Cycloheximide-mediated sensitization to TNF-α-induced apoptosis in human colorectal cancer cell line COLO 205; role of FLIP and metabolic inhibitors

Journal of Physiology and Pharmacology

Volumn 56, Issue SUPPL. 3, 2005, Pages 101-118

  Pajak B ^a   Gajkowska, B ^b   Orzechowski, A ^a  

^a WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

^b POLISH ACADEMY OF SCIENCES   (Poland)

Author keywords

Apoptosis; Colorectal cancer; Cycloheximide; FLIP; TNF

Indexed keywords

CALCIMYCIN; CALCIUM; CYCLOHEXIMIDE; EDETIC ACID; EGTAZIC ACID; FLICE INHIBITORY PROTEIN; PROTEIN NOXA; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; CALCIUM SIGNALING; CANCER CELL CULTURE; CELL DEATH; CELL PROTECTION; CELL STRAIN; CELL SURVIVAL; CELL VIABILITY; COLORECTAL CARCINOMA; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; HUMAN CELL; MEDICAL ASSESSMENT; METABOLIC INHIBITION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SENSITIZATION; SIGNAL TRANSDUCTION;

APOPTOSIS; CALCIMYCIN; CALCIUM; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL LINE, TUMOR; CELL SURVIVAL; CHELATING AGENTS; COLORECTAL NEOPLASMS; CYCLOHEXIMIDE; DACTINOMYCIN; DRUG SYNERGISM; EDETIC ACID; EGTAZIC ACID; ENZYME ACTIVATION; ENZYME ACTIVATORS; HUMANS; IONOPHORES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PROTEIN SYNTHESIS INHIBITORS; SIGNAL TRANSDUCTION; STAUROSPORINE; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS; TUMOR ESCAPE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 31144434529     PISSN: 08675910     EISSN: 08675910     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (31)

1. Gruss HJ, Duyster J, Herrmann F. Structural and biological features of the TNF receptor and TNF ligand superfamilies: interactive signals in the pathobiology of Hodgkin's disease. Ann Oncol 1996; 7: 673-682.
2. Herbeuval J-P, Lambert C, Sabido O, Cottier M, Fournel P, Dy M, Genin C. Macrophages from cancer patients: analysis of TRAIL, TRAIL receptors, and colon tumor cell apoptosis. J Natl Cancer Inst 2003; 95: 611-621.
3. Lin HL, Liu TY, Wu CW, Chi CW. Berberine modulates expression of mdr1 gene product and the responses of digestive tract cancer cells to Paclitaxel. Br J Cancer 1999; 81: 416-22.
4. Salvesen GS, Dixit VM. Caspase activation: the induced-proximity model. Proc Natl Acad Sci 1999; 96: 10964-10967.
5. Duan H, Dixit VM. RAIDD is a new "death" adaptor molecule. Nature 1997; 385: 86-89.
6. Song HY, Regnier CH, Kirschning CJ, Goeddel DV, Rothe M. Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc Natl Acad Sci USA 1997; 94: 9792-9796.
7. Sarma V, Lin Z, Clark L, Rust BM, Tewari M, Noelle RJ, Dixit VM. Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. J Biol Chem 1995; 270: 12343-12346.
8. Chu Z-L, McKinsey TA, Liu L, Gentry JJ, Malim MH, Ballard DW. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control. Proc Natl Acad Sci USA 1997; 94: 10057-10062.
9. Wang C-Y, Mayo MV, Korneluk RG, Goeddel DV, Baldwin MJ. NF-κB antiapoptotis: induction of TRAF1 and TRAF2 and cIAP1 and cIAP2 to suppress caspase-8 activation. Science 1998; 281: 1680-1683.
10. Wu MX, Ao Z, Prasad VS, Wu R, Schlossman SF. IEX-1L, an apoptosis inhibitor involved in NF-κB-mediated cell survival. Science 1998; 281: 998-1001.
11. Zong W-X, Edelstein LC, Chen C, Bash J, Gelinas C. The prosurvival homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis. Genes Dev 1999; 13: 382-387.
12. L. Mol Cell Biol 2000; 20: 2687-2695.
13. Krueger A, Baumann S, Krammer PH, Kirchhoff S. FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis. Mol Cell Biol 2001; 21: 8247-8254.
14. French L, Tschopp J. Inhibition of death receptor signaling by FLICE-inhibitory protein as a mechanism for immune escape of tumors. J Exp Med 1999; 190: 891-893.
15. Micheau O, Lens S, Gaide O, Alevizopoulos K, Tchopp J. NF-κB signals induce the expression of c-FLIP. Mol Cell Biol 2001; 21: 5299-5305.
16. Xiao CW, Asselin E, Tsang BK. Nuclear factor kB-mediated induction of Flice-like inhibitory protein prevents tumor necrosis factor a-induced apoptosis in rat granuloma cells. Biol Reprod 2002; 67: 436-441.
17. Kataoka T, Tschopp J. N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-κB signaling pathway. Mol Cell Biol 2004; 24: 2627-2636.
18. L in colonic adenocarcinoma. J Pathol 2001; 194: 15-19.
19. Kreuz S, Siegmund D, Scheurich P, Wajant H. NF-κB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Mol Cell Biol 2001; 21: 3964-3973.
20. Fulda S, Meyer E, Debatin K-M. Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression. Cancer Res 2000; 60: 3947-3956.
21. Hernandez A, Wang Q-D, Schwartz SA, Evers BM. Sensitization of human colon cancer cells to TRAIL-mediated apoptosis. J Gastrointest Surg 2001; 5: 56-65.
22. Lewis AE, Wong BCY, Langman MJS, Eggo MC. Protein kinase C inhibition induces DNA fragmentation in COLO 205 cells which is blocked by cysteine protease inhibition but not mediated through caspase-3. Exp Cell Res 2003; 289: 1-10.
23. Wang X, Wang Q, Hu W, Evers BM. Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-κB- dependent pathway. Oncogene 2004; 23: 1885-1895.
24. Zhang S, Ong C-N, Shen H-M. Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells. Cancer Lett 2004; 208: 143-153.
25. Jacobson MD, Burne JF, Raff MC. Programmed cell death and Bcl-2 protection in the absence of a nucleus. EMBO J 1994; 13: 1899-1910.
26. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 1976; 72: 248-254.
27. Muro S, Takemasa I, Oba S, Matoba R, Ueno N, Matuyama C, Yamashita R, Sekimoto M, Yamamoto H, Nakamori S, Monden M, Ishii S, Kato K. Identification of expressed genes linked to malignancy of human colorectal carcinoma by parametric clustering of quantitative expression data. Genome Biol 2003; 4: R21.
28. Pucci S, Bonanno E, Pichiorri F, Angeloni C, Spagnoli LG. Modulation of different clusterin isoforms in human colon tumorigenesis. Oncogene 2004, 1-7.
29. 2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells. Cell Death Differ 2005, 12: 101-104.
30. Draper DW, Harris VG, Culver CA, Laster SM. Calcium and its role in the nuclear translocation and activation of cytosolic phospholipase A2 in cells rendered sensitive to TNF-induced apoptosis by cycloheximide. J Immunol 2004; 15: 2416-2423.
31. Bhattacharya J, Chakrabarti MK. Rise of intracellular free calcium levels with activation of inositol triphosphate in a human colonic carcinoma cell line (COLO 205) by heat-stable enterotoxin of Escherichia coli. Biochem Biophys Acta 1998; 27: 1-4.