Mammalian steroid hormones are substrates for the major RND- and MFS-type tripartite multidrug efflux pumps of Escherichia coli

Journal of Bacteriology

Volumn 188, Issue 3, 2006, Pages 1191-1195

  Elkins, Christopher A ^a   Mullis, Lisa B ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRAB PROTEIN; BACTERIAL PROTEIN; BILE ACID; CHOLIC ACID; EMRAB PROTEIN; ESTRADIOL; HYDROCORTISONE; MEMBRANE PROTEIN; PROGESTERONE; STEROID HORMONE; TAUROCHOLIC ACID; TOLC PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENOME; BACTERIAL GROWTH; BACTERIUM MUTANT; ESCHERICHIA COLI; HORMONE ACTION; ISOTOPE LABELING; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

BIOLOGICAL TRANSPORT; DRUG RESISTANCE, MULTIPLE; ESCHERICHIA COLI; MEMBRANE TRANSPORT PROTEINS; PROTON-MOTIVE FORCE; STEROIDS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA;

EID: 31344433137     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.188.3.1191-1195.2006     Document Type: Article

References (25)

1. Baranova, N., and H. Nikaido. 2002. The BaeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. J. Bacteriol. 184:4168-4176.
2. Baron, S. F., and P. B. Hylemon. 1997. Biotransformation of bile acids, cholesterol, and steroid hormones, p. 470-510. In R. I. Mackie and B. A. White (ed.), Gastrointestinal microbiology, vol. I. Gastrointestinal ecosystems and fermentations. International Thomson Publishing, New York, N.Y.
3. Datsenko, K. A., and B. L. Wanner. 2000. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. USA 97:6640-6645.
4. Elkins, C. A., and L. B. Mullis. 2004. Bile-mediated aminoglycoside sensitivity in Lactobacillus species likely results from increased membrane permeability attributable to cholic acid. Appl. Environ. Microbiol. 70:7200-7209.
5. Elkins, C. A., and H. Nikaido. 2003. Chimeric analysis of AcrA function reveals the importance of its C-terminal domain in its interaction with the AcrB multidrug efflux pump. J. Bacteriol. 185:5349-5356.
6. Elkins, C. A., and H. Nikaido. 2002. Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops. J. Bacteriol. 184:6490-6498.
7. George, A. M., and S. B. Levy. 1983. Amplifiable resistance to tetracycline, chloramphenicol, and other antibiotics in Escherichia coli: involvement of a nonplasmid-determined efflux of tetracycline. J. Bacteriol. 155:531-540.
8. Graves, V., E. Suraya, and O. Nishikiza. 1977. Hydrolysis of steroid glucuronides with β-glucuronidase from bovine liver, Helix pomatia and Escherichia coli. Clin. Chem. 23:532-535.
9. Hamilton, K. O., M. A. Yazdanian, and K. L. Audus. 2001. Modulation of P-glycoprotein activity in Calu-3 cells using steroids and beta-ligands. Int. J. Pharm. 228:171-179.
10. Jerse, A. E., N. D. Sharma, A. N. Simms, E. T. Crow, L. A. Snyder, and W. M. Shafer. 2003. A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection. Infect. Immun. 71:5576-5582.
11. Li, X. Z., and H. Nikaido. 2004. Efflux-mediated drug resistance in bacteria. Drugs 64:159-204.
12. Nagakubo, S., K. Nishino, T. Hirata, and A. Yamaguchi. 2002. The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC. J. Bacteriol. 184:4161-4167.
13. Nishino, K., and A. Yamaguchi. 2001. Analysis of a complete library of putative drug transporter genes in Escherichia coli. J. Bacteriol. 183:5803-5812.
14. Paulsen, I. T., J. Chen, K. E. Nelson, and M. H. Saier, Jr. 2001. Comparative genomics of microbial drug efflux systems. J. Mol. Microbiol. Biotechnol. 3:145-150.
15. Prouty, A. M., I. E. Brodsky, S. Falkow, and J. S. Gunn. 2004. Bile-salt-mediated induction of antimicrobial and bile resistance in Salmonella typhimurium. Microbiology 150:775-783.
16. Prouty, A. M., I. E. Brodsky, J. Manos, R. Belas, S. Falkow, and J. S. Gunn. 2004. Transcriptional regulation of Salmonella enterica serovar Typhimurium genes by bile. FEMS Immunol. Med. Microbiol. 41:177-185.
17. Rosenberg, E. Y., D. Bertenthal, M. L. Milles, K. P. Bertrand, and H. Nikaido. 2003. Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein. Mol. Microbiol. 48:1609-1619.
18. Rosenberg, E. Y., D. Ma, and H. Nikaido. 2000. AcrD of Escherichia coli is an aminoglycoside efflux pump. J. Bacteriol. 182:1754-1756.
19. Silver, S., and E. Levine. 1968. Action of steroidal diamines on active transport and permeability properties of Escherichia coli. J. Bacteriol. 96:338-345.
20. Sulavik, M. C., C. Houseweart, C. Cramer, N. Jiwani, N. Murgolo, J. Greene, B. DiDomenico, K. J. Shaw, G. H. Miller, R. Hare, and G. Shimer. 2001. Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes. Antimicrob. Agents Chemother. 45:1126-1136.
21. Thanassi, D. G., L. W. Cheng, and H. Nikaido. 1997. Active efflux of bile salts by Escherichia coli. J. Bacteriol, 179:2512-2518.
22. Van Eldere, J., J. Robben, G. De Pauw, R. Merckx, and H. Eyssen. 1988. Isolation and identification of intestinal steroid-desulfating bacteria from rats and humans. Appl. Environ. Microbiol. 54:2112-2117.
23. Yoshimoto, T., H. Higashi, A. Kanatani, X. S. Lin, H. Nagai, H. Oyama, K. Kurazono, and D. Tsuru. 1991. Cloning and sequencing of the 7 α-hydroxysteroid dehydrogenase gene from Escherichia coli HB101 and characterization of the expressed enzyme. J. Bacteriol. 173:2173-2179.
24. Yu, E. W., G. McDermott, H. I. Zgurskaya, H. Nikaido, and D. E. Koshland, Jr. 2003. Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science 300:976-980.
25. Zgurskaya, H. I., and H. Nikaido. 1999. Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli. Proc. Natl. Acad. Sci. USA 96:7190-7195.