Transient lower esophageal sphincter relaxations in dogs are inhibited by a metabotropic glutamate receptor 5 antagonist

European Journal of Pharmacology

Volumn 519, Issue 1-2, 2005, Pages 154-157

  Jensen, Jörgen ^a   Lehmann, Anders ^a   Uvebrant, Anna ^a   Carlsson, Anita ^a   Jerndal, Gunilla ^a   Nilsson, Karolina ^a   Frisby, Claudine ^b   Blackshaw, L Ashley ^b,c   Mattsson, Jan P ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b ROYAL ADELAIDE HOSPITAL   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

2 methyl 6 (phenylethynyl) pyridine; Gastroesophageal reflux; Glutamate; Lower esophageal sphincter; MPEP

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; GLUTAMATE RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; 6 METHYL 2 (PHENYLETHYNYL)PYRIDINE; 6-METHYL-2-(PHENYLETHYNYL)PYRIDINE; AMINO ACID RECEPTOR BLOCKING AGENT; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 5; PYRIDINE DERIVATIVE; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG INHIBITION; DRUG MECHANISM; FEMALE; GASTROESOPHAGEAL REFLUX; LATENT PERIOD; LOWER ESOPHAGUS SPHINCTER; MALE; NONHUMAN; PRIORITY JOURNAL; SWALLOWING; ANIMAL; BINDING COMPETITION; BINDING SITE; DRUG ANTAGONISM; DRUG EFFECT; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; MUSCLE RELAXATION; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESOPHAGEAL SPHINCTER, LOWER; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GASTROESOPHAGEAL REFLUX; INJECTIONS, INTRAVENOUS; MALE; MUSCLE RELAXATION; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; TRITIUM;

EID: 27744549064     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.07.007     Document Type: Article

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