Metabolic actions of growth hormone in man

Endocrine Journal

Volumn 43, Issue SUPPL., 1996, Pages

  Ho, Ken K Y ^a   O'Sullivan, Anthony J ^a   Hoffman, David M ^a  

^a ST VINCENT S HOSPITAL   (Australia)

Author keywords

Body composition; GH; IGF 1; Metabolism; Sodium

Indexed keywords

GLUCOSE; GROWTH HORMONE; INSULIN; LIPID; SODIUM ION; SOMATOMEDIN C;

ACROMEGALY; ARTICLE; BODY COMPOSITION; CHILD GROWTH; GLUCOSE TRANSPORT; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HUMAN; HYPERINSULINEMIA; LIPOLYSIS; OBESITY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SODIUM RETENTION;

EID: 0030457101     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.43.suppl_s57     Document Type: Article

References (38)

1. Novak L, Hayles A, Cloutier M (1972) Effect of hGH on body composition in hypopituitaiy dwarfs. Four compartment analysis and composite body densitometry. Mayo Clinic Proc 47: 241-246.
2. Rutherford OM, Jones DA, Round JM, Buchanan CR, Preece MA (1991) Changes in skeletal muscle and body composition after discontinuation of growth hormone treatment in growth hormone deficient young adults. Clin Endocrinol 34: 469-475.
3. Beyshah SA, Freemantle C, Thomas E, Rutherford O, Page B, Murphy M, Johnson DG (1995) Abnormal body composition and reduced bone mass in growth hormone deficient hypopituitary adults. Clin Endocrinol 42: 179-189.
4. Hoffman DM, O'Sullivan AJ, Freund J, Ho KKY (1995) Adults with growth hormone deficiency have abnormal body composition but normal energy metabolism. J Clin Endocrinol Metab 80: 72-77.
5. Binnerts A, Swart GR, Wilson JHP, Hoogerbrugge N, Pols HAP, Birkenhager JC, Lamberts SW (1992) The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition. Clin Endocrinol 37: 79-87.
6. Jorgensen JOL, Theusen L, Ingemann-Hansen T, Pedersen SA, Jorgensen J, Christiansen JS (1989) Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1: 1221-1225.
7. Whitehead HM, Boreham C, McIlrath EM, Sheridan B, Kennedy L, Atkinson AB, Hadden DR (1992) Growth hormone treatment of adults with growth hormone deficiency: Results of a 13 month placebo controlled cross-over study. Clin Endocrinol 36: 45-52.
8. Salomon F, Cuneo RC, Hesp R, Sonksen PH (1989) The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. New Engl J Med 321: 1797-1803.
9. Bengtsson B-A, Eden S, Lonn L, Kvist H, Stokland A, Lindstedt G, Boseus I, Tolli J, Sjostrom L, Isaksson OGP (1993) Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J Clin Endocrinol Metab 76: 309-317.
10. Binnerts A, Wilson JH, Lamberts SWJ (1988) The effects of human growth hormone administration in elderly adults with recent weight loss. J Clin Endocrinol Metab 67: 1312-1316.
11. Amato G, Carella C, Fazio S, La Motagna G, Cittadini A, Sabatini D, Marciono-Mone C, L. S, Bellastella A (1993) Body composition, bone metabolism, and heart structure and function in growth hormone (GH) deficient adults before and after GH replacement therapy. J Clin Endocrinol Metab 77: 1671-1676.
12. Lapidus L, Bengtsson C, Larsson B, Pennert K, Rybo E, Sjostrom L (1984) Distribution of adipose tissue and risk of cardiovascular disease and death: A 12 year follow up of participants in the population study of women in Gothenburg, Sweden. Br Med J 289: 1257-1262.
13. Lundgren H, Bengtssen C, Blohme G, Lapidus L, Sjostrom L (1989) Adiposity and adipose tissue distribution in relation to incidence of diabetes in women: Results from a prospective population study in Gothenburg. Int J Obes 13: 413-423.
14. De Boer H, Blok GJ, Voerman HJ, Phillips M, Schouten JA (1994) Serum lipid levels in growth hormone deficient men. Metabolism 43: 199-203.
15. Beyshah SA, Henderseon A, Nithayanathan R, Sharp P, Richmond W (1994) Metabolic abnormalities in growth hormone deficient adults: Carbohydrate tolerance and lipid metabolism. Endocrinol Metab 1: 173-180.
16. Markussis V, Beyshah SA, Fisher C, Sharp P, Nicholaides AN, Johnston DG (1992) Detection of premature atherosclerosis by high resolution ultrasonography in symptom-free hypopituiary adults. Lancet 340: 1188-1192.
17. Rosen T, Bengtsson B-A (1990) Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 336: 285-288.
18. Bengtsson B-A, Brummer R, Eden S, Bosaeus I (1989) Body composition in acromegaly. Clin Endocrinol 30: 121-130.
19. O'Sullivan AJ, Kelly JJ, Hoffman DH, Freund J, Rajkovic IA, Ho KKY (1994) Body composition and energy expenditure in acromegaly. J Clin Endocrinol Metab 78: 381-386.
20. Moller N, Jorgensen JOL, Alberti KGMM, Flyvbjerg A, Schmitz O (1990) Short-term effects of growth hormone on fuel oxidation and regional substrate metabolism in normal man. J Clin Endocrinol Metab 70: 1179-1186.
21. Horber F, Marsh H, Haymond M (1991) Differential effects of prednisone and growth hormone on fuel metabolism and insulin antagonism in humans. Diabetes 40: 141-149.
22. Horber F, Haymond M (1990) Human growth hormone prevents the protein catabolic effects of prednisone in humans. J Clin Invest 86: 265-272.
23. O'Sullivan AJ, Kelly JJ, Hoffman DM, Baxter RC, Ho KKY (1995) Energy metabolism and substrate utilization in acromegaly. J Clin Endocrinol Metab 80: 486-491.
24. Boulware SD, Tamborlane WV, Matthews LS, Sherwin RS (1992) Diverse effects of insulin-like growth factor I on glucose, lipid and amino acid metabolism. Am J Physiol 262: E130-E133.
25. Lewitt MS, Denyer GS, Cooney GJ, Baxter RC (1991) Insulin-like growth factor binding protein 1 modulates glucose levels. Endocrinology 129: 2254-2256.
26. Baxter RC (1993) Circulating binding proteins for the insulin-like growth factors. Trends in Endocrinology and Metabolism 4: 91-95.
27. Ho KY, Weissberger AJ, Stuart MC, Day RO, Lazarus L (1989) The pharmacokinetic, safety and endocrine effects of authentic biosynthetic human growth hormone in normal subjects. Clin Endocrinol 30: 335-345.
28. Kupfer SR, Underwood LE, Baxter RC, Clemmons DR (1993) Enhancement of the anabolic effects of growth hormone and insulin-like growth factor1 by use of both agents simultaneouly. J Clin Invest 91: 391-396.
29. Leung KC, Rajkovic IA, Peters E, Van Wyk JJ, Ho KKY (1996) IGF-1 and insulin down-regulate growth hormone (GH) receptors in rat osteoblasts: evidence for a peripheral feedback loop regulating GH action. Endocrinology 137: 2694-2702.
30. Ikkos D, Ljunggren H, Luft R (1956) Basal metabolic rate in relation to body size and cell mass in acromegaly. Acta Endocrinol 21: 237-234.
31. Karlander S, Vranic M, Efendic S (1986) Increased glucose turnover and glucose cycling in acromegalic patients with normal glucose tolerance. Diabetalogia 29: 778-783.
32. Beck J, McGarry E, Dyrenfurth I, Venning E (1957) Metabolic effects of human and monkey growth hormone in man. Science 125: 884-885.
33. Biglieri E, Watlington C, Forsham P (1961) Sodium retention with human growth hormone and its subfractions. J Clin Endo Metab 21: 361-370.
34. Ho KY, Weissberger AJ (1990) The antinatriuretic action of biosynthetic human growth hormone in man involves activation of the renin-angiotensin system. Metabolism 39: 133-137.
35. Moller J, Jorgensen JOL, Moller N, Hansen KW, Pedersen EB, Christiansen JS (1991) Expansion of extracellular volume and suppression of atrial natriureric peptide after growth hormone administration in normal man. J Clin Endocrinol Metab 70: 1179-1186.
36. Kelly JJ, Yeates P, Freund J, Ho KKY (1993) Sodium hoeostasis and blood pressure in acromegaly: Relation to growth hormone concentration and effects of Sandostatin treatment. Proc of the 34th Ann Scientific Meeting of the Endocrine Society of Australia, Adelaide, Australia, Abstract: 131.
37. Hoffman DM, Crampton L, Sernia C, Nguyen TV, Ho KKY (1996) Short term growth hormone (GH) treatment of GH deficient adults increases body sodium and extracellular water but not blood pressure. J Clin Endocrinol Metab 81: 1123-1128..
38. Rogers SA, Hammerman MR (1989) Growth hormone activates phospholipase C in proximal tubular basolateral membranes from the canine kidney. Proc Natl Acad Sci 86: 6363-6366.