메뉴 건너뛰기




Volumn 59, Issue 6, 2000, Pages 1233-1250

Clinical pharmacology, therapeutic use and potential of COMT inhibitors in Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; CATECHOL METHYLTRANSFERASE INHIBITOR; CHOLINERGIC RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; ENTACAPONE; LEVODOPA; SELEGILINE; TOLCAPONE;

EID: 0034095886     PISSN: 00126667     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003495-200059060-00004     Document Type: Review
Times cited : (172)

References (109)
  • 1
    • 0001077883 scopus 로고
    • O-methylation of epinephrine and other catechols in vitro and in vivo
    • 1. Axelrod J. O-methylation of epinephrine and other catechols in vitro and in vivo. Science 1957; 126: 400-1
    • (1957) Science , vol.126 , pp. 400-401
    • Axelrod, J.1
  • 2
    • 0016829492 scopus 로고
    • Catechol-O-methyl transferase: Pharmacological aspects and physiological role
    • 2. Guldberg HC, Marsden CA. Catechol-O-methyl transferase: pharmacological aspects and physiological role. Pharmacol Rev 1975; 27: 135-206
    • (1975) Pharmacol Rev , vol.27 , pp. 135-206
    • Guldberg, H.C.1    Marsden, C.A.2
  • 3
    • 0015144507 scopus 로고
    • Potentiation of the L-dopa effect in man by the use of catechol-O-methyltransferase inhibitors
    • 3. Ericsson AD. Potentiation of the L-dopa effect in man by the use of catechol-O-methyltransferase inhibitors. J Neurol Sci 1971; 14: 193-7
    • (1971) J Neurol Sci , vol.14 , pp. 193-197
    • Ericsson, A.D.1
  • 4
    • 0021297243 scopus 로고
    • Catechol-O-methyltransferase and Parkinson's disease
    • 4. Reches A, Fahn S. Catechol-O-methyltransferase and Parkinson's disease. Adv Neurol 1984; 40: 171-9
    • (1984) Adv Neurol , vol.40 , pp. 171-179
    • Reches, A.1    Fahn, S.2
  • 5
    • 0025039417 scopus 로고
    • Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease
    • 5. Männistö PT, Kaakkola S. Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease. Pharmacol Toxicol 1990; 66: 317-23
    • (1990) Pharmacol Toxicol , vol.66 , pp. 317-323
    • Männistö, P.T.1    Kaakkola, S.2
  • 6
    • 0004445130 scopus 로고
    • Catechol-O-methyltransferase (COMT) and COMT inhibitors
    • Sandler M, Smith J, editors. Oxford: Oxford University Press
    • 6. Männistö PT, Ulmanen I, Taskinen J, et al. Catechol-O-methyltransferase (COMT) and COMT inhibitors, In: Sandler M, Smith J, editors. Design of enzyme inhibitors as drugs. Oxford: Oxford University Press, 1993; 623-46
    • (1993) Design of Enzyme Inhibitors as Drugs , pp. 623-646
    • Männistö, P.T.1    Ulmanen, I.2    Taskinen, J.3
  • 7
    • 0027935135 scopus 로고
    • General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase
    • 7. Kaakkola S, Gordin A, Männistö PT. General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase. Gen Pharmacol 1994; 25: 813-24
    • (1994) Gen Pharmacol , vol.25 , pp. 813-824
    • Kaakkola, S.1    Gordin, A.2    Männistö, P.T.3
  • 8
    • 0013675681 scopus 로고
    • Human pharmacokinetics of OR-462, a new catechol-O-methyltransferase inhibitor
    • 8. Pentikäinen PJ, Vuorela A, Järvinen M, et al. Human pharmacokinetics of OR-462, a new catechol-O-methyltransferase inhibitor. Eur J Clin Pharmacol 1989; 36 Suppl.: A110
    • (1989) Eur J Clin Pharmacol , vol.36 , Issue.SUPPL.
    • Pentikäinen, P.J.1    Vuorela, A.2    Järvinen, M.3
  • 9
    • 0025046088 scopus 로고
    • Effect of a novel catechol-O-methyltransferase inhibitor, nitecapone, on the metabolism of L-dopa in healthy volunteers
    • 9. Kaakkola S, Gordin A, Järvinen M, et al. Effect of a novel catechol-O-methyltransferase inhibitor, nitecapone, on the metabolism of L-dopa in healthy volunteers. Clin Neuropharmacol 1990; 13: 436-47
    • (1990) Clin Neuropharmacol , vol.13 , pp. 436-447
    • Kaakkola, S.1    Gordin, A.2    Järvinen, M.3
  • 10
    • 0025619387 scopus 로고
    • Effect of the new selective COMT inhibitor CGP28014 A on the formation of 3-O-methyldopa (3OMD) in plasma of healthy subjects
    • 10. Bieck PR, Nilsson E, Antonin KH. Effect of the new selective COMT inhibitor CGP28014 A on the formation of 3-O-methyldopa (3OMD) in plasma of healthy subjects. J Neural Transm Suppl 1990; 32: 387-91
    • (1990) J Neural Transm Suppl , vol.32 , pp. 387-391
    • Bieck, P.R.1    Nilsson, E.2    Antonin, K.H.3
  • 11
    • 0027140027 scopus 로고
    • Clinical pharmacology of the new COMT inhibitor CGP 28,014
    • 11. Bieck PR, Antonin KH, Farger G, et al. Clinical pharmacology of the new COMT inhibitor CGP 28,014. Neurochem Res 1993; 18: 1163-7
    • (1993) Neurochem Res , vol.18 , pp. 1163-1167
    • Bieck, P.R.1    Antonin, K.H.2    Farger, G.3
  • 12
    • 0017684305 scopus 로고
    • Does O-methyl-dopa play a role in levodopa-induced dyskinesias?
    • 12. Feuerstein C, Tanche M, Serre F, et al. Does O-methyl-dopa play a role in levodopa-induced dyskinesias? Acta Neurol Scand 1977; 56: 79-82
    • (1977) Acta Neurol Scand , vol.56 , pp. 79-82
    • Feuerstein, C.1    Tanche, M.2    Serre, F.3
  • 13
    • 0017348146 scopus 로고
    • The clinical picture and plasma levodopa metabolite profile of parkinsonian nonresponders. Treatment with levodopa and decarboxylase inhibitor
    • 13. Rivera-Calimlim L, Tandon D, Anderson F, et al. The clinical picture and plasma levodopa metabolite profile of parkinsonian nonresponders. Treatment with levodopa and decarboxylase inhibitor. Arch Neurol 1977; 34: 228-32
    • (1977) Arch Neurol , vol.34 , pp. 228-232
    • Rivera-Calimlim, L.1    Tandon, D.2    Anderson, F.3
  • 14
    • 0026018261 scopus 로고
    • The significance of 3-O-methyldopa concentrations in the cerebrospinal fluid in the pathogenesis of wearing-off phenomenon in Parkinson's disease
    • 14. Tohgi H, Abe T, Kikuchi T, et al. The significance of 3-O-methyldopa concentrations in the cerebrospinal fluid in the pathogenesis of wearing-off phenomenon in Parkinson's disease. Neurosci Lett 1991; 132: 19-22
    • (1991) Neurosci Lett , vol.132 , pp. 19-22
    • Tohgi, H.1    Abe, T.2    Kikuchi, T.3
  • 15
    • 0016707704 scopus 로고
    • 3-O-Methyldopa uptake and inhibition of L-dopa at the blood-brain barrier
    • 15. Wade LA, Katzman R. 3-O-Methyldopa uptake and inhibition of L-dopa at the blood-brain barrier. Life Sci 1975; 17: 131-6
    • (1975) Life Sci , vol.17 , pp. 131-136
    • Wade, L.A.1    Katzman, R.2
  • 16
    • 0015814692 scopus 로고
    • Evidence for the methylation of apomorphine by catechol-O-methyl-transferase in vivo and in vitro
    • 16. McKenzie GM, White HL. Evidence for the methylation of apomorphine by catechol-O-methyl-transferase in vivo and in vitro. Biochem Pharmacol 1973; 22: 2329-36
    • (1973) Biochem Pharmacol , vol.22 , pp. 2329-2336
    • McKenzie, G.M.1    White, H.L.2
  • 17
    • 0016827885 scopus 로고
    • Effect of catechol-O-methyl-transferase inhibitors on brain apomorphine concentrations and stereotyped behaviour in the rat
    • 17. Symes AL, Lal S, Sourkes TL. Effect of catechol-O-methyl-transferase inhibitors on brain apomorphine concentrations and stereotyped behaviour in the rat. J Pharm Pharmacol 1975; 27: 947-9
    • (1975) J Pharm Pharmacol , vol.27 , pp. 947-949
    • Symes, A.L.1    Lal, S.2    Sourkes, T.L.3
  • 18
    • 0030939067 scopus 로고    scopus 로고
    • Effect of tolcapone on plasma and striatal apomorphine disposition in rats
    • 18. Coudore F, Durif F, Duroux E, et al. Effect of tolcapone on plasma and striatal apomorphine disposition in rats. Neuroreport 1997; 8: 877-80
    • (1997) Neuroreport , vol.8 , pp. 877-880
    • Coudore, F.1    Durif, F.2    Duroux, E.3
  • 19
    • 0027221613 scopus 로고
    • Dihydrexidine: A new potent peripheral dopamine D1 receptor agonist
    • 19. Kohli JD, Horn PT, Glock D, et al. Dihydrexidine: a new potent peripheral dopamine D1 receptor agonist. Eur J Pharmacol 1993; 235: 31-5
    • (1993) Eur J Pharmacol , vol.235 , pp. 31-35
    • Kohli, J.D.1    Horn, P.T.2    Glock, D.3
  • 20
    • 0028203007 scopus 로고
    • Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone
    • 20. Keränen T, Gordin A, Karlsson M, et al. Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone. Eur J Clin Pharmacol 1994; 46: 151-7
    • (1994) Eur J Clin Pharmacol , vol.46 , pp. 151-157
    • Keränen, T.1    Gordin, A.2    Karlsson, M.3
  • 21
    • 0029044201 scopus 로고
    • Integrated pharmacokinetics and pharmacodynamics of the novel catechol-O-methyltransferase inhibitor tolcapone during first administration to humans
    • 21. Dingemanse J, Jorga KM, Schmitt M, et al. Integrated pharmacokinetics and pharmacodynamics of the novel catechol-O-methyltransferase inhibitor tolcapone during first administration to humans. Clin Pharmacol Ther 1995; 57: 508-17
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 508-517
    • Dingemanse, J.1    Jorga, K.M.2    Schmitt, M.3
  • 22
    • 85037969188 scopus 로고
    • Pharmacokinetics of entacapone, a new COMT-inhibitor, in man: A study using stable isotope technique
    • 22. Heikkinen H, Pentikäinen PJ, Saraheimo M, et al. Pharmacokinetics of entacapone, a new COMT-inhibitor, in man: a study using stable isotope technique. New Trends Clin Neuropharm 1994; 8: 301
    • (1994) New Trends Clin Neuropharm , vol.8 , pp. 301
    • Heikkinen, H.1    Pentikäinen, P.J.2    Saraheimo, M.3
  • 23
    • 0031855536 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics after oral and intravenous administration of tolcapone, a novel adjunct to Parkinson's disease therapy
    • 23. Jorga KM, Fotteler B, Heizmann P, et al. Pharmacokinetics and pharmacodynamics after oral and intravenous administration of tolcapone, a novel adjunct to Parkinson's disease therapy. Eur J Clin Pharmacol 1998; 54: 443-7
    • (1998) Eur J Clin Pharmacol , vol.54 , pp. 443-447
    • Jorga, K.M.1    Fotteler, B.2    Heizmann, P.3
  • 24
    • 0027417592 scopus 로고
    • Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans
    • 24. Wikberg T, Vuorela A, Ottoila P, et al. Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans. Drug Metab Dispos 1993; 21 : 81-92
    • (1993) Drug Metab Dispos , vol.21 , pp. 81-92
    • Wikberg, T.1    Vuorela, A.2    Ottoila, P.3
  • 25
    • 85037952140 scopus 로고    scopus 로고
    • Basel: F. Hoffman-La Roche Ltd
    • 25. F. Hoffman-La Roche Ltd. Product monograph Tasmar. Basel: F. Hoffman-La Roche Ltd, 1997: 1-60
    • (1997) Product Monograph Tasmar , pp. 1-60
  • 26
    • 0028907751 scopus 로고
    • Improved therapy of Parkinson's disease with tolcapone, a central and peripheral COMT inhibitor with an S-adenosyl-L-methionine-sparing effect
    • 26. Da Prada M, Borgulya J, Napolitano A, et al. Improved therapy of Parkinson's disease with tolcapone, a central and peripheral COMT inhibitor with an S-adenosyl-L-methionine-sparing effect. Clin Neuropharmacol 1995; 17: S26-S37
    • (1995) Clin Neuropharmacol , vol.17
    • Da Prada, M.1    Borgulya, J.2    Napolitano, A.3
  • 27
    • 0030005858 scopus 로고    scopus 로고
    • Multiple-dose clinical pharmacology of the catechol-O-methyl-transferase inhibitor tolcapone in elderly subjects
    • 27. Dingemanse J, Jorga K, Zürcher G, et al. Multiple-dose clinical pharmacology of the catechol-O-methyl-transferase inhibitor tolcapone in elderly subjects. Eur J Clin Pharmacol 1996; 50: 47-55
    • (1996) Eur J Clin Pharmacol , vol.50 , pp. 47-55
    • Dingemanse, J.1    Jorga, K.2    Zürcher, G.3
  • 28
    • 0013680849 scopus 로고    scopus 로고
    • Tolcapone does not change the pharmacokinetics and pharmacodynamics of the CYP2C9 substrate tolbutamide
    • 28. Jorga K, Fotteler B, Wiegand U. Tolcapone does not change the pharmacokinetics and pharmacodynamics of the CYP2C9 substrate tolbutamide. Mov Disord 1997; 12 Suppl. 1: 100
    • (1997) Mov Disord , vol.12 , Issue.SUPPL. 1 , pp. 100
    • Jorga, K.1    Fotteler, B.2    Wiegand, U.3
  • 29
    • 0001086381 scopus 로고    scopus 로고
    • Pharmacokinetics of entacapone and catechol-O-methyltransferase (COMT) inhibition after frequent multiple dosing of entacapone and effect on levodopa metabolism
    • 29. Gordin A, Huupponen R, Rouru J, et al. Pharmacokinetics of entacapone and catechol-O-methyltransferase (COMT) inhibition after frequent multiple dosing of entacapone and effect on levodopa metabolism. Eur J Neurol 1998; 5 Suppl. 3: S165-S6
    • (1998) Eur J Neurol , vol.5 , Issue.SUPPL. 3
    • Gordin, A.1    Huupponen, R.2    Rouru, J.3
  • 30
    • 0030876269 scopus 로고    scopus 로고
    • Optimizing levodopa pharmacokinetics with multiple tolcapone doses in the elderly
    • 30. Jorga KM, Sedek G, Fotteler B, et al. Optimizing levodopa pharmacokinetics with multiple tolcapone doses in the elderly. Clin Pharmacol Ther 1997; 62: 300-10
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 300-310
    • Jorga, K.M.1    Sedek, G.2    Fotteler, B.3
  • 31
    • 0029150356 scopus 로고
    • Pharmacokinetic-pharmacodynamic interaction between the COMT inhibitor tolcapone and single-dose levodopa
    • 31. Dingemanse J, Jorga K, Zürcher G, et al. Pharmacokinetic-pharmacodynamic interaction between the COMT inhibitor tolcapone and single-dose levodopa. Br J Clin Pharmacol 1995; 40: 253-62
    • (1995) Br J Clin Pharmacol , vol.40 , pp. 253-262
    • Dingemanse, J.1    Jorga, K.2    Zürcher, G.3
  • 32
    • 0013674924 scopus 로고    scopus 로고
    • Why should tolcapone be given at a lower dose to patients with liver cirrhosis?
    • 32. Jorga K, Fotteler B, van Brummelen P. Why should tolcapone be given at a lower dose to patients with liver cirrhosis? Clin Pharmacol Ther 1997; 61: 183
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 183
    • Jorga, K.1    Fotteler, B.2    Van Brummelen, P.3
  • 33
    • 0000687029 scopus 로고    scopus 로고
    • Pharmacokinetics of the COMT inhibitor entacapone in liver failure and the effect of entacapone on liver function
    • 33. Gordin A, Pentikäinen PP, Mäkimartti M, et al. Pharmacokinetics of the COMT inhibitor entacapone in liver failure and the effect of entacapone on liver function. Neurology 1998; 50 Suppl. 4: A387
    • (1998) Neurology , vol.50 , Issue.SUPPL. 4
    • Gordin, A.1    Pentikäinen, P.P.2    Mäkimartti, M.3
  • 35
    • 0024388924 scopus 로고
    • Inhibition of rat liver and duodenum soluble catechol-O-methyltransferase by a tight-binding inhibitor OR-462
    • 35. Schultz E, Nissinen E. Inhibition of rat liver and duodenum soluble catechol-O-methyltransferase by a tight-binding inhibitor OR-462. Biochem Pharmacol 1989; 38: 3953-6
    • (1989) Biochem Pharmacol , vol.38 , pp. 3953-3956
    • Schultz, E.1    Nissinen, E.2
  • 36
    • 0028918413 scopus 로고
    • Kinetics of human soluble and membrane-bound catechol O-methyltransferase: A revised mechanism and description of the thermolabile variant of the enzyme
    • 36. Lotta T, Vidgren J, Tilgmann C, et al. Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 1995; 34: 4202-10
    • (1995) Biochemistry , vol.34 , pp. 4202-4210
    • Lotta, T.1    Vidgren, J.2    Tilgmann, C.3
  • 37
    • 0030746313 scopus 로고    scopus 로고
    • Studies on the tight-binding nature of tolcapone inhibition of soluble and membrane-bound rat brain catechol-O-methyltransferase
    • 37. Borges N, Vieira-Coelho MA, Parada A, et al. Studies on the tight-binding nature of tolcapone inhibition of soluble and membrane-bound rat brain catechol-O-methyltransferase. J Pharmacol Exp Ther 1997; 282: 812-7
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 812-817
    • Borges, N.1    Vieira-Coelho, M.A.2    Parada, A.3
  • 38
    • 0027514196 scopus 로고
    • The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers
    • 38. Keränen T, Gordin A, Harjola VP, et al. The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers. Clin Neuropharmacol 1993; 16: 145-56
    • (1993) Clin Neuropharmacol , vol.16 , pp. 145-156
    • Keränen, T.1    Gordin, A.2    Harjola, V.P.3
  • 39
    • 0030859712 scopus 로고    scopus 로고
    • Effect of tolcapone on plasma levodopa concentrations after coadministration with levodopa/carbidopa to healthy volunteers
    • 39. Sêdek G, Jorga K, Schmitt M, et al. Effect of tolcapone on plasma levodopa concentrations after coadministration with levodopa/carbidopa to healthy volunteers. Clin Neuropharmacol 1997; 20: 531-41
    • (1997) Clin Neuropharmacol , vol.20 , pp. 531-541
    • Sêdek, G.1    Jorga, K.2    Schmitt, M.3
  • 40
    • 0030845466 scopus 로고    scopus 로고
    • The effect of COMT inhibition by tolcapone on tolerability and pharmacokinetics of different levodopa/benserazide formulations
    • 40. Jorga K, Fotteler B, Schmitt M, et al. The effect of COMT inhibition by tolcapone on tolerability and pharmacokinetics of different levodopa/benserazide formulations. Eur Neurol 1997; 38: 59-67
    • (1997) Eur Neurol , vol.38 , pp. 59-67
    • Jorga, K.1    Fotteler, B.2    Schmitt, M.3
  • 41
    • 0013693059 scopus 로고    scopus 로고
    • Effect of entacapone as an adjunct to Sinemet and Madopar on the pharmacokinetics of levodopa in parkinsonian patients
    • 41. Myllylä VV, Sotaniemi KA, Mäkimartti M, et al. Effect of entacapone as an adjunct to Sinemet and Madopar on the pharmacokinetics of levodopa in parkinsonian patients. Mov Disord 1997; 12 Suppl. 1: 103
    • (1997) Mov Disord , vol.12 , Issue.SUPPL. 1 , pp. 103
    • Myllylä, V.V.1    Sotaniemi, K.A.2    Mäkimartti, M.3
  • 42
    • 0031899068 scopus 로고    scopus 로고
    • The effect of tolcapone on levodopa pharmacokinetics is independent of levodopa/carbidopa formulation
    • 42. Jorga K, Fotteler B, Sedek G, et al. The effect of tolcapone on levodopa pharmacokinetics is independent of levodopa/carbidopa formulation. J Neurol 1998; 245: 223-30
    • (1998) J Neurol , vol.245 , pp. 223-230
    • Jorga, K.1    Fotteler, B.2    Sedek, G.3
  • 43
    • 0028891614 scopus 로고
    • Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers
    • 43. Ahtila S, Kaakkola S, Gordin A, et al. Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers. Clin Neuropharmacol 1995; 18: 46-57
    • (1995) Clin Neuropharmacol , vol.18 , pp. 46-57
    • Ahtila, S.1    Kaakkola, S.2    Gordin, A.3
  • 44
    • 0029895288 scopus 로고    scopus 로고
    • A double-blind pharmacokinetic and clinical dose-response study of entacapone as an adjuvant to levodopa therapy in advanced Parkinson's disease
    • 44. Ruottinen HM, Rinne UK. A double-blind pharmacokinetic and clinical dose-response study of entacapone as an adjuvant to levodopa therapy in advanced Parkinson's disease. Clin Neuropharmacol 1996; 19: 283-96
    • (1996) Clin Neuropharmacol , vol.19 , pp. 283-296
    • Ruottinen, H.M.1    Rinne, U.K.2
  • 45
    • 0029881772 scopus 로고    scopus 로고
    • Effect of one month's treatment with peripherally acting catechol-O-methyltransferase inhibitor, entacapone, on pharmacokinetics and motor response to levodopa in advanced parkinsonian patients
    • 45. Ruottinen HM, Rinne UK. Effect of one month's treatment with peripherally acting catechol-O-methyltransferase inhibitor, entacapone, on pharmacokinetics and motor response to levodopa in advanced parkinsonian patients. Clin Neuropharmacol 1996; 19: 222-33
    • (1996) Clin Neuropharmacol , vol.19 , pp. 222-233
    • Ruottinen, H.M.1    Rinne, U.K.2
  • 46
    • 0027445460 scopus 로고
    • Effect of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease
    • 46. Myllylä VV, Sotaniemi KA, Illi A, et al. Effect of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease. Eur J Clin Pharmacol 1993; 45: 419-23
    • (1993) Eur J Clin Pharmacol , vol.45 , pp. 419-423
    • Myllylä, V.V.1    Sotaniemi, K.A.2    Illi, A.3
  • 47
    • 0028286186 scopus 로고
    • Effect of peripheral catechol-O-methyltransferase inhibition on the pharmacokinetics and pharmacodynamics of levodopa in parkinsonian patients
    • 47. Nutt JG, Woodward WR, Beckner RM, et al. Effect of peripheral catechol-O-methyltransferase inhibition on the pharmacokinetics and pharmacodynamics of levodopa in parkinsonian patients. Neurology 1994; 44: 913-9
    • (1994) Neurology , vol.44 , pp. 913-919
    • Nutt, J.G.1    Woodward, W.R.2    Beckner, R.M.3
  • 48
    • 0028979687 scopus 로고
    • Effects of the catechol-O-methyltransferase inhibitor tolcapone in Parkinson's disease: Correlations between concentrations of dopaminergic substances in the plasma and cerebrospinal fluid and clinical improvement
    • 48. Tohgi H, Abe T, Yamazaki K, et al. Effects of the catechol-O-methyltransferase inhibitor tolcapone in Parkinson's disease: correlations between concentrations of dopaminergic substances in the plasma and cerebrospinal fluid and clinical improvement. Neurosci Lett 1995; 192: 165-8
    • (1995) Neurosci Lett , vol.192 , pp. 165-168
    • Tohgi, H.1    Abe, T.2    Yamazaki, K.3
  • 49
    • 0027770982 scopus 로고
    • Catechol-O-methyltransferase inhibitor tolcapone prolongs levodopa/carbidopa action in parkinsonian patients
    • 49. Roberts JW, Cora-Locatelli G, Bravi D, et al. Catechol-O-methyltransferase inhibitor tolcapone prolongs levodopa/carbidopa action in parkinsonian patients. Neurology 1993; 43: 2685-8
    • (1993) Neurology , vol.43 , pp. 2685-2688
    • Roberts, J.W.1    Cora-Locatelli, G.2    Bravi, D.3
  • 50
    • 0029021182 scopus 로고
    • Acute administration of levodopa-benserazide and tolcapone, a COMT inhibitor, Parkinson's disease
    • 50. Limousin P, Pollak P, Pfefen JP, et al. Acute administration of levodopa-benserazide and tolcapone, a COMT inhibitor, Parkinson's disease. Clin Neuropharmacol 1995; 18: 258-65
    • (1995) Clin Neuropharmacol , vol.18 , pp. 258-265
    • Limousin, P.1    Pollak, P.2    Pfefen, J.P.3
  • 51
    • 0030946439 scopus 로고    scopus 로고
    • Effects of tolcapone, a catechol-O-methyltransferase inhibitor, on motor symptoms and pharmacokinetics of levodopa in patients with Parkinson's disease
    • 51. Yamamoto M, Yokochi M, Kuno S, et al. Effects of tolcapone, a catechol-O-methyltransferase inhibitor, on motor symptoms and pharmacokinetics of levodopa in patients with Parkinson's disease. J Neural Transm 1997; 104: 229-36
    • (1997) J Neural Transm , vol.104 , pp. 229-236
    • Yamamoto, M.1    Yokochi, M.2    Kuno, S.3
  • 52
    • 85005235624 scopus 로고
    • Entacapone in combination with standard or controlled-release levodopa/carbidopa: A clinical and pharmacokinetic study in patients with Parkinson's disease
    • 52. Kaakkola S, Teräväinen H, Ahtila S, et al. Entacapone in combination with standard or controlled-release levodopa/carbidopa: a clinical and pharmacokinetic study in patients with Parkinson's disease. Eur J Neurol 1995; 2: 341-7
    • (1995) Eur J Neurol , vol.2 , pp. 341-347
    • Kaakkola, S.1    Teräväinen, H.2    Ahtila, S.3
  • 53
    • 0015089408 scopus 로고
    • The metabolism of L-3-O-methyldopa, a precursor of dopa in man
    • 53. Kuruma I, Bartholini G, Tissot R, et al. The metabolism of L-3-O-methyldopa, a precursor of dopa in man. Clin Pharmacol Ther 1971; 12: 678-82
    • (1971) Clin Pharmacol Ther , vol.12 , pp. 678-682
    • Kuruma, I.1    Bartholini, G.2    Tissot, R.3
  • 54
    • 0030042649 scopus 로고    scopus 로고
    • Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients with levodopa related fluctuations
    • 54. Ruottinen HM, Rinne UK. Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients with levodopa related fluctuations. J Neurol Neurosurg Psychiatry 1996; 60: 36-40
    • (1996) J Neurol Neurosurg Psychiatry , vol.60 , pp. 36-40
    • Ruottinen, H.M.1    Rinne, U.K.2
  • 55
    • 0027436117 scopus 로고
    • The effects of the COMT inhibitor entacapone on haemodynamics and peripheral catecholamine metabolism during exercise
    • 55. Sundberg S, Scheinin M, Illi A, et al. The effects of the COMT inhibitor entacapone on haemodynamics and peripheral catecholamine metabolism during exercise. Br J Clin Pharmacol 1993; 36: 451-6
    • (1993) Br J Clin Pharmacol , vol.36 , pp. 451-456
    • Sundberg, S.1    Scheinin, M.2    Illi, A.3
  • 56
    • 0028046134 scopus 로고
    • COMT inhibition by high-dose entacapone does not affect hemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise
    • 56. Illi A, Sundberg S, Koulu M, et al. COMT inhibition by high-dose entacapone does not affect hemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise. Int J Clin Pharmacol Ther 1994; 32: 582-8
    • (1994) Int J Clin Pharmacol Ther , vol.32 , pp. 582-588
    • Illi, A.1    Sundberg, S.2    Koulu, M.3
  • 57
    • 0027354116 scopus 로고
    • Potent COMT inhibition by Ro 40-7592 in the periphery and in the brain. Preclinical and clinical findings
    • 57. Zürcher G, Dingemanse J, Da Prada M. Potent COMT inhibition by Ro 40-7592 in the periphery and in the brain. Preclinical and clinical findings. Adv Neurol 1993; 60: 641-7
    • (1993) Adv Neurol , vol.60 , pp. 641-647
    • Zürcher, G.1    Dingemanse, J.2    Da Prada, M.3
  • 58
    • 0030818266 scopus 로고    scopus 로고
    • Simultaneous MAO-B and COMT inhibition in L-dopa-treated patients with Parkinson's disease
    • 58. Lyytinen J, Kaakkola S, Ahtila S, et al. Simultaneous MAO-B and COMT inhibition in L-dopa-treated patients with Parkinson's disease. Mov Disord 1997; 12: 497-505
    • (1997) Mov Disord , vol.12 , pp. 497-505
    • Lyytinen, J.1    Kaakkola, S.2    Ahtila, S.3
  • 59
    • 0013695875 scopus 로고    scopus 로고
    • Elevated serum levels of dihydroxyphenylacetic acid (DOPAC) and dopamine after catechol-O-methyltransferase (COMT) inhibition
    • 59. Oechsner M, Stürenburg HJ, Buhmann C, et al. Elevated serum levels of dihydroxyphenylacetic acid (DOPAC) and dopamine after catechol-O-methyltransferase (COMT) inhibition. Eur J Neurol 1998; 5 Suppl. 3: S169
    • (1998) Eur J Neurol , vol.5 , Issue.SUPPL. 3
    • Oechsner, M.1    Stürenburg, H.J.2    Buhmann, C.3
  • 60
    • 0029091101 scopus 로고
    • Acute effects of COMT inhibition on L-DOPA pharmacokinetics in patients treated with carbidopa and selegiline
    • 60. Davis TL, Roznoski M, Burns RS. Acute effects of COMT inhibition on L-DOPA pharmacokinetics in patients treated with carbidopa and selegiline. Clin Neuropharmacol 1995; 18: 333-7
    • (1995) Clin Neuropharmacol , vol.18 , pp. 333-337
    • Davis, T.L.1    Roznoski, M.2    Burns, R.S.3
  • 62
    • 0023819043 scopus 로고
    • Metabolites of 6-[18F]fluoro-L-dopa in human blood
    • 62. Firnau G, Sood S, Chirakal R, et al. Metabolites of 6-[18F]fluoro-L-dopa in human blood. J Nucl Med 1988; 29: 363-9
    • (1988) J Nucl Med , vol.29 , pp. 363-369
    • Firnau, G.1    Sood, S.2    Chirakal, R.3
  • 63
    • 0023484630 scopus 로고
    • Cerebral metabolism of 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine in the primate
    • 63. Firnau G, Sood S, Chirakal R, et al. Cerebral metabolism of 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine in the primate. J Neurochem 1987; 48: 1077-82
    • (1987) J Neurochem , vol.48 , pp. 1077-1082
    • Firnau, G.1    Sood, S.2    Chirakal, R.3
  • 64
    • 0013675458 scopus 로고
    • OR-611 inhibits 3-Omethyldopa formation in primates
    • 64. Guttman M, Leger G, Cedarbaum JM. OR-611 inhibits 3-Omethyldopa formation in primates. Neurology 1991; 41: 213
    • (1991) Neurology , vol.41 , pp. 213
    • Guttman, M.1    Leger, G.2    Cedarbaum, J.M.3
  • 65
    • 0028862753 scopus 로고
    • Positron emission tomography in drug evaluation: Influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-L-dopa in rhesus monkey
    • 65. Günther I, Psylla M, Reddy GN, et al. Positron emission tomography in drug evaluation: influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-L-dopa in rhesus monkey. Nucl Med Biol 1995; 22: 921-7
    • (1995) Nucl Med Biol , vol.22 , pp. 921-927
    • Günther, I.1    Psylla, M.2    Reddy, G.N.3
  • 66
    • 0031005861 scopus 로고    scopus 로고
    • Effects of catechol-O-methyltransferase inhibition on the rates of uptake and reversibility of 6-fluoro-L-dopa trapping in MPTP-induced parkinsonism in monkeys
    • 66. Doudet DJ, Chan GL, Holden JE, et al. Effects of catechol-O-methyltransferase inhibition on the rates of uptake and reversibility of 6-fluoro-L-dopa trapping in MPTP-induced parkinsonism in monkeys. Neuropharmacology 1997; 36: 363-71
    • (1997) Neuropharmacology , vol.36 , pp. 363-371
    • Doudet, D.J.1    Chan, G.L.2    Holden, J.E.3
  • 67
    • 0030613624 scopus 로고    scopus 로고
    • Cerebral 6-[18F]fluoro-L-DOPA uptake in rhesus monkey: Pharmacological influence of aromatic amino acid decarboxylase (AAAD) and catechol-O-methyltransferase (COMT) inhibition
    • 67. Psylla M, Günther I, Antonini A, et al. Cerebral 6-[18F]fluoro-L-DOPA uptake in rhesus monkey: pharmacological influence of aromatic amino acid decarboxylase (AAAD) and catechol-O-methyltransferase (COMT) inhibition. Brain Res 1997; 767: 45-54
    • (1997) Brain Res , vol.767 , pp. 45-54
    • Psylla, M.1    Günther, I.2    Antonini, A.3
  • 68
    • 9844233705 scopus 로고    scopus 로고
    • Graphical analysis of 6-fluoro-L-dopa trapping: Effect of inhibition of catechol-O-methyltransferase
    • 68. Holden JE, Doudet D, Endres CJ, et al. Graphical analysis of 6-fluoro-L-dopa trapping: effect of inhibition of catechol-O-methyltransferase. J Nucl Med 1997; 38: 1568-74
    • (1997) J Nucl Med , vol.38 , pp. 1568-1574
    • Holden, J.E.1    Doudet, D.2    Endres, C.J.3
  • 69
    • 0026609925 scopus 로고
    • [18F]-6-fluorodopa PET scanning in Parkinson's disease after selective COMT inhibition with nitecapone (OR-462)
    • 69. Laihinen A, Rinne JO, Rinne UK, et al. [18F]-6-fluorodopa PET scanning in Parkinson's disease after selective COMT inhibition with nitecapone (OR-462). Neurology 1992; 42: 199-203
    • (1992) Neurology , vol.42 , pp. 199-203
    • Laihinen, A.1    Rinne, J.O.2    Rinne, U.K.3
  • 70
    • 0028128512 scopus 로고
    • The effect of entacapone (OR-611) on brain [18F]-6-L-fluorodopa metabolism: Implications for levodopa therapy of Parkinson's disease
    • 70. Sawle GV, Burn DJ, Morrish PK, et al. The effect of entacapone (OR-611) on brain [18F]-6-L-fluorodopa metabolism: implications for levodopa therapy of Parkinson's disease. Neurology 1994; 44: 1292-7
    • (1994) Neurology , vol.44 , pp. 1292-1297
    • Sawle, G.V.1    Burn, D.J.2    Morrish, P.K.3
  • 71
    • 0029785290 scopus 로고    scopus 로고
    • Fluorodopa positron emission tomography with an inhibitor of catechol-O-methyltransferase: Effect of the plasma 3-O-methyldopa fraction on data analysis
    • 71. Ishikawa T, Dhawan V, Chaly T, et al. Fluorodopa positron emission tomography with an inhibitor of catechol-O-methyltransferase: effect of the plasma 3-O-methyldopa fraction on data analysis. J Cerebral Blood Flow Metab 1996; 16: 854-63
    • (1996) J Cerebral Blood Flow Metab , vol.16 , pp. 854-863
    • Ishikawa, T.1    Dhawan, V.2    Chaly, T.3
  • 72
    • 0029417246 scopus 로고
    • 18F]fluorodopa utilization after COMT inhibition with entacapone studied with PET in advanced Parkinson's disease
    • 18F]fluorodopa utilization after COMT inhibition with entacapone studied with PET in advanced Parkinson's disease. J Neural Transm Park Dis Dem Sect 1995; 10: 91-106
    • (1995) J Neural Transm Park Dis Dem Sect , vol.10 , pp. 91-106
    • Ruottinen, H.1    Rinne, J.2    Ruotsalainen, U.3
  • 73
    • 0030609109 scopus 로고    scopus 로고
    • Striatal 6-[18F]fluorodopa accumulation after combined inhibition of peripheral catechol-O-methyltransferase and monoamine oxidase type B: Differing response in relation to presynaptic dopaminergic dysfunction
    • 73. Ruottinen HM, Rinne JO, Oikonen VJ, et al. Striatal 6-[18F]fluorodopa accumulation after combined inhibition of peripheral catechol-O-methyltransferase and monoamine oxidase type B: differing response in relation to presynaptic dopaminergic dysfunction. Synapse 1997; 27: 336-46
    • (1997) Synapse , vol.27 , pp. 336-346
    • Ruottinen, H.M.1    Rinne, J.O.2    Oikonen, V.J.3
  • 74
    • 0028137620 scopus 로고
    • Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease
    • 74. Merello M, Lees AJ, Webster R, et al. Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 1994; 57: 186-9
    • (1994) J Neurol Neurosurg Psychiatry , vol.57 , pp. 186-189
    • Merello, M.1    Lees, A.J.2    Webster, R.3
  • 75
    • 0029000679 scopus 로고
    • Effects of tolcapone in Parkinson's patients taking L-dihydroxyphenylalanine/carbidopa and selegiline
    • 75. Davis TL, Roznoski M, Burns RS. Effects of tolcapone in Parkinson's patients taking L-dihydroxyphenylalanine/carbidopa and selegiline. Mov Disord 1995; 10: 349-51
    • (1995) Mov Disord , vol.10 , pp. 349-351
    • Davis, T.L.1    Roznoski, M.2    Burns, R.S.3
  • 76
    • 0030778373 scopus 로고    scopus 로고
    • Entacapone improves motor fluctuations in levodopa-treated Parkinson's disease patients
    • 76. Parkinson Study Group. Entacapone improves motor fluctuations in levodopa-treated Parkinson's disease patients. Ann Neurol 1997; 42: 747-55
    • (1997) Ann Neurol , vol.42 , pp. 747-755
  • 77
    • 0031773064 scopus 로고    scopus 로고
    • Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations
    • 77. Rinne UK, Larsen JP, Siden Å, et al. Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations. Neurology 1998; 51: 1309-14
    • (1998) Neurology , vol.51 , pp. 1309-1314
    • Rinne, U.K.1    Larsen, J.P.2    Siden, Å.3
  • 78
    • 17944385730 scopus 로고    scopus 로고
    • Randomized, placebo-controlled study of tolcapone in patients with fluctuating Parkinson disease treated with levodopa-carbidopa
    • 78. Adler CH, Singer C, O'Brien C, et al. Randomized, placebo-controlled study of tolcapone in patients with fluctuating Parkinson disease treated with levodopa-carbidopa. Arch Neurol 1998; 55: 1089-95
    • (1998) Arch Neurol , vol.55 , pp. 1089-1095
    • Adler, C.H.1    Singer, C.2    O'Brien, C.3
  • 79
    • 0031028464 scopus 로고    scopus 로고
    • Tolcapone improves motor function and reduces levodopa requirement in patients with Parkinson's disease experiencing motor fluctuations: A multicenter, double-blind, randomized, placebo-controlled trial
    • Tolcapone Fluctuator Study Group I
    • 79. Kurth MC, Adler CH, Hilaire MS, et al. Tolcapone improves motor function and reduces levodopa requirement in patients with Parkinson's disease experiencing motor fluctuations: a multicenter, double-blind, randomized, placebo-controlled trial. Tolcapone Fluctuator Study Group I. Neurology 1997; 48: 81-7
    • (1997) Neurology , vol.48 , pp. 81-87
    • Kurth, M.C.1    Adler, C.H.2    Hilaire, M.S.3
  • 80
    • 0030700836 scopus 로고    scopus 로고
    • Efficacy and safety of tolcapone in levodopa-treated Parkinson's disease patients with 'wearing-off' phenomenon: A multicentre, double-blind, randomized, placebo-controlled study
    • 80. Myllylä VV, Jackson M, Larsen JP, et al. Efficacy and safety of tolcapone in levodopa-treated Parkinson's disease patients with 'wearing-off' phenomenon: a multicentre, double-blind, randomized, placebo-controlled study. Eur J Neurol 1997; 4: 333-41
    • (1997) Eur J Neurol , vol.4 , pp. 333-341
    • Myllylä, V.V.1    Jackson, M.2    Larsen, J.P.3
  • 81
    • 0030880324 scopus 로고    scopus 로고
    • Catechol-O-methyl-transferase inhibition with tolcapone reduces the 'wearing off' phenomenon and levodopa requirements in fluctuating parkinsonian patients
    • 81. Baas H, Beiske AG, Ghika J, et al. Catechol-O-methyl-transferase inhibition with tolcapone reduces the 'wearing off' phenomenon and levodopa requirements in fluctuating parkinsonian patients. J Neurol Neurosurg Psychiatry 1997; 63: 421-8
    • (1997) J Neurol Neurosurg Psychiatry , vol.63 , pp. 421-428
    • Baas, H.1    Beiske, A.G.2    Ghika, J.3
  • 82
    • 0030669245 scopus 로고    scopus 로고
    • Tolcapone improves motor function in parkinsonian patients with the 'wearing-off' phenomenon: A double-blind, placebo-controlled, multicenter trial
    • 82. Rajput AH, Martin W, Sainthilaire MH, et al. Tolcapone improves motor function in parkinsonian patients with the 'wearing-off' phenomenon: a double-blind, placebo-controlled, multicenter trial. Neurology 1997; 49: 1066-71
    • (1997) Neurology , vol.49 , pp. 1066-1071
    • Rajput, A.H.1    Martin, W.2    Sainthilaire, M.H.3
  • 83
    • 0027174943 scopus 로고
    • Ro 40-7592, a COMT inhibitor, plus levodopa in Parkinson's disease
    • 83. Limousin P, Pollak P, Gervason-Tournier CL, et al. Ro 40-7592, a COMT inhibitor, plus levodopa in Parkinson's disease. Lancet 1993; 341: 1605
    • (1993) Lancet , vol.341 , pp. 1605
    • Limousin, P.1    Pollak, P.2    Gervason-Tournier, C.L.3
  • 84
    • 0013654490 scopus 로고
    • Catechol-O-methyltransferase (COMT) inhibitor Ro 40-7592 prolongs duration of action of levodopa/carbidopa in parkinsonian patients
    • 84. Roberts JW, Cora-Locatelli G, Bravi D, et al. Catechol-O-methyltransferase (COMT) inhibitor Ro 40-7592 prolongs duration of action of levodopa/carbidopa in parkinsonian patients. Neurology 1993; 43 Suppl. 2: A332
    • (1993) Neurology , vol.43 , Issue.SUPPL. 2
    • Roberts, J.W.1    Cora-Locatelli, G.2    Bravi, D.3
  • 85
    • 0030695512 scopus 로고    scopus 로고
    • Tolcapone added to levodopa in stable parkinsonian patients: A double-blind placebo-controlled study
    • 85. Dupont E, Burgunder JM, Findley LJ, et al. Tolcapone added to levodopa in stable parkinsonian patients: a double-blind placebo-controlled study. Mov Disord 1997; 12: 928-34
    • (1997) Mov Disord , vol.12 , pp. 928-934
    • Dupont, E.1    Burgunder, J.M.2    Findley, L.J.3
  • 86
    • 0030833203 scopus 로고    scopus 로고
    • Tolcapone in stable Parkinson's disease: Efficacy and safety of long-term treatment
    • 86. Waters CH, Kurth M, Bailey P, et al. Tolcapone in stable Parkinson's disease: efficacy and safety of long-term treatment. Neurology 1997; 49: 665-71
    • (1997) Neurology , vol.49 , pp. 665-671
    • Waters, C.H.1    Kurth, M.2    Bailey, P.3
  • 87
    • 0030794892 scopus 로고    scopus 로고
    • Tolcapone, bromocriptine, and Parkinson's disease
    • 87. Agid Y, Destee A, Durif F, et al. Tolcapone, bromocriptine, and Parkinson's disease. Lancet 1997; 350: 712-3
    • (1997) Lancet , vol.350 , pp. 712-713
    • Agid, Y.1    Destee, A.2    Durif, F.3
  • 88
    • 0032528718 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase inhibitors in Parkinson's disease
    • 88. Harper J, Vieira B. Catechol-O-methyltransferase inhibitors in Parkinson's disease. Lancet 1998; 352: 578
    • (1998) Lancet , vol.352 , pp. 578
    • Harper, J.1    Vieira, B.2
  • 89
    • 0032572195 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase inhibitors in Parkinson's disease
    • 89. Henry C, Wilson JA. Catechol-O-methyltransferase inhibitors in Parkinson's disease. Lancet 1998; 351: 1965-6
    • (1998) Lancet , vol.351 , pp. 1965-1966
    • Henry, C.1    Wilson, J.A.2
  • 90
    • 7344259588 scopus 로고    scopus 로고
    • A pilot evaluation of the tolerability, safety, and efficacy of tolcapone alone and in combination with oral selegiline in untreated Parkinson's disease patients
    • 90. Hauser RA, Molho E, Shale H, et al. A pilot evaluation of the tolerability, safety, and efficacy of tolcapone alone and in combination with oral selegiline in untreated Parkinson's disease patients. Mov Disord 1998; 13: 643-7
    • (1998) Mov Disord , vol.13 , pp. 643-647
    • Hauser, R.A.1    Molho, E.2    Shale, H.3
  • 91
    • 0032547507 scopus 로고    scopus 로고
    • Tolcapone and fulminant hepatitis
    • 91. Assal F, Spahr L, Hadengue A, et al. Tolcapone and fulminant hepatitis. Lancet 1998; 352: 958
    • (1998) Lancet , vol.352 , pp. 958
    • Assal, F.1    Spahr, L.2    Hadengue, A.3
  • 93
    • 85037953073 scopus 로고    scopus 로고
    • Nutley (NJ): Roche Laboratories Inc.
    • 93. Tasmar Product Label. Nutley (NJ): Roche Laboratories Inc., 1998
    • (1998) Tasmar Product Label
  • 94
    • 0033067361 scopus 로고    scopus 로고
    • The effect of tolcapone on the pharmacokinetics of benserazide
    • 94. Jorga KM, Larsen JP, Beiske A, et al. The effect of tolcapone on the pharmacokinetics of benserazide. Eur J Neurol 1999; 6: 211-19
    • (1999) Eur J Neurol , vol.6 , pp. 211-219
    • Jorga, K.M.1    Larsen, J.P.2    Beiske, A.3
  • 95
    • 0025803672 scopus 로고
    • Central action of benserazide after COMT inhibition demonstrated in vivo by PET
    • 95. Tedroff J, Hartvig P, Bjurling P, et al. Central action of benserazide after COMT inhibition demonstrated in vivo by PET. J Neural Transm Gen Sect 1991; 85: 11-7
    • (1991) J Neural Transm Gen Sect , vol.85 , pp. 11-17
    • Tedroff, J.1    Hartvig, P.2    Bjurling, P.3
  • 96
    • 0029160593 scopus 로고
    • The effect of entacapone on the disposition and hemodynamic effects of intravenous isoproterenol and epinephrine
    • 96. Illi A, Sundberg S, Ojala-Karlsson P, et al. The effect of entacapone on the disposition and hemodynamic effects of intravenous isoproterenol and epinephrine. Clin Pharmacol Ther 1995; 58: 221-7
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 221-227
    • Illi, A.1    Sundberg, S.2    Ojala-Karlsson, P.3
  • 97
    • 0000209717 scopus 로고    scopus 로고
    • Comparison between the effects of L-dopa + entacapone and L-dopa + placebo on exercise capacity, haemodynamics and autonomic function in patients with Parkinson's disease
    • 97. Lyytinen J, Kaakkola S, Teräväinen H, et al. Comparison between the effects of L-dopa + entacapone and L-dopa + placebo on exercise capacity, haemodynamics and autonomic function in patients with Parkinson's disease. Mov Disord 1997; 12 Suppl. 1: 103
    • (1997) Mov Disord , vol.12 , Issue.SUPPL. 1 , pp. 103
    • Lyytinen, J.1    Kaakkola, S.2    Teräväinen, H.3
  • 98
    • 0013675459 scopus 로고    scopus 로고
    • Lack of interaction between ephedrine and combination of tolcapone and sinemet
    • 98. Sedek G, Jorga K, Yoo K, et al. Lack of interaction between ephedrine and combination of tolcapone and sinemet. Neurology 1996; 46 Suppl. 2: 374
    • (1996) Neurology , vol.46 , Issue.SUPPL. 2 , pp. 374
    • Sedek, G.1    Jorga, K.2    Yoo, K.3
  • 99
    • 0029881150 scopus 로고    scopus 로고
    • Simultaneous inhibition of catechol-O-methyltransferase and monoamine oxidase A: Effects on hemodynamics and catecholamine metabolism in healthy volunteers
    • 99. Illi A, Sundberg S, Ojala-Karlsson P, et al. Simultaneous inhibition of catechol-O-methyltransferase and monoamine oxidase A: effects on hemodynamics and catecholamine metabolism in healthy volunteers. Clin Pharmacol Ther 1996; 59: 450-7
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 450-457
    • Illi, A.1    Sundberg, S.2    Ojala-Karlsson, P.3
  • 100
    • 0030476572 scopus 로고    scopus 로고
    • Simultaneous inhibition of catecholamine-O-methylation by entacapone and neuronal uptake by imipramine: Lack of interactions
    • 100. Illi A, Sundberg S, Ojala-Karlsson P, et al. Simultaneous inhibition of catecholamine-O-methylation by entacapone and neuronal uptake by imipramine: lack of interactions. Eur J Clin Pharmacol 1996; 51: 273-6
    • (1996) Eur J Clin Pharmacol , vol.51 , pp. 273-276
    • Illi, A.1    Sundberg, S.2    Ojala-Karlsson, P.3
  • 101
    • 4243253123 scopus 로고    scopus 로고
    • Effect of the COMT inhibitor tolcapone on the hemodynamics effects and tolerability of the combination treatment with levodopa/carbidopa and desipramine in healthy volunteers
    • 101. Jorga K, Fotteler B, Sedek G, et al. Effect of the COMT inhibitor tolcapone on the hemodynamics effects and tolerability of the combination treatment with levodopa/carbidopa and desipramine in healthy volunteers. Neurology 1997; 48 Suppl.: A185
    • (1997) Neurology , vol.48 , Issue.SUPPL.
    • Jorga, K.1    Fotteler, B.2    Sedek, G.3
  • 102
    • 0025972964 scopus 로고
    • Iron supplements: A common cause of drug interactions
    • 102. Campbell NRC, Hasinoff BB. Iron supplements: a common cause of drug interactions. Br J Clin Pharmacol 1991; 31: 251-5
    • (1991) Br J Clin Pharmacol , vol.31 , pp. 251-255
    • Campbell, N.R.C.1    Hasinoff, B.B.2
  • 103
    • 0030838542 scopus 로고    scopus 로고
    • Iron(III)-chelating properties of the novel catechol O-methyltransferase inhibitor entacapone in aqueous solution
    • 103. Orama M, Tilus P, Taskinen J, et al. Iron(III)-chelating properties of the novel catechol O-methyltransferase inhibitor entacapone in aqueous solution. J Pharm Sci 1997; 86: 827-31
    • (1997) J Pharm Sci , vol.86 , pp. 827-831
    • Orama, M.1    Tilus, P.2    Taskinen, J.3
  • 104
    • 0032565377 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase inhibitors for treatment of Parkinson's disease
    • 104. Nutt JG. Catechol-O-methyltransferase inhibitors for treatment of Parkinson's disease. Lancet 1998; 351: 1221-2
    • (1998) Lancet , vol.351 , pp. 1221-1222
    • Nutt, J.G.1
  • 105
    • 0030952242 scopus 로고    scopus 로고
    • Effects of selective catechol-O-methyltransferase inhibitors on single-trial passive avoidance retention in male rats
    • 105. Khromova I, Voronina T, Kraineva VA, et al. Effects of selective catechol-O-methyltransferase inhibitors on single-trial passive avoidance retention in male rats. Behav Brain Res 1997; 86: 49-57
    • (1997) Behav Brain Res , vol.86 , pp. 49-57
    • Khromova, I.1    Voronina, T.2    Kraineva, V.A.3
  • 106
    • 0028276602 scopus 로고
    • Tolcapone: A potential new antidepressant detected in a novel animal model of depression
    • 106. Moreau JL, Borgulya J, Jenck F, et al. Tolcapone: a potential new antidepressant detected in a novel animal model of depression. Behav Pharmacol 1994; 5: 344-50
    • (1994) Behav Pharmacol , vol.5 , pp. 344-350
    • Moreau, J.L.1    Borgulya, J.2    Jenck, F.3
  • 107
    • 0028907751 scopus 로고
    • Improved therapy of Parkinson's Disease with tolcapone, a central and peripheral COMT inhibitor with an S-adenosyl-L-methione-sparing effect
    • 107. Da Prada M, Borgulya J, Napolitano A, et al. Improved therapy of Parkinson's Disease with tolcapone, a central and peripheral COMT inhibitor with an S-adenosyl-L-methione-sparing effect. Clin Neuropharmacol 1994; 17 Suppl. 3: S26-37
    • (1994) Clin Neuropharmacol , vol.17 , Issue.SUPPL. 3
    • Da Prada, M.1    Borgulya, J.2    Napolitano, A.3
  • 108
    • 0031976109 scopus 로고    scopus 로고
    • Inhibitors of catecholamine metabolizing enzymes cause changes in S-adenosyl-methionine and S-adenosylhomocysteine in the rat brain
    • 108. Yassin MS, Cheng H, Ekblom J, et al. Inhibitors of catecholamine metabolizing enzymes cause changes in S-adenosyl-methionine and S-adenosylhomocysteine in the rat brain. Neurochem Int 1998; 32: 53-9
    • (1998) Neurochem Int , vol.32 , pp. 53-59
    • Yassin, M.S.1    Cheng, H.2    Ekblom, J.3
  • 109
    • 0030663092 scopus 로고    scopus 로고
    • Cognitive improvement during tolcapone treatment in Parkinson's disease
    • 109. Gasparini M, Fabrizio E, Bonifati V, et al. Cognitive improvement during tolcapone treatment in Parkinson's disease. J Neural Transm 1997; 104: 887-94
    • (1997) J Neural Transm , vol.104 , pp. 887-894
    • Gasparini, M.1    Fabrizio, E.2    Bonifati, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.