , pp. 387-391
    • Bieck, P.R.1    Nilsson, E.2    Antonin, K.H.3
  • 9
    • 0024377955 scopus 로고
    • Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: Synthesis and structure-activity studies
    • Borgulya J, Bruderer H, Bernauer K, Zürcher G, Da Prada M (1989): Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: Synthesis and structure-activity studies. Helv Chim Acta 72:952-968.
    • (1989) Helv Chim Acta , vol.72 , pp. 952-968
    • Borgulya, J.1    Bruderer, H.2    Bernauer, K.3    Zürcher, G.4    Da Prada, M.5
  • 10
    • 2642634220 scopus 로고    scopus 로고
    • Tolcapone, a new catechol-O-methyltransferase inhibitor for the improvement of levodopa therapy in Parkinson's disease
    • Borroni E, Zürcher G, Da Prada M (1996): Tolcapone, a new catechol-O-methyltransferase inhibitor for the improvement of levodopa therapy in Parkinson's disease. Acta Neurol Scand 94 (Suppl 167):7-8.
    • (1996) Acta Neurol Scand , vol.94 , Issue.167 SUPPL. , pp. 7-8
    • Borroni, E.1    Zürcher, G.2    Da Prada, M.3
  • 12
    • 0023404750 scopus 로고
    • Clinical pharmacokinetics of antiparkinsonian drugs
    • Cedarbaum JM (1987): Clinical pharmacokinetics of antiparkinsonian drugs. Clin Pharmacokinet 13:141-178.
    • (1987) Clin Pharmacokinet , vol.13 , pp. 141-178
    • Cedarbaum, J.M.1
  • 13
    • 0025672606 scopus 로고
    • Effect of nitecapone (OR-462) on the pharmacokinetics of levodopa and 3-O-methyldopa formation in cynomolgus monkeys
    • Cedarbaum JM, Léger G, Reches A, Guttman M (1990): Effect of nitecapone (OR-462) on the pharmacokinetics of levodopa and 3-O-methyldopa formation in cynomolgus monkeys. Clin Neuropharmacol 13:544-552.
    • (1990) Clin Neuropharmacol , vol.13 , pp. 544-552
    • Cedarbaum, J.M.1    Léger, G.2    Reches, A.3    Guttman, M.4
  • 14
    • 0025911879 scopus 로고
    • Reduction of circulating 3-O-methyldopa by inhibition of catechol-O-methyltransferase with OR-611 and OR-462 in cynomolgus monkeys: Implications for the treatment of Parkinson's disease
    • Cedarbaum JM, Leger G, Guttman M (1991): Reduction of circulating 3-O-methyldopa by inhibition of catechol-O-methyltransferase with OR-611 and OR-462 in cynomolgus monkeys: Implications for the treatment of Parkinson's disease. Clin Neuropharmacol 14:330-342.
    • (1991) Clin Neuropharmacol , vol.14 , pp. 330-342
    • Cedarbaum, J.M.1    Leger, G.2    Guttman, M.3
  • 15
    • 0021611785 scopus 로고
    • The pharmacology of Parkinson's disease: Basic aspects and recent advances
    • Da Prada M, Keller HH, Pieri L, Kettler R, Haefely W (1984). The pharmacology of Parkinson's disease: Basic aspects and recent advances. Experientia 40:1165-1172.
    • (1984) Experientia , vol.40 , pp. 1165-1172
    • Da Prada, M.1    Keller, H.H.2    Pieri, L.3    Kettler, R.4    Haefely, W.5
  • 16
    • 0028907751 scopus 로고
    • Improved therapy of Parkinson's disease with tolcapone, a central and peripheral COMT inhibitor with an S-adenosyl-L-methionine-sparing effect
    • Da Prada M, Borgulya J, Napolitano A, Zürcher G (1994a): Improved therapy of Parkinson's disease with tolcapone, a central and peripheral COMT inhibitor with an S-adenosyl-L-methionine-sparing effect. Clin Neuropharmacol 17 (Suppl. 3):S26-S37.
    • (1994) Clin Neuropharmacol , vol.17 , Issue.3 SUPPL.
    • Da Prada, M.1    Borgulya, J.2    Napolitano, A.3    Zürcher, G.4
  • 17
    • 2642592466 scopus 로고
    • Remodelling the kinetics and dynamics of levodopa therapy in Parkinson's disease by inhibiting MAO-B with lazabemide and COMT with tolcapone
    • Poewe W, Lees A (eds): Basel Editiones Roche
    • Da Prada M, Zürcher G, Kettler R, Dingemanse J, Jorga K, Dubuis R (1994b): Remodelling the kinetics and dynamics of levodopa therapy in Parkinson's disease by inhibiting MAO-B with lazabemide and COMT with tolcapone. In Poewe W, Lees A (eds): Antiparkinson Therapy: 20 Years of Madopar®. Basel Editiones Roche, pp 93-111.
    • (1994) Antiparkinson Therapy: 20 Years of Madopar® , pp. 93-111
    • Da Prada, M.1    Zürcher, G.2    Kettler, R.3    Dingemanse, J.4    Jorga, K.5    Dubuis, R.6
  • 18
    • 0008939066 scopus 로고
    • Tolcapone (To) inhibits both peripheral and central catechol-O-methyltransferase (COMT)
    • Da Prada M, Zürcher G, Napolitano A (1995): Tolcapone (To) inhibits both peripheral and central catechol-O-methyltransferase (COMT). Neurology 45 (Suppl. 4):A252-A253.
    • (1995) Neurology , vol.45 , Issue.4 SUPPL.
    • Da Prada, M.1    Zürcher, G.2    Napolitano, A.3
  • 19
    • 0029091101 scopus 로고
    • Acute effects of COMT inhibition on L-dopa pharmacokinetics in patients treated with carbidopa and selegiline
    • Davis TL, Roznoski M, Burns RS (1995a): Acute effects of COMT inhibition on L-dopa pharmacokinetics in patients treated with carbidopa and selegiline. Clin Neuropharmacol 18:333-337.
    • (1995) Clin Neuropharmacol , vol.18 , pp. 333-337
    • Davis, T.L.1    Roznoski, M.2    Burns, R.S.3
  • 20
    • 0029000679 scopus 로고
    • Effects of tolcapone in Parkinson's patients taking L-dihydroxyphenylalanine/carbidopa and selegiline
    • Davis TL, Roznoski M, Burns RS (1995b): Effects of tolcapone in Parkinson's patients taking L-dihydroxyphenylalanine/carbidopa and selegiline. Mov Disord 10:349-351.
    • (1995) Mov Disord , vol.10 , pp. 349-351
    • Davis, T.L.1    Roznoski, M.2    Burns, R.S.3
  • 21
    • 0029044201 scopus 로고
    • Integrated pharmacokinetics and pharmacodynamics of the novel catechol-O-methyltransferase inhibitor tolcapone during first administration to humans
    • Dingemanse J, Jorga KM, Schmitt M, Gieschke R, Fotteler B, Zürcher G, Da Prada M, Van Brummelen P (1995a): Integrated pharmacokinetics and pharmacodynamics of the novel catechol-O-methyltransferase inhibitor tolcapone during first administration to humans. Clin Pharmacol Ther 57:508-517.
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 508-517
    • Dingemanse, J.1    Jorga, K.M.2    Schmitt, M.3    Gieschke, R.4    Fotteler, B.5    Zürcher, G.6    Da Prada, M.7    Van Brummelen, P.8
  • 25
    • 0343005422 scopus 로고    scopus 로고
    • Multicenter evaluation of tolcapone (Tasmar) when given together with levodopa to Parkinson disease patients who exhibit end-of-dose wearing-off
    • Dorflinger EE, Rajput A, Martin W, Saint-Hilaire M-H, Chernik D, Yoo K, Shimoun G, Pedder S, and the Tolcapone Fluctuator II Study Group (1996): Multicenter evaluation of tolcapone (Tasmar) when given together with levodopa to Parkinson disease patients who exhibit end-of-dose wearing-off. Neurology 46:A474.
    • (1996) Neurology , vol.46
    • Dorflinger, E.E.1    Rajput, A.2    Martin, W.3    Saint-Hilaire, M.-H.4    Chernik, D.5    Yoo, K.6    Shimoun, G.7    Pedder, S.8
  • 26
    • 2642668947 scopus 로고    scopus 로고
    • Tolcapone added to L-dopa in stable parkinsonian patients. a double-blind placebo controlled study
    • Dupont E, Burgunder J-M, Findley JL, Olsson J-E, Dubuis R, and the Tolcapone in Parkinson's Disease Study Group (1996): Tolcapone added to L-dopa in stable parkinsonian patients. A double-blind placebo controlled study. Acta Neurol Scand 94 (Suppl 167):8.
    • (1996) Acta Neurol Scand , vol.94 , Issue.167 SUPPL. , pp. 8
    • Dupont, E.1    Burgunder, J.-M.2    Findley, J.L.3    Olsson, J.-E.4    Dubuis, R.5
  • 28
  • 29
    • 0001002059 scopus 로고
    • Adverse effects of levodopa in Parkinson's disease
    • Calne DB (ed): Berlin: Springer Verlag PD
    • Fahn S (1989): Adverse effects of levodopa in Parkinson's disease. In Calne DB (ed): Drugs for the Treatment of Parkinson's Disease. Berlin: Springer Verlag PD, pp 385-409.
    • (1989) Drugs for the Treatment of Parkinson's Disease , pp. 385-409
    • Fahn, S.1
  • 30
    • 0002859737 scopus 로고
    • Adverse effects of levodopa
    • Olanow CW, Lieberman AN (eds): Carnforth: Parthenon Publishing Group
    • Fahn S (1992): Adverse effects of levodopa. In: Olanow CW, Lieberman AN (eds): The Scientific Basis for the Treatment of Parkinson's Disease. Carnforth: Parthenon Publishing Group, pp 89-112.
    • (1992) The Scientific Basis for the Treatment of Parkinson's Disease , pp. 89-112
    • Fahn, S.1
  • 31
    • 0000224448 scopus 로고
    • Unified Parkinson's Disease Rating Scale
    • Fahn S, Marsden CD, Calne DB, Goldstein M (eds): Florham Park, NJ: Macmillan Health Care Information
    • Fahn S, Elton R, Members of the UPDRS Development Committee (1987): Unified Parkinson's Disease Rating Scale. In Fahn S, Marsden CD, Calne DB, Goldstein M (eds): Recent Developments in Parkinson's Disease, Vol. 2. Florham Park, NJ: Macmillan Health Care Information, pp 153-163, 293-304.
    • (1987) Recent Developments in Parkinson's Disease , vol.2 , pp. 153-163
    • Fahn, S.1    Elton, R.2
  • 33
    • 0029117493 scopus 로고
    • Synergistic interactions between COMT-/MAO-inhibitors and L-dopa in MPTP-treated mice
    • Fredriksson A, Archer T (1995): Synergistic interactions between COMT-/MAO-inhibitors and L-dopa in MPTP-treated mice. J Neural Transm 102:19-34.
    • (1995) J Neural Transm , vol.102 , pp. 19-34
    • Fredriksson, A.1    Archer, T.2
  • 35
    • 0016829492 scopus 로고
    • Catechol-O-methyltransferase: Pharmacological aspects and physiological role
    • Guldberg HC, Marsden CD (1975): Catechol-O-methyltransferase: pharmacological aspects and physiological role. Pharmacol Rev 27:135-206.
    • (1975) Pharmacol Rev , vol.27 , pp. 135-206
    • Guldberg, H.C.1    Marsden, C.D.2
  • 39
    • 0019123620 scopus 로고
    • Benserazide and carbidopa as substrates of catechol-O-methyltransferase: New mechanism of action in Parkinson's disease
    • Hagan RM, Raxworthy MJ, Gulliver PA (1980): Benserazide and carbidopa as substrates of catechol-O-methyltransferase: New mechanism of action in Parkinson's disease. Biochem Pharmacol 29:3123-3126.
    • (1980) Biochem Pharmacol , vol.29 , pp. 3123-3126
    • Hagan, R.M.1    Raxworthy, M.J.2    Gulliver, P.A.3
  • 40
    • 0028838259 scopus 로고
    • Concentration-effect relationship of levodopa in patients with Parkinson's disease
    • Harder S, Baas H, Rietbrock S (1995): Concentration-effect relationship of levodopa in patients with Parkinson's disease. Clin Pharmacokinet 29:243-256.
    • (1995) Clin Pharmacokinet , vol.29 , pp. 243-256
    • Harder, S.1    Baas, H.2    Rietbrock, S.3
  • 41
    • 0022451735 scopus 로고
    • The pharmacokinetics of intravenous and oral levodopa in patients with Parkinson's disease who exhibit on-off fluctuations
    • Hardie RJ, Malcolm SL, Lees AJ, Stern GM, Allen JG (1986): The pharmacokinetics of intravenous and oral levodopa in patients with Parkinson's disease who exhibit on-off fluctuations. Br J Clin Pharmacol 22:429-436.
    • (1986) Br J Clin Pharmacol , vol.22 , pp. 429-436
    • Hardie, R.J.1    Malcolm, S.L.2    Lees, A.J.3    Stern, G.M.4    Allen, J.G.5
  • 42
    • 0026788619 scopus 로고
    • Regional brain kinetics of 6-fluoro-(β-11C)-L-dopa and (β-11C)-L-dopa following COMT inhibition. a study in vivo using positron emission tomography
    • Hartvig P, Linder KJ, Tedroff J, Bjurling P, Hörnfelt K, Langström B (1992): Regional brain kinetics of 6-fluoro-(β-11C)-L-dopa and (β-11C)-L-dopa following COMT inhibition. A study in vivo using positron emission tomography. J Neural Transm 87:15-22.
    • (1992) J Neural Transm , vol.87 , pp. 15-22
    • Hartvig, P.1    Linder, K.J.2    Tedroff, J.3    Bjurling, P.4    Hörnfelt, K.5    Langström, B.6
  • 43
    • 2642597525 scopus 로고    scopus 로고
    • Tolerability and efficacy of tolcapone(Tasmar®) in untreated Parkinson's disease (PD)
    • Hauser R, Dorflinger E, Pedder S, Shimoun G, Yoo K, Molho E, Shale H, and the Tolcapone De Novo Study Group (1996): Tolerability and efficacy of tolcapone(Tasmar®) in untreated Parkinson's disease (PD). Mov Disord 11 (Suppl 1):147.
    • (1996) Mov Disord , vol.11 , Issue.1 SUPPL. , pp. 147
    • Hauser, R.1    Dorflinger, E.2    Pedder, S.3    Shimoun, G.4    Yoo, K.5    Molho, E.6    Shale, H.7
  • 45
    • 2642621018 scopus 로고    scopus 로고
    • Latest news on treatments in R&D for Parkinson's disease
    • Higgins G (1996): Latest news on treatments in R&D for Parkinson's disease. Inpharma 1042:9-10.
    • (1996) Inpharma , vol.1042 , pp. 9-10
    • Higgins, G.1
  • 46
    • 0023263919 scopus 로고
    • Biochemical pathophysiology of Parkinson's disease
    • Hornykiewicz O, Kish SJ (1986): Biochemical pathophysiology of Parkinson's disease. Adv Neurol 45:19-34.
    • (1986) Adv Neurol , vol.45 , pp. 19-34
    • Hornykiewicz, O.1    Kish, S.J.2
  • 48
    • 0028046134 scopus 로고
    • COMT inhibition by high-dose entacapone does not affect haemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise
    • Illi A, Sundberg S, Koulu M, Scheinin M, Heinävaara S, Gordin A (1994): COMT inhibition by high-dose entacapone does not affect haemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise. Int J Clin Pharmacol Ther 32:582-588.
    • (1994) Int J Clin Pharmacol Ther , vol.32 , pp. 582-588
    • Illi, A.1    Sundberg, S.2    Koulu, M.3    Scheinin, M.4    Heinävaara, S.5    Gordin, A.6
  • 49
    • 0029160593 scopus 로고
    • The effect of entacapone on the disposition and haemodynamic effects of intravenous isoproterenol and epinephrine
    • Illi A, Sundberg S, Ojala-Karlsson P, Korhonen P, Scheinin M, Gordin A (1995): The effect of entacapone on the disposition and haemodynamic effects of intravenous isoproterenol and epinephrine. Clin Pharmacol Ther 58:221-227.
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 221-227
    • Illi, A.1    Sundberg, S.2    Ojala-Karlsson, P.3    Korhonen, P.4    Scheinin, M.5    Gordin, A.6
  • 50
    • 0029881150 scopus 로고    scopus 로고
    • Simultaneous inhibition of catechol-O-methyltransferase and monoamine oxidase A: Effects on haemodynamics and catecholamine metabolism in healthy volunteers
    • Illi A, Sundberg S, Ojala-Karlsson P, Scheinin M, Gordin A (1996a): Simultaneous inhibition of catechol-O-methyltransferase and monoamine oxidase A: Effects on haemodynamics and catecholamine metabolism in healthy volunteers. Clin Pharmacol Ther 59:450-457.
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 450-457
    • Illi, A.1    Sundberg, S.2    Ojala-Karlsson, P.3    Scheinin, M.4    Gordin, A.5
  • 51
    • 0030476572 scopus 로고    scopus 로고
    • Simultaneous inhibition of catecholamine-O-methylation by entacapone and neuronal uptake by imipramine: Lack of interactions
    • Illi A, Sundberg S, Ojala-Karlsson P, Scheinin M, Gordin A (1996b): Simultaneous inhibition of catecholamine-O-methylation by entacapone and neuronal uptake by imipramine: Lack of interactions. Eur J Clin Pharmacol 51:273-276.
    • (1996) Eur J Clin Pharmacol , vol.51 , pp. 273-276
    • Illi, A.1    Sundberg, S.2    Ojala-Karlsson, P.3    Scheinin, M.4    Gordin, A.5
  • 52
    • 0029785290 scopus 로고    scopus 로고
    • Fluorodopa positron emission tomography with an inhibitor of catechol-O-methyltransferase: Effect of the plasma 3-O-methyldopa fraction on data analysis
    • Ishikawa T, Dhawan V, Chaly T, Robeson W, Belakhlef A, Mandel F, Dahl R, Margouleff C, Eidelberg D (1996): Fluorodopa positron emission tomography with an inhibitor of catechol-O-methyltransferase: Effect of the plasma 3-O-methyldopa fraction on data analysis. J Cereb Blood Flow Metab 16:854-863.
    • (1996) J Cereb Blood Flow Metab , vol.16 , pp. 854-863
    • Ishikawa, T.1    Dhawan, V.2    Chaly, T.3    Robeson, W.4    Belakhlef, A.5    Mandel, F.6    Dahl, R.7    Margouleff, C.8    Eidelberg, D.9
  • 53
    • 24844456695 scopus 로고
    • Interaction of the COMT inhibitor entacapone with L-dopa in MPTP treated common marmosets
    • Jenner P, Smith LA (1993): Interaction of the COMT inhibitor entacapone with L-dopa in MPTP treated common marmosets. Can J Neurol Sci 20 (Suppl. 4):S211.
    • (1993) Can J Neurol Sci , vol.20 , Issue.4 SUPPL.
    • Jenner, P.1    Smith, L.A.2
  • 54
    • 0042393522 scopus 로고    scopus 로고
    • Clinical pharmacology of COMT-inhibitors: Differences and similarities between entacapone and tolcapone
    • Jorga K, Fotteler B (1996): Clinical pharmacology of COMT-inhibitors: Differences and similarities between entacapone and tolcapone. Acta Neurol Scand 94 (Suppl. 167):8.
    • (1996) Acta Neurol Scand , vol.94 , Issue.167 SUPPL. , pp. 8
    • Jorga, K.1    Fotteler, B.2
  • 55
    • 0009727991 scopus 로고
    • Effect of the novel COMT-inhibitor tolcapone on L-dopa pharmacokinetics when combined with different Sinemet formulations
    • Jorga KM, Sedek G (1995): Effect of the novel COMT-inhibitor tolcapone on L-dopa pharmacokinetics when combined with different Sinemet formulations. Neurology 45 (Suppl. 4):A291.
    • (1995) Neurology , vol.45 , Issue.4 SUPPL.
    • Jorga, K.M.1    Sedek, G.2
  • 56
    • 0006060522 scopus 로고
    • Pharmacokinetics-pharmacodynamics of a novel COMT inhibitor during multiple dosing regimens
    • Jorga K, Dingemanse J, Fotteler B, Zürcher G (1993): Pharmacokinetics-pharmacodynamics of a novel COMT inhibitor during multiple dosing regimens. Clin Pharmacol Ther 53:180.
    • (1993) Clin Pharmacol Ther , vol.53 , pp. 180
    • Jorga, K.1    Dingemanse, J.2    Fotteler, B.3    Zürcher, G.4
  • 58
    • 0026688379 scopus 로고
    • Effects of COMT inhibitors on striatal dopamine metabolism: A microdialysis study
    • Kaakkola S, Wurtman RJ (1992): Effects of COMT inhibitors on striatal dopamine metabolism: A microdialysis study. Brain Res 587:241-249.
    • (1992) Brain Res , vol.587 , pp. 241-249
    • Kaakkola, S.1    Wurtman, R.J.2
  • 60
    • 0027935135 scopus 로고
    • General properties and clinical possibilities of new selective inhibitors of catechol-O-methyltransferase
    • Kaakkola S, Gordin A, Männistö PT (1994a): General properties and clinical possibilities of new selective inhibitors of catechol-O-methyltransferase. Gen Pharmacol 25:813-824.
    • (1994) Gen Pharmacol , vol.25 , pp. 813-824
    • Kaakkola, S.1    Gordin, A.2    Männistö, P.T.3
  • 61
    • 0028078890 scopus 로고
    • Effect of entacapone, a COMT inhibitor, on clinical disability and levodopa metabolism in parkinsonian patients
    • Kaakkola S, Teräväinen H, Ahtila S, Rita H, Gordin A (1994b): Effect of entacapone, a COMT inhibitor, on clinical disability and levodopa metabolism in parkinsonian patients. Neurology 44:77-80.
    • (1994) Neurology , vol.44 , pp. 77-80
    • Kaakkola, S.1    Teräväinen, H.2    Ahtila, S.3    Rita, H.4    Gordin, A.5
  • 62
    • 85005235624 scopus 로고
    • Entacapone in combination with standard or controlled-release levodopa/carbidopa: A clinical and pharmacokinetic study in patients with Parkinson's disease
    • Kaakkola S, Teräväinen H, Ahtila S, Karlsson M, Naukkarinen T, Rita H, Gordin A (1995): Entacapone in combination with standard or controlled-release levodopa/carbidopa: A clinical and pharmacokinetic study in patients with Parkinson's disease. Eur J Neurol 2:341-347.
    • (1995) Eur J Neurol , vol.2 , pp. 341-347
    • Kaakkola, S.1    Teräväinen, H.2    Ahtila, S.3    Karlsson, M.4    Naukkarinen, T.5    Rita, H.6    Gordin, A.7
  • 63
    • 2642605833 scopus 로고    scopus 로고
    • A population PK/ PD model for the anti-parkinsonian triple therapy: Levodopa (LD), dopadecarboxylase (DDC) inhibitor and catechol-O-methyltransferase (COMT) inhibitor
    • June 14-15; Sandwich
    • Karlsson MO, Naukkarinen T, Lennernds H (1996): A population PK/ PD model for the anti-parkinsonian triple therapy: Levodopa (LD), dopadecarboxylase (DDC) inhibitor and catechol-O-methyltransferase (COMT) inhibitor. Meeting of the Population Approach Group in Europe; June 14-15; Sandwich.
    • (1996) Meeting of the Population Approach Group in Europe
    • Karlsson, M.O.1    Naukkarinen, T.2    Lennernds, H.3
  • 66
    • 0029827782 scopus 로고    scopus 로고
    • COMT inhibition by entacapone does not affect growth hormone or prolactin secretion in healthy volunteers
    • Keränen T, Gordin A, Koulu M, Scheinin M, Antila S, Sundberg S, Wikberg T (1996): COMT inhibition by entacapone does not affect growth hormone or prolactin secretion in healthy volunteers. J Neural Transm 103:729-736.
    • (1996) J Neural Transm , vol.103 , pp. 729-736
    • Keränen, T.1    Gordin, A.2    Koulu, M.3    Scheinin, M.4    Antila, S.5    Sundberg, S.6    Wikberg, T.7
  • 67
    • 0022369108 scopus 로고
    • Catecholamine metabolism: Basic aspects and clinical significance
    • Kopin IJ (1985): Catecholamine metabolism: Basic aspects and clinical significance. Pharmacol Rev 37:333-364.
    • (1985) Pharmacol Rev , vol.37 , pp. 333-364
    • Kopin, I.J.1
  • 68
    • 2642661923 scopus 로고
    • Efficacy results of tolcapone at three dose levels in levodopa-treated patients with wearing-off phenomenon
    • June 17-21; Munich
    • Kurth M (1995): Efficacy results of tolcapone at three dose levels in levodopa-treated patients with wearing-off phenomenon. Fifth Meeting of the European Neurological Society; June 17-21; Munich.
    • (1995) Fifth Meeting of the European Neurological Society
    • Kurth, M.1
  • 69
    • 2642656763 scopus 로고
    • Tolcapone improves motor function and reduces levodopa requirement in patients with Parkinson's disease (PD) experiencing end-of-dose motor fluctuations
    • Kurth MC, Adler CH, St. Hilaire M, Singer C, Waters C, Chernik DA, Dorflinger E, Yoo K, and the Tolcapone Fluctuator Study GROUP I (1995): Tolcapone improves motor function and reduces levodopa requirement in patients with Parkinson's disease (PD) experiencing end-of-dose motor fluctuations. Neurology 45 (Suppl. 4):A275-A276.
    • (1995) Neurology , vol.45 , Issue.4 SUPPL.
    • Kurth, M.C.1    Adler, C.H.2    St Hilaire, M.3    Singer, C.4    Waters, C.5    Chernik, D.A.6    Dorflinger, E.7    Yoo, K.8
  • 72
    • 0029799630 scopus 로고    scopus 로고
    • Interspecies scaling of tolcapone, a new inhibitor of catechol-O-methyltransferase (COMT). Use of in vitro data from hepatocytes to predict metabolic clearance in animals and humans
    • Lave Th, Dupin S, Schmitt M, Kapps M, Meyer J, Morgenroth B, Chou RC, Jaeck D, Coassolo Ph (1996): Interspecies scaling of tolcapone, a new inhibitor of catechol-O-methyltransferase (COMT). Use of in vitro data from hepatocytes to predict metabolic clearance in animals and humans. Xenobiotica 26:839-851.
    • (1996) Xenobiotica , vol.26 , pp. 839-851
    • Lave, Th.1    Dupin, S.2    Schmitt, M.3    Kapps, M.4    Meyer, J.5    Morgenroth, B.6    Chou, R.C.7    Jaeck, D.8    Coassolo, Ph.9
  • 73
    • 0025695511 scopus 로고
    • Nigrostriatal dopaminergic system assessed in-vivo by positron emission tomography in healthy volunteer subjects and patients with Parkinson's disease
    • Leenders KL, Salmon EP, Tyrrell P, Perani D, Brooks DJ, Sager H, Jones T, Marsden CD, Frackowiak RS (1990): Nigrostriatal dopaminergic system assessed in-vivo by positron emission tomography in healthy volunteer subjects and patients with Parkinson's disease. Arch Neurol 47:1290-1298.
    • (1990) Arch Neurol , vol.47 , pp. 1290-1298
    • Leenders, K.L.1    Salmon, E.P.2    Tyrrell, P.3    Perani, D.4    Brooks, D.J.5    Sager, H.6    Jones, T.7    Marsden, C.D.8    Frackowiak, R.S.9
  • 74
    • 0343002294 scopus 로고
    • Therapy with dopaminergic drugs in Parkinson's disease
    • Koller WC (ed): New York: Marcel Dekker
    • LeWitt PA (1992): Therapy with dopaminergic drugs in Parkinson's disease. In Koller WC (ed): Handbook of Parkinson's Disease, 2nd ed. New York: Marcel Dekker, pp 469-508.
    • (1992) Handbook of Parkinson's Disease, 2nd Ed. , pp. 469-508
    • LeWitt, P.A.1
  • 75
    • 2642626109 scopus 로고    scopus 로고
    • Tolcapone produces sustained improvement for Parkinson's disease patients with a stable response to levodopa
    • LeWitt PA (1996): Tolcapone produces sustained improvement for Parkinson's disease patients with a stable response to levodopa. Mov Disord 11 (Suppl. 1):272.
    • (1996) Mov Disord , vol.11 , Issue.1 SUPPL. , pp. 272
    • LeWitt, P.A.1
  • 78
    • 0023737434 scopus 로고
    • Favourable effect of catechol-O-methyltransferase inhibition by OR-462 in experimental models of Parkinson's disease
    • Lindén IB, Nissinen E, Etemadzadeh E, Kaakkola S, Männistö P, Pohto P (1988): Favourable effect of catechol-O-methyltransferase inhibition by OR-462 in experimental models of Parkinson's disease. J Pharmacol Exp Ther 247:289-293.
    • (1988) J Pharmacol Exp Ther , vol.247 , pp. 289-293
    • Lindén, I.B.1    Nissinen, E.2    Etemadzadeh, E.3    Kaakkola, S.4    Männistö, P.5    Pohto, P.6
  • 80
    • 2642660920 scopus 로고    scopus 로고
    • The effect of peripheral COMT inhibition on plasma L-dopa and 3-OMD in L-dopa/DCI treated patients with Parkinson's disease
    • Lyytinen J, Kaakkola S, Teräväinen H (1996): The effect of peripheral COMT inhibition on plasma L-dopa and 3-OMD in L-dopa/DCI treated patients with Parkinson's disease. Mov Disord 11 (Suppl. 1):198.
    • (1996) Mov Disord , vol.11 , Issue.1 SUPPL. , pp. 198
    • Lyytinen, J.1    Kaakkola, S.2    Teräväinen, H.3
  • 81
    • 84951515357 scopus 로고
    • Clinical potential of catechol-O-methyltransferase (COMT) inhibitors as adjuvants in Parkinson's disease
    • Männistö PT (1994): Clinical potential of catechol-O-methyltransferase (COMT) inhibitors as adjuvants in Parkinson's disease. CNS Drugs 1:172-179.
    • (1994) CNS Drugs , vol.1 , pp. 172-179
    • Männistö, P.T.1
  • 82
    • 0024511327 scopus 로고
    • New selective COMT inhibitors: Useful adjuncts for Parkinson's disease?
    • Männistö PT, Kaakkola S (1989): New selective COMT inhibitors: Useful adjuncts for Parkinson's disease? Trends Pharmacol Sci 10:54-56.
    • (1989) Trends Pharmacol Sci , vol.10 , pp. 54-56
    • Männistö, P.T.1    Kaakkola, S.2
  • 83
    • 0025039417 scopus 로고
    • Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease
    • Männistö PT, Kaakkola S (1990): Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease. Pharmacol Toxicol 66:317-323.
    • (1990) Pharmacol Toxicol , vol.66 , pp. 317-323
    • Männistö, P.T.1    Kaakkola, S.2
  • 84
    • 0023809040 scopus 로고
    • Properties of novel effective and highly selective inhibitors of catechol-O-methyltransferase
    • Männistö PT, Kaakkola S, Nissinen E, Linden IB, Pohto P (1988): Properties of novel effective and highly selective inhibitors of catechol-O-methyltransferase. Life Sci 43:1465-1471.
    • (1988) Life Sci , vol.43 , pp. 1465-1471
    • Männistö, P.T.1    Kaakkola, S.2    Nissinen, E.3    Linden, I.B.4    Pohto, P.5
  • 85
    • 0026570182 scopus 로고
    • Different in vivo properties of three new inhibitors of catechol-O-methyltransferase in the rat
    • Männistö PT, Tuomainen P, Tuominen RT (1992a): Different in vivo properties of three new inhibitors of catechol-O-methyltransferase in the rat. Br J Pharmacol 105:569-574.
    • (1992) Br J Pharmacol , vol.105 , pp. 569-574
    • Männistö, P.T.1    Tuomainen, P.2    Tuominen, R.T.3
  • 88
    • 0027988507 scopus 로고
    • Problems with long-term levodopa therapy for Parkinson's disease
    • Marsden CD (1994b): Problems with long-term levodopa therapy for Parkinson's disease. Clin Neuropharmacol 17 (Suppl. 2):S32-S44.
    • (1994) Clin Neuropharmacol , vol.17 , Issue.2 SUPPL.
    • Marsden, C.D.1
  • 89
    • 0028137620 scopus 로고
    • Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease
    • Merello M, Lees AJ, Webster R, Bovingdon M, Gordin A (1994): Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 57:186-189.
    • (1994) J Neurol Neurosurg Psychiatry , vol.57 , pp. 186-189
    • Merello, M.1    Lees, A.J.2    Webster, R.3    Bovingdon, M.4    Gordin, A.5
  • 90
    • 0027329960 scopus 로고
    • 18-F]fluoro-L-dopa metabolism and positron emission tomography after catechol-O-methyltransferase inhibition in normal and hemi-parkinsonian monkeys
    • 18-F]fluoro-L-dopa metabolism and positron emission tomography after catechol-O-methyltransferase inhibition in normal and hemi-parkinsonian monkeys. Brain Res 626:1-13.
    • (1993) Brain Res , vol.626 , pp. 1-13
    • Miletich, R.S.1    Comi, G.2    Bankiewicz, K.3    Plunkett, R.4    Adams, R.5    Di Chiro, G.6    Kopin, I.J.7
  • 92
    • 0027250362 scopus 로고
    • Therapy with central active catechol-O-methyltransferase (COMT)-inhibitors: Is addition of monoamine oxidase (MAO)-inhibitors necessary to slow progress of neurodegenerative disorders?
    • Müller T, Kuhn W, Przuntek H (1993): Therapy with central active catechol-O-methyltransferase (COMT)-inhibitors: Is addition of monoamine oxidase (MAO)-inhibitors necessary to slow progress of neurodegenerative disorders? J Neural Transm Gen Sect 92:187-195.
    • (1993) J Neural Transm Gen Sect , vol.92 , pp. 187-195
    • Müller, T.1    Kuhn, W.2    Przuntek, H.3
  • 93
    • 0343316396 scopus 로고
    • Clinical efficacy of tolcapone in L-dopa-treated parkinsonian patients with 'wearing-off' phenomenon: A multicenter double-blind study
    • Myllylä VV, and the Tolcapone in PD Study Group I (1995): Clinical efficacy of tolcapone in L-dopa-treated parkinsonian patients with 'wearing-off' phenomenon: A multicenter double-blind study. Neurology 45 (Suppl. 4):A276.
    • (1995) Neurology , vol.45 , Issue.4 SUPPL.
    • Myllylä, V.V.1
  • 94
    • 0027445460 scopus 로고
    • Effects of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease
    • Myllylä W, Sotaniemi KA, Illi A, Suominen K, Keränen T (1993): Effects of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease. Eur J Clin Pharmacol 45:419-423.
    • (1993) Eur J Clin Pharmacol , vol.45 , pp. 419-423
    • Myllylä, W.1    Sotaniemi, K.A.2    Illi, A.3    Suominen, K.4    Keränen, T.5
  • 95
    • 24844478631 scopus 로고    scopus 로고
    • Acute and long-term tolcapone administration improves levodopa bioavailability and motor response in parkinsonian patients
    • Napolitano A, Del Dotto P, Petrozzi L, Dell'Agnello MG, Renna M, Bonuccelli U (1996): Acute and long-term tolcapone administration improves levodopa bioavailability and motor response in parkinsonian patients. Neurology 46:A375.
    • (1996) Neurology , vol.46
    • Napolitano, A.1    Del Dotto, P.2    Petrozzi, L.3    DelL'Agnello, M.G.4    Renna, M.5    Bonuccelli, U.6
  • 96
    • 0026671534 scopus 로고
    • Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone
    • Nissinen E, Lindén IB, Schultz E, Pohto P (1992): Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone. Naunyn Schmiedebergs Arch Pharmacol 346:262-266.
    • (1992) Naunyn Schmiedebergs Arch Pharmacol , vol.346 , pp. 262-266
    • Nissinen, E.1    Lindén, I.B.2    Schultz, E.3    Pohto, P.4
  • 97
    • 2642597524 scopus 로고    scopus 로고
    • Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations. a 6-month multicenter, placebo-controlled, double-blind, parallel group study
    • NOMECOMT Study Group (1996): Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations. A 6-month multicenter, placebo-controlled, double-blind, parallel group study. Mov Disord 11 (Suppl. 1):267.
    • (1996) Mov Disord , vol.11 , Issue.1 SUPPL. , pp. 267
  • 99
    • 0023265840 scopus 로고
    • 3-O-Methyldopa and the response to levodopa in Parkinson's disease
    • Nutt JG, Woodward WR, Gancher ST, Merrick D (1987): 3-O-Methyldopa and the response to levodopa in Parkinson's disease. Ann Neurol 21:584-588.
    • (1987) Ann Neurol , vol.21 , pp. 584-588
    • Nutt, J.G.1    Woodward, W.R.2    Gancher, S.T.3    Merrick, D.4
  • 101
    • 0025242960 scopus 로고
    • Oxidation reactions in Parkinson's disease
    • Olanow CW (1990): Oxidation reactions in Parkinson's disease. Neurology 40 (Suppl 3):32-37.
    • (1990) Neurology , vol.40 , Issue.3 SUPPL. , pp. 32-37
    • Olanow, C.W.1
  • 102
    • 2642600516 scopus 로고    scopus 로고
    • The COMT inhibitor entacapone improves parkinsonian features in fluctuating patients
    • Parkinson Study Group (1996): The COMT inhibitor entacapone improves parkinsonian features in fluctuating patients. Mov Disord 11 (Suppl. 1):268.
    • (1996) Mov Disord , vol.11 , Issue.1 SUPPL. , pp. 268
  • 106
    • 0027272072 scopus 로고
    • Inhibition of catechol-O-methyltransferase by 1-vinyl derivatives of nitrocatechols and nitroguaiacols
    • Pérez RA, Fernández-Alvarez E, Nieto O, Piedrafita FJ (1993): Inhibition of catechol-O-methyltransferase by 1-vinyl derivatives of nitrocatechols and nitroguaiacols. Biochem Pharmacol 45:1973-1981.
    • (1993) Biochem Pharmacol , vol.45 , pp. 1973-1981
    • Pérez, R.A.1    Fernández-Alvarez, E.2    Nieto, O.3    Piedrafita, F.J.4
  • 107
    • 0026874287 scopus 로고
    • In vivo and in vitro studies of the dopaminergic system in movement disorders
    • Playford ED, Brooks DJ (1992): In vivo and in vitro studies of the dopaminergic system in movement disorders. Cerebrovasc Brain Metab Rev 4:144-171.
    • (1992) Cerebrovasc Brain Metab Rev , vol.4 , pp. 144-171
    • Playford, E.D.1    Brooks, D.J.2
  • 108
    • 2642598494 scopus 로고    scopus 로고
    • Comparison of efficacy and safety of tolcapone and bromocriptine in the treatment of parkinsonian patients
    • Pollak P (1996): Comparison of efficacy and safety of tolcapone and bromocriptine in the treatment of parkinsonian patients. Mov Disord 11 (Suppl. 1):272.
    • (1996) Mov Disord , vol.11 , Issue.1 SUPPL. , pp. 272
    • Pollak, P.1
  • 109
    • 24844454300 scopus 로고
    • 18F]fluoro-L-dopa (FD) kinetics and metabolism following inhibition of catechol-O-methyltransferase (COMT) and aromatic amino acid decarboxylase (AAAD)
    • 18F]fluoro-L-dopa (FD) kinetics and metabolism following inhibition of catechol-O-methyltransferase (COMT) and aromatic amino acid decarboxylase (AAAD). J Neurol 242 (Suppl. 2):S15-S16.
    • (1995) J Neurol , vol.242 , Issue.2 SUPPL.
    • Psylla, M.1    Vontobel, P.2    Antonini, A.3    Gunther, I.4    Leenders, K.L.5
  • 110
    • 0021211101 scopus 로고
    • Control of on/off phenomenon by continuous intravenous infusion of levodopa
    • Quinn N, Parkes JD, Marsden CD (1984): Control of on/off phenomenon by continuous intravenous infusion of levodopa. Neurology 34:1131-1136.
    • (1984) Neurology , vol.34 , pp. 1131-1136
    • Quinn, N.1    Parkes, J.D.2    Marsden, C.D.3
  • 112
    • 2642660919 scopus 로고    scopus 로고
    • Efficacy of tolcapone in the treatment of Parkinson's disease patients experiencing wearing-off phenomenon: The North American experience
    • Rajput A (1996): Efficacy of tolcapone in the treatment of Parkinson's disease patients experiencing wearing-off phenomenon: The North American experience. Mov Disord 11 (Suppl. 1):271.
    • (1996) Mov Disord , vol.11 , Issue.1 SUPPL. , pp. 271
    • Rajput, A.1
  • 113
    • 2642689122 scopus 로고    scopus 로고
    • A multicenter double-blind placebo-controlled study of tolcapone added to levodopa in fluctuating Parkinson's disease
    • Ransmayr G, Poewe W, on Behalf of the Tolcapone Study Group (1996): A multicenter double-blind placebo-controlled study of tolcapone added to levodopa in fluctuating Parkinson's disease. Mov Disord 11 (Suppl. 1):271.
    • (1996) Mov Disord , vol.11 , Issue.1 SUPPL. , pp. 271
    • Ransmayr, G.1    Poewe, W.2
  • 114
    • 0019985169 scopus 로고
    • 3-O-Methyldopa blocks dopa metabolism in rat corpus striatum
    • Reches A, Fahn S (1982): 3-O-Methyldopa blocks dopa metabolism in rat corpus striatum. Ann Neurol 12:267-271.
    • (1982) Ann Neurol , vol.12 , pp. 267-271
    • Reches, A.1    Fahn, S.2
  • 115
    • 0020045716 scopus 로고
    • 3-O-Methyldopa inhibits rotations induced by levodopa in rats after unilateral destruction of the nigrostriatal pathway
    • Reches A, Mielke LR, Fahn S (1982): 3-O-Methyldopa inhibits rotations induced by levodopa in rats after unilateral destruction of the nigrostriatal pathway. Neurology 32:887-888.
    • (1982) Neurology , vol.32 , pp. 887-888
    • Reches, A.1    Mielke, L.R.2    Fahn, S.3
  • 116
    • 0018960332 scopus 로고
    • Catechol-O-methyltransferase activity: A determinant of levodopa response
    • Reilly DK, Rivera-Calimlim L, Van Dyke D (1980): Catechol-O-methyltransferase activity: A determinant of levodopa response. Clin Pharmacol Ther 28:278-286.
    • (1980) Clin Pharmacol Ther , vol.28 , pp. 278-286
    • Reilly, D.K.1    Rivera-Calimlim, L.2    Van Dyke, D.3
  • 117
    • 0020351439 scopus 로고
    • Contribution of sulfate conjugation, deamination, and O-methylation to metabolism of dopamine and norepinephrine in human brain
    • Rivett AJ, Eddy BJ, Roth JA (1982): Contribution of sulfate conjugation, deamination, and O-methylation to metabolism of dopamine and norepinephrine in human brain. J Neurochem 39:1009-1016.
    • (1982) J Neurochem , vol.39 , pp. 1009-1016
    • Rivett, A.J.1    Eddy, B.J.2    Roth, J.A.3
  • 118
    • 0027770982 scopus 로고
    • Catechol-O-methyltransferase inhibitor tolcapone prolongs levodopa/carbidopa action in parkinsonian patients
    • Roberts JW, Cora-Locatelli G, Bravi D, Amantea MA, Mouradian MM, Chase TN (1993): Catechol-O-methyltransferase inhibitor tolcapone prolongs levodopa/carbidopa action in parkinsonian patients. Neurology 43:2685-2688.
    • (1993) Neurology , vol.43 , pp. 2685-2688
    • Roberts, J.W.1    Cora-Locatelli, G.2    Bravi, D.3    Amantea, M.A.4    Mouradian, M.M.5    Chase, T.N.6
  • 119
    • 0029895288 scopus 로고    scopus 로고
    • A double-blind pharmacokinetic and clinical dose-response study of entacapone as an adjuvant to levodopa therapy in advanced Parkinson's disease
    • Ruottinen HM, Rinne UK (1996a): A double-blind pharmacokinetic and clinical dose-response study of entacapone as an adjuvant to levodopa therapy in advanced Parkinson's disease. Clin Neuropharmacol 19:283-296.
    • (1996) Clin Neuropharmacol , vol.19 , pp. 283-296
    • Ruottinen, H.M.1    Rinne, U.K.2
  • 120
    • 0029881772 scopus 로고    scopus 로고
    • Effect of one month's treatment with peripherally acting catechol-O-methyltransferase inhibitor, entacapone, on pharmacokinetics and motor response to levodopa in advanced parkinsonian patients
    • Ruottinen HM, Rinne UK (1996b): Effect of one month's treatment with peripherally acting catechol-O-methyltransferase inhibitor, entacapone, on pharmacokinetics and motor response to levodopa in advanced parkinsonian patients. Clin Neuropharmacol 19:222-233.
    • (1996) Clin Neuropharmacol , vol.19 , pp. 222-233
    • Ruottinen, H.M.1    Rinne, U.K.2
  • 121
    • 0030042649 scopus 로고    scopus 로고
    • Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients with levodopa related fluctuations
    • Ruottinen HM, Rinne UK (1996c): Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients with levodopa related fluctuations. J Neurol Neurosurg Psychiatry 60:36-40.
    • (1996) J Neurol Neurosurg Psychiatry , vol.60 , pp. 36-40
    • Ruottinen, H.M.1    Rinne, U.K.2
  • 123
    • 24844465737 scopus 로고    scopus 로고
    • Change in fluorodopa accumulation differs in L-dopa-treated and de novo parkinsonian patients after inhibition of peripheral catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAO-B)
    • Ruottinen HM, Rinne JO, Bergman JR, Haaparanta MT, Solin OH, Ruotsalainen UH, Oikonen VJ, Rinne UK (1996): Change in fluorodopa accumulation differs in L-dopa-treated and de novo parkinsonian patients after inhibition of peripheral catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAO-B). J Neurol 243 (Suppl. 2):S8.
    • (1996) J Neurol , vol.243 , Issue.2 SUPPL.
    • Ruottinen, H.M.1    Rinne, J.O.2    Bergman, J.R.3    Haaparanta, M.T.4    Solin, O.H.5    Ruotsalainen, U.H.6    Oikonen, V.J.7    Rinne, U.K.8
  • 125
    • 0025890425 scopus 로고
    • Inhibition of human erythrocyte and gastroduodenal catechol-O-methyltransferase activity by nitecapone
    • Schultz, E, Tarpila S, Bäckström AC, Gordin A, Nissinen E, Pohto P (1991): Inhibition of human erythrocyte and gastroduodenal catechol-O-methyltransferase activity by nitecapone. Eur J Clin Pharmacol 40:577-580.
    • (1991) Eur J Clin Pharmacol , vol.40 , pp. 577-580
    • Schultz, E.1    Tarpila, S.2    Bäckström, A.C.3    Gordin, A.4    Nissinen, E.5    Pohto, P.6
  • 126
  • 127
    • 0013675459 scopus 로고    scopus 로고
    • Lack of interaction between ephedrine and combination of tolcapone and Sinemet
    • Sedek G, Jorga K, Voo K, Hood J (1996): Lack of interaction between ephedrine and combination of tolcapone and Sinemet. Neurology 46:A374.
    • (1996) Neurology , vol.46
    • Sedek, G.1    Jorga, K.2    Voo, K.3    Hood, J.4
  • 128
    • 0029348624 scopus 로고
    • The use of PET in Parkinson's disease
    • Shinotoh H, Calne DB (1995): The use of PET in Parkinson's disease. Brain Cogn 28:297-310.
    • (1995) Brain Cogn , vol.28 , pp. 297-310
    • Shinotoh, H.1    Calne, D.B.2
  • 129
    • 0016587362 scopus 로고
    • On-off response: Clinical and biochemical correlations during oral and intravenous levodopa administration in parkinsonian patients
    • Shoulson I, Glaubiger GA, Chase TN (1975): On-off response: Clinical and biochemical correlations during oral and intravenous levodopa administration in parkinsonian patients. Neurology 25:1144-1148.
    • (1975) Neurology , vol.25 , pp. 1144-1148
    • Shoulson, I.1    Glaubiger, G.A.2    Chase, T.N.3
  • 130
    • 24844439566 scopus 로고    scopus 로고
    • A Nordic multicentre trial on entacapone in patients with Parkinson's disease and end-of-dose fluctuations
    • Sidén Å, and the NOMECOMT Study Group (1996): A Nordic multicentre trial on entacapone in patients with Parkinson's disease and end-of-dose fluctuations. Acta Neurol Scand 94 (Suppl. 167):6.
    • (1996) Acta Neurol Scand , vol.94 , Issue.167 SUPPL. , pp. 6
    • Sidén, Å.1
  • 133
    • 0022492532 scopus 로고
    • The presence of catechol-O-methyltransferase activity in separately cultured cerebromicrovascular endothelial and smooth muscle cells
    • Spatz M, Kaneda N, Sumi C, Nagatsu I, Creveling CR, Nagatsu T (1986): The presence of catechol-O-methyltransferase activity in separately cultured cerebromicrovascular endothelial and smooth muscle cells. Brain Res 381:363-367.
    • (1986) Brain Res , vol.381 , pp. 363-367
    • Spatz, M.1    Kaneda, N.2    Sumi, C.3    Nagatsu, I.4    Creveling, C.R.5    Nagatsu, T.6
  • 135
    • 0030029826 scopus 로고    scopus 로고
    • Motor fluctuations in levodopa treatment: Clinical pharmacology
    • Stocchi F, Bonamartini A, Vacca L, Ruggieri S (1996): Motor fluctuations in levodopa treatment: Clinical pharmacology. Eur Neurol 36 (Suppl. 1):38-42.
    • (1996) Eur Neurol , vol.36 , Issue.1 SUPPL. , pp. 38-42
    • Stocchi, F.1    Bonamartini, A.2    Vacca, L.3    Ruggieri, S.4
  • 137
    • 0025740329 scopus 로고
    • COMT inhibition with nitecapone does not affect the tyramine pressor response
    • Sundberg S, Gordin A (1991): COMT inhibition with nitecapone does not affect the tyramine pressor response. Br J Clin Pharmacol 32:130-132.
    • (1991) Br J Clin Pharmacol , vol.32 , pp. 130-132
    • Sundberg, S.1    Gordin, A.2
  • 139
    • 0027436117 scopus 로고
    • The effects of the COMT inhibitor entacapone on haemodynamics and peripheral catecholamine metabolism during exercise
    • Sundberg S, Scheinin M, Illi A, Akkila J, Gordin A, Keränen T (1993a): The effects of the COMT inhibitor entacapone on haemodynamics and peripheral catecholamine metabolism during exercise. Br J Clin Pharmacol 36:451-456.
    • (1993) Br J Clin Pharmacol , vol.36 , pp. 451-456
    • Sundberg, S.1    Scheinin, M.2    Illi, A.3    Akkila, J.4    Gordin, A.5    Keränen, T.6
  • 140
    • 0027478136 scopus 로고
    • The effects of the COMT inhibitor nitecapone for one week on exercise haemodynamics and catecholamine disposition
    • Sundberg S, Scheinin M, Ojala-Karlsson P, Akkila J, Gordin A (1993b): The effects of the COMT inhibitor nitecapone for one week on exercise haemodynamics and catecholamine disposition. Eur J Clin Pharmacol 44:287-290.
    • (1993) Eur J Clin Pharmacol , vol.44 , pp. 287-290
    • Sundberg, S.1    Scheinin, M.2    Ojala-Karlsson, P.3    Akkila, J.4    Gordin, A.5
  • 142
    • 0026018261 scopus 로고
    • The significance of 3-O-methyldopa concentrations in the cerebrospinal fluid in the pathogenesis of wearing-off phenomenon in Parkinson's disease
    • Tohgi H, Abe T, Kikuchi T, Takahashi S, Nozaki Y (1991): The significance of 3-O-methyldopa concentrations in the cerebrospinal fluid in the pathogenesis of wearing-off phenomenon in Parkinson's disease. Neurosci Lett 132:19-22.
    • (1991) Neurosci Lett , vol.132 , pp. 19-22
    • Tohgi, H.1    Abe, T.2    Kikuchi, T.3    Takahashi, S.4    Nozaki, Y.5
  • 143
    • 0028979687 scopus 로고
    • Effects of the catechol-O-methyltransferase inhibitor tolcapone in Parkinson's disease: Correlations between concentrations of dopaminergic substances in the plasma and cerebrospinal fluid and clinical improvement
    • Tohgi H, Abe T, Yamazaki K, Saheki M, Takahashi S, Tsukamoto Y (1995): Effects of the catechol-O-methyltransferase inhibitor tolcapone in Parkinson's disease: Correlations between concentrations of dopaminergic substances in the plasma and cerebrospinal fluid and clinical improvement. Neurosci Lett 192:165-168.
    • (1995) Neurosci Lett , vol.192 , pp. 165-168
    • Tohgi, H.1    Abe, T.2    Yamazaki, K.3    Saheki, M.4    Takahashi, S.5    Tsukamoto, Y.6
  • 144
    • 0027522199 scopus 로고
    • Effects of three types of catechol-O-methylation inhibitors on L-3,4-dihydroxyphenylalanine-induced circling behaviour in rats
    • Törnwall M, Männistö PT (1993): Effects of three types of catechol-O-methylation inhibitors on L-3,4-dihydroxyphenylalanine-induced circling behaviour in rats. Eur J Pharmacol 250:77-84.
    • (1993) Eur J Pharmacol , vol.250 , pp. 77-84
    • Törnwall, M.1    Männistö, P.T.2
  • 145
    • 0027000870 scopus 로고
    • Neurochemical and psychomotor interactions of new selective COMT inhibitors with clorgyline and nomifensine in levodopa-treated rats and mice
    • Törnwall M, Tuomainen P, Männistö PT (1992): Neurochemical and psychomotor interactions of new selective COMT inhibitors with clorgyline and nomifensine in levodopa-treated rats and mice. Arch Int Pharmacodyn 320:5-20.
    • (1992) Arch Int Pharmacodyn , vol.320 , pp. 5-20
    • Törnwall, M.1    Tuomainen, P.2    Männistö, P.T.3
  • 146
    • 0029896413 scopus 로고    scopus 로고
    • Validation of assay of catechol-O-methyltransferase activity in human erythrocytes
    • Tuomainen P, Reenila I, Männistö PT (1996): Validation of assay of catechol-O-methyltransferase activity in human erythrocytes. J Pharm Biomed Anal 14:515-523.
    • (1996) J Pharm Biomed Anal , vol.14 , pp. 515-523
    • Tuomainen, P.1    Reenila, I.2    Männistö, P.T.3
  • 148
    • 0016707704 scopus 로고
    • 3-O-Methyldopa inhibition of L-dopa at the blood-brain barrier
    • Wade LA, Katzman R (1975): 3-O-Methyldopa inhibition of L-dopa at the blood-brain barrier. Life Sci 17:131-136.
    • (1975) Life Sci , vol.17 , pp. 131-136
    • Wade, L.A.1    Katzman, R.2
  • 150
    • 0001242395 scopus 로고    scopus 로고
    • Evaluation of the efficacy and safety of tolcapone (Tasmar) in Parkinson's disease patients with a stable response to levodopa
    • Waters CH, Kurth MC, Shulman L, Bailey P, Shale H, Dorflinger E, Yoo K, Shimoun G, Pedder S, and the Tolcapone Stable Study Group (1996): Evaluation of the efficacy and safety of tolcapone (Tasmar) in Parkinson's disease patients with a stable response to levodopa. Neurology 46:A160.
    • (1996) Neurology , vol.46
    • Ch, W.1    Kurth, M.C.2    Shulman, L.3    Bailey, P.4    Shale, H.5    Dorflinger, E.6    Yoo, K.7    Shimoun, G.8    Pedder, S.9
  • 151
    • 0345113906 scopus 로고
    • Improving quality of life in Parkinson's disease: An experimental study of tolcapone
    • Welsh MD, Ved N, Waters CH (1995): Improving quality of life in Parkinson's disease: An experimental study of tolcapone. Qual Life Res 4:503.
    • (1995) Qual Life Res , vol.4 , pp. 503
    • Welsh, M.D.1    Ved, N.2    Waters, C.H.3
  • 152
    • 0027417592 scopus 로고
    • Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans
    • Wikberg T, Vuorela A, Ottoila P, Taskinen J (1993): Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans. Drug Metab Dispos 21:81-92.
    • (1993) Drug Metab Dispos , vol.21 , pp. 81-92
    • Wikberg, T.1    Vuorela, A.2    Ottoila, P.3    Taskinen, J.4
  • 153
    • 0029099867 scopus 로고
    • Selegiline. a review of its clinical efficacy in Parkinson's disease and its clinical potential in Alzheimer's disease
    • Wiseman LR, McTavish D (1995): Selegiline. A review of its clinical efficacy in Parkinson's disease and its clinical potential in Alzheimer's disease. CNS Drugs 4:230-246.
    • (1995) CNS Drugs , vol.4 , pp. 230-246
    • Wiseman, L.R.1    McTavish, D.2
  • 155
    • 0025657620 scopus 로고
    • Ro 40-7592: Inhibition of COMT in rat brain and extracerebral tissues
    • Zürcher G, Colzi A, Da Prada M (1990a): Ro 40-7592: Inhibition of COMT in rat brain and extracerebral tissues. J Neural Transm 32:375-380.
    • (1990) J Neural Transm , vol.32 , pp. 375-380
    • Zürcher, G.1    Colzi, A.2    Da Prada, M.3
  • 156
    • 0025157730 scopus 로고
    • Ro 40-7592, a novel, very potent and orally active inhibitor of catechol-O-methyltransferase: A pharmacological study in rats
    • Zürcher G, Keller HH, Kettler R, Borgulya J, Bonetti EP, Eigenmann R, Da Prada M (1990b): Ro 40-7592, a novel, very potent and orally active inhibitor of catechol-O-methyltransferase: A pharmacological study in rats. Adv Neurol 53:497-503.
    • (1990) Adv Neurol , vol.53 , pp. 497-503
    • Zürcher, G.1    Keller, H.H.2    Kettler, R.3    Borgulya, J.4    Bonetti, E.P.5    Eigenmann, R.6    Da Prada, M.7
  • 157
    • 0002623505 scopus 로고
    • Ro 40-7592, a potent inhibitor of extracerebral and brain catechol-O-methyltransferase: Preclinical and clinical findings
    • Agnoli A, Campanella G (eds): Rome: John Libbey
    • Zürcher G, Dingemanse J, Da Prada M (1991): Ro 40-7592, a potent inhibitor of extracerebral and brain catechol-O-methyltransferase: Preclinical and clinical findings. In Agnoli A, Campanella G (eds): New Developments in Therapy of Parkinson's Disease. Rome: John Libbey, pp 37-43.
    • (1991) New Developments in Therapy of Parkinson's Disease , pp. 37-43
    • Zürcher, G.1    Dingemanse, J.2    Da Prada, M.3
  • 158
    • 0027354116 scopus 로고
    • Potent COMT inhibition by Ro 40-7592 in the periphery and in the brain-preclinical and clinical findings
    • Zürcher G, Dingemanse J, Da Prada M (1993): Potent COMT inhibition by Ro 40-7592 in the periphery and in the brain-preclinical and clinical findings. Adv Neurol 60:641-647.
    • (1993) Adv Neurol , vol.60 , pp. 641-647
    • Zürcher, G.1    Dingemanse, J.2    Da Prada, M.3
  • 159
    • 0030059823 scopus 로고    scopus 로고
    • Assessment of catechol-O-methyltransferase activity and its inhibition in erythrocytes of animals and humans
    • Zürcher G, Da Prada M, Dingemanse J (1996): Assessment of catechol-O-methyltransferase activity and its inhibition in erythrocytes of animals and humans. Biomed Chromatogr 10:32-36.
    • (1996) Biomed Chromatogr , vol.10 , pp. 32-36
    • Zürcher, G.1    Da Prada, M.2    Dingemanse, J.3


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